PubMed:19647786 / 176-1343
Annnotations
PubMed_Structured_Abstracts
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-1167 | BACKGROUND | denotes | Since its discovery in the early 1980s, O-linked-beta-N-acetylglucosamine (O-GlcNAc), a single sugar modification on the hydroxyl group of serine or threonine residues, has changed our views of protein glycosylation. While other forms of protein glycosylation modify proteins on the cell surface or within luminal compartments of the secretory machinery, O-GlcNAc modifies myriad nucleocytoplasmic proteins. GlcNAcylated proteins are involved in transcription, ubiquitination, cell cycle, and stress responses. GlcNAcylation is similar to protein phosphorylation in terms of stoichiometry, localization and cycling. To date, only two enzymes are known to regulate GlcNAcylation in mammals: O-GlcNAc transferase (OGT), which catalyzes the addition of O-GlcNAc, and beta-N-acetylglucosaminidase (O-GlcNAcase), a neutral hexosaminidase responsible for O-GlcNAc removal. OGT and O-GlcNAcase are regulated by RNA splicing, by nutrients, and by post-translational modifications. Their specificities are controlled by many transiently associated targeting subunits. As methods for detecting O-GlcNAc have improved our understanding of O-GlcNAc's functions has grown rapidly. |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_19647786_2_0 | 40-73 | expanded | denotes | O-linked-beta-N-acetylglucosamine |
| SS2_19647786_2_0 | 75-83 | abbr | denotes | O-GlcNAc |
| SS1_19647786_6_0 | 690-710 | expanded | denotes | O-GlcNAc transferase |
| SS2_19647786_6_0 | 712-715 | abbr | denotes | OGT |
| SS1_19647786_6_1 | 750-792 | expanded | denotes | O-GlcNAc, and beta-N-acetylglucosaminidase |
| SS2_19647786_6_1 | 794-805 | abbr | denotes | O-GlcNAcase |
| AE1_19647786_2_0 | SS1_19647786_2_0 | SS2_19647786_2_0 | abbreviatedTo | O-linked-beta-N-acetylglucosamine,O-GlcNAc |
| AE1_19647786_6_0 | SS1_19647786_6_0 | SS2_19647786_6_0 | abbreviatedTo | O-GlcNAc transferase,OGT |
| AE1_19647786_6_1 | SS1_19647786_6_1 | SS2_19647786_6_1 | abbreviatedTo | "O-GlcNAc, and beta-N-acetylglucosaminidase",O-GlcNAcase |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T3 | 54-73 | chem:24139 | denotes | N-acetylglucosamine |
| PD-NGLY1-deficiency-B_T4 | 77-83 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T5 | 357-363 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T6 | 692-698 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T7 | 752-758 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T8 | 851-857 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T9 | 1086-1092 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T10 | 1130-1138 | chem:24139 | denotes | GlcNAc's |
| PD-NGLY1-deficiency-B_T11 | 764-792 | hgnc:24622 | denotes | beta-N-acetylglucosaminidase |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T2 | 75-83 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 355-363 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T4 | 690-698 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T5 | 750-758 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T6 | 849-857 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T7 | 1084-1092 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 380-397 | Body_part | denotes | nucleocytoplasmic | http://purl.obolibrary.org/obo/GO_0005622 |
| T2 | 477-487 | Body_part | denotes | cell cycle | http://purl.obolibrary.org/obo/UBERON_2000098 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 0-216 | Sentence | denotes | Since its discovery in the early 1980s, O-linked-beta-N-acetylglucosamine (O-GlcNAc), a single sugar modification on the hydroxyl group of serine or threonine residues, has changed our views of protein glycosylation. |
| T5 | 217-407 | Sentence | denotes | While other forms of protein glycosylation modify proteins on the cell surface or within luminal compartments of the secretory machinery, O-GlcNAc modifies myriad nucleocytoplasmic proteins. |
| T6 | 408-510 | Sentence | denotes | GlcNAcylated proteins are involved in transcription, ubiquitination, cell cycle, and stress responses. |
| T7 | 511-615 | Sentence | denotes | GlcNAcylation is similar to protein phosphorylation in terms of stoichiometry, localization and cycling. |
| T8 | 616-866 | Sentence | denotes | To date, only two enzymes are known to regulate GlcNAcylation in mammals: O-GlcNAc transferase (OGT), which catalyzes the addition of O-GlcNAc, and beta-N-acetylglucosaminidase (O-GlcNAcase), a neutral hexosaminidase responsible for O-GlcNAc removal. |
| T9 | 867-972 | Sentence | denotes | OGT and O-GlcNAcase are regulated by RNA splicing, by nutrients, and by post-translational modifications. |
| T10 | 973-1058 | Sentence | denotes | Their specificities are controlled by many transiently associated targeting subunits. |
| T11 | 1059-1167 | Sentence | denotes | As methods for detecting O-GlcNAc have improved our understanding of O-GlcNAc's functions has grown rapidly. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T2 | 75-83 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 355-363 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T4 | 690-698 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T5 | 750-758 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T6 | 849-857 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T7 | 1084-1092 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T2 | 75-83 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 355-363 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T4 | 690-698 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T5 | 750-758 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T6 | 849-857 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T7 | 1084-1092 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T2 | 75-83 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 355-363 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T4 | 690-698 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T5 | 750-758 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T6 | 849-857 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T7 | 1084-1092 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 380-397 | Body_part | denotes | nucleocytoplasmic | http://purl.obolibrary.org/obo/GO_0005622 |
| T2 | 477-487 | Body_part | denotes | cell cycle | http://purl.obolibrary.org/obo/UBERON_2000098 |