PubMed:19880293 JSON TXT

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LitCoin-sentences

{"project":"LitCoin-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":66},"obj":"Sentence"},{"id":"T2","span":{"begin":67,"end":78},"obj":"Sentence"},{"id":"T3","span":{"begin":79,"end":172},"obj":"Sentence"},{"id":"T4","span":{"begin":173,"end":298},"obj":"Sentence"},{"id":"T5","span":{"begin":299,"end":450},"obj":"Sentence"},{"id":"T6","span":{"begin":451,"end":590},"obj":"Sentence"},{"id":"T7","span":{"begin":591,"end":653},"obj":"Sentence"},{"id":"T8","span":{"begin":654,"end":664},"obj":"Sentence"},{"id":"T9","span":{"begin":665,"end":786},"obj":"Sentence"},{"id":"T10","span":{"begin":787,"end":795},"obj":"Sentence"},{"id":"T11","span":{"begin":796,"end":939},"obj":"Sentence"},{"id":"T12","span":{"begin":940,"end":1204},"obj":"Sentence"},{"id":"T13","span":{"begin":1205,"end":1362},"obj":"Sentence"},{"id":"T14","span":{"begin":1363,"end":1371},"obj":"Sentence"},{"id":"T15","span":{"begin":1372,"end":1609},"obj":"Sentence"},{"id":"T16","span":{"begin":1610,"end":1750},"obj":"Sentence"},{"id":"T17","span":{"begin":1751,"end":1890},"obj":"Sentence"},{"id":"T18","span":{"begin":1891,"end":2004},"obj":"Sentence"},{"id":"T19","span":{"begin":2005,"end":2225},"obj":"Sentence"},{"id":"T20","span":{"begin":2226,"end":2359},"obj":"Sentence"},{"id":"T21","span":{"begin":2360,"end":2467},"obj":"Sentence"},{"id":"T22","span":{"begin":2468,"end":2520},"obj":"Sentence"}],"text":"Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients.\nBACKGROUND: Psoriasis is a common dermatological disorder, in which autoimmunity plays an important role. CD4(+)CD25(+) regulatory T cells (T-regs) have been suggested to be involved in the pathogenesis of some autoimmune diseases. T-regs express the fork head/winged helix transcription factor, FOXP3, which appears to be of key importance in the development and function of T-regs. Studies have found that single-nucleotide polymorphisms (SNPs) in the FOXP3 gene contribute to susceptibility to some autoimmune disorders. However, information about FOXP3 gene in psoriasis is limited.\nOBJECTIVE: This study evaluated the association between FOXP3 gene SNPs and susceptibility to psoriasis in a Han Chinese population.\nMETHODS: In a hospital-based case-control study, 524 patients with psoriasis and 549 psoriasis-free controls were recruited according to age and gender. We investigated four SNPs in the FOXP3 gene (-6054, deletion/ATT; -3279, A/C; -924, A/G; IVS9+459, A/G) in psoriatic patients, and assessed allele and genotype frequencies in psoriatic patients (237 females, 287 males) and normal controls (272 females, 277 males). The polymorphisms were genotyped using the PCR sequence-specific primer (PCR-SSP) technique and PCR-restriction fragment length polymorphism (RFLP) analysis.\nRESULTS: We found that increased risk of psoriasis was associated with the FOXP3 -3279 AC genotype (adjusted OR, 1.32; 95% CI, 1.01-1.74) and the combined AC+AA genotype (adjusted OR, 1.38; 95% CI, 1.07-1.78), compared with the -3279 CC genotype. We also found that an increased risk of psoriasis was associated with the FOXP3 IVS9+459 GG genotype (adjusted OR, 2.24; 95% CI, 1.41-3.58). However, the combined GA+GG genotype showed no such tendency (adjusted OR=1.28; 95% CI, 1.00-1.64), compared with the IVS9+459 AA genotype. There was no evidence of an increased risk associated with the FOXP3-6054 deletion/ATT or FOXP3-924 A/G genotype. In combined genotype analyses, the FOXP3-3279 AC+AA genotype was more obviously associated in males (adjusted OR=1.60, 95% CI=1.11-2.31) and severe psoriasis patients (PASI score \u003e20; adjusted OR=1.97, 95% CI=1.41-2.75). Meanwhile, the FOXP3 IVS9+459 GA+GG genotype was also associated with severe psoriasis patients (adjusted OR=1.69, 95% CI=1.21-2.36).\nCONCLUSIONS: FOXP3 polymorphisms appear to contribute to the risk of psoriasis in a Han Chinese population. Larger studies are needed to confirm these findings."}

LitCoin-entities

LitCoin_Mondo

{"project":"LitCoin_Mondo","denotations":[{"id":"T1","span":{"begin":47,"end":56},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":79,"end":88},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":278,"end":297},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":632,"end":641},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":748,"end":757},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":854,"end":863},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":872,"end":881},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":1404,"end":1413},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":1650,"end":1659},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":2153,"end":2162},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":2303,"end":2312},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":2429,"end":2438},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0005083"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0005083"},{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005083"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"0005083"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0005083"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"0005083"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0005083"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0007179"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0005083"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"0005083"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0005083"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0005083"}],"text":"Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients.\nBACKGROUND: Psoriasis is a common dermatological disorder, in which autoimmunity plays an important role. CD4(+)CD25(+) regulatory T cells (T-regs) have been suggested to be involved in the pathogenesis of some autoimmune diseases. T-regs express the fork head/winged helix transcription factor, FOXP3, which appears to be of key importance in the development and function of T-regs. Studies have found that single-nucleotide polymorphisms (SNPs) in the FOXP3 gene contribute to susceptibility to some autoimmune disorders. However, information about FOXP3 gene in psoriasis is limited.\nOBJECTIVE: This study evaluated the association between FOXP3 gene SNPs and susceptibility to psoriasis in a Han Chinese population.\nMETHODS: In a hospital-based case-control study, 524 patients with psoriasis and 549 psoriasis-free controls were recruited according to age and gender. We investigated four SNPs in the FOXP3 gene (-6054, deletion/ATT; -3279, A/C; -924, A/G; IVS9+459, A/G) in psoriatic patients, and assessed allele and genotype frequencies in psoriatic patients (237 females, 287 males) and normal controls (272 females, 277 males). The polymorphisms were genotyped using the PCR sequence-specific primer (PCR-SSP) technique and PCR-restriction fragment length polymorphism (RFLP) analysis.\nRESULTS: We found that increased risk of psoriasis was associated with the FOXP3 -3279 AC genotype (adjusted OR, 1.32; 95% CI, 1.01-1.74) and the combined AC+AA genotype (adjusted OR, 1.38; 95% CI, 1.07-1.78), compared with the -3279 CC genotype. We also found that an increased risk of psoriasis was associated with the FOXP3 IVS9+459 GG genotype (adjusted OR, 2.24; 95% CI, 1.41-3.58). However, the combined GA+GG genotype showed no such tendency (adjusted OR=1.28; 95% CI, 1.00-1.64), compared with the IVS9+459 AA genotype. There was no evidence of an increased risk associated with the FOXP3-6054 deletion/ATT or FOXP3-924 A/G genotype. In combined genotype analyses, the FOXP3-3279 AC+AA genotype was more obviously associated in males (adjusted OR=1.60, 95% CI=1.11-2.31) and severe psoriasis patients (PASI score \u003e20; adjusted OR=1.97, 95% CI=1.41-2.75). Meanwhile, the FOXP3 IVS9+459 GA+GG genotype was also associated with severe psoriasis patients (adjusted OR=1.69, 95% CI=1.21-2.36).\nCONCLUSIONS: FOXP3 polymorphisms appear to contribute to the risk of psoriasis in a Han Chinese population. Larger studies are needed to confirm these findings."}

LitCoin-GeneOrGeneProduct-v0

LitCoin-GeneOrGeneProduct-v2

LitCoin-Disease-MeSH

LitCoin-GeneOrGeneProduct-v3

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T1","span":{"begin":21,"end":26},"obj":"GeneOrGeneProduct"},{"id":"T2","span":{"begin":179,"end":183},"obj":"GeneOrGeneProduct"},{"id":"T3","span":{"begin":318,"end":327},"obj":"GeneOrGeneProduct"},{"id":"T4","span":{"begin":328,"end":361},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":363,"end":368},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":521,"end":526},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":618,"end":623},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":710,"end":715},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":973,"end":978},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":1438,"end":1443},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":1684,"end":1689},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":1954,"end":1959},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":1981,"end":1986},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":2040,"end":2045},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":2241,"end":2246},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":2373,"end":2378},"obj":"GeneOrGeneProduct"}],"text":"Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients.\nBACKGROUND: Psoriasis is a common dermatological disorder, in which autoimmunity plays an important role. CD4(+)CD25(+) regulatory T cells (T-regs) have been suggested to be involved in the pathogenesis of some autoimmune diseases. T-regs express the fork head/winged helix transcription factor, FOXP3, which appears to be of key importance in the development and function of T-regs. Studies have found that single-nucleotide polymorphisms (SNPs) in the FOXP3 gene contribute to susceptibility to some autoimmune disorders. However, information about FOXP3 gene in psoriasis is limited.\nOBJECTIVE: This study evaluated the association between FOXP3 gene SNPs and susceptibility to psoriasis in a Han Chinese population.\nMETHODS: In a hospital-based case-control study, 524 patients with psoriasis and 549 psoriasis-free controls were recruited according to age and gender. We investigated four SNPs in the FOXP3 gene (-6054, deletion/ATT; -3279, A/C; -924, A/G; IVS9+459, A/G) in psoriatic patients, and assessed allele and genotype frequencies in psoriatic patients (237 females, 287 males) and normal controls (272 females, 277 males). The polymorphisms were genotyped using the PCR sequence-specific primer (PCR-SSP) technique and PCR-restriction fragment length polymorphism (RFLP) analysis.\nRESULTS: We found that increased risk of psoriasis was associated with the FOXP3 -3279 AC genotype (adjusted OR, 1.32; 95% CI, 1.01-1.74) and the combined AC+AA genotype (adjusted OR, 1.38; 95% CI, 1.07-1.78), compared with the -3279 CC genotype. We also found that an increased risk of psoriasis was associated with the FOXP3 IVS9+459 GG genotype (adjusted OR, 2.24; 95% CI, 1.41-3.58). However, the combined GA+GG genotype showed no such tendency (adjusted OR=1.28; 95% CI, 1.00-1.64), compared with the IVS9+459 AA genotype. There was no evidence of an increased risk associated with the FOXP3-6054 deletion/ATT or FOXP3-924 A/G genotype. In combined genotype analyses, the FOXP3-3279 AC+AA genotype was more obviously associated in males (adjusted OR=1.60, 95% CI=1.11-2.31) and severe psoriasis patients (PASI score \u003e20; adjusted OR=1.97, 95% CI=1.41-2.75). Meanwhile, the FOXP3 IVS9+459 GA+GG genotype was also associated with severe psoriasis patients (adjusted OR=1.69, 95% CI=1.21-2.36).\nCONCLUSIONS: FOXP3 polymorphisms appear to contribute to the risk of psoriasis in a Han Chinese population. Larger studies are needed to confirm these findings."}

LitCoin_Mondo_095

LitCoin-MeSH-Disease-2

LitCoin-MONDO_bioort2019

LitCoin-NCBITaxon-2

{"project":"LitCoin-NCBITaxon-2","denotations":[{"id":"T1","span":{"begin":57,"end":65},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":840,"end":848},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":1057,"end":1065},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":1125,"end":1133},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":2163,"end":2171},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":2313,"end":2321},"obj":"OrganismTaxon"}],"text":"Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients.\nBACKGROUND: Psoriasis is a common dermatological disorder, in which autoimmunity plays an important role. CD4(+)CD25(+) regulatory T cells (T-regs) have been suggested to be involved in the pathogenesis of some autoimmune diseases. T-regs express the fork head/winged helix transcription factor, FOXP3, which appears to be of key importance in the development and function of T-regs. Studies have found that single-nucleotide polymorphisms (SNPs) in the FOXP3 gene contribute to susceptibility to some autoimmune disorders. However, information about FOXP3 gene in psoriasis is limited.\nOBJECTIVE: This study evaluated the association between FOXP3 gene SNPs and susceptibility to psoriasis in a Han Chinese population.\nMETHODS: In a hospital-based case-control study, 524 patients with psoriasis and 549 psoriasis-free controls were recruited according to age and gender. We investigated four SNPs in the FOXP3 gene (-6054, deletion/ATT; -3279, A/C; -924, A/G; IVS9+459, A/G) in psoriatic patients, and assessed allele and genotype frequencies in psoriatic patients (237 females, 287 males) and normal controls (272 females, 277 males). The polymorphisms were genotyped using the PCR sequence-specific primer (PCR-SSP) technique and PCR-restriction fragment length polymorphism (RFLP) analysis.\nRESULTS: We found that increased risk of psoriasis was associated with the FOXP3 -3279 AC genotype (adjusted OR, 1.32; 95% CI, 1.01-1.74) and the combined AC+AA genotype (adjusted OR, 1.38; 95% CI, 1.07-1.78), compared with the -3279 CC genotype. We also found that an increased risk of psoriasis was associated with the FOXP3 IVS9+459 GG genotype (adjusted OR, 2.24; 95% CI, 1.41-3.58). However, the combined GA+GG genotype showed no such tendency (adjusted OR=1.28; 95% CI, 1.00-1.64), compared with the IVS9+459 AA genotype. There was no evidence of an increased risk associated with the FOXP3-6054 deletion/ATT or FOXP3-924 A/G genotype. In combined genotype analyses, the FOXP3-3279 AC+AA genotype was more obviously associated in males (adjusted OR=1.60, 95% CI=1.11-2.31) and severe psoriasis patients (PASI score \u003e20; adjusted OR=1.97, 95% CI=1.41-2.75). Meanwhile, the FOXP3 IVS9+459 GA+GG genotype was also associated with severe psoriasis patients (adjusted OR=1.69, 95% CI=1.21-2.36).\nCONCLUSIONS: FOXP3 polymorphisms appear to contribute to the risk of psoriasis in a Han Chinese population. Larger studies are needed to confirm these findings."}

LitCoin-training-merged

DisGeNET

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":1438,"end":1443},"obj":"gene:50943"},{"id":"T1","span":{"begin":1404,"end":1413},"obj":"disease:C0033860"},{"id":"T2","span":{"begin":1684,"end":1689},"obj":"gene:50943"},{"id":"T3","span":{"begin":1650,"end":1659},"obj":"disease:C0033860"},{"id":"T4","span":{"begin":2373,"end":2378},"obj":"gene:50943"},{"id":"T5","span":{"begin":2429,"end":2438},"obj":"disease:C0033860"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients.\nBACKGROUND: Psoriasis is a common dermatological disorder, in which autoimmunity plays an important role. CD4(+)CD25(+) regulatory T cells (T-regs) have been suggested to be involved in the pathogenesis of some autoimmune diseases. T-regs express the fork head/winged helix transcription factor, FOXP3, which appears to be of key importance in the development and function of T-regs. Studies have found that single-nucleotide polymorphisms (SNPs) in the FOXP3 gene contribute to susceptibility to some autoimmune disorders. However, information about FOXP3 gene in psoriasis is limited.\nOBJECTIVE: This study evaluated the association between FOXP3 gene SNPs and susceptibility to psoriasis in a Han Chinese population.\nMETHODS: In a hospital-based case-control study, 524 patients with psoriasis and 549 psoriasis-free controls were recruited according to age and gender. We investigated four SNPs in the FOXP3 gene (-6054, deletion/ATT; -3279, A/C; -924, A/G; IVS9+459, A/G) in psoriatic patients, and assessed allele and genotype frequencies in psoriatic patients (237 females, 287 males) and normal controls (272 females, 277 males). The polymorphisms were genotyped using the PCR sequence-specific primer (PCR-SSP) technique and PCR-restriction fragment length polymorphism (RFLP) analysis.\nRESULTS: We found that increased risk of psoriasis was associated with the FOXP3 -3279 AC genotype (adjusted OR, 1.32; 95% CI, 1.01-1.74) and the combined AC+AA genotype (adjusted OR, 1.38; 95% CI, 1.07-1.78), compared with the -3279 CC genotype. We also found that an increased risk of psoriasis was associated with the FOXP3 IVS9+459 GG genotype (adjusted OR, 2.24; 95% CI, 1.41-3.58). However, the combined GA+GG genotype showed no such tendency (adjusted OR=1.28; 95% CI, 1.00-1.64), compared with the IVS9+459 AA genotype. There was no evidence of an increased risk associated with the FOXP3-6054 deletion/ATT or FOXP3-924 A/G genotype. In combined genotype analyses, the FOXP3-3279 AC+AA genotype was more obviously associated in males (adjusted OR=1.60, 95% CI=1.11-2.31) and severe psoriasis patients (PASI score \u003e20; adjusted OR=1.97, 95% CI=1.41-2.75). Meanwhile, the FOXP3 IVS9+459 GA+GG genotype was also associated with severe psoriasis patients (adjusted OR=1.69, 95% CI=1.21-2.36).\nCONCLUSIONS: FOXP3 polymorphisms appear to contribute to the risk of psoriasis in a Han Chinese population. Larger studies are needed to confirm these findings."}

Allie

{"project":"Allie","denotations":[{"id":"SS1_19880293_5_0","span":{"begin":475,"end":506},"obj":"expanded"},{"id":"SS2_19880293_5_0","span":{"begin":508,"end":512},"obj":"abbr"},{"id":"SS1_19880293_12_0","span":{"begin":1248,"end":1276},"obj":"expanded"},{"id":"SS2_19880293_12_0","span":{"begin":1278,"end":1285},"obj":"abbr"},{"id":"SS1_19880293_12_1","span":{"begin":1301,"end":1345},"obj":"expanded"},{"id":"SS2_19880293_12_1","span":{"begin":1347,"end":1351},"obj":"abbr"}],"relations":[{"id":"AE1_19880293_5_0","pred":"abbreviatedTo","subj":"SS1_19880293_5_0","obj":"SS2_19880293_5_0"},{"id":"AE1_19880293_12_0","pred":"abbreviatedTo","subj":"SS1_19880293_12_0","obj":"SS2_19880293_12_0"},{"id":"AE1_19880293_12_1","pred":"abbreviatedTo","subj":"SS1_19880293_12_1","obj":"SS2_19880293_12_1"}],"text":"Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients.\nBACKGROUND: Psoriasis is a common dermatological disorder, in which autoimmunity plays an important role. CD4(+)CD25(+) regulatory T cells (T-regs) have been suggested to be involved in the pathogenesis of some autoimmune diseases. T-regs express the fork head/winged helix transcription factor, FOXP3, which appears to be of key importance in the development and function of T-regs. Studies have found that single-nucleotide polymorphisms (SNPs) in the FOXP3 gene contribute to susceptibility to some autoimmune disorders. However, information about FOXP3 gene in psoriasis is limited.\nOBJECTIVE: This study evaluated the association between FOXP3 gene SNPs and susceptibility to psoriasis in a Han Chinese population.\nMETHODS: In a hospital-based case-control study, 524 patients with psoriasis and 549 psoriasis-free controls were recruited according to age and gender. We investigated four SNPs in the FOXP3 gene (-6054, deletion/ATT; -3279, A/C; -924, A/G; IVS9+459, A/G) in psoriatic patients, and assessed allele and genotype frequencies in psoriatic patients (237 females, 287 males) and normal controls (272 females, 277 males). The polymorphisms were genotyped using the PCR sequence-specific primer (PCR-SSP) technique and PCR-restriction fragment length polymorphism (RFLP) analysis.\nRESULTS: We found that increased risk of psoriasis was associated with the FOXP3 -3279 AC genotype (adjusted OR, 1.32; 95% CI, 1.01-1.74) and the combined AC+AA genotype (adjusted OR, 1.38; 95% CI, 1.07-1.78), compared with the -3279 CC genotype. We also found that an increased risk of psoriasis was associated with the FOXP3 IVS9+459 GG genotype (adjusted OR, 2.24; 95% CI, 1.41-3.58). However, the combined GA+GG genotype showed no such tendency (adjusted OR=1.28; 95% CI, 1.00-1.64), compared with the IVS9+459 AA genotype. There was no evidence of an increased risk associated with the FOXP3-6054 deletion/ATT or FOXP3-924 A/G genotype. In combined genotype analyses, the FOXP3-3279 AC+AA genotype was more obviously associated in males (adjusted OR=1.60, 95% CI=1.11-2.31) and severe psoriasis patients (PASI score \u003e20; adjusted OR=1.97, 95% CI=1.41-2.75). Meanwhile, the FOXP3 IVS9+459 GA+GG genotype was also associated with severe psoriasis patients (adjusted OR=1.69, 95% CI=1.21-2.36).\nCONCLUSIONS: FOXP3 polymorphisms appear to contribute to the risk of psoriasis in a Han Chinese population. Larger studies are needed to confirm these findings."}

DisGeNET5_gene_disease

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"19880293-16#0#5#gene50943","span":{"begin":2373,"end":2378},"obj":"gene50943"},{"id":"19880293-16#56#65#diseaseC0033860","span":{"begin":2429,"end":2438},"obj":"diseaseC0033860"},{"id":"19880293-2#6#10#gene3559","span":{"begin":179,"end":183},"obj":"gene3559"},{"id":"19880293-2#6#10#gene3669","span":{"begin":179,"end":183},"obj":"gene3669"},{"id":"19880293-2#105#124#diseaseC0004364","span":{"begin":278,"end":297},"obj":"diseaseC0004364"},{"id":"19880293-4#70#75#gene50943","span":{"begin":521,"end":526},"obj":"gene50943"},{"id":"19880293-4#118#138#diseaseC0004364","span":{"begin":569,"end":589},"obj":"diseaseC0004364"}],"relations":[{"id":"0#5#gene5094356#65#diseaseC0033860","pred":"associated_with","subj":"19880293-16#0#5#gene50943","obj":"19880293-16#56#65#diseaseC0033860"},{"id":"6#10#gene3559105#124#diseaseC0004364","pred":"associated_with","subj":"19880293-2#6#10#gene3559","obj":"19880293-2#105#124#diseaseC0004364"},{"id":"6#10#gene3669105#124#diseaseC0004364","pred":"associated_with","subj":"19880293-2#6#10#gene3669","obj":"19880293-2#105#124#diseaseC0004364"},{"id":"70#75#gene50943118#138#diseaseC0004364","pred":"associated_with","subj":"19880293-4#70#75#gene50943","obj":"19880293-4#118#138#diseaseC0004364"}],"text":"Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients.\nBACKGROUND: Psoriasis is a common dermatological disorder, in which autoimmunity plays an important role. CD4(+)CD25(+) regulatory T cells (T-regs) have been suggested to be involved in the pathogenesis of some autoimmune diseases. T-regs express the fork head/winged helix transcription factor, FOXP3, which appears to be of key importance in the development and function of T-regs. Studies have found that single-nucleotide polymorphisms (SNPs) in the FOXP3 gene contribute to susceptibility to some autoimmune disorders. However, information about FOXP3 gene in psoriasis is limited.\nOBJECTIVE: This study evaluated the association between FOXP3 gene SNPs and susceptibility to psoriasis in a Han Chinese population.\nMETHODS: In a hospital-based case-control study, 524 patients with psoriasis and 549 psoriasis-free controls were recruited according to age and gender. We investigated four SNPs in the FOXP3 gene (-6054, deletion/ATT; -3279, A/C; -924, A/G; IVS9+459, A/G) in psoriatic patients, and assessed allele and genotype frequencies in psoriatic patients (237 females, 287 males) and normal controls (272 females, 277 males). The polymorphisms were genotyped using the PCR sequence-specific primer (PCR-SSP) technique and PCR-restriction fragment length polymorphism (RFLP) analysis.\nRESULTS: We found that increased risk of psoriasis was associated with the FOXP3 -3279 AC genotype (adjusted OR, 1.32; 95% CI, 1.01-1.74) and the combined AC+AA genotype (adjusted OR, 1.38; 95% CI, 1.07-1.78), compared with the -3279 CC genotype. We also found that an increased risk of psoriasis was associated with the FOXP3 IVS9+459 GG genotype (adjusted OR, 2.24; 95% CI, 1.41-3.58). However, the combined GA+GG genotype showed no such tendency (adjusted OR=1.28; 95% CI, 1.00-1.64), compared with the IVS9+459 AA genotype. There was no evidence of an increased risk associated with the FOXP3-6054 deletion/ATT or FOXP3-924 A/G genotype. In combined genotype analyses, the FOXP3-3279 AC+AA genotype was more obviously associated in males (adjusted OR=1.60, 95% CI=1.11-2.31) and severe psoriasis patients (PASI score \u003e20; adjusted OR=1.97, 95% CI=1.41-2.75). Meanwhile, the FOXP3 IVS9+459 GA+GG genotype was also associated with severe psoriasis patients (adjusted OR=1.69, 95% CI=1.21-2.36).\nCONCLUSIONS: FOXP3 polymorphisms appear to contribute to the risk of psoriasis in a Han Chinese population. Larger studies are needed to confirm these findings."}

tmVarCorpus

{"project":"tmVarCorpus","denotations":[{"id":"T1","span":{"begin":985,"end":1004},"obj":"DNAMutation:c|DEL|-6054|ATT"},{"id":"T2","span":{"begin":1006,"end":1016},"obj":"DNAMutation:c|SUB|A|-3279|C"},{"id":"T3","span":{"begin":1018,"end":1027},"obj":"DNAMutation:c|SUB|A|-924|G"},{"id":"T4","span":{"begin":1029,"end":1042},"obj":"DNAMutation:c|SUB|A|IVS9+459|G"},{"id":"T5","span":{"begin":1959,"end":1977},"obj":"DNAMutation:c|DEL|-6054|ATT"},{"id":"T6","span":{"begin":1986,"end":1994},"obj":"DNAMutation:c|SUB|A|-924|G"}],"text":"Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients.\nBACKGROUND: Psoriasis is a common dermatological disorder, in which autoimmunity plays an important role. CD4(+)CD25(+) regulatory T cells (T-regs) have been suggested to be involved in the pathogenesis of some autoimmune diseases. T-regs express the fork head/winged helix transcription factor, FOXP3, which appears to be of key importance in the development and function of T-regs. Studies have found that single-nucleotide polymorphisms (SNPs) in the FOXP3 gene contribute to susceptibility to some autoimmune disorders. However, information about FOXP3 gene in psoriasis is limited.\nOBJECTIVE: This study evaluated the association between FOXP3 gene SNPs and susceptibility to psoriasis in a Han Chinese population.\nMETHODS: In a hospital-based case-control study, 524 patients with psoriasis and 549 psoriasis-free controls were recruited according to age and gender. We investigated four SNPs in the FOXP3 gene (-6054, deletion/ATT; -3279, A/C; -924, A/G; IVS9+459, A/G) in psoriatic patients, and assessed allele and genotype frequencies in psoriatic patients (237 females, 287 males) and normal controls (272 females, 277 males). The polymorphisms were genotyped using the PCR sequence-specific primer (PCR-SSP) technique and PCR-restriction fragment length polymorphism (RFLP) analysis.\nRESULTS: We found that increased risk of psoriasis was associated with the FOXP3 -3279 AC genotype (adjusted OR, 1.32; 95% CI, 1.01-1.74) and the combined AC+AA genotype (adjusted OR, 1.38; 95% CI, 1.07-1.78), compared with the -3279 CC genotype. We also found that an increased risk of psoriasis was associated with the FOXP3 IVS9+459 GG genotype (adjusted OR, 2.24; 95% CI, 1.41-3.58). However, the combined GA+GG genotype showed no such tendency (adjusted OR=1.28; 95% CI, 1.00-1.64), compared with the IVS9+459 AA genotype. There was no evidence of an increased risk associated with the FOXP3-6054 deletion/ATT or FOXP3-924 A/G genotype. In combined genotype analyses, the FOXP3-3279 AC+AA genotype was more obviously associated in males (adjusted OR=1.60, 95% CI=1.11-2.31) and severe psoriasis patients (PASI score \u003e20; adjusted OR=1.97, 95% CI=1.41-2.75). Meanwhile, the FOXP3 IVS9+459 GA+GG genotype was also associated with severe psoriasis patients (adjusted OR=1.69, 95% CI=1.21-2.36).\nCONCLUSIONS: FOXP3 polymorphisms appear to contribute to the risk of psoriasis in a Han Chinese population. Larger studies are needed to confirm these findings."}