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PubMed:1985913 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 941-950 Glycan_Motif denotes T antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-88 Sentence denotes Transcriptional activation and nuclear targeting signals of the human androgen receptor.
T2 89-235 Sentence denotes The androgen receptor (AR) is a signal-transducing protein required for sexual differentiation, development, and expression of the male phenotype.
T3 236-475 Sentence denotes A series of human AR deletion mutants were created either by site-directed mutagenesis using restriction enzyme digestion, the polymerase chain reaction, or, for a series of unidirectional NH2-terminal deletions, exonuclease III digestion.
T4 476-663 Sentence denotes Receptor mutants were expressed in monkey kidney COS cells as truncated AR proteins between 20 and 107 kDa as revealed on immunoblots, where wild type AR was a doublet of 114 and 108 kDa.
T5 664-816 Sentence denotes Subcellular localization by immunocytochemical staining demonstrated androgen-dependent nuclear uptake of AR from a perinuclear region of the cytoplasm.
T6 817-1016 Sentence denotes A nuclear targeting signal similar in sequence and position to the glucocorticoid receptor and homologous to the SV40 large T antigen was required for androgen-induced nuclear uptake of wild type AR.
T7 1017-1150 Sentence denotes AR mutants lacking the NH2-terminal and/or steroid binding domains were constitutively nuclear with reduced transcriptional activity.
T8 1151-1363 Sentence denotes Transcriptional activation by wild type AR was androgen-dependent in cotransfection studies of CV1 cells using the chloramphenicol acetyltransferase reporter gene linked to the mouse mammary tumor virus promoter.
T9 1364-1599 Sentence denotes Deletion mutagenesis revealed within the NH2-terminal region a domain required for full transcriptional activity and within the steroid binding domain, an inhibitory function, deletion of which yielded a constitutively active receptor.
T10 1600-1764 Sentence denotes Inhibition of wild type AR by coexpression with an inactive NH2-terminal fragment suggested competition for nuclear factors required for transcriptional regulation.
T11 1765-1882 Sentence denotes These studies demonstrate a concerted interplay among the domains of the AR protein in regulating gene transcription.
T1 0-88 Sentence denotes Transcriptional activation and nuclear targeting signals of the human androgen receptor.
T2 89-235 Sentence denotes The androgen receptor (AR) is a signal-transducing protein required for sexual differentiation, development, and expression of the male phenotype.
T3 236-475 Sentence denotes A series of human AR deletion mutants were created either by site-directed mutagenesis using restriction enzyme digestion, the polymerase chain reaction, or, for a series of unidirectional NH2-terminal deletions, exonuclease III digestion.
T4 476-663 Sentence denotes Receptor mutants were expressed in monkey kidney COS cells as truncated AR proteins between 20 and 107 kDa as revealed on immunoblots, where wild type AR was a doublet of 114 and 108 kDa.
T5 664-816 Sentence denotes Subcellular localization by immunocytochemical staining demonstrated androgen-dependent nuclear uptake of AR from a perinuclear region of the cytoplasm.
T6 817-1016 Sentence denotes A nuclear targeting signal similar in sequence and position to the glucocorticoid receptor and homologous to the SV40 large T antigen was required for androgen-induced nuclear uptake of wild type AR.
T7 1017-1150 Sentence denotes AR mutants lacking the NH2-terminal and/or steroid binding domains were constitutively nuclear with reduced transcriptional activity.
T8 1151-1363 Sentence denotes Transcriptional activation by wild type AR was androgen-dependent in cotransfection studies of CV1 cells using the chloramphenicol acetyltransferase reporter gene linked to the mouse mammary tumor virus promoter.
T9 1364-1599 Sentence denotes Deletion mutagenesis revealed within the NH2-terminal region a domain required for full transcriptional activity and within the steroid binding domain, an inhibitory function, deletion of which yielded a constitutively active receptor.
T10 1600-1764 Sentence denotes Inhibition of wild type AR by coexpression with an inactive NH2-terminal fragment suggested competition for nuclear factors required for transcriptional regulation.
T11 1765-1882 Sentence denotes These studies demonstrate a concerted interplay among the domains of the AR protein in regulating gene transcription.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 220-224 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T2 518-524 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 941-950 https://glytoucan.org/Structures/Glycans/G00031MO denotes T antigen

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 941-950 http://www.glycoepitope.jp/epitopes/EP0020 denotes T antigen

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1191-1193 gene:367 denotes AR
T1 1334-1347 disease:C1458155 denotes mammary tumor
R1 T0 T1 associated_with AR,mammary tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
1985913-7#40#42#gene367 1191-1193 gene367 denotes AR
1985913-7#183#196#diseaseC1458155 1334-1347 diseaseC1458155 denotes mammary tumor
40#42#gene367183#196#diseaseC1458155 1985913-7#40#42#gene367 1985913-7#183#196#diseaseC1458155 associated_with AR,mammary tumor

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 941-950 Glycan denotes T antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1334-1347 Disease denotes mammary tumor http://purl.obolibrary.org/obo/MONDO_0007254

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 220-224 Body_part denotes male http://purl.obolibrary.org/obo/MAT_0000029
T2 518-524 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1342-1347 Phenotype denotes tumor HP:0002664

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 941-950 Glycan denotes T antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1342-1347 Phenotype denotes tumor HP:0002664

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 1334-1347 Disease denotes mammary tumor MONDO:0007254

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 941-950 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T antigen http://www.glycoepitope.jp/epitopes/EP0020

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 64-69 Organism denotes human 9606
T2 248-253 Organism denotes human 9606
T3 511-517 Organism denotes monkey 9479|9527
T5 1328-1353 Organism denotes mouse mammary tumor virus 11757

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-88 Sentence denotes Transcriptional activation and nuclear targeting signals of the human androgen receptor.
T2 89-235 Sentence denotes The androgen receptor (AR) is a signal-transducing protein required for sexual differentiation, development, and expression of the male phenotype.
T3 236-475 Sentence denotes A series of human AR deletion mutants were created either by site-directed mutagenesis using restriction enzyme digestion, the polymerase chain reaction, or, for a series of unidirectional NH2-terminal deletions, exonuclease III digestion.
T4 476-663 Sentence denotes Receptor mutants were expressed in monkey kidney COS cells as truncated AR proteins between 20 and 107 kDa as revealed on immunoblots, where wild type AR was a doublet of 114 and 108 kDa.
T5 664-816 Sentence denotes Subcellular localization by immunocytochemical staining demonstrated androgen-dependent nuclear uptake of AR from a perinuclear region of the cytoplasm.
T6 817-1016 Sentence denotes A nuclear targeting signal similar in sequence and position to the glucocorticoid receptor and homologous to the SV40 large T antigen was required for androgen-induced nuclear uptake of wild type AR.
T7 1017-1150 Sentence denotes AR mutants lacking the NH2-terminal and/or steroid binding domains were constitutively nuclear with reduced transcriptional activity.
T8 1151-1363 Sentence denotes Transcriptional activation by wild type AR was androgen-dependent in cotransfection studies of CV1 cells using the chloramphenicol acetyltransferase reporter gene linked to the mouse mammary tumor virus promoter.
T9 1364-1599 Sentence denotes Deletion mutagenesis revealed within the NH2-terminal region a domain required for full transcriptional activity and within the steroid binding domain, an inhibitory function, deletion of which yielded a constitutively active receptor.
T10 1600-1764 Sentence denotes Inhibition of wild type AR by coexpression with an inactive NH2-terminal fragment suggested competition for nuclear factors required for transcriptional regulation.
T11 1765-1882 Sentence denotes These studies demonstrate a concerted interplay among the domains of the AR protein in regulating gene transcription.

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 518-524 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T2 806-815 Body_part denotes cytoplasm http://purl.obolibrary.org/obo/GO_0005737

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 518-524 Body_part denotes kidney FMA:7203
T2 792-815 Body_part denotes region of the cytoplasm FMA:72443

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 220-224 Body_part denotes male http://purl.obolibrary.org/obo/MAT_0000029
T2 518-524 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 64-69 OrganismTaxon denotes human 9606
T2 248-253 OrganismTaxon denotes human 9606
T3 511-517 OrganismTaxon denotes monkey 9479|9527
T5 1328-1353 OrganismTaxon denotes mouse mammary tumor virus 11757

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 941-950 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T antigen http://www.glycoepitope.jp/epitopes/EP0020

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 518-524 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T2 806-815 Body_part denotes cytoplasm http://purl.obolibrary.org/obo/GO_0005737