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PubMed:19840121 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-110 Sentence denotes Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2.
TextSentencer_T2 111-303 Sentence denotes BACE2 is homologous to BACE1, a beta-secretase that is involved in the amyloidogenic pathway of amyloid precursor protein (APP), and maps to the Down syndrome critical region of chromosome 21.
TextSentencer_T3 304-521 Sentence denotes Alzheimer disease neuropathology is common in Down syndrome patients at relatively early ages, and it has thus been speculated that BACE2 co-overexpression with APP would promote the early neurodegenerative phenotype.
TextSentencer_T4 522-589 Sentence denotes However, the in vivo function of BACE2 has not yet been elucidated.
TextSentencer_T5 590-712 Sentence denotes The aim of the present work has been to analyse the impact of in vivo BACE2 overexpression using a transgenic mouse model.
TextSentencer_T6 713-840 Sentence denotes Our results suggest that BACE2 is not involved in the amyloidogenic pathway, cognitive dysfunction or cholinergic degeneration.
TextSentencer_T7 841-1040 Sentence denotes However, TgBACE2 animals showed increased anxiety-like behaviour along with increased numbers of noradrenergic neurones in locus coeruleus, thus suggesting an unexpected role of BACE2 overexpression.
T1 0-110 Sentence denotes Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2.
T2 111-303 Sentence denotes BACE2 is homologous to BACE1, a beta-secretase that is involved in the amyloidogenic pathway of amyloid precursor protein (APP), and maps to the Down syndrome critical region of chromosome 21.
T3 304-521 Sentence denotes Alzheimer disease neuropathology is common in Down syndrome patients at relatively early ages, and it has thus been speculated that BACE2 co-overexpression with APP would promote the early neurodegenerative phenotype.
T4 522-589 Sentence denotes However, the in vivo function of BACE2 has not yet been elucidated.
T5 590-712 Sentence denotes The aim of the present work has been to analyse the impact of in vivo BACE2 overexpression using a transgenic mouse model.
T6 713-840 Sentence denotes Our results suggest that BACE2 is not involved in the amyloidogenic pathway, cognitive dysfunction or cholinergic degeneration.
T7 841-1040 Sentence denotes However, TgBACE2 animals showed increased anxiety-like behaviour along with increased numbers of noradrenergic neurones in locus coeruleus, thus suggesting an unexpected role of BACE2 overexpression.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 111-116 gene:25825 denotes BACE2
T1 256-285 disease:C1860787 denotes Down syndrome critical region
T2 134-139 gene:23621 denotes BACE1
T3 256-285 disease:C1860787 denotes Down syndrome critical region
T4 436-441 gene:25825 denotes BACE2
T5 304-321 disease:C0002395 denotes Alzheimer disease
T6 1019-1024 gene:25825 denotes BACE2
T7 883-890 disease:C0003469 denotes anxiety
R1 T0 T1 associated_with BACE2,Down syndrome critical region
R2 T2 T3 associated_with BACE1,Down syndrome critical region
R3 T4 T5 associated_with BACE2,Alzheimer disease
R4 T6 T7 associated_with BACE2,anxiety

Allie

Id Subject Object Predicate Lexical cue
SS1_19840121_1_0 207-232 expanded denotes amyloid precursor protein
SS2_19840121_1_0 234-237 abbr denotes APP
AE1_19840121_1_0 SS1_19840121_1_0 SS2_19840121_1_0 abbreviatedTo amyloid precursor protein,APP

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19840121-1#0#5#gene25825 111-116 gene25825 denotes BACE2
19840121-1#23#28#gene23621 134-139 gene23621 denotes BACE1
19840121-1#96#121#gene351 207-232 gene351 denotes amyloid precursor protein
19840121-1#123#126#gene351 234-237 gene351 denotes APP
19840121-1#145#174#diseaseC1860787 256-285 diseaseC1860787 denotes Down syndrome critical region
19840121-5#25#30#gene25825 738-743 gene25825 denotes BACE2
19840121-5#77#98#diseaseC0338656 790-811 diseaseC0338656 denotes cognitive dysfunction
19840121-6#178#183#gene25825 1019-1024 gene25825 denotes BACE2
19840121-6#42#49#diseaseC0003467 883-890 diseaseC0003467 denotes anxiety
19840121-6#42#49#diseaseC0003469 883-890 diseaseC0003469 denotes anxiety
0#5#gene25825145#174#diseaseC1860787 19840121-1#0#5#gene25825 19840121-1#145#174#diseaseC1860787 associated_with BACE2,Down syndrome critical region
23#28#gene23621145#174#diseaseC1860787 19840121-1#23#28#gene23621 19840121-1#145#174#diseaseC1860787 associated_with BACE1,Down syndrome critical region
96#121#gene351145#174#diseaseC1860787 19840121-1#96#121#gene351 19840121-1#145#174#diseaseC1860787 associated_with amyloid precursor protein,Down syndrome critical region
123#126#gene351145#174#diseaseC1860787 19840121-1#123#126#gene351 19840121-1#145#174#diseaseC1860787 associated_with APP,Down syndrome critical region
25#30#gene2582577#98#diseaseC0338656 19840121-5#25#30#gene25825 19840121-5#77#98#diseaseC0338656 associated_with BACE2,cognitive dysfunction
178#183#gene2582542#49#diseaseC0003467 19840121-6#178#183#gene25825 19840121-6#42#49#diseaseC0003467 associated_with BACE2,anxiety
178#183#gene2582542#49#diseaseC0003469 19840121-6#178#183#gene25825 19840121-6#42#49#diseaseC0003469 associated_with BACE2,anxiety

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T340 1019-1024 gene:25825 denotes BACE2
T341 883-890 disease:C0003467 denotes anxiety
R1 T340 T341 associated_with BACE2,anxiety
R2 T340 T341 associated_with BACE2,anxiety

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 952-960 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurones