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PubMed:19789368 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer.
T2 97-185 Sentence denotes Vitamin D is associated with decreased risks of various cancers, including colon cancer.
T3 186-332 Sentence denotes The vitamin D receptor (VDR) is a transcription factor, which plays an important role in cellular differentiation and inhibition of proliferation.
T4 333-475 Sentence denotes A link between VDR and the RAS-mitogen-activated protein kinase (MAPK) or phosphatidylinositol 3-kinase (PI3K)-AKT pathway has been suggested.
T5 476-590 Sentence denotes However, the prognostic role of VDR expression or its relationship with PIK3CA or KRAS mutation remains uncertain.
T6 591-722 Sentence denotes Among 619 colorectal cancers in two prospective cohort studies, 233 (38%) tumors showed VDR overexpression by immunohistochemistry.
T7 723-1050 Sentence denotes We analyzed for PIK3CA and KRAS mutations and LINE-1 methylation by Pyrosequencing, microsatellite instability (MSI), and DNA methylation (epigenetic changes) in eight CpG island methylator phenotype (CIMP)-specific promoters [CACNA1G, CDKN2A (p16), CRABP1, IGF2, MLH1, NEUROG1, RUNX3, and SOCS1] by MethyLight (real-time PCR).
T8 1051-1318 Sentence denotes VDR overexpression was significantly associated with KRAS mutation (odds ratio, 1.55; 95% confidence interval, 1.11-2.16) and PIK3CA mutation (odds ratio, 2.17; 95% confidence interval, 1.36-3.47), both of which persisted in multivariate logistic regression analysis.
T9 1319-1577 Sentence denotes VDR was not independently associated with body mass index, family history of colorectal cancer, tumor location (colon versus rectum), stage, tumor grade, signet ring cells, CIMP, MSI, LINE-1 hypomethylation, BRAF, p53, p21, beta-catenin, or cyclooxygenase-2.
T10 1578-1677 Sentence denotes VDR expression was not significantly related with patient survival, prognosis, or clinical outcome.
T11 1678-1792 Sentence denotes In conclusion, VDR overexpression in colorectal cancer is independently associated with PIK3CA and KRAS mutations.
T12 1793-1976 Sentence denotes Our data support potential interactions between the VDR, RAS-MAPK and PI3K-AKT pathways, and possible influence by KRAS or PIK3CA mutation on therapy or chemoprevention targeting VDR.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
6516 0-18 GeneOrGeneProduct denotes Vitamin D receptor NCBIGene:7421
6517 49-55 GeneOrGeneProduct denotes PIK3CA NCBIGene:5290
6518 60-64 GeneOrGeneProduct denotes KRAS NCBIGene:3845
6519 78-95 DiseaseOrPhenotypicFeature denotes colorectal cancer MESH:D015179
6520 97-106 ChemicalEntity denotes Vitamin D MESH:D014807
6521 153-160 DiseaseOrPhenotypicFeature denotes cancers MESH:D009369
6522 172-184 DiseaseOrPhenotypicFeature denotes colon cancer MESH:D015179
6523 190-208 GeneOrGeneProduct denotes vitamin D receptor NCBIGene:7421
6524 210-213 GeneOrGeneProduct denotes VDR NCBIGene:7421
6525 348-351 GeneOrGeneProduct denotes VDR NCBIGene:7421
6526 360-363 GeneOrGeneProduct denotes RAS NCBIGene:3845
6527 364-396 GeneOrGeneProduct denotes mitogen-activated protein kinase NCBIGene:1432
6528 398-402 GeneOrGeneProduct denotes MAPK NCBIGene:1432
6529 407-436 GeneOrGeneProduct denotes phosphatidylinositol 3-kinase NCBIGene:5290
6530 438-442 GeneOrGeneProduct denotes PI3K NCBIGene:5290
6531 444-447 GeneOrGeneProduct denotes AKT NCBIGene:207
6532 508-511 GeneOrGeneProduct denotes VDR NCBIGene:7421
6533 548-554 GeneOrGeneProduct denotes PIK3CA NCBIGene:5290
6534 558-562 GeneOrGeneProduct denotes KRAS NCBIGene:3845
6535 601-619 DiseaseOrPhenotypicFeature denotes colorectal cancers MESH:D015179
6536 665-671 DiseaseOrPhenotypicFeature denotes tumors MESH:D009369
6537 679-682 GeneOrGeneProduct denotes VDR NCBIGene:7421
6538 739-745 GeneOrGeneProduct denotes PIK3CA NCBIGene:5290
6539 750-754 GeneOrGeneProduct denotes KRAS NCBIGene:3845
6540 950-957 GeneOrGeneProduct denotes CACNA1G NCBIGene:8913
6541 959-965 GeneOrGeneProduct denotes CDKN2A NCBIGene:1029
6542 967-970 GeneOrGeneProduct denotes p16 NCBIGene:1029
6543 973-979 GeneOrGeneProduct denotes CRABP1 NCBIGene:1381
6544 981-985 GeneOrGeneProduct denotes IGF2 NCBIGene:3481
6545 987-991 GeneOrGeneProduct denotes MLH1 NCBIGene:4292
6546 993-1000 GeneOrGeneProduct denotes NEUROG1 NCBIGene:4762
6547 1002-1007 GeneOrGeneProduct denotes RUNX3 NCBIGene:864
6548 1013-1018 GeneOrGeneProduct denotes SOCS1 NCBIGene:8651
6549 1051-1054 GeneOrGeneProduct denotes VDR NCBIGene:7421
6550 1104-1108 GeneOrGeneProduct denotes KRAS NCBIGene:3845
6551 1177-1183 GeneOrGeneProduct denotes PIK3CA NCBIGene:5290
6552 1319-1322 GeneOrGeneProduct denotes VDR NCBIGene:7421
6553 1396-1413 DiseaseOrPhenotypicFeature denotes colorectal cancer MESH:D015179
6554 1415-1420 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
6555 1460-1465 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
6556 1527-1531 GeneOrGeneProduct denotes BRAF NCBIGene:673
6557 1533-1536 GeneOrGeneProduct denotes p53 NCBIGene:7157
6558 1538-1541 GeneOrGeneProduct denotes p21 NCBIGene:1026
6559 1543-1555 GeneOrGeneProduct denotes beta-catenin NCBIGene:1499
6560 1560-1576 GeneOrGeneProduct denotes cyclooxygenase-2 NCBIGene:5743
6561 1578-1581 GeneOrGeneProduct denotes VDR NCBIGene:7421
6562 1628-1635 OrganismTaxon denotes patient NCBITaxon:9606
6563 1693-1696 GeneOrGeneProduct denotes VDR NCBIGene:7421
6564 1715-1732 DiseaseOrPhenotypicFeature denotes colorectal cancer MESH:D015179
6565 1766-1772 GeneOrGeneProduct denotes PIK3CA NCBIGene:5290
6566 1777-1781 GeneOrGeneProduct denotes KRAS NCBIGene:3845
6567 1845-1848 GeneOrGeneProduct denotes VDR NCBIGene:7421
6568 1850-1853 GeneOrGeneProduct denotes RAS NCBIGene:3845
6569 1854-1858 GeneOrGeneProduct denotes MAPK NCBIGene:1432
6570 1863-1867 GeneOrGeneProduct denotes PI3K NCBIGene:5290
6571 1868-1871 GeneOrGeneProduct denotes AKT NCBIGene:207
6572 1908-1912 GeneOrGeneProduct denotes KRAS NCBIGene:3845
6573 1916-1922 GeneOrGeneProduct denotes PIK3CA NCBIGene:5290
6574 1972-1975 GeneOrGeneProduct denotes VDR NCBIGene:7421

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 78-95 DiseaseOrPhenotypicFeature denotes colorectal cancer 0005575
T2 89-95 DiseaseOrPhenotypicFeature denotes cancer 0004992
T3 153-160 DiseaseOrPhenotypicFeature denotes cancers 0004992
T4 178-184 DiseaseOrPhenotypicFeature denotes cancer 0004992
T5 601-619 DiseaseOrPhenotypicFeature denotes colorectal cancers 0005575
T6 1396-1413 DiseaseOrPhenotypicFeature denotes colorectal cancer 0005575
T7 1407-1413 DiseaseOrPhenotypicFeature denotes cancer 0004992
T8 1715-1732 DiseaseOrPhenotypicFeature denotes colorectal cancer 0005575
T9 1726-1732 DiseaseOrPhenotypicFeature denotes cancer 0004992

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-18 GeneOrGeneProduct denotes Vitamin D receptor
T2 49-55 GeneOrGeneProduct denotes PIK3CA
T3 60-64 GeneOrGeneProduct denotes KRAS
T4 65-95 GeneOrGeneProduct denotes mutations in colorectal cancer
T5 190-208 GeneOrGeneProduct denotes vitamin D receptor
T6 210-213 GeneOrGeneProduct denotes VDR
T7 220-240 GeneOrGeneProduct denotes transcription factor
T8 335-339 GeneOrGeneProduct denotes link
T9 348-351 GeneOrGeneProduct denotes VDR
T10 364-396 GeneOrGeneProduct denotes mitogen-activated protein kinase
T11 398-402 GeneOrGeneProduct denotes MAPK
T12 407-436 GeneOrGeneProduct denotes phosphatidylinositol 3-kinase
T13 438-442 GeneOrGeneProduct denotes PI3K
T14 508-511 GeneOrGeneProduct denotes VDR
T15 548-554 GeneOrGeneProduct denotes PIK3CA
T16 558-562 GeneOrGeneProduct denotes KRAS
T17 563-571 GeneOrGeneProduct denotes mutation
T18 665-671 GeneOrGeneProduct denotes tumors
T19 679-682 GeneOrGeneProduct denotes VDR
T20 739-745 GeneOrGeneProduct denotes PIK3CA
T21 750-754 GeneOrGeneProduct denotes KRAS
T22 755-764 GeneOrGeneProduct denotes mutations
T23 769-773 GeneOrGeneProduct denotes LINE
T24 845-860 GeneOrGeneProduct denotes DNA methylation
T25 950-957 GeneOrGeneProduct denotes CACNA1G
T26 959-965 GeneOrGeneProduct denotes CDKN2A
T27 973-979 GeneOrGeneProduct denotes CRABP1
T28 981-985 GeneOrGeneProduct denotes IGF2
T29 987-991 GeneOrGeneProduct denotes MLH1
T30 993-1000 GeneOrGeneProduct denotes NEUROG1
T31 1002-1007 GeneOrGeneProduct denotes RUNX3
T32 1013-1018 GeneOrGeneProduct denotes SOCS1
T33 1035-1044 GeneOrGeneProduct denotes real-time
T34 1051-1054 GeneOrGeneProduct denotes VDR
T35 1104-1108 GeneOrGeneProduct denotes KRAS
T36 1109-1117 GeneOrGeneProduct denotes mutation
T37 1177-1183 GeneOrGeneProduct denotes PIK3CA
T38 1184-1192 GeneOrGeneProduct denotes mutation
T39 1263-1272 GeneOrGeneProduct denotes persisted
T40 1319-1322 GeneOrGeneProduct denotes VDR
T41 1361-1376 GeneOrGeneProduct denotes body mass index
T42 1415-1420 GeneOrGeneProduct denotes tumor
T43 1460-1465 GeneOrGeneProduct denotes tumor
T44 1480-1484 GeneOrGeneProduct denotes ring
T45 1485-1490 GeneOrGeneProduct denotes cells
T46 1503-1507 GeneOrGeneProduct denotes LINE
T47 1527-1531 GeneOrGeneProduct denotes BRAF
T48 1543-1555 GeneOrGeneProduct denotes beta-catenin
T49 1560-1576 GeneOrGeneProduct denotes cyclooxygenase-2
T50 1578-1581 GeneOrGeneProduct denotes VDR
T51 1693-1696 GeneOrGeneProduct denotes VDR
T52 1766-1772 GeneOrGeneProduct denotes PIK3CA
T53 1777-1781 GeneOrGeneProduct denotes KRAS
T54 1782-1791 GeneOrGeneProduct denotes mutations
T55 1845-1848 GeneOrGeneProduct denotes VDR
T56 1854-1858 GeneOrGeneProduct denotes MAPK
T57 1863-1867 GeneOrGeneProduct denotes PI3K
T58 1908-1912 GeneOrGeneProduct denotes KRAS
T59 1916-1922 GeneOrGeneProduct denotes PIK3CA
T60 1923-1931 GeneOrGeneProduct denotes mutation
T61 1972-1975 GeneOrGeneProduct denotes VDR

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-18 GeneOrGeneProduct denotes Vitamin D receptor
T2 49-55 GeneOrGeneProduct denotes PIK3CA
T3 60-64 GeneOrGeneProduct denotes KRAS
T4 65-95 GeneOrGeneProduct denotes mutations in colorectal cancer
T5 190-208 GeneOrGeneProduct denotes vitamin D receptor
T6 210-213 GeneOrGeneProduct denotes VDR
T7 220-240 GeneOrGeneProduct denotes transcription factor
T8 335-339 GeneOrGeneProduct denotes link
T9 348-351 GeneOrGeneProduct denotes VDR
T10 364-396 GeneOrGeneProduct denotes mitogen-activated protein kinase
T11 398-402 GeneOrGeneProduct denotes MAPK
T12 407-436 GeneOrGeneProduct denotes phosphatidylinositol 3-kinase
T13 438-442 GeneOrGeneProduct denotes PI3K
T14 508-511 GeneOrGeneProduct denotes VDR
T15 548-554 GeneOrGeneProduct denotes PIK3CA
T16 558-562 GeneOrGeneProduct denotes KRAS
T17 679-682 GeneOrGeneProduct denotes VDR
T18 739-745 GeneOrGeneProduct denotes PIK3CA
T19 750-754 GeneOrGeneProduct denotes KRAS
T20 845-860 GeneOrGeneProduct denotes DNA methylation
T21 950-957 GeneOrGeneProduct denotes CACNA1G
T22 959-965 GeneOrGeneProduct denotes CDKN2A
T23 973-979 GeneOrGeneProduct denotes CRABP1
T24 981-985 GeneOrGeneProduct denotes IGF2
T25 987-991 GeneOrGeneProduct denotes MLH1
T26 993-1000 GeneOrGeneProduct denotes NEUROG1
T27 1002-1007 GeneOrGeneProduct denotes RUNX3
T28 1013-1018 GeneOrGeneProduct denotes SOCS1
T29 1035-1044 GeneOrGeneProduct denotes real-time
T30 1051-1054 GeneOrGeneProduct denotes VDR
T31 1104-1108 GeneOrGeneProduct denotes KRAS
T32 1177-1183 GeneOrGeneProduct denotes PIK3CA
T33 1319-1322 GeneOrGeneProduct denotes VDR
T34 1361-1376 GeneOrGeneProduct denotes body mass index
T35 1480-1484 GeneOrGeneProduct denotes ring
T36 1527-1531 GeneOrGeneProduct denotes BRAF
T37 1543-1555 GeneOrGeneProduct denotes beta-catenin
T38 1560-1576 GeneOrGeneProduct denotes cyclooxygenase-2
T39 1578-1581 GeneOrGeneProduct denotes VDR
T40 1693-1696 GeneOrGeneProduct denotes VDR
T41 1766-1772 GeneOrGeneProduct denotes PIK3CA
T42 1777-1781 GeneOrGeneProduct denotes KRAS
T43 1845-1848 GeneOrGeneProduct denotes VDR
T44 1854-1858 GeneOrGeneProduct denotes MAPK
T45 1863-1867 GeneOrGeneProduct denotes PI3K
T46 1908-1912 GeneOrGeneProduct denotes KRAS
T47 1916-1922 GeneOrGeneProduct denotes PIK3CA
T48 1972-1975 GeneOrGeneProduct denotes VDR

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 78-95 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T2 153-160 DiseaseOrPhenotypicFeature denotes cancers D009369
T3 172-184 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T4 601-619 DiseaseOrPhenotypicFeature denotes colorectal cancers D015179
T5 665-671 DiseaseOrPhenotypicFeature denotes tumors D009369
T6 807-833 DiseaseOrPhenotypicFeature denotes microsatellite instability D053842
T7 835-838 DiseaseOrPhenotypicFeature denotes MSI D053842
T8 1396-1413 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T9 1415-1420 DiseaseOrPhenotypicFeature denotes tumor D009369
T10 1460-1465 DiseaseOrPhenotypicFeature denotes tumor D009369
T11 1498-1501 DiseaseOrPhenotypicFeature denotes MSI D053842
T12 1715-1732 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-18 GeneOrGeneProduct denotes Vitamin D receptor
T2 49-55 GeneOrGeneProduct denotes PIK3CA
T3 60-64 GeneOrGeneProduct denotes KRAS
T4 65-95 GeneOrGeneProduct denotes mutations in colorectal cancer
T5 190-208 GeneOrGeneProduct denotes vitamin D receptor
T6 210-213 GeneOrGeneProduct denotes VDR
T7 220-240 GeneOrGeneProduct denotes transcription factor
T8 348-351 GeneOrGeneProduct denotes VDR
T9 364-396 GeneOrGeneProduct denotes mitogen-activated protein kinase
T10 398-402 GeneOrGeneProduct denotes MAPK
T11 407-436 GeneOrGeneProduct denotes phosphatidylinositol 3-kinase
T12 438-442 GeneOrGeneProduct denotes PI3K
T13 508-511 GeneOrGeneProduct denotes VDR
T14 548-554 GeneOrGeneProduct denotes PIK3CA
T15 558-562 GeneOrGeneProduct denotes KRAS
T16 679-682 GeneOrGeneProduct denotes VDR
T17 739-745 GeneOrGeneProduct denotes PIK3CA
T18 750-754 GeneOrGeneProduct denotes KRAS
T19 950-957 GeneOrGeneProduct denotes CACNA1G
T20 959-965 GeneOrGeneProduct denotes CDKN2A
T21 973-979 GeneOrGeneProduct denotes CRABP1
T22 981-985 GeneOrGeneProduct denotes IGF2
T23 987-991 GeneOrGeneProduct denotes MLH1
T24 993-1000 GeneOrGeneProduct denotes NEUROG1
T25 1002-1007 GeneOrGeneProduct denotes RUNX3
T26 1013-1018 GeneOrGeneProduct denotes SOCS1
T27 1051-1054 GeneOrGeneProduct denotes VDR
T28 1104-1108 GeneOrGeneProduct denotes KRAS
T29 1177-1183 GeneOrGeneProduct denotes PIK3CA
T30 1319-1322 GeneOrGeneProduct denotes VDR
T31 1480-1484 GeneOrGeneProduct denotes ring
T32 1527-1531 GeneOrGeneProduct denotes BRAF
T33 1543-1555 GeneOrGeneProduct denotes beta-catenin
T34 1560-1576 GeneOrGeneProduct denotes cyclooxygenase-2
T35 1578-1581 GeneOrGeneProduct denotes VDR
T36 1693-1696 GeneOrGeneProduct denotes VDR
T37 1766-1772 GeneOrGeneProduct denotes PIK3CA
T38 1777-1781 GeneOrGeneProduct denotes KRAS
T39 1845-1848 GeneOrGeneProduct denotes VDR
T40 1854-1858 GeneOrGeneProduct denotes MAPK
T41 1863-1867 GeneOrGeneProduct denotes PI3K
T42 1908-1912 GeneOrGeneProduct denotes KRAS
T43 1916-1922 GeneOrGeneProduct denotes PIK3CA
T44 1972-1975 GeneOrGeneProduct denotes VDR

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 78-95 DiseaseOrPhenotypicFeature denotes colorectal cancer 0024331|0005575
T3 172-184 DiseaseOrPhenotypicFeature denotes colon cancer 0021063|0005575|0002032
T6 601-619 DiseaseOrPhenotypicFeature denotes colorectal cancers 0024331|0005575
T8 1396-1413 DiseaseOrPhenotypicFeature denotes colorectal cancer 0024331|0005575
T10 1415-1420 DiseaseOrPhenotypicFeature denotes tumor 0005070
T11 1460-1465 DiseaseOrPhenotypicFeature denotes tumor 0005070
T12 1715-1732 DiseaseOrPhenotypicFeature denotes colorectal cancer 0024331|0005575

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 78-95 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T2 153-160 DiseaseOrPhenotypicFeature denotes cancers D009369
T3 172-184 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T4 601-619 DiseaseOrPhenotypicFeature denotes colorectal cancers D015179
T5 665-671 DiseaseOrPhenotypicFeature denotes tumors DISEASE|D009369
T7 807-833 DiseaseOrPhenotypicFeature denotes microsatellite instability D053842
T8 835-838 DiseaseOrPhenotypicFeature denotes MSI D053842
T9 1396-1413 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T10 1415-1420 DiseaseOrPhenotypicFeature denotes tumor D009369
T11 1460-1465 DiseaseOrPhenotypicFeature denotes tumor D009369
T12 1498-1501 DiseaseOrPhenotypicFeature denotes MSI D053842
T13 1715-1732 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 78-95 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T2 153-160 DiseaseOrPhenotypicFeature denotes cancers D009369
T3 172-184 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T4 601-619 DiseaseOrPhenotypicFeature denotes colorectal cancers D015179
T5 665-671 DiseaseOrPhenotypicFeature denotes tumors D009369
T6 1396-1413 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T7 1415-1420 DiseaseOrPhenotypicFeature denotes tumor D009369
T8 1460-1465 DiseaseOrPhenotypicFeature denotes tumor D009369
T9 1715-1732 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 1628-1635 OrganismTaxon denotes patient

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-9 ChemicalEntity denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T2 97-106 ChemicalEntity denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T3 190-199 ChemicalEntity denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T4 360-363 ChemicalEntity denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T5 407-427 ChemicalEntity denotes phosphatidylinositol D010716|http://purl.obolibrary.org/obo/CHEBI_28874
T7 891-894 ChemicalEntity denotes CpG http://purl.obolibrary.org/obo/CHEBI_165823
T8 1560-1576 ChemicalEntity denotes cyclooxygenase-2 D051546
T9 1850-1853 ChemicalEntity denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T9 1850-1853 ChemicalEntity denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T8 1560-1576 ChemicalEntity denotes cyclooxygenase-2 D051546
T7 891-894 ChemicalEntity denotes CpG http://purl.obolibrary.org/obo/CHEBI_165823
T5 407-427 ChemicalEntity denotes phosphatidylinositol http://purl.obolibrary.org/obo/CHEBI_28874|D010716
T4 360-363 ChemicalEntity denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T3 190-199 ChemicalEntity denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T2 97-106 ChemicalEntity denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T1 0-9 ChemicalEntity denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T44 1972-1975 GeneOrGeneProduct denotes VDR
T43 1916-1922 GeneOrGeneProduct denotes PIK3CA
T42 1908-1912 GeneOrGeneProduct denotes KRAS
T41 1863-1867 GeneOrGeneProduct denotes PI3K
T40 1854-1858 GeneOrGeneProduct denotes MAPK
T39 1845-1848 GeneOrGeneProduct denotes VDR
T38 1777-1781 GeneOrGeneProduct denotes KRAS
T37 1766-1772 GeneOrGeneProduct denotes PIK3CA
T36 1693-1696 GeneOrGeneProduct denotes VDR
T35 1578-1581 GeneOrGeneProduct denotes VDR
T34 1560-1576 GeneOrGeneProduct denotes cyclooxygenase-2
T33 1543-1555 GeneOrGeneProduct denotes beta-catenin
T32 1527-1531 GeneOrGeneProduct denotes BRAF
T31 1480-1484 GeneOrGeneProduct denotes ring
T30 1319-1322 GeneOrGeneProduct denotes VDR
T29 1177-1183 GeneOrGeneProduct denotes PIK3CA
T28 1104-1108 GeneOrGeneProduct denotes KRAS
T27 1051-1054 GeneOrGeneProduct denotes VDR
T26 1013-1018 GeneOrGeneProduct denotes SOCS1
T25 1002-1007 GeneOrGeneProduct denotes RUNX3
T24 993-1000 GeneOrGeneProduct denotes NEUROG1
T23 987-991 GeneOrGeneProduct denotes MLH1
T22 981-985 GeneOrGeneProduct denotes IGF2
T21 973-979 GeneOrGeneProduct denotes CRABP1
T20 959-965 GeneOrGeneProduct denotes CDKN2A
T19 950-957 GeneOrGeneProduct denotes CACNA1G
T18 750-754 GeneOrGeneProduct denotes KRAS
T17 739-745 GeneOrGeneProduct denotes PIK3CA
T16 679-682 GeneOrGeneProduct denotes VDR
T15 558-562 GeneOrGeneProduct denotes KRAS
T14 548-554 GeneOrGeneProduct denotes PIK3CA
T13 508-511 GeneOrGeneProduct denotes VDR
T12 438-442 GeneOrGeneProduct denotes PI3K
T11 407-436 GeneOrGeneProduct denotes phosphatidylinositol 3-kinase
T10 398-402 GeneOrGeneProduct denotes MAPK
T34288 364-396 GeneOrGeneProduct denotes mitogen-activated protein kinase
T80714 348-351 GeneOrGeneProduct denotes VDR
T58069 220-240 GeneOrGeneProduct denotes transcription factor
T6 210-213 GeneOrGeneProduct denotes VDR
T90802 190-208 GeneOrGeneProduct denotes vitamin D receptor
T97493 65-95 GeneOrGeneProduct denotes mutations in colorectal cancer
T35770 60-64 GeneOrGeneProduct denotes KRAS
T48336 49-55 GeneOrGeneProduct denotes PIK3CA
T52845 0-18 GeneOrGeneProduct denotes Vitamin D receptor
T68871 1715-1732 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T75143 1460-1465 DiseaseOrPhenotypicFeature denotes tumor D009369
T89154 1415-1420 DiseaseOrPhenotypicFeature denotes tumor D009369
T5052 1396-1413 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T69382 665-671 DiseaseOrPhenotypicFeature denotes tumors D009369
T75425 601-619 DiseaseOrPhenotypicFeature denotes colorectal cancers D015179
T56557 172-184 DiseaseOrPhenotypicFeature denotes colon cancer D003110
T80096 153-160 DiseaseOrPhenotypicFeature denotes cancers D009369
T23568 78-95 DiseaseOrPhenotypicFeature denotes colorectal cancer D015179
T47283 1628-1635 OrganismTaxon denotes patient

DisGeNET

Id Subject Object Predicate Lexical cue
T0 49-55 gene:5290 denotes PIK3CA
T1 78-95 disease:C0009402 denotes colorectal cancer
T2 49-55 gene:5290 denotes PIK3CA
T3 78-95 disease:C1527249 denotes colorectal cancer
T4 60-64 gene:3845 denotes KRAS
T5 78-95 disease:C0009402 denotes colorectal cancer
T6 60-64 gene:3845 denotes KRAS
T7 78-95 disease:C1527249 denotes colorectal cancer
R1 T0 T1 associated_with PIK3CA,colorectal cancer
R2 T2 T3 associated_with PIK3CA,colorectal cancer
R3 T4 T5 associated_with KRAS,colorectal cancer
R4 T6 T7 associated_with KRAS,colorectal cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19789368-0#0#18#gene7421 0-18 gene7421 denotes Vitamin D receptor
19789368-0#49#55#gene5290 49-55 gene5290 denotes PIK3CA
19789368-0#60#64#gene3845 60-64 gene3845 denotes KRAS
19789368-0#78#95#diseaseC0009402 78-95 diseaseC0009402 denotes colorectal cancer
19789368-0#78#95#diseaseC1527249 78-95 diseaseC1527249 denotes colorectal cancer
19789368-0#78#95#diseaseC0009402 78-95 diseaseC0009402 denotes colorectal cancer
19789368-0#78#95#diseaseC1527249 78-95 diseaseC1527249 denotes colorectal cancer
19789368-0#78#95#diseaseC0009402 78-95 diseaseC0009402 denotes colorectal cancer
19789368-0#78#95#diseaseC1527249 78-95 diseaseC1527249 denotes colorectal cancer
0#18#gene742178#95#diseaseC0009402 19789368-0#0#18#gene7421 19789368-0#78#95#diseaseC0009402 associated_with Vitamin D receptor,colorectal cancer
0#18#gene742178#95#diseaseC1527249 19789368-0#0#18#gene7421 19789368-0#78#95#diseaseC1527249 associated_with Vitamin D receptor,colorectal cancer
0#18#gene742178#95#diseaseC0009402 19789368-0#0#18#gene7421 19789368-0#78#95#diseaseC0009402 associated_with Vitamin D receptor,colorectal cancer
0#18#gene742178#95#diseaseC1527249 19789368-0#0#18#gene7421 19789368-0#78#95#diseaseC1527249 associated_with Vitamin D receptor,colorectal cancer
0#18#gene742178#95#diseaseC0009402 19789368-0#0#18#gene7421 19789368-0#78#95#diseaseC0009402 associated_with Vitamin D receptor,colorectal cancer
0#18#gene742178#95#diseaseC1527249 19789368-0#0#18#gene7421 19789368-0#78#95#diseaseC1527249 associated_with Vitamin D receptor,colorectal cancer
49#55#gene529078#95#diseaseC0009402 19789368-0#49#55#gene5290 19789368-0#78#95#diseaseC0009402 associated_with PIK3CA,colorectal cancer
49#55#gene529078#95#diseaseC1527249 19789368-0#49#55#gene5290 19789368-0#78#95#diseaseC1527249 associated_with PIK3CA,colorectal cancer
49#55#gene529078#95#diseaseC0009402 19789368-0#49#55#gene5290 19789368-0#78#95#diseaseC0009402 associated_with PIK3CA,colorectal cancer
49#55#gene529078#95#diseaseC1527249 19789368-0#49#55#gene5290 19789368-0#78#95#diseaseC1527249 associated_with PIK3CA,colorectal cancer
49#55#gene529078#95#diseaseC0009402 19789368-0#49#55#gene5290 19789368-0#78#95#diseaseC0009402 associated_with PIK3CA,colorectal cancer
49#55#gene529078#95#diseaseC1527249 19789368-0#49#55#gene5290 19789368-0#78#95#diseaseC1527249 associated_with PIK3CA,colorectal cancer
60#64#gene384578#95#diseaseC0009402 19789368-0#60#64#gene3845 19789368-0#78#95#diseaseC0009402 associated_with KRAS,colorectal cancer
60#64#gene384578#95#diseaseC1527249 19789368-0#60#64#gene3845 19789368-0#78#95#diseaseC1527249 associated_with KRAS,colorectal cancer
60#64#gene384578#95#diseaseC0009402 19789368-0#60#64#gene3845 19789368-0#78#95#diseaseC0009402 associated_with KRAS,colorectal cancer
60#64#gene384578#95#diseaseC1527249 19789368-0#60#64#gene3845 19789368-0#78#95#diseaseC1527249 associated_with KRAS,colorectal cancer
60#64#gene384578#95#diseaseC0009402 19789368-0#60#64#gene3845 19789368-0#78#95#diseaseC0009402 associated_with KRAS,colorectal cancer
60#64#gene384578#95#diseaseC1527249 19789368-0#60#64#gene3845 19789368-0#78#95#diseaseC1527249 associated_with KRAS,colorectal cancer