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PubMed:19825989 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo.
T2 131-209 Sentence denotes Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4).
T3 210-364 Sentence denotes The d-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth.
T4 365-442 Sentence denotes We evaluated the role of HRH3 in the regulation of cholangiocarcinoma growth.
T5 443-567 Sentence denotes Expression of HRH3 in intrahepatic and extrahepatic cell lines, normal cholangiocytes, and human tissue arrays was measured.
T6 568-796 Sentence denotes In Mz-ChA-1 cells stimulated with (R)-(alpha)-(-)-methylhistamine dihydrobromide (RAMH), we measured (a) cell growth, (b) IP(3) and cyclic AMP levels, and (c) phosphorylation of PKC and mitogen-activated protein kinase isoforms.
T7 797-940 Sentence denotes Localization of PKCalpha was visualized by immunofluorescence in cell smears and immunoblotting for PKCalpha in cytosol and membrane fractions.
T8 941-1113 Sentence denotes Following knockdown of PKCalpha, Mz-ChA-1 cells were stimulated with RAMH before evaluating cell growth and extracellular signal-regulated kinase (ERK)-1/2 phosphorylation.
T9 1114-1164 Sentence denotes In vivo experiments were done in BALB/c nude mice.
T10 1165-1245 Sentence denotes Mice were treated with saline or RAMH for 44 days and tumor volume was measured.
T11 1246-1428 Sentence denotes Tumors were excised and evaluated for proliferation, apoptosis, and expression of PKCalpha, vascular endothelial growth factor (VEGF)-A, VEGF-C, VEGF receptor 2, and VEGF receptor 3.
T12 1429-1468 Sentence denotes HRH3 expression was found in all cells.
T13 1469-1523 Sentence denotes RAMH inhibited the growth of cholangiocarcinoma cells.
T14 1524-1618 Sentence denotes RAMH increased IP(3) levels and PKCalpha phosphorylation and decreased ERK1/2 phosphorylation.
T15 1619-1752 Sentence denotes RAMH induced a shift in the localization of PKCalpha expression from the cytosolic domain into the membrane region of Mz-ChA-1 cells.
T16 1753-1876 Sentence denotes Silencing of PKCalpha prevented RAMH inhibition of Mz-ChA-1 cell growth and ablated RAMH effects on ERK1/2 phosphorylation.
T17 1877-1990 Sentence denotes In vivo, RAMH decreased tumor growth and expression of VEGF and its receptors; PKCalpha expression was increased.
T18 1991-2078 Sentence denotes RAMH inhibits cholangiocarcinoma growth by PKCalpha-dependent ERK1/2 dephosphorylation.
T19 2079-2182 Sentence denotes Modulation of PKCalpha by histamine receptors may be important in regulating cholangiocarcinoma growth.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 534-539 OrganismTaxon denotes human NCBItxid:9606
T2 1159-1163 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T4 1165-1169 OrganismTaxon denotes Mice NCBItxid:10095|NCBItxid:10088

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
6575 0-21 GeneOrGeneProduct denotes H3 histamine receptor NCBIGene:11255
6576 45-66 GeneOrGeneProduct denotes protein kinase Calpha NCBIGene:5578
6577 90-108 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma MESH:D018281
6578 131-140 ChemicalEntity denotes Histamine MESH:D006632
6579 181-185 GeneOrGeneProduct denotes HRH1 NCBIGene:3269
6580 187-191 GeneOrGeneProduct denotes HRH2 NCBIGene:3274
6581 193-197 GeneOrGeneProduct denotes HRH3 NCBIGene:11255
6582 203-207 GeneOrGeneProduct denotes HRH4 NCBIGene:59340
6583 214-248 ChemicalEntity denotes d-myo-inositol 1,4,5-trisphosphate MESH:D015544
6584 250-255 ChemicalEntity denotes IP(3) MESH:D015544
6585 257-263 ChemicalEntity denotes Ca(2+) MESH:D002118
6586 264-280 GeneOrGeneProduct denotes protein kinase C NCBIGene:5578
6587 282-285 GeneOrGeneProduct denotes PKC NCBIGene:5578
6588 287-319 GeneOrGeneProduct denotes mitogen-activated protein kinase NCBIGene:5594|NCBIGene:5595
6589 338-356 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma MESH:D018281
6590 390-394 GeneOrGeneProduct denotes HRH3 NCBIGene:11255
6591 416-434 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma MESH:D018281
6592 457-461 GeneOrGeneProduct denotes HRH3 NCBIGene:11255
6593 534-539 OrganismTaxon denotes human NCBITaxon:9606
6594 571-579 CellLine denotes Mz-ChA-1 NCBITaxon:9606
6595 602-648 ChemicalEntity denotes (R)-(alpha)-(-)-methylhistamine dihydrobromide MESH:C069357
6596 650-654 ChemicalEntity denotes RAMH MESH:C069357
6597 690-695 ChemicalEntity denotes IP(3) MESH:D015544
6598 700-710 ChemicalEntity denotes cyclic AMP MESH:D000242
6599 746-749 GeneOrGeneProduct denotes PKC NCBIGene:5578
6600 754-786 GeneOrGeneProduct denotes mitogen-activated protein kinase NCBIGene:5594|NCBIGene:5595
6601 813-821 GeneOrGeneProduct denotes PKCalpha NCBIGene:5578
6602 897-905 GeneOrGeneProduct denotes PKCalpha NCBIGene:5578
6603 964-972 GeneOrGeneProduct denotes PKCalpha NCBIGene:5578
6604 974-982 CellLine denotes Mz-ChA-1 NCBITaxon:9606
6605 1010-1014 ChemicalEntity denotes RAMH MESH:C069357
6606 1049-1096 GeneOrGeneProduct denotes extracellular signal-regulated kinase (ERK)-1/2 NCBIGene:5595;5594
6607 1147-1153 CellLine denotes BALB/c NCBITaxon:10090
6608 1159-1163 OrganismTaxon denotes mice NCBITaxon:10090
6609 1165-1169 OrganismTaxon denotes Mice NCBITaxon:10090
6610 1198-1202 ChemicalEntity denotes RAMH MESH:C069357
6611 1219-1224 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
6612 1246-1252 DiseaseOrPhenotypicFeature denotes Tumors MESH:D009369
6613 1328-1336 GeneOrGeneProduct denotes PKCalpha NCBIGene:5578
6614 1338-1381 GeneOrGeneProduct denotes vascular endothelial growth factor (VEGF)-A NCBIGene:7422
6615 1383-1389 GeneOrGeneProduct denotes VEGF-C NCBIGene:7424
6616 1391-1406 GeneOrGeneProduct denotes VEGF receptor 2 NCBIGene:3791
6617 1412-1427 GeneOrGeneProduct denotes VEGF receptor 3 NCBIGene:2324
6618 1429-1433 GeneOrGeneProduct denotes HRH3 NCBIGene:11255
6619 1469-1473 ChemicalEntity denotes RAMH MESH:C069357
6620 1498-1516 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma MESH:D018281
6621 1524-1528 ChemicalEntity denotes RAMH MESH:C069357
6622 1539-1544 ChemicalEntity denotes IP(3) MESH:D015544
6623 1556-1564 GeneOrGeneProduct denotes PKCalpha NCBIGene:5578
6624 1595-1601 GeneOrGeneProduct denotes ERK1/2 NCBIGene:5595;5594
6625 1619-1623 ChemicalEntity denotes RAMH MESH:C069357
6626 1663-1671 GeneOrGeneProduct denotes PKCalpha NCBIGene:5578
6627 1737-1745 CellLine denotes Mz-ChA-1 NCBITaxon:9606
6628 1766-1774 GeneOrGeneProduct denotes PKCalpha NCBIGene:5578
6629 1785-1789 ChemicalEntity denotes RAMH MESH:C069357
6630 1804-1812 CellLine denotes Mz-ChA-1 NCBITaxon:9606
6631 1837-1841 ChemicalEntity denotes RAMH MESH:C069357
6632 1853-1859 GeneOrGeneProduct denotes ERK1/2 NCBIGene:5595;5594
6633 1886-1890 ChemicalEntity denotes RAMH MESH:C069357
6634 1901-1906 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
6635 1932-1936 GeneOrGeneProduct denotes VEGF NCBIGene:7422;7424
6636 1956-1964 GeneOrGeneProduct denotes PKCalpha NCBIGene:5578
6637 1991-1995 ChemicalEntity denotes RAMH MESH:C069357
6638 2005-2023 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma MESH:D018281
6639 2034-2042 GeneOrGeneProduct denotes PKCalpha NCBIGene:5578
6640 2053-2059 GeneOrGeneProduct denotes ERK1/2 NCBIGene:5595;5594
6641 2093-2101 GeneOrGeneProduct denotes PKCalpha NCBIGene:5578
6642 2105-2124 GeneOrGeneProduct denotes histamine receptors NCBIGene:11255|NCBIGene:3269|NCBIGene:3274|NCBIGene:59340
6643 2156-2174 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma MESH:D018281

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 90-108 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma 0019087
T2 338-356 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma 0019087
T3 416-434 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma 0019087
T4 1347-1358 DiseaseOrPhenotypicFeature denotes endothelial 0015292
T5 1498-1516 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma 0019087
T6 2005-2023 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma 0019087
T7 2156-2174 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma 0019087

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 13-21 GeneOrGeneProduct denotes receptor
T2 22-30 GeneOrGeneProduct denotes mediated
T3 31-41 GeneOrGeneProduct denotes activation
T4 45-59 GeneOrGeneProduct denotes protein kinase
T5 60-66 GeneOrGeneProduct denotes Calpha
T6 80-86 GeneOrGeneProduct denotes growth
T7 141-150 GeneOrGeneProduct denotes regulates
T8 170-179 GeneOrGeneProduct denotes receptors
T9 181-185 GeneOrGeneProduct denotes HRH1
T10 187-191 GeneOrGeneProduct denotes HRH2
T11 193-197 GeneOrGeneProduct denotes HRH3
T12 203-207 GeneOrGeneProduct denotes HRH4
T13 216-219 GeneOrGeneProduct denotes myo
T14 220-228 GeneOrGeneProduct denotes inositol
T15 264-280 GeneOrGeneProduct denotes protein kinase C
T16 282-285 GeneOrGeneProduct denotes PKC
T17 287-319 GeneOrGeneProduct denotes mitogen-activated protein kinase
T18 328-337 GeneOrGeneProduct denotes regulates
T19 357-363 GeneOrGeneProduct denotes growth
T20 390-394 GeneOrGeneProduct denotes HRH3
T21 402-412 GeneOrGeneProduct denotes regulation
T22 435-441 GeneOrGeneProduct denotes growth
T23 457-461 GeneOrGeneProduct denotes HRH3
T24 495-499 GeneOrGeneProduct denotes cell
T25 500-505 GeneOrGeneProduct denotes lines
T26 571-573 GeneOrGeneProduct denotes Mz
T27 574-579 GeneOrGeneProduct denotes ChA-1
T28 580-585 GeneOrGeneProduct denotes cells
T29 607-612 GeneOrGeneProduct denotes alpha
T30 673-677 GeneOrGeneProduct denotes cell
T31 678-684 GeneOrGeneProduct denotes growth
T32 687-694 GeneOrGeneProduct denotes b) IP(3
T33 707-710 GeneOrGeneProduct denotes AMP
T34 746-749 GeneOrGeneProduct denotes PKC
T35 754-786 GeneOrGeneProduct denotes mitogen-activated protein kinase
T36 813-821 GeneOrGeneProduct denotes PKCalpha
T37 862-866 GeneOrGeneProduct denotes cell
T38 897-905 GeneOrGeneProduct denotes PKCalpha
T39 909-916 GeneOrGeneProduct denotes cytosol
T40 951-960 GeneOrGeneProduct denotes knockdown
T41 964-972 GeneOrGeneProduct denotes PKCalpha
T42 974-976 GeneOrGeneProduct denotes Mz
T43 977-982 GeneOrGeneProduct denotes ChA-1
T44 983-988 GeneOrGeneProduct denotes cells
T45 1033-1037 GeneOrGeneProduct denotes cell
T46 1038-1044 GeneOrGeneProduct denotes growth
T47 1049-1086 GeneOrGeneProduct denotes extracellular signal-regulated kinase
T48 1087-1096 GeneOrGeneProduct denotes (ERK)-1/2
T49 1154-1158 GeneOrGeneProduct denotes nude
T50 1159-1163 GeneOrGeneProduct denotes mice
T51 1165-1169 GeneOrGeneProduct denotes Mice
T52 1203-1209 GeneOrGeneProduct denotes for 44
T53 1219-1224 GeneOrGeneProduct denotes tumor
T54 1246-1252 GeneOrGeneProduct denotes Tumors
T55 1258-1265 GeneOrGeneProduct denotes excised
T56 1299-1308 GeneOrGeneProduct denotes apoptosis
T57 1328-1336 GeneOrGeneProduct denotes PKCalpha
T58 1338-1372 GeneOrGeneProduct denotes vascular endothelial growth factor
T59 1374-1378 GeneOrGeneProduct denotes VEGF
T60 1383-1389 GeneOrGeneProduct denotes VEGF-C
T61 1391-1404 GeneOrGeneProduct denotes VEGF receptor
T62 1412-1425 GeneOrGeneProduct denotes VEGF receptor
T63 1429-1433 GeneOrGeneProduct denotes HRH3
T64 1458-1461 GeneOrGeneProduct denotes all
T65 1462-1467 GeneOrGeneProduct denotes cells
T66 1488-1494 GeneOrGeneProduct denotes growth
T67 1517-1522 GeneOrGeneProduct denotes cells
T68 1556-1564 GeneOrGeneProduct denotes PKCalpha
T69 1595-1601 GeneOrGeneProduct denotes ERK1/2
T70 1624-1631 GeneOrGeneProduct denotes induced
T71 1634-1639 GeneOrGeneProduct denotes shift
T72 1663-1671 GeneOrGeneProduct denotes PKCalpha
T73 1692-1701 GeneOrGeneProduct denotes cytosolic
T74 1737-1739 GeneOrGeneProduct denotes Mz
T75 1740-1745 GeneOrGeneProduct denotes ChA-1
T76 1746-1751 GeneOrGeneProduct denotes cells
T77 1766-1774 GeneOrGeneProduct denotes PKCalpha
T78 1804-1806 GeneOrGeneProduct denotes Mz
T79 1807-1812 GeneOrGeneProduct denotes ChA-1
T80 1813-1817 GeneOrGeneProduct denotes cell
T81 1818-1824 GeneOrGeneProduct denotes growth
T82 1853-1859 GeneOrGeneProduct denotes ERK1/2
T83 1901-1906 GeneOrGeneProduct denotes tumor
T84 1907-1913 GeneOrGeneProduct denotes growth
T85 1932-1936 GeneOrGeneProduct denotes VEGF
T86 1945-1954 GeneOrGeneProduct denotes receptors
T87 1956-1964 GeneOrGeneProduct denotes PKCalpha
T88 2024-2030 GeneOrGeneProduct denotes growth
T89 2034-2042 GeneOrGeneProduct denotes PKCalpha
T90 2053-2059 GeneOrGeneProduct denotes ERK1/2
T91 2093-2101 GeneOrGeneProduct denotes PKCalpha
T92 2115-2124 GeneOrGeneProduct denotes receptors
T93 2145-2155 GeneOrGeneProduct denotes regulating
T94 2175-2181 GeneOrGeneProduct denotes growth

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 13-21 GeneOrGeneProduct denotes receptor
T2 45-59 GeneOrGeneProduct denotes protein kinase
T3 60-66 GeneOrGeneProduct denotes Calpha
T4 80-86 GeneOrGeneProduct denotes growth
T5 181-185 GeneOrGeneProduct denotes HRH1
T6 187-191 GeneOrGeneProduct denotes HRH2
T7 193-197 GeneOrGeneProduct denotes HRH3
T8 203-207 GeneOrGeneProduct denotes HRH4
T9 220-228 GeneOrGeneProduct denotes inositol
T10 264-280 GeneOrGeneProduct denotes protein kinase C
T11 282-285 GeneOrGeneProduct denotes PKC
T12 287-319 GeneOrGeneProduct denotes mitogen-activated protein kinase
T13 357-363 GeneOrGeneProduct denotes growth
T14 390-394 GeneOrGeneProduct denotes HRH3
T15 435-441 GeneOrGeneProduct denotes growth
T16 457-461 GeneOrGeneProduct denotes HRH3
T17 495-499 GeneOrGeneProduct denotes cell
T18 500-505 GeneOrGeneProduct denotes lines
T19 607-612 GeneOrGeneProduct denotes alpha
T20 673-677 GeneOrGeneProduct denotes cell
T21 678-684 GeneOrGeneProduct denotes growth
T22 746-749 GeneOrGeneProduct denotes PKC
T23 754-786 GeneOrGeneProduct denotes mitogen-activated protein kinase
T24 813-821 GeneOrGeneProduct denotes PKCalpha
T25 862-866 GeneOrGeneProduct denotes cell
T26 897-905 GeneOrGeneProduct denotes PKCalpha
T27 951-960 GeneOrGeneProduct denotes knockdown
T28 964-972 GeneOrGeneProduct denotes PKCalpha
T29 1033-1037 GeneOrGeneProduct denotes cell
T30 1038-1044 GeneOrGeneProduct denotes growth
T31 1049-1086 GeneOrGeneProduct denotes extracellular signal-regulated kinase
T32 1088-1091 GeneOrGeneProduct denotes ERK
T33 1154-1158 GeneOrGeneProduct denotes nude
T34 1299-1308 GeneOrGeneProduct denotes apoptosis
T35 1328-1336 GeneOrGeneProduct denotes PKCalpha
T36 1338-1372 GeneOrGeneProduct denotes vascular endothelial growth factor
T37 1374-1378 GeneOrGeneProduct denotes VEGF
T38 1383-1389 GeneOrGeneProduct denotes VEGF-C
T39 1391-1404 GeneOrGeneProduct denotes VEGF receptor
T40 1412-1425 GeneOrGeneProduct denotes VEGF receptor
T41 1429-1433 GeneOrGeneProduct denotes HRH3
T42 1488-1494 GeneOrGeneProduct denotes growth
T43 1556-1564 GeneOrGeneProduct denotes PKCalpha
T44 1595-1601 GeneOrGeneProduct denotes ERK1/2
T45 1663-1671 GeneOrGeneProduct denotes PKCalpha
T46 1692-1701 GeneOrGeneProduct denotes cytosolic
T47 1766-1774 GeneOrGeneProduct denotes PKCalpha
T48 1813-1817 GeneOrGeneProduct denotes cell
T49 1818-1824 GeneOrGeneProduct denotes growth
T50 1853-1859 GeneOrGeneProduct denotes ERK1/2
T51 1907-1913 GeneOrGeneProduct denotes growth
T52 1932-1936 GeneOrGeneProduct denotes VEGF
T53 1956-1964 GeneOrGeneProduct denotes PKCalpha
T54 2024-2030 GeneOrGeneProduct denotes growth
T55 2034-2042 GeneOrGeneProduct denotes PKCalpha
T56 2053-2059 GeneOrGeneProduct denotes ERK1/2
T57 2093-2101 GeneOrGeneProduct denotes PKCalpha
T58 2175-2181 GeneOrGeneProduct denotes growth

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 90-108 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T2 338-356 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T3 416-434 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T4 1219-1224 DiseaseOrPhenotypicFeature denotes tumor D009369
T5 1246-1252 DiseaseOrPhenotypicFeature denotes Tumors D009369
T6 1498-1516 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T7 1901-1906 DiseaseOrPhenotypicFeature denotes tumor D009369
T8 2005-2023 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T9 2156-2174 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 90-108 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma 0019087
T2 250-252 DiseaseOrPhenotypicFeature denotes IP 0010631
T3 338-356 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma 0019087
T4 416-434 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma 0019087
T5 690-692 DiseaseOrPhenotypicFeature denotes IP 0010631
T6 1219-1224 DiseaseOrPhenotypicFeature denotes tumor 0005070
T7 1498-1516 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma 0019087
T8 1539-1541 DiseaseOrPhenotypicFeature denotes IP 0010631
T9 1901-1906 DiseaseOrPhenotypicFeature denotes tumor 0005070
T10 2005-2023 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma 0019087
T11 2156-2174 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma 0019087

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 90-108 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T2 338-356 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T3 416-434 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T4 1219-1224 DiseaseOrPhenotypicFeature denotes tumor D009369
T5 1246-1252 DiseaseOrPhenotypicFeature denotes Tumors DISEASE|D009369
T7 1498-1516 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T8 1901-1906 DiseaseOrPhenotypicFeature denotes tumor D009369
T9 2005-2023 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T10 2156-2174 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 90-108 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T2 338-356 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T3 416-434 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T4 1219-1224 DiseaseOrPhenotypicFeature denotes tumor D009369
T5 1246-1252 DiseaseOrPhenotypicFeature denotes Tumors D009369
T6 1498-1516 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T7 1901-1906 DiseaseOrPhenotypicFeature denotes tumor D009369
T8 2005-2023 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T9 2156-2174 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281

LitCoin_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 571-579 CellLine denotes Mz-ChA-1 CVCL_6932
T2 974-982 CellLine denotes Mz-ChA-1 CVCL_6932
T3 1737-1745 CellLine denotes Mz-ChA-1 CVCL_6932
T4 1804-1812 CellLine denotes Mz-ChA-1 CVCL_6932

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 534-539 OrganismTaxon denotes human
T2 1159-1163 OrganismTaxon denotes mice
T3 1165-1169 OrganismTaxon denotes Mice

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 3-12 ChemicalEntity denotes histamine D006632|http://purl.obolibrary.org/obo/CHEBI_58432|http://purl.obolibrary.org/obo/CHEBI_18295
T4 131-140 ChemicalEntity denotes Histamine http://purl.obolibrary.org/obo/CHEBI_18295
T5 214-248 ChemicalEntity denotes d-myo-inositol 1,4,5-trisphosphate http://purl.obolibrary.org/obo/CHEBI_16595
T6 250-255 ChemicalEntity denotes IP(3) ChemicalEntity
T7 602-633 ChemicalEntity denotes (R)-(alpha)-(-)-methylhistamine http://purl.obolibrary.org/obo/CHEBI_73337
T8 650-654 ChemicalEntity denotes RAMH ChemicalEntity
T9 690-695 ChemicalEntity denotes IP(3) ChemicalEntity
T10 700-710 ChemicalEntity denotes cyclic AMP http://purl.obolibrary.org/obo/CHEBI_17489
T11 1010-1014 ChemicalEntity denotes RAMH ChemicalEntity
T12 1198-1202 ChemicalEntity denotes RAMH ChemicalEntity
T13 1469-1473 ChemicalEntity denotes RAMH ChemicalEntity
T14 1524-1528 ChemicalEntity denotes RAMH ChemicalEntity
T15 1539-1544 ChemicalEntity denotes IP(3) ChemicalEntity
T16 1619-1623 ChemicalEntity denotes RAMH ChemicalEntity
T17 1785-1789 ChemicalEntity denotes RAMH ChemicalEntity
T18 1837-1841 ChemicalEntity denotes RAMH ChemicalEntity
T19 1886-1890 ChemicalEntity denotes RAMH ChemicalEntity
T20 1991-1995 ChemicalEntity denotes RAMH ChemicalEntity
T21 2105-2114 ChemicalEntity denotes histamine D006632|http://purl.obolibrary.org/obo/CHEBI_58432|http://purl.obolibrary.org/obo/CHEBI_18295

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 60-66 GeneOrGeneProduct denotes Calpha
T2 181-185 GeneOrGeneProduct denotes HRH1
T3 187-191 GeneOrGeneProduct denotes HRH2
T4 193-197 GeneOrGeneProduct denotes HRH3
T5 203-207 GeneOrGeneProduct denotes HRH4
T6 264-280 GeneOrGeneProduct denotes protein kinase C
T7 282-285 GeneOrGeneProduct denotes PKC
T8 287-319 GeneOrGeneProduct denotes mitogen-activated protein kinase
T9 390-394 GeneOrGeneProduct denotes HRH3
T10 457-461 GeneOrGeneProduct denotes HRH3
T11 607-612 GeneOrGeneProduct denotes alpha
T12 746-749 GeneOrGeneProduct denotes PKC
T13 754-786 GeneOrGeneProduct denotes mitogen-activated protein kinase
T14 813-821 GeneOrGeneProduct denotes PKCalpha
T15 897-905 GeneOrGeneProduct denotes PKCalpha
T16 964-972 GeneOrGeneProduct denotes PKCalpha
T17 1049-1086 GeneOrGeneProduct denotes extracellular signal-regulated kinase
T18 1088-1091 GeneOrGeneProduct denotes ERK
T19 1328-1336 GeneOrGeneProduct denotes PKCalpha
T20 1338-1372 GeneOrGeneProduct denotes vascular endothelial growth factor
T21 1374-1378 GeneOrGeneProduct denotes VEGF
T22 1383-1389 GeneOrGeneProduct denotes VEGF-C
T24 1391-1404 GeneOrGeneProduct denotes VEGF receptor
T26 1412-1425 GeneOrGeneProduct denotes VEGF receptor
T28 1429-1433 GeneOrGeneProduct denotes HRH3
T29 1556-1564 GeneOrGeneProduct denotes PKCalpha
T30 1595-1601 GeneOrGeneProduct denotes ERK1/2
T31 1663-1671 GeneOrGeneProduct denotes PKCalpha
T32 1766-1774 GeneOrGeneProduct denotes PKCalpha
T33 1853-1859 GeneOrGeneProduct denotes ERK1/2
T34 1932-1936 GeneOrGeneProduct denotes VEGF
T35 1956-1964 GeneOrGeneProduct denotes PKCalpha
T36 2034-2042 GeneOrGeneProduct denotes PKCalpha
T37 2053-2059 GeneOrGeneProduct denotes ERK1/2
T38 2093-2101 GeneOrGeneProduct denotes PKCalpha

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T4 1804-1812 CellLine denotes Mz-ChA-1 CVCL_6932
T3 1737-1745 CellLine denotes Mz-ChA-1 CVCL_6932
T2 974-982 CellLine denotes Mz-ChA-1 CVCL_6932
T1 571-579 CellLine denotes Mz-ChA-1 CVCL_6932
T21 2105-2114 ChemicalEntity denotes histamine http://purl.obolibrary.org/obo/CHEBI_18295|http://purl.obolibrary.org/obo/CHEBI_58432|D006632
T20 1991-1995 ChemicalEntity denotes RAMH ChemicalEntity
T19 1886-1890 ChemicalEntity denotes RAMH ChemicalEntity
T18 1837-1841 ChemicalEntity denotes RAMH ChemicalEntity
T17 1785-1789 ChemicalEntity denotes RAMH ChemicalEntity
T16 1619-1623 ChemicalEntity denotes RAMH ChemicalEntity
T15 1539-1544 ChemicalEntity denotes IP(3) ChemicalEntity
T14 1524-1528 ChemicalEntity denotes RAMH ChemicalEntity
T13 1469-1473 ChemicalEntity denotes RAMH ChemicalEntity
T12 1198-1202 ChemicalEntity denotes RAMH ChemicalEntity
T11 1010-1014 ChemicalEntity denotes RAMH ChemicalEntity
T10 700-710 ChemicalEntity denotes cyclic AMP http://purl.obolibrary.org/obo/CHEBI_17489
T9 690-695 ChemicalEntity denotes IP(3) ChemicalEntity
T8 650-654 ChemicalEntity denotes RAMH ChemicalEntity
T7 602-633 ChemicalEntity denotes (R)-(alpha)-(-)-methylhistamine http://purl.obolibrary.org/obo/CHEBI_73337
T6 250-255 ChemicalEntity denotes IP(3) ChemicalEntity
T5 214-248 ChemicalEntity denotes d-myo-inositol 1,4,5-trisphosphate http://purl.obolibrary.org/obo/CHEBI_16595
T76272 131-140 ChemicalEntity denotes Histamine http://purl.obolibrary.org/obo/CHEBI_18295
T72502 3-12 ChemicalEntity denotes histamine http://purl.obolibrary.org/obo/CHEBI_18295|http://purl.obolibrary.org/obo/CHEBI_58432|D006632
T38 2093-2101 GeneOrGeneProduct denotes PKCalpha
T37 2053-2059 GeneOrGeneProduct denotes ERK1/2
T36 2034-2042 GeneOrGeneProduct denotes PKCalpha
T35 1956-1964 GeneOrGeneProduct denotes PKCalpha
T34 1932-1936 GeneOrGeneProduct denotes VEGF
T33 1853-1859 GeneOrGeneProduct denotes ERK1/2
T32 1766-1774 GeneOrGeneProduct denotes PKCalpha
T31 1663-1671 GeneOrGeneProduct denotes PKCalpha
T30 1595-1601 GeneOrGeneProduct denotes ERK1/2
T29 1556-1564 GeneOrGeneProduct denotes PKCalpha
T28 1429-1433 GeneOrGeneProduct denotes HRH3
T26 1412-1425 GeneOrGeneProduct denotes VEGF receptor
T24 1391-1404 GeneOrGeneProduct denotes VEGF receptor
T22 1383-1389 GeneOrGeneProduct denotes VEGF-C
T73307 1374-1378 GeneOrGeneProduct denotes VEGF
T4708 1338-1372 GeneOrGeneProduct denotes vascular endothelial growth factor
T75089 1328-1336 GeneOrGeneProduct denotes PKCalpha
T67282 1088-1091 GeneOrGeneProduct denotes ERK
T42079 1049-1086 GeneOrGeneProduct denotes extracellular signal-regulated kinase
T12180 964-972 GeneOrGeneProduct denotes PKCalpha
T79472 897-905 GeneOrGeneProduct denotes PKCalpha
T14737 813-821 GeneOrGeneProduct denotes PKCalpha
T38736 754-786 GeneOrGeneProduct denotes mitogen-activated protein kinase
T68374 746-749 GeneOrGeneProduct denotes PKC
T35078 607-612 GeneOrGeneProduct denotes alpha
T29699 457-461 GeneOrGeneProduct denotes HRH3
T54993 390-394 GeneOrGeneProduct denotes HRH3
T95096 287-319 GeneOrGeneProduct denotes mitogen-activated protein kinase
T8250 282-285 GeneOrGeneProduct denotes PKC
T33008 264-280 GeneOrGeneProduct denotes protein kinase C
T11288 203-207 GeneOrGeneProduct denotes HRH4
T92349 193-197 GeneOrGeneProduct denotes HRH3
T56813 187-191 GeneOrGeneProduct denotes HRH2
T49937 181-185 GeneOrGeneProduct denotes HRH1
T73420 60-66 GeneOrGeneProduct denotes Calpha
T31943 2156-2174 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T68433 2005-2023 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T45359 1901-1906 DiseaseOrPhenotypicFeature denotes tumor D009369
T43664 1498-1516 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T58422 1246-1252 DiseaseOrPhenotypicFeature denotes Tumors D009369
T77039 1219-1224 DiseaseOrPhenotypicFeature denotes tumor D009369
T78751 416-434 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T40942 338-356 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T77924 90-108 DiseaseOrPhenotypicFeature denotes cholangiocarcinoma D018281
T71823 1165-1169 OrganismTaxon denotes Mice
T6249 1159-1163 OrganismTaxon denotes mice
T49266 534-539 OrganismTaxon denotes human

DisGeNET

Id Subject Object Predicate Lexical cue
T0 390-394 gene:11255 denotes HRH3
T1 416-434 disease:C0206698 denotes cholangiocarcinoma
R1 T0 T1 associated_with HRH3,cholangiocarcinoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19825989-3#25#29#gene11255 390-394 gene11255 denotes HRH3
19825989-3#51#69#diseaseC0206698 416-434 diseaseC0206698 denotes cholangiocarcinoma
25#29#gene1125551#69#diseaseC0206698 19825989-3#25#29#gene11255 19825989-3#51#69#diseaseC0206698 associated_with HRH3,cholangiocarcinoma