PubMed:19782135
Annnotations
c_corpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-9 | Q6QHT9 | denotes | Aromatase |
T2 | 0-9 | Q92112 | denotes | Aromatase |
T3 | 0-9 | P11511 | denotes | Aromatase |
T4 | 0-9 | P19098 | denotes | Aromatase |
T5 | 0-9 | Q92111 | denotes | Aromatase |
T6 | 0-9 | P79699 | denotes | Aromatase |
T7 | 0-9 | P28649 | denotes | Aromatase |
T8 | 0-9 | Q29605 | denotes | Aromatase |
T9 | 0-9 | Q5QQX7 | denotes | Aromatase |
T10 | 0-9 | P22443 | denotes | Aromatase |
T11 | 0-9 | Q9XS28 | denotes | Aromatase |
T13 | 0-9 | Q69FB6 | denotes | Aromatase |
T14 | 0-9 | PR:000006100 | denotes | Aromatase |
T15 | 0-9 | Q6YI21 | denotes | Aromatase |
T16 | 0-9 | Q92087 | denotes | Aromatase |
T17 | 0-9 | O46512 | denotes | Aromatase |
T18 | 0-9 | O42145 | denotes | Aromatase |
T19 | 0-9 | Q95M61 | denotes | Aromatase |
T20 | 0-9 | P46194 | denotes | Aromatase |
T21 | 0-9 | P70091 | denotes | Aromatase |
T12 | 0-9 | D001141 | denotes | Aromatase |
T22 | 22-30 | D004967 | denotes | estrogen |
T23 | 22-30 | D004967 | denotes | estrogen |
T24 | 22-30 | CHEBI:50114 | denotes | estrogen |
T26 | 45-49 | CVCL_5552 | denotes | DCIS |
T25 | 45-49 | D002285 | denotes | DCIS |
T27 | 45-49 | D002285 | denotes | DCIS |
T30 | 51-75 | D002285 | denotes | ductal carcinoma in situ |
T31 | 51-75 | D002285 | denotes | ductal carcinoma in situ |
T36 | 80-85 | D006801 | denotes | human |
T37 | 86-92 | UBERON:0000310 | denotes | breast |
T40 | 101-118 | D002278 | denotes | carcinoma in situ |
T41 | 101-118 | D002278 | denotes | carcinoma in situ |
T43 | 122-126 | CVCL_5552 | denotes | DCIS |
T42 | 122-126 | D002285 | denotes | DCIS |
T44 | 122-126 | D002285 | denotes | DCIS |
T45 | 299-303 | UBERON:0000025 | denotes | duct |
T46 | 299-303 | UBERON:0000058 | denotes | duct |
T47 | 364-373 | D004967 | denotes | estrogens |
T48 | 364-373 | D004967 | denotes | estrogens |
T49 | 364-373 | CHEBI:50114 | denotes | estrogens |
T50 | 430-437 | D004194 | denotes | disease |
T51 | 430-437 | D004194 | denotes | disease |
T52 | 476-487 | D006965 | denotes | hyperplasia |
T53 | 476-487 | D006965 | denotes | hyperplasia |
T55 | 491-495 | CVCL_5552 | denotes | DCIS |
T54 | 491-495 | D002285 | denotes | DCIS |
T56 | 491-495 | D002285 | denotes | DCIS |
T57 | 533-542 | D002277 | denotes | carcinoma |
T58 | 533-542 | D002277 | denotes | carcinoma |
T60 | 548-552 | CVCL_5552 | denotes | DCIS |
T59 | 548-552 | D002285 | denotes | DCIS |
T61 | 548-552 | D002285 | denotes | DCIS |
T62 | 554-562 | D004967 | denotes | Estrogen |
T63 | 554-562 | D004967 | denotes | Estrogen |
T64 | 554-562 | CHEBI:50114 | denotes | Estrogen |
T65 | 554-571 | Q9PVZ9 | denotes | Estrogen receptor |
T66 | 554-571 | Q9YHT3 | denotes | Estrogen receptor |
T67 | 554-571 | P57717 | denotes | Estrogen receptor |
T68 | 554-571 | Q9QZJ5 | denotes | Estrogen receptor |
T69 | 554-571 | Q29040 | denotes | Estrogen receptor |
T70 | 554-571 | P49886 | denotes | Estrogen receptor |
T71 | 554-571 | P50240 | denotes | Estrogen receptor |
T72 | 554-571 | Q91424 | denotes | Estrogen receptor |
T73 | 554-571 | Q9YHZ7 | denotes | Estrogen receptor |
T74 | 554-571 | P06211 | denotes | Estrogen receptor |
T75 | 554-571 | P16058 | denotes | Estrogen receptor |
T76 | 554-571 | P50242 | denotes | Estrogen receptor |
T77 | 554-571 | Q53AD2 | denotes | Estrogen receptor |
T78 | 554-571 | P49885 | denotes | Estrogen receptor |
T79 | 554-571 | P49884 | denotes | Estrogen receptor |
T80 | 554-571 | P19785 | denotes | Estrogen receptor |
T81 | 554-571 | Q91250 | denotes | Estrogen receptor |
T82 | 554-571 | P81559 | denotes | Estrogen receptor |
T83 | 554-571 | Q9TV98 | denotes | Estrogen receptor |
T84 | 554-571 | PR:000007204 | denotes | Estrogen receptor |
T85 | 554-571 | Q9YH33 | denotes | Estrogen receptor |
T86 | 554-571 | P50241 | denotes | Estrogen receptor |
T87 | 554-571 | P06212 | denotes | Estrogen receptor |
T88 | 554-571 | P03372 | denotes | Estrogen receptor |
T89 | 554-571 | O42132 | denotes | Estrogen receptor |
T90 | 554-571 | P57753 | denotes | Estrogen receptor |
T91 | 573-582 | Q9PVZ9 | denotes | ER) alpha |
T92 | 573-582 | Q9YHT3 | denotes | ER) alpha |
T93 | 573-582 | P57717 | denotes | ER) alpha |
T94 | 573-582 | Q9QZJ5 | denotes | ER) alpha |
T95 | 573-582 | Q29040 | denotes | ER) alpha |
T96 | 573-582 | P49886 | denotes | ER) alpha |
T97 | 573-582 | P50240 | denotes | ER) alpha |
T98 | 573-582 | Q91424 | denotes | ER) alpha |
T99 | 573-582 | Q9YHZ7 | denotes | ER) alpha |
T100 | 573-582 | P06211 | denotes | ER) alpha |
T101 | 573-582 | P16058 | denotes | ER) alpha |
T102 | 573-582 | P50242 | denotes | ER) alpha |
T103 | 573-582 | Q53AD2 | denotes | ER) alpha |
T104 | 573-582 | P49885 | denotes | ER) alpha |
T105 | 573-582 | P49884 | denotes | ER) alpha |
T106 | 573-582 | P19785 | denotes | ER) alpha |
T107 | 573-582 | Q91250 | denotes | ER) alpha |
T108 | 573-582 | P81559 | denotes | ER) alpha |
T109 | 573-582 | Q9TV98 | denotes | ER) alpha |
T110 | 573-582 | PR:000007204 | denotes | ER) alpha |
T111 | 573-582 | Q9YH33 | denotes | ER) alpha |
T112 | 573-582 | P50241 | denotes | ER) alpha |
T113 | 573-582 | P06212 | denotes | ER) alpha |
T114 | 573-582 | P03372 | denotes | ER) alpha |
T115 | 573-582 | O42132 | denotes | ER) alpha |
T116 | 573-582 | P57753 | denotes | ER) alpha |
T117 | 577-582 | CHEBI:30216 | denotes | alpha |
T118 | 610-637 | D002285 | denotes | atypical ductal hyperplasia |
T119 | 610-637 | D002285 | denotes | atypical ductal hyperplasia |
T123 | 652-656 | CVCL_5552 | denotes | DCIS |
T122 | 652-656 | D002285 | denotes | DCIS |
T124 | 652-656 | D002285 | denotes | DCIS |
T126 | 698-707 | 10324 | denotes | tamoxifen |
T125 | 698-707 | D013629 | denotes | tamoxifen |
T127 | 698-707 | CHEBI:41774 | denotes | tamoxifen |
T128 | 698-707 | D013629 | denotes | tamoxifen |
T129 | 734-744 | D012008 | denotes | recurrence |
T130 | 734-744 | D012008 | denotes | recurrence |
T132 | 748-752 | CVCL_5552 | denotes | DCIS |
T131 | 748-752 | D002285 | denotes | DCIS |
T133 | 748-752 | D002285 | denotes | DCIS |
T134 | 789-798 | D002277 | denotes | carcinoma |
T135 | 789-798 | D002277 | denotes | carcinoma |
T136 | 813-821 | D004967 | denotes | estrogen |
T137 | 813-821 | D004967 | denotes | estrogen |
T138 | 813-821 | CHEBI:50114 | denotes | estrogen |
T140 | 839-843 | CVCL_5552 | denotes | DCIS |
T139 | 839-843 | D002285 | denotes | DCIS |
T141 | 839-843 | D002285 | denotes | DCIS |
T142 | 893-899 | 37565 | denotes | tandem |
T143 | 893-899 | SO:0001513 | denotes | tandem |
T144 | 970-976 | UBERON:0000310 | denotes | breast |
T145 | 1036-1045 | D002277 | denotes | carcinoma |
T146 | 1036-1045 | D002277 | denotes | carcinoma |
T147 | 1047-1056 | Q6QHT9 | denotes | Aromatase |
T148 | 1047-1056 | Q92112 | denotes | Aromatase |
T149 | 1047-1056 | P11511 | denotes | Aromatase |
T150 | 1047-1056 | P19098 | denotes | Aromatase |
T151 | 1047-1056 | Q92111 | denotes | Aromatase |
T152 | 1047-1056 | P79699 | denotes | Aromatase |
T153 | 1047-1056 | P28649 | denotes | Aromatase |
T154 | 1047-1056 | Q29605 | denotes | Aromatase |
T155 | 1047-1056 | Q5QQX7 | denotes | Aromatase |
T156 | 1047-1056 | P22443 | denotes | Aromatase |
T157 | 1047-1056 | Q9XS28 | denotes | Aromatase |
T159 | 1047-1056 | Q69FB6 | denotes | Aromatase |
T160 | 1047-1056 | PR:000006100 | denotes | Aromatase |
T161 | 1047-1056 | Q6YI21 | denotes | Aromatase |
T162 | 1047-1056 | Q92087 | denotes | Aromatase |
T163 | 1047-1056 | O46512 | denotes | Aromatase |
T164 | 1047-1056 | O42145 | denotes | Aromatase |
T165 | 1047-1056 | Q95M61 | denotes | Aromatase |
T166 | 1047-1056 | P46194 | denotes | Aromatase |
T167 | 1047-1056 | P70091 | denotes | Aromatase |
T158 | 1047-1056 | D001141 | denotes | Aromatase |
T170 | 1057-1061 | SO:0000234 | denotes | mRNA |
T168 | 1057-1061 | D012333 | denotes | mRNA |
T169 | 1057-1061 | CHEBI:33699 | denotes | mRNA |
T172 | 1114-1118 | CVCL_5552 | denotes | DCIS |
T171 | 1114-1118 | D002285 | denotes | DCIS |
T173 | 1114-1118 | D002285 | denotes | DCIS |
T174 | 1149-1152 | Q41249 | denotes | PCR |
T175 | 1149-1152 | O66148 | denotes | PCR |
T176 | 1149-1152 | Q59987 | denotes | PCR |
T177 | 1149-1152 | Q01289 | denotes | PCR |
T178 | 1149-1152 | O80333 | denotes | PCR |
T179 | 1149-1152 | P15904 | denotes | PCR |
T180 | 1149-1152 | Q9SDT1 | denotes | PCR |
T181 | 1149-1152 | Q39617 | denotes | PCR |
T182 | 1242-1248 | UBERON:0000310 | denotes | breast |
T183 | 1287-1296 | D002277 | denotes | carcinoma |
T184 | 1287-1296 | D002277 | denotes | carcinoma |
T185 | 1322-1331 | Q6QHT9 | denotes | aromatase |
T186 | 1322-1331 | Q92112 | denotes | aromatase |
T187 | 1322-1331 | P11511 | denotes | aromatase |
T188 | 1322-1331 | P19098 | denotes | aromatase |
T189 | 1322-1331 | Q92111 | denotes | aromatase |
T190 | 1322-1331 | P79699 | denotes | aromatase |
T191 | 1322-1331 | P28649 | denotes | aromatase |
T192 | 1322-1331 | Q29605 | denotes | aromatase |
T193 | 1322-1331 | Q5QQX7 | denotes | aromatase |
T194 | 1322-1331 | P22443 | denotes | aromatase |
T195 | 1322-1331 | Q9XS28 | denotes | aromatase |
T197 | 1322-1331 | Q69FB6 | denotes | aromatase |
T198 | 1322-1331 | PR:000006100 | denotes | aromatase |
T199 | 1322-1331 | Q6YI21 | denotes | aromatase |
T200 | 1322-1331 | Q92087 | denotes | aromatase |
T201 | 1322-1331 | O46512 | denotes | aromatase |
T202 | 1322-1331 | O42145 | denotes | aromatase |
T203 | 1322-1331 | Q95M61 | denotes | aromatase |
T204 | 1322-1331 | P46194 | denotes | aromatase |
T205 | 1322-1331 | P70091 | denotes | aromatase |
T196 | 1322-1331 | D001141 | denotes | aromatase |
T206 | 1404-1413 | D002277 | denotes | carcinoma |
T207 | 1404-1413 | D002277 | denotes | carcinoma |
T208 | 1415-1424 | Q6QHT9 | denotes | Aromatase |
T209 | 1415-1424 | Q92112 | denotes | Aromatase |
T210 | 1415-1424 | P11511 | denotes | Aromatase |
T211 | 1415-1424 | P19098 | denotes | Aromatase |
T212 | 1415-1424 | Q92111 | denotes | Aromatase |
T213 | 1415-1424 | P79699 | denotes | Aromatase |
T214 | 1415-1424 | P28649 | denotes | Aromatase |
T215 | 1415-1424 | Q29605 | denotes | Aromatase |
T216 | 1415-1424 | Q5QQX7 | denotes | Aromatase |
T217 | 1415-1424 | P22443 | denotes | Aromatase |
T218 | 1415-1424 | Q9XS28 | denotes | Aromatase |
T220 | 1415-1424 | Q69FB6 | denotes | Aromatase |
T221 | 1415-1424 | PR:000006100 | denotes | Aromatase |
T222 | 1415-1424 | Q6YI21 | denotes | Aromatase |
T223 | 1415-1424 | Q92087 | denotes | Aromatase |
T224 | 1415-1424 | O46512 | denotes | Aromatase |
T225 | 1415-1424 | O42145 | denotes | Aromatase |
T226 | 1415-1424 | Q95M61 | denotes | Aromatase |
T227 | 1415-1424 | P46194 | denotes | Aromatase |
T228 | 1415-1424 | P70091 | denotes | Aromatase |
T219 | 1415-1424 | D001141 | denotes | Aromatase |
T229 | 1457-1463 | UBERON:0000310 | denotes | breast |
T230 | 1464-1476 | D009369 | denotes | malignancies |
T231 | 1464-1476 | D009369 | denotes | malignancies |
T233 | 1487-1491 | CVCL_5552 | denotes | DCIS |
T232 | 1487-1491 | D002285 | denotes | DCIS |
T234 | 1487-1491 | D002285 | denotes | DCIS |
T238 | 1547-1556 | 4083 | denotes | estradiol |
T235 | 1547-1556 | CHEBI:16469 | denotes | estradiol |
T236 | 1547-1556 | CHEBI:23965 | denotes | estradiol |
T237 | 1547-1556 | D004958 | denotes | estradiol |
T239 | 1547-1556 | D004958 | denotes | estradiol |
T240 | 1628-1637 | Q6QHT9 | denotes | aromatase |
T241 | 1628-1637 | Q92112 | denotes | aromatase |
T242 | 1628-1637 | P11511 | denotes | aromatase |
T243 | 1628-1637 | P19098 | denotes | aromatase |
T244 | 1628-1637 | Q92111 | denotes | aromatase |
T245 | 1628-1637 | P79699 | denotes | aromatase |
T246 | 1628-1637 | P28649 | denotes | aromatase |
T247 | 1628-1637 | Q29605 | denotes | aromatase |
T248 | 1628-1637 | Q5QQX7 | denotes | aromatase |
T249 | 1628-1637 | P22443 | denotes | aromatase |
T250 | 1628-1637 | Q9XS28 | denotes | aromatase |
T252 | 1628-1637 | Q69FB6 | denotes | aromatase |
T253 | 1628-1637 | PR:000006100 | denotes | aromatase |
T254 | 1628-1637 | Q6YI21 | denotes | aromatase |
T255 | 1628-1637 | Q92087 | denotes | aromatase |
T256 | 1628-1637 | O46512 | denotes | aromatase |
T257 | 1628-1637 | O42145 | denotes | aromatase |
T258 | 1628-1637 | Q95M61 | denotes | aromatase |
T259 | 1628-1637 | P46194 | denotes | aromatase |
T260 | 1628-1637 | P70091 | denotes | aromatase |
T261 | 1628-1648 | D047072 | denotes | aromatase inhibitors |
T262 | 1628-1648 | D047072 | denotes | aromatase inhibitors |
T263 | 1628-1648 | CHEBI:50790 | denotes | aromatase inhibitors |
T266 | 1682-1686 | CVCL_5552 | denotes | DCIS |
T265 | 1682-1686 | D002285 | denotes | DCIS |
T267 | 1682-1686 | D002285 | denotes | DCIS |
Allie
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
SS1_19782135_0_0 | 51-75 | expanded | denotes | ductal carcinoma in situ |
SS2_19782135_0_0 | 45-49 | abbr | denotes | DCIS |
SS1_19782135_3_0 | 554-571 | expanded | denotes | Estrogen receptor |
SS2_19782135_3_0 | 573-575 | abbr | denotes | ER |
AE1_19782135_0_0 | SS1_19782135_0_0 | SS2_19782135_0_0 | abbreviatedTo | ductal carcinoma in situ,DCIS |
AE1_19782135_3_0 | SS1_19782135_3_0 | SS2_19782135_3_0 | abbreviatedTo | Estrogen receptor,ER |
UseCases_ArguminSci_Discourse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-93 | DRI_Background | denotes | Aromatase and in situ estrogen production in DCIS (ductal carcinoma in situ) of human breast. |
T2 | 94-318 | DRI_Background | denotes | Ductal carcinoma in situ or DCIS belongs to intraductal proliferative lesions, which are a group of cytologically and architecturally diverse ductal proliferations, typically originating from the terminal duct-lobular units. |
T3 | 319-553 | DRI_Challenge | denotes | In these intraductal proliferative diseases, estrogens are considered to be involved in the progression of the disease especially from ductal non-neoplastic hyperplasia to DCIS and possibly development of invasive carcinoma from DCIS. |
T4 | 554-657 | DRI_Background | denotes | Estrogen receptor (ER) alpha is abundantly expressed in atypical ductal hyperplasia and low grade DCIS. |
T5 | 658-799 | DRI_Outcome | denotes | Suppression of estrogenic actions using tamoxifen resulted in inhibition of recurrence of DCIS and/or of progression into invasive carcinoma. |
T6 | 800-1046 | DRI_Background | denotes | Intratumoral estrogen concentration in DCIS determined by liquid chromatography/electrospray tandem mass spectrometry is significantly higher than that in non-neoplastic breast tissues with statistically not lower than that in invasive carcinoma. |
T7 | 1047-1297 | DRI_Background | denotes | Aromatase mRNA expression in both stromal and parenchymal cells of DCIS determined by quantitative RT-PCR following laser capture microdissection was also much higher than that in non-neoplastic breast, although lower than that in invasive carcinoma. |
T8 | 1298-1414 | DRI_Background | denotes | Immunohistochemistry of aromatase also revealed the similar patterns of immunolocalization as in invasive carcinoma. |
T9 | 1415-1557 | DRI_Background | denotes | Aromatase is overexpressed in noninvasive breast malignancies including DCIS and results in elevated concentrations of intratumoral estradiol. |
T10 | 1558-1696 | DRI_Background | denotes | These findings could provide the scientific rationale as to employing aromatase inhibitors in the management of ER positive DCIS patients. |
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 94-318 | DRI_Background | denotes | Ductal carcinoma in situ or DCIS belongs to intraductal proliferative lesions, which are a group of cytologically and architecturally diverse ductal proliferations, typically originating from the terminal duct-lobular units. |
T2 | 319-553 | DRI_Challenge | denotes | In these intraductal proliferative diseases, estrogens are considered to be involved in the progression of the disease especially from ductal non-neoplastic hyperplasia to DCIS and possibly development of invasive carcinoma from DCIS. |
T3 | 554-657 | DRI_Background | denotes | Estrogen receptor (ER) alpha is abundantly expressed in atypical ductal hyperplasia and low grade DCIS. |
T4 | 658-799 | DRI_Outcome | denotes | Suppression of estrogenic actions using tamoxifen resulted in inhibition of recurrence of DCIS and/or of progression into invasive carcinoma. |
T5 | 800-1046 | DRI_Background | denotes | Intratumoral estrogen concentration in DCIS determined by liquid chromatography/electrospray tandem mass spectrometry is significantly higher than that in non-neoplastic breast tissues with statistically not lower than that in invasive carcinoma. |
T6 | 1047-1297 | DRI_Background | denotes | Aromatase mRNA expression in both stromal and parenchymal cells of DCIS determined by quantitative RT-PCR following laser capture microdissection was also much higher than that in non-neoplastic breast, although lower than that in invasive carcinoma. |
T7 | 1298-1414 | DRI_Background | denotes | Immunohistochemistry of aromatase also revealed the similar patterns of immunolocalization as in invasive carcinoma. |
T8 | 1415-1557 | DRI_Background | denotes | Aromatase is overexpressed in noninvasive breast malignancies including DCIS and results in elevated concentrations of intratumoral estradiol. |
T9 | 1558-1696 | DRI_Background | denotes | These findings could provide the scientific rationale as to employing aromatase inhibitors in the management of ER positive DCIS patients. |