PubMed:1988951
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 26-43 | cell_line | denotes | B-cell population |
| T2 | 78-119 | DNA | denotes | human interferon regulatory factor 1 gene |
| T3 | 140-151 | protein | denotes | Interferons |
| T4 | 153-157 | protein | denotes | IFNs |
| T5 | 182-200 | protein | denotes | antiviral proteins |
| T6 | 271-275 | protein | denotes | IFNs |
| T7 | 302-308 | cell_type | denotes | normal |
| T8 | 313-335 | cell_type | denotes | transformed cell types |
| T9 | 351-365 | protein | denotes | nuclear factor |
| T10 | 367-372 | protein | denotes | IRF-1 |
| T11 | 374-404 | protein | denotes | interferon regulatory factor 1 |
| T12 | 422-432 | DNA | denotes | type I IFN |
| T13 | 442-470 | DNA | denotes | IFN-inducible gene promoters |
| T14 | 509-514 | protein | denotes | IRF-1 |
| T15 | 538-541 | protein | denotes | IFN |
| T16 | 601-611 | DNA | denotes | IRF-1 gene |
| T17 | 630-633 | protein | denotes | IFN |
| T18 | 747-763 | DNA | denotes | human IRF-1 gene |
| T19 | 778-819 | DNA | denotes | human immunoglobulin heavy-chain enhancer |
| T20 | 924-937 | cell_type | denotes | B lymphocytes |
| T21 | 939-946 | cell_type | denotes | B cells |
| T22 | 977-994 | cell_type | denotes | bone marrow cells |
| T23 | 1101-1118 | cell_type | denotes | B-cell population |
| T24 | 1129-1157 | cell_line | denotes | transgenic bone marrow cells |
| T25 | 1176-1213 | cell_line | denotes | bone marrow-derived stromal cell line |
| T26 | 1234-1240 | cell_type | denotes | B-cell |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-139 | Sentence | denotes | Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice. |
| S2 | 140-261 | Sentence | denotes | Interferons (IFNs) are well known both as antiviral proteins and as potent regulators of cell growth and differentiation. |
| S3 | 262-336 | Sentence | denotes | In fact, IFNs inhibit growth of various normal and transformed cell types. |
| S4 | 337-498 | Sentence | denotes | Previously, a nuclear factor, IRF-1 (interferon regulatory factor 1), which binds to type I IFN and some IFN-inducible gene promoters, was identified and cloned. |
| S5 | 499-689 | Sentence | denotes | Since the IRF-1 gene is both virus and IFN inducible, an intriguing issue is raised as to whether the IRF-1 gene is functioning in IFN-mediated regulation of cell growth and differentiation. |
| S6 | 690-820 | Sentence | denotes | In this study, we generated transgenic mice carrying the human IRF-1 gene linked to the human immunoglobulin heavy-chain enhancer. |
| S7 | 821-948 | Sentence | denotes | In the transgenic mice, all the lymphoid tissues examined showed a dramatic reduction in the number of B lymphocytes (B cells). |
| S8 | 949-1119 | Sentence | denotes | Preparation and analysis of bone marrow cells from the chimeric mice indicated that the bone marrow is the effective site for specific depletion of the B-cell population. |
| S9 | 1120-1260 | Sentence | denotes | In fact, transgenic bone marrow cells cocultured with a bone marrow-derived stromal cell line revealed an altered B-cell maturation pattern. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C2 | 22-43 | NP | denotes | the B-cell population |
| C1 | 0-43 | NP | denotes | Specific depletion of the B-cell population |
| C4 | 78-114 | NP | denotes | human interferon regulatory factor 1 |
| C3 | 78-119 | NP | denotes | human interferon regulatory factor 1 gene |
| C5 | 123-138 | NP | denotes | transgenic mice |
| C6 | 140-158 | NP | denotes | Interferons (IFNs) |
| C7 | 271-275 | NP | denotes | IFNs |
| C8 | 349-365 | NP | denotes | a nuclear factor |
| C9 | 367-405 | NP | denotes | IRF-1 (interferon regulatory factor 1) |
| C10 | 407-412 | NP | denotes | which |
| C11 | 422-432 | NP | denotes | type I IFN |
| C12 | 505-519 | NP | denotes | the IRF-1 gene |
| C13 | 597-611 | NP | denotes | the IRF-1 gene |
| C15 | 743-763 | NP | denotes | the human IRF-1 gene |
| C14 | 718-819 | NP | denotes | transgenic mice carrying the human IRF-1 gene linked to the human immunoglobulin heavy-chain enhancer |
| C16 | 824-843 | NP | denotes | the transgenic mice |
| C18 | 977-988 | NP | denotes | bone marrow |
| C17 | 977-1017 | NP | denotes | bone marrow cells from the chimeric mice |
| C19 | 1033-1048 | NP | denotes | the bone marrow |
| C21 | 1097-1118 | NP | denotes | the B-cell population |
| C20 | 1075-1118 | NP | denotes | specific depletion of the B-cell population |
| C22 | 1129-1157 | NP | denotes | transgenic bone marrow cells |
| R1 | C7 | C6 | coref-ident | IFNs,Interferons (IFNs) |
| R2 | C8 | C9 | coref-appos | a nuclear factor,IRF-1 (interferon regulatory factor 1) |
| R3 | C9 | C4 | coref-ident | IRF-1 (interferon regulatory factor 1),human interferon regulatory factor 1 |
| R4 | C10 | C9 | coref-relat | which,IRF-1 (interferon regulatory factor 1) |
| R5 | C11 | C9 | coref-other | type I IFN,IRF-1 (interferon regulatory factor 1) |
| R6 | C12 | C3 | coref-ident | the IRF-1 gene,human interferon regulatory factor 1 gene |
| R7 | C13 | C12 | coref-ident | the IRF-1 gene,the IRF-1 gene |
| R8 | C15 | C13 | coref-ident | the human IRF-1 gene,the IRF-1 gene |
| R9 | C14 | C5 | coref-other | transgenic mice carrying the human IRF-1 gene linked to the human immunoglobulin heavy-chain enhancer,transgenic mice |
| R10 | C16 | C14 | coref-ident | the transgenic mice,transgenic mice carrying the human IRF-1 gene linked to the human immunoglobulin heavy-chain enhancer |
| R11 | C19 | C18 | coref-ident | the bone marrow,bone marrow |
| R12 | C21 | C2 | coref-ident | the B-cell population,the B-cell population |
| R13 | C20 | C1 | coref-ident | specific depletion of the B-cell population,Specific depletion of the B-cell population |
| R14 | C22 | C17 | coref-other | transgenic bone marrow cells,bone marrow cells from the chimeric mice |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 26-43 | cell_line | denotes | B-cell population |
| T2 | 55-74 | other_name | denotes | aberrant expression |
| T3 | 78-114 | protein_molecule | denotes | human interferon regulatory factor 1 |
| T4 | 123-138 | multi_cell | denotes | transgenic mice |
| T5 | 140-151 | protein_family_or_group | denotes | Interferons |
| T6 | 153-157 | protein_family_or_group | denotes | IFNs |
| T7 | 182-200 | protein_family_or_group | denotes | antiviral proteins |
| T8 | 215-225 | other_name | denotes | regulators |
| T9 | 229-240 | other_name | denotes | cell growth |
| T10 | 245-260 | other_name | denotes | differentiation |
| T11 | 271-275 | protein_family_or_group | denotes | IFNs |
| T12 | 302-308 | cell_type | denotes | normal |
| T13 | 313-335 | cell_type | denotes | transformed cell types |
| T14 | 351-365 | protein_family_or_group | denotes | nuclear factor |
| T15 | 367-372 | protein_molecule | denotes | IRF-1 |
| T16 | 374-404 | protein_molecule | denotes | interferon regulatory factor 1 |
| T17 | 422-432 | DNA_domain_or_region | denotes | type I IFN |
| T18 | 442-445 | protein_family_or_group | denotes | IFN |
| T19 | 509-514 | protein_molecule | denotes | IRF-1 |
| T20 | 538-541 | protein_family_or_group | denotes | IFN |
| T21 | 601-606 | protein_molecule | denotes | IRF-1 |
| T22 | 630-633 | protein_family_or_group | denotes | IFN |
| T23 | 657-668 | other_name | denotes | cell growth |
| T24 | 673-688 | other_name | denotes | differentiation |
| T25 | 718-733 | multi_cell | denotes | transgenic mice |
| T26 | 747-752 | DNA_domain_or_region | denotes | human |
| T27 | 753-758 | protein_molecule | denotes | IRF-1 |
| T28 | 778-810 | protein_subunit | denotes | human immunoglobulin heavy-chain |
| T29 | 828-843 | multi_cell | denotes | transgenic mice |
| T30 | 853-869 | tissue | denotes | lymphoid tissues |
| T31 | 924-937 | cell_type | denotes | B lymphocytes |
| T32 | 939-946 | cell_type | denotes | B cells |
| T33 | 977-994 | cell_type | denotes | bone marrow cells |
| T34 | 1037-1048 | tissue | denotes | bone marrow |
| T35 | 1101-1118 | cell_type | denotes | B-cell population |
| T36 | 1129-1157 | cell_line | denotes | transgenic bone marrow cells |
| T37 | 1176-1213 | cell_line | denotes | bone marrow-derived stromal cell line |
| T38 | 1234-1240 | cell_type | denotes | B-cell |