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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-109 Sentence denotes Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration.
TextSentencer_T2 110-220 Sentence denotes Slit regulates migration of not only neurons, but also nonneuronal cells, such as leukocytes and cancer cells.
TextSentencer_T3 221-290 Sentence denotes Slit effect on cancer cell migration has not been well-characterized.
TextSentencer_T4 291-403 Sentence denotes In this study, we used several different assays to examine Slit effect on breast cancer cell migration in vitro.
TextSentencer_T5 404-678 Sentence denotes We show that ubiquitin-specific protease 33 (USP33)/VDU1, originally identified as a von Hippel-Lindau tumor suppressor (VHL) protein-interacting deubiquitinating enzyme, binds to the Robo1 receptor, and that USP33 is required for Slit responsiveness in breast cancer cells.
TextSentencer_T6 679-799 Sentence denotes Slit induces redistribution of Robo1 from intracellular compartments to the plasma membrane in a USP33-dependent manner.
TextSentencer_T7 800-898 Sentence denotes Slit impairs directional migration of breast cancer cells without affecting their migration speed.
TextSentencer_T8 899-959 Sentence denotes This inhibitory effect is Robo-mediated and USP33-dependent.
TextSentencer_T9 960-1090 Sentence denotes These data uncover a previously unknown function of USP33 and reveal a new player in Slit-Robo signaling in cancer cell migration.
T1 0-109 Sentence denotes Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration.
T2 110-220 Sentence denotes Slit regulates migration of not only neurons, but also nonneuronal cells, such as leukocytes and cancer cells.
T3 221-290 Sentence denotes Slit effect on cancer cell migration has not been well-characterized.
T4 291-403 Sentence denotes In this study, we used several different assays to examine Slit effect on breast cancer cell migration in vitro.
T5 404-678 Sentence denotes We show that ubiquitin-specific protease 33 (USP33)/VDU1, originally identified as a von Hippel-Lindau tumor suppressor (VHL) protein-interacting deubiquitinating enzyme, binds to the Robo1 receptor, and that USP33 is required for Slit responsiveness in breast cancer cells.
T6 679-799 Sentence denotes Slit induces redistribution of Robo1 from intracellular compartments to the plasma membrane in a USP33-dependent manner.
T7 800-898 Sentence denotes Slit impairs directional migration of breast cancer cells without affecting their migration speed.
T8 899-959 Sentence denotes This inhibitory effect is Robo-mediated and USP33-dependent.
T9 960-1090 Sentence denotes These data uncover a previously unknown function of USP33 and reveal a new player in Slit-Robo signaling in cancer cell migration.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 417-447 gene:23032 denotes ubiquitin-specific protease 33
T1 658-671 disease:C0006142 denotes breast cancer
T2 417-447 gene:23032 denotes ubiquitin-specific protease 33
T3 658-671 disease:C0678222 denotes breast cancer
T4 449-454 gene:23032 denotes USP33
T5 658-671 disease:C0006142 denotes breast cancer
T6 449-454 gene:23032 denotes USP33
T7 658-671 disease:C0678222 denotes breast cancer
T8 456-460 gene:23032 denotes VDU1
T9 658-671 disease:C0006142 denotes breast cancer
T10 456-460 gene:23032 denotes VDU1
T11 658-671 disease:C0678222 denotes breast cancer
T12 489-523 gene:7428 denotes von Hippel-Lindau tumor suppressor
T13 658-671 disease:C0006142 denotes breast cancer
T14 489-523 gene:7428 denotes von Hippel-Lindau tumor suppressor
T15 658-671 disease:C0678222 denotes breast cancer
T16 525-528 gene:7428 denotes VHL
T17 658-671 disease:C0006142 denotes breast cancer
T18 525-528 gene:7428 denotes VHL
T19 658-671 disease:C0678222 denotes breast cancer
T20 588-593 gene:6091 denotes Robo1
T21 658-671 disease:C0006142 denotes breast cancer
T22 588-593 gene:6091 denotes Robo1
T23 658-671 disease:C0678222 denotes breast cancer
T24 613-618 gene:23032 denotes USP33
T25 658-671 disease:C0006142 denotes breast cancer
T26 613-618 gene:23032 denotes USP33
T27 658-671 disease:C0678222 denotes breast cancer
R1 T0 T1 associated_with ubiquitin-specific protease 33,breast cancer
R2 T2 T3 associated_with ubiquitin-specific protease 33,breast cancer
R3 T4 T5 associated_with USP33,breast cancer
R4 T6 T7 associated_with USP33,breast cancer
R5 T8 T9 associated_with VDU1,breast cancer
R6 T10 T11 associated_with VDU1,breast cancer
R7 T12 T13 associated_with von Hippel-Lindau tumor suppressor,breast cancer
R8 T14 T15 associated_with von Hippel-Lindau tumor suppressor,breast cancer
R9 T16 T17 associated_with VHL,breast cancer
R10 T18 T19 associated_with VHL,breast cancer
R11 T20 T21 associated_with Robo1,breast cancer
R12 T22 T23 associated_with Robo1,breast cancer
R13 T24 T25 associated_with USP33,breast cancer
R14 T26 T27 associated_with USP33,breast cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19706539-0#24#29#gene23032 24-29 gene23032 denotes USP33
19706539-0#30#34#gene23032 30-34 gene23032 denotes VDU1
19706539-0#80#93#diseaseC0006142 80-93 diseaseC0006142 denotes breast cancer
19706539-0#80#93#diseaseC0678222 80-93 diseaseC0678222 denotes breast cancer
19706539-0#80#93#diseaseC0006142 80-93 diseaseC0006142 denotes breast cancer
19706539-0#80#93#diseaseC0678222 80-93 diseaseC0678222 denotes breast cancer
19706539-4#85#119#gene7428 489-523 gene7428 denotes von Hippel-Lindau tumor suppressor
19706539-4#121#124#gene7428 525-528 gene7428 denotes VHL
19706539-4#184#189#gene6091 588-593 gene6091 denotes Robo1
19706539-4#254#267#diseaseC0006142 658-671 diseaseC0006142 denotes breast cancer
19706539-4#254#267#diseaseC0678222 658-671 diseaseC0678222 denotes breast cancer
19706539-4#254#267#diseaseC0006142 658-671 diseaseC0006142 denotes breast cancer
19706539-4#254#267#diseaseC0678222 658-671 diseaseC0678222 denotes breast cancer
19706539-4#254#267#diseaseC0006142 658-671 diseaseC0006142 denotes breast cancer
19706539-4#254#267#diseaseC0678222 658-671 diseaseC0678222 denotes breast cancer
24#29#gene2303280#93#diseaseC0006142 19706539-0#24#29#gene23032 19706539-0#80#93#diseaseC0006142 associated_with USP33,breast cancer
24#29#gene2303280#93#diseaseC0678222 19706539-0#24#29#gene23032 19706539-0#80#93#diseaseC0678222 associated_with USP33,breast cancer
24#29#gene2303280#93#diseaseC0006142 19706539-0#24#29#gene23032 19706539-0#80#93#diseaseC0006142 associated_with USP33,breast cancer
24#29#gene2303280#93#diseaseC0678222 19706539-0#24#29#gene23032 19706539-0#80#93#diseaseC0678222 associated_with USP33,breast cancer
30#34#gene2303280#93#diseaseC0006142 19706539-0#30#34#gene23032 19706539-0#80#93#diseaseC0006142 associated_with VDU1,breast cancer
30#34#gene2303280#93#diseaseC0678222 19706539-0#30#34#gene23032 19706539-0#80#93#diseaseC0678222 associated_with VDU1,breast cancer
30#34#gene2303280#93#diseaseC0006142 19706539-0#30#34#gene23032 19706539-0#80#93#diseaseC0006142 associated_with VDU1,breast cancer
30#34#gene2303280#93#diseaseC0678222 19706539-0#30#34#gene23032 19706539-0#80#93#diseaseC0678222 associated_with VDU1,breast cancer
85#119#gene7428254#267#diseaseC0006142 19706539-4#85#119#gene7428 19706539-4#254#267#diseaseC0006142 associated_with von Hippel-Lindau tumor suppressor,breast cancer
85#119#gene7428254#267#diseaseC0678222 19706539-4#85#119#gene7428 19706539-4#254#267#diseaseC0678222 associated_with von Hippel-Lindau tumor suppressor,breast cancer
85#119#gene7428254#267#diseaseC0006142 19706539-4#85#119#gene7428 19706539-4#254#267#diseaseC0006142 associated_with von Hippel-Lindau tumor suppressor,breast cancer
85#119#gene7428254#267#diseaseC0678222 19706539-4#85#119#gene7428 19706539-4#254#267#diseaseC0678222 associated_with von Hippel-Lindau tumor suppressor,breast cancer
85#119#gene7428254#267#diseaseC0006142 19706539-4#85#119#gene7428 19706539-4#254#267#diseaseC0006142 associated_with von Hippel-Lindau tumor suppressor,breast cancer
85#119#gene7428254#267#diseaseC0678222 19706539-4#85#119#gene7428 19706539-4#254#267#diseaseC0678222 associated_with von Hippel-Lindau tumor suppressor,breast cancer
121#124#gene7428254#267#diseaseC0006142 19706539-4#121#124#gene7428 19706539-4#254#267#diseaseC0006142 associated_with VHL,breast cancer
121#124#gene7428254#267#diseaseC0678222 19706539-4#121#124#gene7428 19706539-4#254#267#diseaseC0678222 associated_with VHL,breast cancer
121#124#gene7428254#267#diseaseC0006142 19706539-4#121#124#gene7428 19706539-4#254#267#diseaseC0006142 associated_with VHL,breast cancer
121#124#gene7428254#267#diseaseC0678222 19706539-4#121#124#gene7428 19706539-4#254#267#diseaseC0678222 associated_with VHL,breast cancer
121#124#gene7428254#267#diseaseC0006142 19706539-4#121#124#gene7428 19706539-4#254#267#diseaseC0006142 associated_with VHL,breast cancer
121#124#gene7428254#267#diseaseC0678222 19706539-4#121#124#gene7428 19706539-4#254#267#diseaseC0678222 associated_with VHL,breast cancer
184#189#gene6091254#267#diseaseC0006142 19706539-4#184#189#gene6091 19706539-4#254#267#diseaseC0006142 associated_with Robo1,breast cancer
184#189#gene6091254#267#diseaseC0678222 19706539-4#184#189#gene6091 19706539-4#254#267#diseaseC0678222 associated_with Robo1,breast cancer
184#189#gene6091254#267#diseaseC0006142 19706539-4#184#189#gene6091 19706539-4#254#267#diseaseC0006142 associated_with Robo1,breast cancer
184#189#gene6091254#267#diseaseC0678222 19706539-4#184#189#gene6091 19706539-4#254#267#diseaseC0678222 associated_with Robo1,breast cancer
184#189#gene6091254#267#diseaseC0006142 19706539-4#184#189#gene6091 19706539-4#254#267#diseaseC0006142 associated_with Robo1,breast cancer
184#189#gene6091254#267#diseaseC0678222 19706539-4#184#189#gene6091 19706539-4#254#267#diseaseC0678222 associated_with Robo1,breast cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1492 24-29 gene:23032 denotes USP33
T1493 80-93 disease:C0006142 denotes breast cancer
T1494 30-34 gene:23032 denotes VDU1
T1495 489-523 gene:7428 denotes von Hippel-Lindau tumor suppressor
T1496 658-671 disease:C0006142 denotes breast cancer
T1497 525-528 gene:7428 denotes VHL
T1498 588-593 gene:6091 denotes Robo1
R1 T1492 T1493 associated_with USP33,breast cancer
R2 T1492 T1493 associated_with USP33,breast cancer
R3 T1494 T1493 associated_with VDU1,breast cancer
R4 T1494 T1493 associated_with VDU1,breast cancer
R5 T1495 T1496 associated_with von Hippel-Lindau tumor suppressor,breast cancer
R6 T1495 T1496 associated_with von Hippel-Lindau tumor suppressor,breast cancer
R7 T1497 T1496 associated_with VHL,breast cancer
R8 T1497 T1496 associated_with VHL,breast cancer
R9 T1498 T1496 associated_with Robo1,breast cancer
R10 T1498 T1496 associated_with Robo1,breast cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 80-86 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 365-371 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 658-664 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 838-844 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 80-86 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 365-371 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 658-664 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 838-844 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 147-154 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons