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PubMed:1978333 JSONTXT

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LitCoin-PubTator-for-Tuning

Id Subject Object Predicate Lexical cue tao:has_database_id
1 14-19 OrganismTaxon denotes human Tax:9606
10 168-173 OrganismTaxon denotes human Tax:9606
11 251-260 ChemicalEntity denotes gonococci
12 335-364 ChemicalEntity denotes gonococcal lipopolysaccharide
13 389-436 ChemicalEntity denotes cytidine 5'-monophospho-N-acetylneuraminic acid MESH:D003569
14 438-446 ChemicalEntity denotes CMP-NANA MESH:D003569
15 560-572 DiseaseOrPhenotypicFeature denotes inflammation MESH:D007249
16 1225-1229 OrganismTaxon denotes to 9 Tax:1214577
17 1298-1306 ChemicalEntity denotes CMP-NANA MESH:D003569

LitCoin-Disease-Tuning-1

Id Subject Object Predicate Lexical cue ID:
T1 190-197 DiseaseOrPhenotypicFeature denotes strains D013180
T2 560-572 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249

LitEisuke

Id Subject Object Predicate Lexical cue #label
T1 560-572 DiseaseOrPhenotypicFeature denotes inflammation D007249

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-88 Sentence denotes Resistance to human serum of gonococci in urethral exudates is reduced by neuraminidase.
T2 89-231 Sentence denotes Gonococci examined directly from urethral exudates are resistant to killing by human serum, but most strains become susceptible on subculture.
T3 232-573 Sentence denotes Previous work with gonococci grown in vitro indicates that resistance in vivo is due to sialylation of gonococcal lipopolysaccharide (LPS) by a host factor, cytidine 5'-monophospho-N-acetylneuraminic acid (CMP-NANA) or a related compound present in urogenital secretions and blood cells including phagocytes, which exude during inflammation.
T4 574-672 Sentence denotes This sialylation inhibits the reaction between bactericidal IgM in serum and its target LPS sites.
T5 673-738 Sentence denotes Here, we confirm the indication by using gonococci grown in vivo.
T6 739-922 Sentence denotes Crucial to the above conclusions was the marked reduction of CMP-NANA-conferred serum resistance when gonococci were treated with neuraminidase to remove sialyl groups from their LPS.
T7 923-1172 Sentence denotes We now show that the serum resistance of gonococci in urethral exudates was reduced by treatment with neuraminidase from more than 95% (calculated in relation to controls incubated with heated serum) to 2-11% according to sample and incubation time.
T8 1173-1307 Sentence denotes Subculture of the gonococci also reduced resistance to 9-11% but resistance was restored to more than 95% by incubation with CMP-NANA.
T9 1308-1502 Sentence denotes This work is the culmination of an investigation that underlines the need to identify specific host factors and the virulence determinants they induce in vivo in future studies of pathogenicity.
T1 0-88 Sentence denotes Resistance to human serum of gonococci in urethral exudates is reduced by neuraminidase.
T2 89-231 Sentence denotes Gonococci examined directly from urethral exudates are resistant to killing by human serum, but most strains become susceptible on subculture.
T3 232-573 Sentence denotes Previous work with gonococci grown in vitro indicates that resistance in vivo is due to sialylation of gonococcal lipopolysaccharide (LPS) by a host factor, cytidine 5'-monophospho-N-acetylneuraminic acid (CMP-NANA) or a related compound present in urogenital secretions and blood cells including phagocytes, which exude during inflammation.
T4 574-672 Sentence denotes This sialylation inhibits the reaction between bactericidal IgM in serum and its target LPS sites.
T5 673-738 Sentence denotes Here, we confirm the indication by using gonococci grown in vivo.
T6 739-922 Sentence denotes Crucial to the above conclusions was the marked reduction of CMP-NANA-conferred serum resistance when gonococci were treated with neuraminidase to remove sialyl groups from their LPS.
T7 923-1172 Sentence denotes We now show that the serum resistance of gonococci in urethral exudates was reduced by treatment with neuraminidase from more than 95% (calculated in relation to controls incubated with heated serum) to 2-11% according to sample and incubation time.
T8 1173-1307 Sentence denotes Subculture of the gonococci also reduced resistance to 9-11% but resistance was restored to more than 95% by incubation with CMP-NANA.
T9 1308-1502 Sentence denotes This work is the culmination of an investigation that underlines the need to identify specific host factors and the virulence determinants they induce in vivo in future studies of pathogenicity.