PubMed:19931172 JSONTXT

{"project":"PubCasesHPO","denotations":[{"id":"TI1","span":{"begin":20,"end":37},"obj":"HP:0007687"},{"id":"AB1","span":{"begin":154,"end":162},"obj":"HP:0002665"},{"id":"AB2","span":{"begin":168,"end":176},"obj":"HP:0001909"},{"id":"AB3","span":{"begin":221,"end":228},"obj":"HP:0000979"},{"id":"AB4","span":{"begin":233,"end":260},"obj":"HP:0001890"},{"id":"AB5","span":{"begin":478,"end":484},"obj":"HP:0000508"},{"id":"AB6","span":{"begin":531,"end":559},"obj":"HP:0006721"},{"id":"AB7","span":{"begin":561,"end":567},"obj":"HP:0000508"},{"id":"AB8","span":{"begin":720,"end":726},"obj":"HP:0000508"},{"id":"AB9","span":{"begin":847,"end":853},"obj":"HP:0000508"}],"text":"Vincristine-induced unilateral ptosis in a child.\nVincristine is a vinca alkaloid used in combination with other agents in the treatment of solid tumors, lymphoma, and leukemia, as well as for idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia. A dose-limiting complication of vinca alkaloids is neurotoxicity. Vincristine is the oldest and also the most neurotoxic agent in this group. Described here is the case of a 4-year-old girl with unilateral palpebral ptosis. She has been diagnosed with precursor B-cell acute lymphoblastic leukemia. Ptosis was noted on the 45th day of therapy, and the last vincristine was administered on the 28th day of protocol 1. Vincristine-induced unilateral palpebral ptosis is a novel finding. Experience with this case suggests conservative treatment, with periodic examination, especially if ptosis is mild."}

{"project":"PubCasesORDO","denotations":[{"id":"AB1","span":{"begin":514,"end":559},"obj":"ORDO:99860"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"text":"Vincristine-induced unilateral ptosis in a child.\nVincristine is a vinca alkaloid used in combination with other agents in the treatment of solid tumors, lymphoma, and leukemia, as well as for idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia. A dose-limiting complication of vinca alkaloids is neurotoxicity. Vincristine is the oldest and also the most neurotoxic agent in this group. Described here is the case of a 4-year-old girl with unilateral palpebral ptosis. She has been diagnosed with precursor B-cell acute lymphoblastic leukemia. Ptosis was noted on the 45th day of therapy, and the last vincristine was administered on the 28th day of protocol 1. Vincristine-induced unilateral palpebral ptosis is a novel finding. Experience with this case suggests conservative treatment, with periodic examination, especially if ptosis is mild."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":49},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":50,"end":261},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":262,"end":327},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":328,"end":403},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":404,"end":485},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":486,"end":560},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":561,"end":678},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":679,"end":746},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":747,"end":862},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":49},"obj":"Sentence"},{"id":"T2","span":{"begin":50,"end":261},"obj":"Sentence"},{"id":"T3","span":{"begin":262,"end":327},"obj":"Sentence"},{"id":"T4","span":{"begin":328,"end":403},"obj":"Sentence"},{"id":"T5","span":{"begin":404,"end":485},"obj":"Sentence"},{"id":"T6","span":{"begin":486,"end":560},"obj":"Sentence"},{"id":"T7","span":{"begin":561,"end":678},"obj":"Sentence"},{"id":"T8","span":{"begin":679,"end":746},"obj":"Sentence"},{"id":"T9","span":{"begin":747,"end":862},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Vincristine-induced unilateral ptosis in a child.\nVincristine is a vinca alkaloid used in combination with other agents in the treatment of solid tumors, lymphoma, and leukemia, as well as for idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia. A dose-limiting complication of vinca alkaloids is neurotoxicity. Vincristine is the oldest and also the most neurotoxic agent in this group. Described here is the case of a 4-year-old girl with unilateral palpebral ptosis. She has been diagnosed with precursor B-cell acute lymphoblastic leukemia. Ptosis was noted on the 45th day of therapy, and the last vincristine was administered on the 28th day of protocol 1. Vincristine-induced unilateral palpebral ptosis is a novel finding. Experience with this case suggests conservative treatment, with periodic examination, especially if ptosis is mild."}