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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-70 Sentence denotes IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway.
T2 71-185 Sentence denotes Transcription factors of IRF family, IRF-3, IRF-5 and IRF-7 play a critical role in the innate antiviral response.
T3 186-386 Sentence denotes In infected cells, IRF-3 and IRF-7 are activated by TBK-1 and IKK epsilon mediated phosphorylation, while the kinase, phosphorylating IRF-5 in the MyD88 signalling pathway has not yet been identified.
T4 387-521 Sentence denotes We now show that IKK alpha phosphorylates IRF-5 and induces formation of IRF-5 dimers, which have been indicative of IRF-5 activation.
T5 522-695 Sentence denotes However, IKK alpha induced IRF-5 phosphorylation exerts inhibitory effect on the transcriptional activation of type 1 interferon and promoters of the inflammatory cytokines.
T6 696-899 Sentence denotes Addressing the molecular mechanism of IKK alpha mediated inhibition of IRF-5 activity, we show that phosphorylation of IRF-5 by IKK alpha inhibits K63 ubiquitination that is essential for IRF-5 activity.
T7 900-1016 Sentence denotes Furthermore, we have identified interaction of IRF-5 with alkaline phosphatase, which causes its de-phosphorylation.
T8 1017-1152 Sentence denotes The observation that MyD88 activated IRF-5 induces expression of alkaline phosphatase suggests that IRF-5 is under autoregulating loop.
T9 1153-1403 Sentence denotes Thus these completely new observations identify IKK alpha kinase and alkaline phosphatase as negative regulators of IRF-5 activity in MyD88 pathway and implicate their role in the control of the inflammatory response by attenuation of IRF-5 activity.
T1 0-70 Sentence denotes IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway.
T2 71-185 Sentence denotes Transcription factors of IRF family, IRF-3, IRF-5 and IRF-7 play a critical role in the innate antiviral response.
T3 186-386 Sentence denotes In infected cells, IRF-3 and IRF-7 are activated by TBK-1 and IKK epsilon mediated phosphorylation, while the kinase, phosphorylating IRF-5 in the MyD88 signalling pathway has not yet been identified.
T4 387-521 Sentence denotes We now show that IKK alpha phosphorylates IRF-5 and induces formation of IRF-5 dimers, which have been indicative of IRF-5 activation.
T5 522-695 Sentence denotes However, IKK alpha induced IRF-5 phosphorylation exerts inhibitory effect on the transcriptional activation of type 1 interferon and promoters of the inflammatory cytokines.
T6 696-899 Sentence denotes Addressing the molecular mechanism of IKK alpha mediated inhibition of IRF-5 activity, we show that phosphorylation of IRF-5 by IKK alpha inhibits K63 ubiquitination that is essential for IRF-5 activity.
T7 900-1016 Sentence denotes Furthermore, we have identified interaction of IRF-5 with alkaline phosphatase, which causes its de-phosphorylation.
T8 1017-1152 Sentence denotes The observation that MyD88 activated IRF-5 induces expression of alkaline phosphatase suggests that IRF-5 is under autoregulating loop.
T9 1153-1403 Sentence denotes Thus these completely new observations identify IKK alpha kinase and alkaline phosphatase as negative regulators of IRF-5 activity in MyD88 pathway and implicate their role in the control of the inflammatory response by attenuation of IRF-5 activity.

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 0-8 Protein denotes IKKalpha
T2 30-35 Protein denotes IRF-5
T3 50-55 Protein denotes MyD88
T4 56-61 Protein denotes TRAF6
T5 108-113 Protein denotes IRF-3
T6 115-120 Protein denotes IRF-5
T7 125-130 Protein denotes IRF-7
T8 205-210 Protein denotes IRF-3
T9 215-220 Protein denotes IRF-7
T10 238-243 Protein denotes TBK-1
T11 248-259 Protein denotes IKK epsilon
T12 320-325 Protein denotes IRF-5
T13 333-338 Protein denotes MyD88
T14 404-413 Protein denotes IKK alpha
T15 429-434 Protein denotes IRF-5
T16 460-465 Protein denotes IRF-5
T17 504-509 Protein denotes IRF-5
T18 531-540 Protein denotes IKK alpha
T19 549-554 Protein denotes IRF-5
T20 734-743 Protein denotes IKK alpha
T21 767-772 Protein denotes IRF-5
T22 815-820 Protein denotes IRF-5
T23 824-833 Protein denotes IKK alpha
T24 884-889 Protein denotes IRF-5
T25 947-952 Protein denotes IRF-5
T26 1038-1043 Protein denotes MyD88
T27 1054-1059 Protein denotes IRF-5
T28 1117-1122 Protein denotes IRF-5
T29 1201-1210 Protein denotes IKK alpha
T30 1269-1274 Protein denotes IRF-5
T31 1287-1292 Protein denotes MyD88
T32 1388-1393 Protein denotes IRF-5