
PubMed:1967259
Annnotations
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 5-11 | gene:6737 | denotes | Ro(SSA |
T1 | 78-106 | disease:C0024141 | denotes | systemic lupus erythematosus |
R1 | T0 | T1 | associated_with | Ro(SSA,systemic lupus erythematosus |
jnlpba-st-training
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-27 | protein | denotes | Anti-Ro(SSA) autoantibodies |
T2 | 48-74 | DNA | denotes | T cell receptor beta genes |
T3 | 237-251 | protein | denotes | autoantibodies |
T4 | 274-295 | protein | denotes | HLA class II antigens |
T5 | 300-314 | protein | denotes | autoantibodies |
T6 | 322-340 | protein | denotes | ribonucleoproteins |
T7 | 341-348 | protein | denotes | Ro(SSA) |
T8 | 353-360 | protein | denotes | La(SSB) |
T9 | 407-429 | protein | denotes | HLA class II molecules |
T10 | 449-465 | protein | denotes | T cell receptors |
T11 | 467-471 | protein | denotes | TCRs |
T12 | 497-505 | DNA | denotes | TCR gene |
T13 | 540-563 | protein | denotes | anti-Ro(SSA) antibodies |
T14 | 575-616 | DNA | denotes | restriction fragment length polymorphisms |
T15 | 618-623 | DNA | denotes | RFLPs |
T16 | 657-685 | DNA | denotes | TCR constant region C beta 1 |
T17 | 707-720 | DNA | denotes | C beta 2 gene |
T18 | 815-829 | DNA | denotes | TCR beta locus |
T19 | 836-845 | DNA | denotes | RFLP pair |
T20 | 877-884 | protein | denotes | Ro(SSA) |
T21 | 910-917 | protein | denotes | Ro(SSA) |
T22 | 944-951 | protein | denotes | La(SSB) |
T23 | 952-963 | protein | denotes | precipitins |
T24 | 1007-1018 | protein | denotes | precipitins |
T25 | 1117-1122 | DNA | denotes | RFLPs |
T26 | 1200-1209 | DNA | denotes | TCR genes |
T27 | 1259-1282 | protein | denotes | anti-Ro(SSA) antibodies |
T28 | 1324-1329 | DNA | denotes | RFLPs |
T29 | 1334-1355 | protein | denotes | HLA class II antigens |
T30 | 1392-1399 | protein | denotes | Ro(SSA) |
T31 | 1484-1494 | DNA | denotes | loci occur |
T32 | 1510-1517 | protein | denotes | Ro(SSA) |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
1967259-0#5#11#gene6737 | 5-11 | gene6737 | denotes | Ro(SSA |
1967259-0#78#106#diseaseC0024141 | 78-106 | diseaseC0024141 | denotes | systemic lupus erythematosus |
5#11#gene673778#106#diseaseC0024141 | 1967259-0#5#11#gene6737 | 1967259-0#78#106#diseaseC0024141 | associated_with | Ro(SSA,systemic lupus erythematosus |
pubmed-sentences-benchmark
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
S1 | 0-116 | Sentence | denotes | Anti-Ro(SSA) autoantibodies are associated with T cell receptor beta genes in systemic lupus erythematosus patients. |
S2 | 117-252 | Sentence | denotes | Several of the heterogeneous clinical manifestations of systemic lupus erythematosus have been associated with specific autoantibodies. |
S3 | 253-398 | Sentence | denotes | Associations between HLA class II antigens and autoantibodies to the ribonucleoproteins Ro(SSA) and La(SSB) have been reported in these patients. |
S4 | 399-564 | Sentence | denotes | Because HLA class II molecules present antigen to T cell receptors (TCRs), we have searched for a TCR gene associated with the production of anti-Ro(SSA) antibodies. |
S5 | 565-830 | Sentence | denotes | A pair of restriction fragment length polymorphisms (RFLPs), one of which hybridizes to the TCR constant region C beta 1 and the other to the C beta 2 gene, has been identified, suggesting these may be genotypic markers for an extended region of the TCR beta locus. |
S6 | 831-1032 | Sentence | denotes | This RFLP pair occurs in 76% of patients with Ro(SSA) precipitins, 84% of anti-Ro(SSA)-positive patients lacking La(SSB) precipitins, but only 41% of the patients lacking both precipitins (P = 0.0004). |
S7 | 1033-1283 | Sentence | denotes | This disproportionate occurrence in a subset of lupus patients indicates that these RFLPs are not disease susceptibility markers, but rather are important markers for TCR genes whose products are involved in the production of anti-Ro(SSA) antibodies. |
S8 | 1284-1518 | Sentence | denotes | The majority of patients who have these RFLPs and HLA class II antigens previously associated with the anti-Ro(SSA) response make this antibody, suggesting that interactions between products of these loci occur in response to Ro(SSA). |
genia-medco-coref
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
C1 | 78-115 | NP | denotes | systemic lupus erythematosus patients |
C2 | 341-348 | NP | denotes | Ro(SSA) |
C3 | 383-397 | NP | denotes | these patients |
C4 | 540-563 | NP | denotes | anti-Ro(SSA) antibodies |
C5 | 565-616 | NP | denotes | A pair of restriction fragment length polymorphisms |
C6 | 754-759 | NP | denotes | these |
C7 | 831-845 | NP | denotes | This RFLP pair |
C8 | 981-1018 | NP | denotes | the patients lacking both precipitins |
C10 | 1081-1095 | NP | denotes | lupus patients |
C9 | 1069-1095 | NP | denotes | a subset of lupus patients |
C11 | 1111-1122 | NP | denotes | these RFLPs |
C12 | 1259-1282 | NP | denotes | anti-Ro(SSA) antibodies |
C13 | 1318-1329 | NP | denotes | these RFLPs |
C14 | 1414-1427 | NP | denotes | this antibody |
C15 | 1510-1517 | NP | denotes | Ro(SSA) |
R1 | C3 | C1 | coref-ident | these patients,systemic lupus erythematosus patients |
R2 | C6 | C5 | coref-pron | these,A pair of restriction fragment length polymorphisms |
R3 | C7 | C5 | coref-ident | This RFLP pair,A pair of restriction fragment length polymorphisms |
R4 | C10 | C3 | coref-ident | lupus patients,these patients |
R5 | C9 | C8 | coref-ident | a subset of lupus patients,the patients lacking both precipitins |
R6 | C11 | C7 | coref-ident | these RFLPs,This RFLP pair |
R7 | C12 | C4 | coref-ident | anti-Ro(SSA) antibodies,anti-Ro(SSA) antibodies |
R8 | C13 | C11 | coref-ident | these RFLPs,these RFLPs |
R9 | C14 | C12 | coref-ident | this antibody,anti-Ro(SSA) antibodies |
R10 | C15 | C2 | coref-ident | Ro(SSA),Ro(SSA) |
GENIAcorpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11 | 353-360 | protein_molecule | denotes | La(SSB) |
T1 | 0-27 | protein_family_or_group | denotes | Anti-Ro(SSA) autoantibodies |
T2 | 48-74 | DNA_family_or_group | denotes | T cell receptor beta genes |
T3 | 78-106 | other_name | denotes | systemic lupus erythematosus |
T4 | 132-169 | other_name | denotes | heterogeneous clinical manifestations |
T5 | 173-201 | other_name | denotes | systemic lupus erythematosus |
T6 | 237-251 | protein_family_or_group | denotes | autoantibodies |
T7 | 274-295 | protein_family_or_group | denotes | HLA class II antigens |
T8 | 300-314 | protein_family_or_group | denotes | autoantibodies |
T9 | 322-340 | protein_family_or_group | denotes | ribonucleoproteins |
T10 | 341-348 | protein_molecule | denotes | Ro(SSA) |
T12 | 407-429 | protein_family_or_group | denotes | HLA class II molecules |
T13 | 449-465 | protein_family_or_group | denotes | T cell receptors |
T14 | 467-471 | protein_family_or_group | denotes | TCRs |
T15 | 497-505 | DNA_family_or_group | denotes | TCR gene |
T16 | 540-545 | protein_family_or_group | denotes | anti- |
T17 | 545-552 | protein_molecule | denotes | Ro(SSA) |
T18 | 575-616 | DNA_family_or_group | denotes | restriction fragment length polymorphisms |
T19 | 618-623 | DNA_family_or_group | denotes | RFLPs |
T20 | 657-685 | DNA_domain_or_region | denotes | TCR constant region C beta 1 |
T21 | 707-720 | DNA_domain_or_region | denotes | C beta 2 gene |
T22 | 767-784 | other_name | denotes | genotypic markers |
T23 | 815-829 | DNA_domain_or_region | denotes | TCR beta locus |
T24 | 836-845 | DNA_domain_or_region | denotes | RFLP pair |
T25 | 863-871 | multi_cell | denotes | patients |
T26 | 877-884 | protein_molecule | denotes | Ro(SSA) |
T27 | 905-910 | multi_cell | denotes | anti- |
T28 | 910-917 | protein_molecule | denotes | Ro(SSA) |
T29 | 927-935 | multi_cell | denotes | patients |
T30 | 944-951 | protein_molecule | denotes | La(SSB) |
T31 | 952-963 | protein_family_or_group | denotes | precipitins |
T32 | 985-993 | multi_cell | denotes | patients |
T33 | 1007-1018 | protein_family_or_group | denotes | precipitins |
T34 | 1081-1086 | multi_cell | denotes | lupus |
T35 | 1087-1095 | multi_cell | denotes | patients |
T36 | 1117-1122 | DNA_family_or_group | denotes | RFLPs |
T37 | 1200-1209 | DNA_domain_or_region | denotes | TCR genes |
T38 | 1259-1264 | protein_family_or_group | denotes | anti- |
T39 | 1264-1271 | protein_molecule | denotes | Ro(SSA) |
T40 | 1300-1308 | multi_cell | denotes | patients |
T41 | 1324-1329 | DNA_family_or_group | denotes | RFLPs |
T42 | 1334-1355 | protein_molecule | denotes | HLA class II antigens |
T43 | 1387-1392 | other_name | denotes | anti- |
T44 | 1392-1399 | protein_molecule | denotes | Ro(SSA) |
T45 | 1484-1494 | DNA_domain_or_region | denotes | loci occur |
T46 | 1510-1517 | protein_molecule | denotes | Ro(SSA) |