
PubMed:19825989
Annnotations
LitCoin-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-130 | Sentence | denotes | H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo. |
T2 | 131-209 | Sentence | denotes | Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). |
T3 | 210-364 | Sentence | denotes | The d-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth. |
T4 | 365-442 | Sentence | denotes | We evaluated the role of HRH3 in the regulation of cholangiocarcinoma growth. |
T5 | 443-567 | Sentence | denotes | Expression of HRH3 in intrahepatic and extrahepatic cell lines, normal cholangiocytes, and human tissue arrays was measured. |
T6 | 568-796 | Sentence | denotes | In Mz-ChA-1 cells stimulated with (R)-(alpha)-(-)-methylhistamine dihydrobromide (RAMH), we measured (a) cell growth, (b) IP(3) and cyclic AMP levels, and (c) phosphorylation of PKC and mitogen-activated protein kinase isoforms. |
T7 | 797-940 | Sentence | denotes | Localization of PKCalpha was visualized by immunofluorescence in cell smears and immunoblotting for PKCalpha in cytosol and membrane fractions. |
T8 | 941-1113 | Sentence | denotes | Following knockdown of PKCalpha, Mz-ChA-1 cells were stimulated with RAMH before evaluating cell growth and extracellular signal-regulated kinase (ERK)-1/2 phosphorylation. |
T9 | 1114-1164 | Sentence | denotes | In vivo experiments were done in BALB/c nude mice. |
T10 | 1165-1245 | Sentence | denotes | Mice were treated with saline or RAMH for 44 days and tumor volume was measured. |
T11 | 1246-1428 | Sentence | denotes | Tumors were excised and evaluated for proliferation, apoptosis, and expression of PKCalpha, vascular endothelial growth factor (VEGF)-A, VEGF-C, VEGF receptor 2, and VEGF receptor 3. |
T12 | 1429-1468 | Sentence | denotes | HRH3 expression was found in all cells. |
T13 | 1469-1523 | Sentence | denotes | RAMH inhibited the growth of cholangiocarcinoma cells. |
T14 | 1524-1618 | Sentence | denotes | RAMH increased IP(3) levels and PKCalpha phosphorylation and decreased ERK1/2 phosphorylation. |
T15 | 1619-1752 | Sentence | denotes | RAMH induced a shift in the localization of PKCalpha expression from the cytosolic domain into the membrane region of Mz-ChA-1 cells. |
T16 | 1753-1876 | Sentence | denotes | Silencing of PKCalpha prevented RAMH inhibition of Mz-ChA-1 cell growth and ablated RAMH effects on ERK1/2 phosphorylation. |
T17 | 1877-1990 | Sentence | denotes | In vivo, RAMH decreased tumor growth and expression of VEGF and its receptors; PKCalpha expression was increased. |
T18 | 1991-2078 | Sentence | denotes | RAMH inhibits cholangiocarcinoma growth by PKCalpha-dependent ERK1/2 dephosphorylation. |
T19 | 2079-2182 | Sentence | denotes | Modulation of PKCalpha by histamine receptors may be important in regulating cholangiocarcinoma growth. |
LitCoin-entities-OrganismTaxon-PD
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 534-539 | OrganismTaxon | denotes | human | NCBItxid:9606 |
T2 | 1159-1163 | OrganismTaxon | denotes | mice | NCBItxid:10095|NCBItxid:10088 |
T4 | 1165-1169 | OrganismTaxon | denotes | Mice | NCBItxid:10095|NCBItxid:10088 |
LitCoin-entities
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
6575 | 0-21 | GeneOrGeneProduct | denotes | H3 histamine receptor | NCBIGene:11255 |
6576 | 45-66 | GeneOrGeneProduct | denotes | protein kinase Calpha | NCBIGene:5578 |
6577 | 90-108 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | MESH:D018281 |
6578 | 131-140 | ChemicalEntity | denotes | Histamine | MESH:D006632 |
6579 | 181-185 | GeneOrGeneProduct | denotes | HRH1 | NCBIGene:3269 |
6580 | 187-191 | GeneOrGeneProduct | denotes | HRH2 | NCBIGene:3274 |
6581 | 193-197 | GeneOrGeneProduct | denotes | HRH3 | NCBIGene:11255 |
6582 | 203-207 | GeneOrGeneProduct | denotes | HRH4 | NCBIGene:59340 |
6583 | 214-248 | ChemicalEntity | denotes | d-myo-inositol 1,4,5-trisphosphate | MESH:D015544 |
6584 | 250-255 | ChemicalEntity | denotes | IP(3) | MESH:D015544 |
6585 | 257-263 | ChemicalEntity | denotes | Ca(2+) | MESH:D002118 |
6586 | 264-280 | GeneOrGeneProduct | denotes | protein kinase C | NCBIGene:5578 |
6587 | 282-285 | GeneOrGeneProduct | denotes | PKC | NCBIGene:5578 |
6588 | 287-319 | GeneOrGeneProduct | denotes | mitogen-activated protein kinase | NCBIGene:5594|NCBIGene:5595 |
6589 | 338-356 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | MESH:D018281 |
6590 | 390-394 | GeneOrGeneProduct | denotes | HRH3 | NCBIGene:11255 |
6591 | 416-434 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | MESH:D018281 |
6592 | 457-461 | GeneOrGeneProduct | denotes | HRH3 | NCBIGene:11255 |
6593 | 534-539 | OrganismTaxon | denotes | human | NCBITaxon:9606 |
6594 | 571-579 | CellLine | denotes | Mz-ChA-1 | NCBITaxon:9606 |
6595 | 602-648 | ChemicalEntity | denotes | (R)-(alpha)-(-)-methylhistamine dihydrobromide | MESH:C069357 |
6596 | 650-654 | ChemicalEntity | denotes | RAMH | MESH:C069357 |
6597 | 690-695 | ChemicalEntity | denotes | IP(3) | MESH:D015544 |
6598 | 700-710 | ChemicalEntity | denotes | cyclic AMP | MESH:D000242 |
6599 | 746-749 | GeneOrGeneProduct | denotes | PKC | NCBIGene:5578 |
6600 | 754-786 | GeneOrGeneProduct | denotes | mitogen-activated protein kinase | NCBIGene:5594|NCBIGene:5595 |
6601 | 813-821 | GeneOrGeneProduct | denotes | PKCalpha | NCBIGene:5578 |
6602 | 897-905 | GeneOrGeneProduct | denotes | PKCalpha | NCBIGene:5578 |
6603 | 964-972 | GeneOrGeneProduct | denotes | PKCalpha | NCBIGene:5578 |
6604 | 974-982 | CellLine | denotes | Mz-ChA-1 | NCBITaxon:9606 |
6605 | 1010-1014 | ChemicalEntity | denotes | RAMH | MESH:C069357 |
6606 | 1049-1096 | GeneOrGeneProduct | denotes | extracellular signal-regulated kinase (ERK)-1/2 | NCBIGene:5595;5594 |
6607 | 1147-1153 | CellLine | denotes | BALB/c | NCBITaxon:10090 |
6608 | 1159-1163 | OrganismTaxon | denotes | mice | NCBITaxon:10090 |
6609 | 1165-1169 | OrganismTaxon | denotes | Mice | NCBITaxon:10090 |
6610 | 1198-1202 | ChemicalEntity | denotes | RAMH | MESH:C069357 |
6611 | 1219-1224 | DiseaseOrPhenotypicFeature | denotes | tumor | MESH:D009369 |
6612 | 1246-1252 | DiseaseOrPhenotypicFeature | denotes | Tumors | MESH:D009369 |
6613 | 1328-1336 | GeneOrGeneProduct | denotes | PKCalpha | NCBIGene:5578 |
6614 | 1338-1381 | GeneOrGeneProduct | denotes | vascular endothelial growth factor (VEGF)-A | NCBIGene:7422 |
6615 | 1383-1389 | GeneOrGeneProduct | denotes | VEGF-C | NCBIGene:7424 |
6616 | 1391-1406 | GeneOrGeneProduct | denotes | VEGF receptor 2 | NCBIGene:3791 |
6617 | 1412-1427 | GeneOrGeneProduct | denotes | VEGF receptor 3 | NCBIGene:2324 |
6618 | 1429-1433 | GeneOrGeneProduct | denotes | HRH3 | NCBIGene:11255 |
6619 | 1469-1473 | ChemicalEntity | denotes | RAMH | MESH:C069357 |
6620 | 1498-1516 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | MESH:D018281 |
6621 | 1524-1528 | ChemicalEntity | denotes | RAMH | MESH:C069357 |
6622 | 1539-1544 | ChemicalEntity | denotes | IP(3) | MESH:D015544 |
6623 | 1556-1564 | GeneOrGeneProduct | denotes | PKCalpha | NCBIGene:5578 |
6624 | 1595-1601 | GeneOrGeneProduct | denotes | ERK1/2 | NCBIGene:5595;5594 |
6625 | 1619-1623 | ChemicalEntity | denotes | RAMH | MESH:C069357 |
6626 | 1663-1671 | GeneOrGeneProduct | denotes | PKCalpha | NCBIGene:5578 |
6627 | 1737-1745 | CellLine | denotes | Mz-ChA-1 | NCBITaxon:9606 |
6628 | 1766-1774 | GeneOrGeneProduct | denotes | PKCalpha | NCBIGene:5578 |
6629 | 1785-1789 | ChemicalEntity | denotes | RAMH | MESH:C069357 |
6630 | 1804-1812 | CellLine | denotes | Mz-ChA-1 | NCBITaxon:9606 |
6631 | 1837-1841 | ChemicalEntity | denotes | RAMH | MESH:C069357 |
6632 | 1853-1859 | GeneOrGeneProduct | denotes | ERK1/2 | NCBIGene:5595;5594 |
6633 | 1886-1890 | ChemicalEntity | denotes | RAMH | MESH:C069357 |
6634 | 1901-1906 | DiseaseOrPhenotypicFeature | denotes | tumor | MESH:D009369 |
6635 | 1932-1936 | GeneOrGeneProduct | denotes | VEGF | NCBIGene:7422;7424 |
6636 | 1956-1964 | GeneOrGeneProduct | denotes | PKCalpha | NCBIGene:5578 |
6637 | 1991-1995 | ChemicalEntity | denotes | RAMH | MESH:C069357 |
6638 | 2005-2023 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | MESH:D018281 |
6639 | 2034-2042 | GeneOrGeneProduct | denotes | PKCalpha | NCBIGene:5578 |
6640 | 2053-2059 | GeneOrGeneProduct | denotes | ERK1/2 | NCBIGene:5595;5594 |
6641 | 2093-2101 | GeneOrGeneProduct | denotes | PKCalpha | NCBIGene:5578 |
6642 | 2105-2124 | GeneOrGeneProduct | denotes | histamine receptors | NCBIGene:11255|NCBIGene:3269|NCBIGene:3274|NCBIGene:59340 |
6643 | 2156-2174 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | MESH:D018281 |
LitCoin_Mondo
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 90-108 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | 0019087 |
T2 | 338-356 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | 0019087 |
T3 | 416-434 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | 0019087 |
T4 | 1347-1358 | DiseaseOrPhenotypicFeature | denotes | endothelial | 0015292 |
T5 | 1498-1516 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | 0019087 |
T6 | 2005-2023 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | 0019087 |
T7 | 2156-2174 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | 0019087 |
LitCoin-GeneOrGeneProduct-v0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 13-21 | GeneOrGeneProduct | denotes | receptor |
T2 | 22-30 | GeneOrGeneProduct | denotes | mediated |
T3 | 31-41 | GeneOrGeneProduct | denotes | activation |
T4 | 45-59 | GeneOrGeneProduct | denotes | protein kinase |
T5 | 60-66 | GeneOrGeneProduct | denotes | Calpha |
T6 | 80-86 | GeneOrGeneProduct | denotes | growth |
T7 | 141-150 | GeneOrGeneProduct | denotes | regulates |
T8 | 170-179 | GeneOrGeneProduct | denotes | receptors |
T9 | 181-185 | GeneOrGeneProduct | denotes | HRH1 |
T10 | 187-191 | GeneOrGeneProduct | denotes | HRH2 |
T11 | 193-197 | GeneOrGeneProduct | denotes | HRH3 |
T12 | 203-207 | GeneOrGeneProduct | denotes | HRH4 |
T13 | 216-219 | GeneOrGeneProduct | denotes | myo |
T14 | 220-228 | GeneOrGeneProduct | denotes | inositol |
T15 | 264-280 | GeneOrGeneProduct | denotes | protein kinase C |
T16 | 282-285 | GeneOrGeneProduct | denotes | PKC |
T17 | 287-319 | GeneOrGeneProduct | denotes | mitogen-activated protein kinase |
T18 | 328-337 | GeneOrGeneProduct | denotes | regulates |
T19 | 357-363 | GeneOrGeneProduct | denotes | growth |
T20 | 390-394 | GeneOrGeneProduct | denotes | HRH3 |
T21 | 402-412 | GeneOrGeneProduct | denotes | regulation |
T22 | 435-441 | GeneOrGeneProduct | denotes | growth |
T23 | 457-461 | GeneOrGeneProduct | denotes | HRH3 |
T24 | 495-499 | GeneOrGeneProduct | denotes | cell |
T25 | 500-505 | GeneOrGeneProduct | denotes | lines |
T26 | 571-573 | GeneOrGeneProduct | denotes | Mz |
T27 | 574-579 | GeneOrGeneProduct | denotes | ChA-1 |
T28 | 580-585 | GeneOrGeneProduct | denotes | cells |
T29 | 607-612 | GeneOrGeneProduct | denotes | alpha |
T30 | 673-677 | GeneOrGeneProduct | denotes | cell |
T31 | 678-684 | GeneOrGeneProduct | denotes | growth |
T32 | 687-694 | GeneOrGeneProduct | denotes | b) IP(3 |
T33 | 707-710 | GeneOrGeneProduct | denotes | AMP |
T34 | 746-749 | GeneOrGeneProduct | denotes | PKC |
T35 | 754-786 | GeneOrGeneProduct | denotes | mitogen-activated protein kinase |
T36 | 813-821 | GeneOrGeneProduct | denotes | PKCalpha |
T37 | 862-866 | GeneOrGeneProduct | denotes | cell |
T38 | 897-905 | GeneOrGeneProduct | denotes | PKCalpha |
T39 | 909-916 | GeneOrGeneProduct | denotes | cytosol |
T40 | 951-960 | GeneOrGeneProduct | denotes | knockdown |
T41 | 964-972 | GeneOrGeneProduct | denotes | PKCalpha |
T42 | 974-976 | GeneOrGeneProduct | denotes | Mz |
T43 | 977-982 | GeneOrGeneProduct | denotes | ChA-1 |
T44 | 983-988 | GeneOrGeneProduct | denotes | cells |
T45 | 1033-1037 | GeneOrGeneProduct | denotes | cell |
T46 | 1038-1044 | GeneOrGeneProduct | denotes | growth |
T47 | 1049-1086 | GeneOrGeneProduct | denotes | extracellular signal-regulated kinase |
T48 | 1087-1096 | GeneOrGeneProduct | denotes | (ERK)-1/2 |
T49 | 1154-1158 | GeneOrGeneProduct | denotes | nude |
T50 | 1159-1163 | GeneOrGeneProduct | denotes | mice |
T51 | 1165-1169 | GeneOrGeneProduct | denotes | Mice |
T52 | 1203-1209 | GeneOrGeneProduct | denotes | for 44 |
T53 | 1219-1224 | GeneOrGeneProduct | denotes | tumor |
T54 | 1246-1252 | GeneOrGeneProduct | denotes | Tumors |
T55 | 1258-1265 | GeneOrGeneProduct | denotes | excised |
T56 | 1299-1308 | GeneOrGeneProduct | denotes | apoptosis |
T57 | 1328-1336 | GeneOrGeneProduct | denotes | PKCalpha |
T58 | 1338-1372 | GeneOrGeneProduct | denotes | vascular endothelial growth factor |
T59 | 1374-1378 | GeneOrGeneProduct | denotes | VEGF |
T60 | 1383-1389 | GeneOrGeneProduct | denotes | VEGF-C |
T61 | 1391-1404 | GeneOrGeneProduct | denotes | VEGF receptor |
T62 | 1412-1425 | GeneOrGeneProduct | denotes | VEGF receptor |
T63 | 1429-1433 | GeneOrGeneProduct | denotes | HRH3 |
T64 | 1458-1461 | GeneOrGeneProduct | denotes | all |
T65 | 1462-1467 | GeneOrGeneProduct | denotes | cells |
T66 | 1488-1494 | GeneOrGeneProduct | denotes | growth |
T67 | 1517-1522 | GeneOrGeneProduct | denotes | cells |
T68 | 1556-1564 | GeneOrGeneProduct | denotes | PKCalpha |
T69 | 1595-1601 | GeneOrGeneProduct | denotes | ERK1/2 |
T70 | 1624-1631 | GeneOrGeneProduct | denotes | induced |
T71 | 1634-1639 | GeneOrGeneProduct | denotes | shift |
T72 | 1663-1671 | GeneOrGeneProduct | denotes | PKCalpha |
T73 | 1692-1701 | GeneOrGeneProduct | denotes | cytosolic |
T74 | 1737-1739 | GeneOrGeneProduct | denotes | Mz |
T75 | 1740-1745 | GeneOrGeneProduct | denotes | ChA-1 |
T76 | 1746-1751 | GeneOrGeneProduct | denotes | cells |
T77 | 1766-1774 | GeneOrGeneProduct | denotes | PKCalpha |
T78 | 1804-1806 | GeneOrGeneProduct | denotes | Mz |
T79 | 1807-1812 | GeneOrGeneProduct | denotes | ChA-1 |
T80 | 1813-1817 | GeneOrGeneProduct | denotes | cell |
T81 | 1818-1824 | GeneOrGeneProduct | denotes | growth |
T82 | 1853-1859 | GeneOrGeneProduct | denotes | ERK1/2 |
T83 | 1901-1906 | GeneOrGeneProduct | denotes | tumor |
T84 | 1907-1913 | GeneOrGeneProduct | denotes | growth |
T85 | 1932-1936 | GeneOrGeneProduct | denotes | VEGF |
T86 | 1945-1954 | GeneOrGeneProduct | denotes | receptors |
T87 | 1956-1964 | GeneOrGeneProduct | denotes | PKCalpha |
T88 | 2024-2030 | GeneOrGeneProduct | denotes | growth |
T89 | 2034-2042 | GeneOrGeneProduct | denotes | PKCalpha |
T90 | 2053-2059 | GeneOrGeneProduct | denotes | ERK1/2 |
T91 | 2093-2101 | GeneOrGeneProduct | denotes | PKCalpha |
T92 | 2115-2124 | GeneOrGeneProduct | denotes | receptors |
T93 | 2145-2155 | GeneOrGeneProduct | denotes | regulating |
T94 | 2175-2181 | GeneOrGeneProduct | denotes | growth |
LitCoin-GeneOrGeneProduct-v2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 13-21 | GeneOrGeneProduct | denotes | receptor |
T2 | 45-59 | GeneOrGeneProduct | denotes | protein kinase |
T3 | 60-66 | GeneOrGeneProduct | denotes | Calpha |
T4 | 80-86 | GeneOrGeneProduct | denotes | growth |
T5 | 181-185 | GeneOrGeneProduct | denotes | HRH1 |
T6 | 187-191 | GeneOrGeneProduct | denotes | HRH2 |
T7 | 193-197 | GeneOrGeneProduct | denotes | HRH3 |
T8 | 203-207 | GeneOrGeneProduct | denotes | HRH4 |
T9 | 220-228 | GeneOrGeneProduct | denotes | inositol |
T10 | 264-280 | GeneOrGeneProduct | denotes | protein kinase C |
T11 | 282-285 | GeneOrGeneProduct | denotes | PKC |
T12 | 287-319 | GeneOrGeneProduct | denotes | mitogen-activated protein kinase |
T13 | 357-363 | GeneOrGeneProduct | denotes | growth |
T14 | 390-394 | GeneOrGeneProduct | denotes | HRH3 |
T15 | 435-441 | GeneOrGeneProduct | denotes | growth |
T16 | 457-461 | GeneOrGeneProduct | denotes | HRH3 |
T17 | 495-499 | GeneOrGeneProduct | denotes | cell |
T18 | 500-505 | GeneOrGeneProduct | denotes | lines |
T19 | 607-612 | GeneOrGeneProduct | denotes | alpha |
T20 | 673-677 | GeneOrGeneProduct | denotes | cell |
T21 | 678-684 | GeneOrGeneProduct | denotes | growth |
T22 | 746-749 | GeneOrGeneProduct | denotes | PKC |
T23 | 754-786 | GeneOrGeneProduct | denotes | mitogen-activated protein kinase |
T24 | 813-821 | GeneOrGeneProduct | denotes | PKCalpha |
T25 | 862-866 | GeneOrGeneProduct | denotes | cell |
T26 | 897-905 | GeneOrGeneProduct | denotes | PKCalpha |
T27 | 951-960 | GeneOrGeneProduct | denotes | knockdown |
T28 | 964-972 | GeneOrGeneProduct | denotes | PKCalpha |
T29 | 1033-1037 | GeneOrGeneProduct | denotes | cell |
T30 | 1038-1044 | GeneOrGeneProduct | denotes | growth |
T31 | 1049-1086 | GeneOrGeneProduct | denotes | extracellular signal-regulated kinase |
T32 | 1088-1091 | GeneOrGeneProduct | denotes | ERK |
T33 | 1154-1158 | GeneOrGeneProduct | denotes | nude |
T34 | 1299-1308 | GeneOrGeneProduct | denotes | apoptosis |
T35 | 1328-1336 | GeneOrGeneProduct | denotes | PKCalpha |
T36 | 1338-1372 | GeneOrGeneProduct | denotes | vascular endothelial growth factor |
T37 | 1374-1378 | GeneOrGeneProduct | denotes | VEGF |
T38 | 1383-1389 | GeneOrGeneProduct | denotes | VEGF-C |
T39 | 1391-1404 | GeneOrGeneProduct | denotes | VEGF receptor |
T40 | 1412-1425 | GeneOrGeneProduct | denotes | VEGF receptor |
T41 | 1429-1433 | GeneOrGeneProduct | denotes | HRH3 |
T42 | 1488-1494 | GeneOrGeneProduct | denotes | growth |
T43 | 1556-1564 | GeneOrGeneProduct | denotes | PKCalpha |
T44 | 1595-1601 | GeneOrGeneProduct | denotes | ERK1/2 |
T45 | 1663-1671 | GeneOrGeneProduct | denotes | PKCalpha |
T46 | 1692-1701 | GeneOrGeneProduct | denotes | cytosolic |
T47 | 1766-1774 | GeneOrGeneProduct | denotes | PKCalpha |
T48 | 1813-1817 | GeneOrGeneProduct | denotes | cell |
T49 | 1818-1824 | GeneOrGeneProduct | denotes | growth |
T50 | 1853-1859 | GeneOrGeneProduct | denotes | ERK1/2 |
T51 | 1907-1913 | GeneOrGeneProduct | denotes | growth |
T52 | 1932-1936 | GeneOrGeneProduct | denotes | VEGF |
T53 | 1956-1964 | GeneOrGeneProduct | denotes | PKCalpha |
T54 | 2024-2030 | GeneOrGeneProduct | denotes | growth |
T55 | 2034-2042 | GeneOrGeneProduct | denotes | PKCalpha |
T56 | 2053-2059 | GeneOrGeneProduct | denotes | ERK1/2 |
T57 | 2093-2101 | GeneOrGeneProduct | denotes | PKCalpha |
T58 | 2175-2181 | GeneOrGeneProduct | denotes | growth |
LitCoin-Disease-MeSH
Id | Subject | Object | Predicate | Lexical cue | originalLabel |
---|---|---|---|---|---|
T1 | 90-108 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T2 | 338-356 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T3 | 416-434 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T4 | 1219-1224 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 |
T5 | 1246-1252 | DiseaseOrPhenotypicFeature | denotes | Tumors | D009369 |
T6 | 1498-1516 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T7 | 1901-1906 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 |
T8 | 2005-2023 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T9 | 2156-2174 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
LitCoin_Mondo_095
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 90-108 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | 0019087 |
T2 | 250-252 | DiseaseOrPhenotypicFeature | denotes | IP | 0010631 |
T3 | 338-356 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | 0019087 |
T4 | 416-434 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | 0019087 |
T5 | 690-692 | DiseaseOrPhenotypicFeature | denotes | IP | 0010631 |
T6 | 1219-1224 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
T7 | 1498-1516 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | 0019087 |
T8 | 1539-1541 | DiseaseOrPhenotypicFeature | denotes | IP | 0010631 |
T9 | 1901-1906 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
T10 | 2005-2023 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | 0019087 |
T11 | 2156-2174 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | 0019087 |
LitCoin-MeSH-Disease-2
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 90-108 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T2 | 338-356 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T3 | 416-434 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T4 | 1219-1224 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 |
T5 | 1246-1252 | DiseaseOrPhenotypicFeature | denotes | Tumors | DISEASE|D009369 |
T7 | 1498-1516 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T8 | 1901-1906 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 |
T9 | 2005-2023 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T10 | 2156-2174 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
LitCoin-MONDO_bioort2019
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T1 | 90-108 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T2 | 338-356 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T3 | 416-434 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T4 | 1219-1224 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 |
T5 | 1246-1252 | DiseaseOrPhenotypicFeature | denotes | Tumors | D009369 |
T6 | 1498-1516 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T7 | 1901-1906 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 |
T8 | 2005-2023 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
T9 | 2156-2174 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 |
LitCoin_CellLine
Id | Subject | Object | Predicate | Lexical cue | cellosaurus_accession_id |
---|---|---|---|---|---|
T1 | 571-579 | CellLine | denotes | Mz-ChA-1 | CVCL_6932 |
T2 | 974-982 | CellLine | denotes | Mz-ChA-1 | CVCL_6932 |
T3 | 1737-1745 | CellLine | denotes | Mz-ChA-1 | CVCL_6932 |
T4 | 1804-1812 | CellLine | denotes | Mz-ChA-1 | CVCL_6932 |
LitCoin-NCBITaxon-2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 534-539 | OrganismTaxon | denotes | human |
T2 | 1159-1163 | OrganismTaxon | denotes | mice |
T3 | 1165-1169 | OrganismTaxon | denotes | Mice |
LitCoin-Chemical-MeSH-CHEBI
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 3-12 | ChemicalEntity | denotes | histamine | D006632|http://purl.obolibrary.org/obo/CHEBI_58432|http://purl.obolibrary.org/obo/CHEBI_18295 |
T4 | 131-140 | ChemicalEntity | denotes | Histamine | http://purl.obolibrary.org/obo/CHEBI_18295 |
T5 | 214-248 | ChemicalEntity | denotes | d-myo-inositol 1,4,5-trisphosphate | http://purl.obolibrary.org/obo/CHEBI_16595 |
T6 | 250-255 | ChemicalEntity | denotes | IP(3) | ChemicalEntity |
T7 | 602-633 | ChemicalEntity | denotes | (R)-(alpha)-(-)-methylhistamine | http://purl.obolibrary.org/obo/CHEBI_73337 |
T8 | 650-654 | ChemicalEntity | denotes | RAMH | ChemicalEntity |
T9 | 690-695 | ChemicalEntity | denotes | IP(3) | ChemicalEntity |
T10 | 700-710 | ChemicalEntity | denotes | cyclic AMP | http://purl.obolibrary.org/obo/CHEBI_17489 |
T11 | 1010-1014 | ChemicalEntity | denotes | RAMH | ChemicalEntity |
T12 | 1198-1202 | ChemicalEntity | denotes | RAMH | ChemicalEntity |
T13 | 1469-1473 | ChemicalEntity | denotes | RAMH | ChemicalEntity |
T14 | 1524-1528 | ChemicalEntity | denotes | RAMH | ChemicalEntity |
T15 | 1539-1544 | ChemicalEntity | denotes | IP(3) | ChemicalEntity |
T16 | 1619-1623 | ChemicalEntity | denotes | RAMH | ChemicalEntity |
T17 | 1785-1789 | ChemicalEntity | denotes | RAMH | ChemicalEntity |
T18 | 1837-1841 | ChemicalEntity | denotes | RAMH | ChemicalEntity |
T19 | 1886-1890 | ChemicalEntity | denotes | RAMH | ChemicalEntity |
T20 | 1991-1995 | ChemicalEntity | denotes | RAMH | ChemicalEntity |
T21 | 2105-2114 | ChemicalEntity | denotes | histamine | D006632|http://purl.obolibrary.org/obo/CHEBI_58432|http://purl.obolibrary.org/obo/CHEBI_18295 |
LitCoin-GeneOrGeneProduct-v3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 60-66 | GeneOrGeneProduct | denotes | Calpha |
T2 | 181-185 | GeneOrGeneProduct | denotes | HRH1 |
T3 | 187-191 | GeneOrGeneProduct | denotes | HRH2 |
T4 | 193-197 | GeneOrGeneProduct | denotes | HRH3 |
T5 | 203-207 | GeneOrGeneProduct | denotes | HRH4 |
T6 | 264-280 | GeneOrGeneProduct | denotes | protein kinase C |
T7 | 282-285 | GeneOrGeneProduct | denotes | PKC |
T8 | 287-319 | GeneOrGeneProduct | denotes | mitogen-activated protein kinase |
T9 | 390-394 | GeneOrGeneProduct | denotes | HRH3 |
T10 | 457-461 | GeneOrGeneProduct | denotes | HRH3 |
T11 | 607-612 | GeneOrGeneProduct | denotes | alpha |
T12 | 746-749 | GeneOrGeneProduct | denotes | PKC |
T13 | 754-786 | GeneOrGeneProduct | denotes | mitogen-activated protein kinase |
T14 | 813-821 | GeneOrGeneProduct | denotes | PKCalpha |
T15 | 897-905 | GeneOrGeneProduct | denotes | PKCalpha |
T16 | 964-972 | GeneOrGeneProduct | denotes | PKCalpha |
T17 | 1049-1086 | GeneOrGeneProduct | denotes | extracellular signal-regulated kinase |
T18 | 1088-1091 | GeneOrGeneProduct | denotes | ERK |
T19 | 1328-1336 | GeneOrGeneProduct | denotes | PKCalpha |
T20 | 1338-1372 | GeneOrGeneProduct | denotes | vascular endothelial growth factor |
T21 | 1374-1378 | GeneOrGeneProduct | denotes | VEGF |
T22 | 1383-1389 | GeneOrGeneProduct | denotes | VEGF-C |
T24 | 1391-1404 | GeneOrGeneProduct | denotes | VEGF receptor |
T26 | 1412-1425 | GeneOrGeneProduct | denotes | VEGF receptor |
T28 | 1429-1433 | GeneOrGeneProduct | denotes | HRH3 |
T29 | 1556-1564 | GeneOrGeneProduct | denotes | PKCalpha |
T30 | 1595-1601 | GeneOrGeneProduct | denotes | ERK1/2 |
T31 | 1663-1671 | GeneOrGeneProduct | denotes | PKCalpha |
T32 | 1766-1774 | GeneOrGeneProduct | denotes | PKCalpha |
T33 | 1853-1859 | GeneOrGeneProduct | denotes | ERK1/2 |
T34 | 1932-1936 | GeneOrGeneProduct | denotes | VEGF |
T35 | 1956-1964 | GeneOrGeneProduct | denotes | PKCalpha |
T36 | 2034-2042 | GeneOrGeneProduct | denotes | PKCalpha |
T37 | 2053-2059 | GeneOrGeneProduct | denotes | ERK1/2 |
T38 | 2093-2101 | GeneOrGeneProduct | denotes | PKCalpha |
LitCoin-training-merged
Id | Subject | Object | Predicate | Lexical cue | #label | ID: | cellosaurus_accession_id |
---|---|---|---|---|---|---|---|
T4 | 1804-1812 | CellLine | denotes | Mz-ChA-1 | CVCL_6932 | ||
T3 | 1737-1745 | CellLine | denotes | Mz-ChA-1 | CVCL_6932 | ||
T2 | 974-982 | CellLine | denotes | Mz-ChA-1 | CVCL_6932 | ||
T1 | 571-579 | CellLine | denotes | Mz-ChA-1 | CVCL_6932 | ||
T21 | 2105-2114 | ChemicalEntity | denotes | histamine | http://purl.obolibrary.org/obo/CHEBI_18295|http://purl.obolibrary.org/obo/CHEBI_58432|D006632 | ||
T20 | 1991-1995 | ChemicalEntity | denotes | RAMH | ChemicalEntity | ||
T19 | 1886-1890 | ChemicalEntity | denotes | RAMH | ChemicalEntity | ||
T18 | 1837-1841 | ChemicalEntity | denotes | RAMH | ChemicalEntity | ||
T17 | 1785-1789 | ChemicalEntity | denotes | RAMH | ChemicalEntity | ||
T16 | 1619-1623 | ChemicalEntity | denotes | RAMH | ChemicalEntity | ||
T15 | 1539-1544 | ChemicalEntity | denotes | IP(3) | ChemicalEntity | ||
T14 | 1524-1528 | ChemicalEntity | denotes | RAMH | ChemicalEntity | ||
T13 | 1469-1473 | ChemicalEntity | denotes | RAMH | ChemicalEntity | ||
T12 | 1198-1202 | ChemicalEntity | denotes | RAMH | ChemicalEntity | ||
T11 | 1010-1014 | ChemicalEntity | denotes | RAMH | ChemicalEntity | ||
T10 | 700-710 | ChemicalEntity | denotes | cyclic AMP | http://purl.obolibrary.org/obo/CHEBI_17489 | ||
T9 | 690-695 | ChemicalEntity | denotes | IP(3) | ChemicalEntity | ||
T8 | 650-654 | ChemicalEntity | denotes | RAMH | ChemicalEntity | ||
T7 | 602-633 | ChemicalEntity | denotes | (R)-(alpha)-(-)-methylhistamine | http://purl.obolibrary.org/obo/CHEBI_73337 | ||
T6 | 250-255 | ChemicalEntity | denotes | IP(3) | ChemicalEntity | ||
T5 | 214-248 | ChemicalEntity | denotes | d-myo-inositol 1,4,5-trisphosphate | http://purl.obolibrary.org/obo/CHEBI_16595 | ||
T76272 | 131-140 | ChemicalEntity | denotes | Histamine | http://purl.obolibrary.org/obo/CHEBI_18295 | ||
T72502 | 3-12 | ChemicalEntity | denotes | histamine | http://purl.obolibrary.org/obo/CHEBI_18295|http://purl.obolibrary.org/obo/CHEBI_58432|D006632 | ||
T38 | 2093-2101 | GeneOrGeneProduct | denotes | PKCalpha | |||
T37 | 2053-2059 | GeneOrGeneProduct | denotes | ERK1/2 | |||
T36 | 2034-2042 | GeneOrGeneProduct | denotes | PKCalpha | |||
T35 | 1956-1964 | GeneOrGeneProduct | denotes | PKCalpha | |||
T34 | 1932-1936 | GeneOrGeneProduct | denotes | VEGF | |||
T33 | 1853-1859 | GeneOrGeneProduct | denotes | ERK1/2 | |||
T32 | 1766-1774 | GeneOrGeneProduct | denotes | PKCalpha | |||
T31 | 1663-1671 | GeneOrGeneProduct | denotes | PKCalpha | |||
T30 | 1595-1601 | GeneOrGeneProduct | denotes | ERK1/2 | |||
T29 | 1556-1564 | GeneOrGeneProduct | denotes | PKCalpha | |||
T28 | 1429-1433 | GeneOrGeneProduct | denotes | HRH3 | |||
T26 | 1412-1425 | GeneOrGeneProduct | denotes | VEGF receptor | |||
T24 | 1391-1404 | GeneOrGeneProduct | denotes | VEGF receptor | |||
T22 | 1383-1389 | GeneOrGeneProduct | denotes | VEGF-C | |||
T73307 | 1374-1378 | GeneOrGeneProduct | denotes | VEGF | |||
T4708 | 1338-1372 | GeneOrGeneProduct | denotes | vascular endothelial growth factor | |||
T75089 | 1328-1336 | GeneOrGeneProduct | denotes | PKCalpha | |||
T67282 | 1088-1091 | GeneOrGeneProduct | denotes | ERK | |||
T42079 | 1049-1086 | GeneOrGeneProduct | denotes | extracellular signal-regulated kinase | |||
T12180 | 964-972 | GeneOrGeneProduct | denotes | PKCalpha | |||
T79472 | 897-905 | GeneOrGeneProduct | denotes | PKCalpha | |||
T14737 | 813-821 | GeneOrGeneProduct | denotes | PKCalpha | |||
T38736 | 754-786 | GeneOrGeneProduct | denotes | mitogen-activated protein kinase | |||
T68374 | 746-749 | GeneOrGeneProduct | denotes | PKC | |||
T35078 | 607-612 | GeneOrGeneProduct | denotes | alpha | |||
T29699 | 457-461 | GeneOrGeneProduct | denotes | HRH3 | |||
T54993 | 390-394 | GeneOrGeneProduct | denotes | HRH3 | |||
T95096 | 287-319 | GeneOrGeneProduct | denotes | mitogen-activated protein kinase | |||
T8250 | 282-285 | GeneOrGeneProduct | denotes | PKC | |||
T33008 | 264-280 | GeneOrGeneProduct | denotes | protein kinase C | |||
T11288 | 203-207 | GeneOrGeneProduct | denotes | HRH4 | |||
T92349 | 193-197 | GeneOrGeneProduct | denotes | HRH3 | |||
T56813 | 187-191 | GeneOrGeneProduct | denotes | HRH2 | |||
T49937 | 181-185 | GeneOrGeneProduct | denotes | HRH1 | |||
T73420 | 60-66 | GeneOrGeneProduct | denotes | Calpha | |||
T31943 | 2156-2174 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 | ||
T68433 | 2005-2023 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 | ||
T45359 | 1901-1906 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 | ||
T43664 | 1498-1516 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 | ||
T58422 | 1246-1252 | DiseaseOrPhenotypicFeature | denotes | Tumors | D009369 | ||
T77039 | 1219-1224 | DiseaseOrPhenotypicFeature | denotes | tumor | D009369 | ||
T78751 | 416-434 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 | ||
T40942 | 338-356 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 | ||
T77924 | 90-108 | DiseaseOrPhenotypicFeature | denotes | cholangiocarcinoma | D018281 | ||
T71823 | 1165-1169 | OrganismTaxon | denotes | Mice | |||
T6249 | 1159-1163 | OrganismTaxon | denotes | mice | |||
T49266 | 534-539 | OrganismTaxon | denotes | human |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 390-394 | gene:11255 | denotes | HRH3 |
T1 | 416-434 | disease:C0206698 | denotes | cholangiocarcinoma |
R1 | T0 | T1 | associated_with | HRH3,cholangiocarcinoma |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
19825989-3#25#29#gene11255 | 390-394 | gene11255 | denotes | HRH3 |
19825989-3#51#69#diseaseC0206698 | 416-434 | diseaseC0206698 | denotes | cholangiocarcinoma |
25#29#gene1125551#69#diseaseC0206698 | 19825989-3#25#29#gene11255 | 19825989-3#51#69#diseaseC0206698 | associated_with | HRH3,cholangiocarcinoma |