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PubMed:19565319 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-120 Sentence denotes Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder.
T2 121-225 Sentence denotes Autism spectrum disorders (ASDs) are heterogeneous disorders presenting with increased rates of anxiety.
T3 226-342 Sentence denotes The adenosine A(2A) receptor gene (ADORA2A) is associated with panic disorder and is located on chromosome 22q11.23.
T4 343-467 Sentence denotes Its gene product, the adenosine A(2A) receptor, is strongly expressed in the caudate nucleus, which also is involved in ASD.
T5 468-769 Sentence denotes As autistic symptoms are increased in individuals with 22q11.2 deletion syndrome, and large 22q11.2 deletions and duplications have been observed in ASD individuals, in this study, 98 individuals with ASD and 234 control individuals were genotyped for eight single-nucleotide polymorphisms in ADORA2A.
T6 770-936 Sentence denotes Nominal association with the disorder was observed for rs2236624-CC, and phenotypic variability in ASD symptoms was influenced by rs3761422, rs5751876 and rs35320474.
T7 937-1035 Sentence denotes In addition, association of ADORA2A variants with anxiety was replicated for individuals with ASD.
T8 1036-1182 Sentence denotes Findings point toward a possible mediating role of ADORA2A variants on phenotypic expression in ASD that need to be replicated in a larger sample.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
6262 0-24 GeneOrGeneProduct denotes Adenosine A(2A) receptor NCBIGene:135
6263 31-38 GeneOrGeneProduct denotes ADORA2A NCBIGene:135
6264 62-79 DiseaseOrPhenotypicFeature denotes autistic symptoms MESH:D001321
6265 84-91 DiseaseOrPhenotypicFeature denotes anxiety MESH:D001008
6266 95-119 DiseaseOrPhenotypicFeature denotes autism spectrum disorder MESH:D000067877
6267 121-146 DiseaseOrPhenotypicFeature denotes Autism spectrum disorders MESH:D000067877
6268 148-152 DiseaseOrPhenotypicFeature denotes ASDs MESH:D000067877
6269 217-224 DiseaseOrPhenotypicFeature denotes anxiety MESH:D001008
6270 230-254 GeneOrGeneProduct denotes adenosine A(2A) receptor NCBIGene:135
6271 261-268 GeneOrGeneProduct denotes ADORA2A NCBIGene:135
6272 289-303 DiseaseOrPhenotypicFeature denotes panic disorder MESH:D016584
6273 365-389 GeneOrGeneProduct denotes adenosine A(2A) receptor NCBIGene:135
6274 463-466 DiseaseOrPhenotypicFeature denotes ASD MESH:D000067877
6275 471-488 DiseaseOrPhenotypicFeature denotes autistic symptoms MESH:D001321
6276 523-548 DiseaseOrPhenotypicFeature denotes 22q11.2 deletion syndrome MESH:D004062
6277 560-577 DiseaseOrPhenotypicFeature denotes 22q11.2 deletions MESH:D004062
6278 617-620 DiseaseOrPhenotypicFeature denotes ASD MESH:D000067877
6279 669-672 DiseaseOrPhenotypicFeature denotes ASD MESH:D000067877
6280 761-768 GeneOrGeneProduct denotes ADORA2A NCBIGene:135
6281 825-834 SequenceVariant denotes rs2236624 DBSNP:rs2236624
6282 869-872 DiseaseOrPhenotypicFeature denotes ASD MESH:D000067877
6283 900-909 SequenceVariant denotes rs3761422 DBSNP:rs3761422
6284 911-920 SequenceVariant denotes rs5751876 DBSNP:rs5751876
6285 925-935 SequenceVariant denotes rs35320474 DBSNP:rs35320474
6286 965-972 GeneOrGeneProduct denotes ADORA2A NCBIGene:135
6287 987-994 DiseaseOrPhenotypicFeature denotes anxiety MESH:D001008
6288 1031-1034 DiseaseOrPhenotypicFeature denotes ASD MESH:D000067877
6289 1087-1094 GeneOrGeneProduct denotes ADORA2A NCBIGene:135
6290 1132-1135 DiseaseOrPhenotypicFeature denotes ASD MESH:D000067877

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 84-91 DiseaseOrPhenotypicFeature denotes anxiety 0011918
T2 95-119 DiseaseOrPhenotypicFeature denotes autism spectrum disorder 0005258
T3 95-101 DiseaseOrPhenotypicFeature denotes autism 0005260
T4 121-146 DiseaseOrPhenotypicFeature denotes Autism spectrum disorders 0005258
T5 217-224 DiseaseOrPhenotypicFeature denotes anxiety 0011918
T6 289-303 DiseaseOrPhenotypicFeature denotes panic disorder 0005383
T7 523-548 DiseaseOrPhenotypicFeature denotes 22q11.2 deletion syndrome 0018923
T8 987-994 DiseaseOrPhenotypicFeature denotes anxiety 0011918

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 825-834 SequenceVariant denotes rs2236624
T2 900-909 SequenceVariant denotes rs3761422
T3 911-920 SequenceVariant denotes rs5751876
T4 925-935 SequenceVariant denotes rs35320474

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 16-24 GeneOrGeneProduct denotes receptor
T2 31-38 GeneOrGeneProduct denotes ADORA2A
T3 84-91 GeneOrGeneProduct denotes anxiety
T4 148-152 GeneOrGeneProduct denotes ASDs
T5 217-224 GeneOrGeneProduct denotes anxiety
T6 246-254 GeneOrGeneProduct denotes receptor
T7 261-268 GeneOrGeneProduct denotes ADORA2A
T8 352-359 GeneOrGeneProduct denotes product
T9 381-389 GeneOrGeneProduct denotes receptor
T10 428-435 GeneOrGeneProduct denotes nucleus
T11 463-470 GeneOrGeneProduct denotes ASD. As
T12 540-548 GeneOrGeneProduct denotes syndrome
T13 554-559 GeneOrGeneProduct denotes large
T14 582-594 GeneOrGeneProduct denotes duplications
T15 761-768 GeneOrGeneProduct denotes ADORA2A
T16 965-972 GeneOrGeneProduct denotes ADORA2A
T17 987-994 GeneOrGeneProduct denotes anxiety
T18 1036-1044 GeneOrGeneProduct denotes Findings
T19 1045-1050 GeneOrGeneProduct denotes point
T20 1069-1078 GeneOrGeneProduct denotes mediating
T21 1087-1094 GeneOrGeneProduct denotes ADORA2A
T22 1163-1167 GeneOrGeneProduct denotes in a

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 16-24 GeneOrGeneProduct denotes receptor
T2 31-38 GeneOrGeneProduct denotes ADORA2A
T3 84-91 GeneOrGeneProduct denotes anxiety
T4 217-224 GeneOrGeneProduct denotes anxiety
T5 246-254 GeneOrGeneProduct denotes receptor
T6 261-268 GeneOrGeneProduct denotes ADORA2A
T7 352-359 GeneOrGeneProduct denotes product
T8 381-389 GeneOrGeneProduct denotes receptor
T9 428-435 GeneOrGeneProduct denotes nucleus
T10 540-548 GeneOrGeneProduct denotes syndrome
T11 554-559 GeneOrGeneProduct denotes large
T12 761-768 GeneOrGeneProduct denotes ADORA2A
T13 965-972 GeneOrGeneProduct denotes ADORA2A
T14 987-994 GeneOrGeneProduct denotes anxiety
T15 1087-1094 GeneOrGeneProduct denotes ADORA2A

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 84-91 DiseaseOrPhenotypicFeature denotes anxiety DISEASE
T2 95-119 DiseaseOrPhenotypicFeature denotes autism spectrum disorder D000067877
T3 121-146 DiseaseOrPhenotypicFeature denotes Autism spectrum disorders D000067877
T4 148-152 DiseaseOrPhenotypicFeature denotes ASDs D000067877
T5 217-224 DiseaseOrPhenotypicFeature denotes anxiety DISEASE
T6 289-303 DiseaseOrPhenotypicFeature denotes panic disorder D016584
T7 523-548 DiseaseOrPhenotypicFeature denotes 22q11.2 deletion syndrome D004062
T8 987-994 DiseaseOrPhenotypicFeature denotes anxiety DISEASE

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-24 GeneOrGeneProduct denotes Adenosine A(2A) receptor
T2 31-38 GeneOrGeneProduct denotes ADORA2A
T3 230-254 GeneOrGeneProduct denotes adenosine A(2A) receptor
T4 261-268 GeneOrGeneProduct denotes ADORA2A
T5 365-389 GeneOrGeneProduct denotes adenosine A(2A) receptor
T6 761-768 GeneOrGeneProduct denotes ADORA2A
T7 965-972 GeneOrGeneProduct denotes ADORA2A
T8 1087-1094 GeneOrGeneProduct denotes ADORA2A

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 84-91 DiseaseOrPhenotypicFeature denotes anxiety 0011918|0005618
T3 95-119 DiseaseOrPhenotypicFeature denotes autism spectrum disorder 0005260|0005258
T5 121-146 DiseaseOrPhenotypicFeature denotes Autism spectrum disorders 0005260|0005258
T7 148-152 DiseaseOrPhenotypicFeature denotes ASDs 0005260
T8 217-224 DiseaseOrPhenotypicFeature denotes anxiety 0011918|0005618
T10 289-303 DiseaseOrPhenotypicFeature denotes panic disorder 0008187|0005383
T12 463-466 DiseaseOrPhenotypicFeature denotes ASD 0006664
T13 523-548 DiseaseOrPhenotypicFeature denotes 22q11.2 deletion syndrome 0018923
T14 617-620 DiseaseOrPhenotypicFeature denotes ASD 0006664
T15 669-672 DiseaseOrPhenotypicFeature denotes ASD 0006664
T16 835-837 DiseaseOrPhenotypicFeature denotes CC 0019087
T17 869-872 DiseaseOrPhenotypicFeature denotes ASD 0006664
T18 987-994 DiseaseOrPhenotypicFeature denotes anxiety 0011918|0005618
T20 1031-1034 DiseaseOrPhenotypicFeature denotes ASD 0006664
T21 1132-1135 DiseaseOrPhenotypicFeature denotes ASD 0006664

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 62-79 DiseaseOrPhenotypicFeature denotes autistic symptoms DISEASE
T2 84-91 DiseaseOrPhenotypicFeature denotes anxiety DISEASE
T3 95-119 DiseaseOrPhenotypicFeature denotes autism spectrum disorder D000067877
T4 121-146 DiseaseOrPhenotypicFeature denotes Autism spectrum disorders D000067877
T5 148-152 DiseaseOrPhenotypicFeature denotes ASDs D000067877
T6 217-224 DiseaseOrPhenotypicFeature denotes anxiety DISEASE
T7 289-303 DiseaseOrPhenotypicFeature denotes panic disorder D016584
T8 463-466 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T9 471-488 DiseaseOrPhenotypicFeature denotes autistic symptoms DISEASE
T10 523-548 DiseaseOrPhenotypicFeature denotes 22q11.2 deletion syndrome D004062
T11 560-577 DiseaseOrPhenotypicFeature denotes 22q11.2 deletions DISEASE
T12 617-620 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T13 669-672 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T14 869-872 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T15 987-994 DiseaseOrPhenotypicFeature denotes anxiety DISEASE
T16 1031-1034 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T17 1132-1135 DiseaseOrPhenotypicFeature denotes ASD DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 62-79 DiseaseOrPhenotypicFeature denotes autistic symptoms DISEASE
T2 84-91 DiseaseOrPhenotypicFeature denotes anxiety DISEASE
T3 95-119 DiseaseOrPhenotypicFeature denotes autism spectrum disorder D000067877
T4 121-146 DiseaseOrPhenotypicFeature denotes Autism spectrum disorders D000067877
T5 148-152 DiseaseOrPhenotypicFeature denotes ASDs D000067877
T6 217-224 DiseaseOrPhenotypicFeature denotes anxiety DISEASE
T7 289-303 DiseaseOrPhenotypicFeature denotes panic disorder D016584
T8 463-466 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T9 471-488 DiseaseOrPhenotypicFeature denotes autistic symptoms DISEASE
T10 523-548 DiseaseOrPhenotypicFeature denotes 22q11.2 deletion syndrome D004062
T11 560-577 DiseaseOrPhenotypicFeature denotes 22q11.2 deletions DISEASE
T12 617-620 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T13 669-672 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T14 869-872 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T15 987-994 DiseaseOrPhenotypicFeature denotes anxiety DISEASE
T16 1031-1034 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T17 1132-1135 DiseaseOrPhenotypicFeature denotes ASD DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-9 ChemicalEntity denotes Adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T2 230-239 ChemicalEntity denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T3 365-374 ChemicalEntity denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T3 365-374 ChemicalEntity denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T2 230-239 ChemicalEntity denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T1 0-9 ChemicalEntity denotes Adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T8 1087-1094 GeneOrGeneProduct denotes ADORA2A
T7 965-972 GeneOrGeneProduct denotes ADORA2A
T6 761-768 GeneOrGeneProduct denotes ADORA2A
T5 365-389 GeneOrGeneProduct denotes adenosine A(2A) receptor
T4 261-268 GeneOrGeneProduct denotes ADORA2A
T4923 230-254 GeneOrGeneProduct denotes adenosine A(2A) receptor
T33196 31-38 GeneOrGeneProduct denotes ADORA2A
T81556 0-24 GeneOrGeneProduct denotes Adenosine A(2A) receptor
T17 1132-1135 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T16 1031-1034 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T15 987-994 DiseaseOrPhenotypicFeature denotes anxiety DISEASE
T14 869-872 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T13 669-672 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T12 617-620 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T11 560-577 DiseaseOrPhenotypicFeature denotes 22q11.2 deletions DISEASE
T10 523-548 DiseaseOrPhenotypicFeature denotes 22q11.2 deletion syndrome D004062
T9 471-488 DiseaseOrPhenotypicFeature denotes autistic symptoms DISEASE
T64829 463-466 DiseaseOrPhenotypicFeature denotes ASD DISEASE
T35824 289-303 DiseaseOrPhenotypicFeature denotes panic disorder D016584
T28018 217-224 DiseaseOrPhenotypicFeature denotes anxiety DISEASE
T199 148-152 DiseaseOrPhenotypicFeature denotes ASDs D000067877
T68139 121-146 DiseaseOrPhenotypicFeature denotes Autism spectrum disorders D000067877
T47675 95-119 DiseaseOrPhenotypicFeature denotes autism spectrum disorder D000067877
T64220 84-91 DiseaseOrPhenotypicFeature denotes anxiety DISEASE
T99639 62-79 DiseaseOrPhenotypicFeature denotes autistic symptoms DISEASE
T89964 925-935 SequenceVariant denotes rs35320474
T824 911-920 SequenceVariant denotes rs5751876
T61586 900-909 SequenceVariant denotes rs3761422
T87823 825-834 SequenceVariant denotes rs2236624

DisGeNET

Id Subject Object Predicate Lexical cue
T0 261-268 gene:135 denotes ADORA2A
T1 289-303 disease:C0030319 denotes panic disorder
T2 261-268 gene:135 denotes ADORA2A
T3 289-303 disease:C1868649 denotes panic disorder
T4 669-672 gene:414 denotes ASD
T5 523-548 disease:C0012236 denotes 22q11.2 deletion syndrome
T6 669-672 gene:414 denotes ASD
T7 523-548 disease:C0220704 denotes 22q11.2 deletion syndrome
T8 965-972 gene:135 denotes ADORA2A
T9 987-994 disease:C0003469 denotes anxiety
T10 1031-1034 gene:414 denotes ASD
T11 987-994 disease:C0003469 denotes anxiety
R1 T0 T1 associated_with ADORA2A,panic disorder
R2 T2 T3 associated_with ADORA2A,panic disorder
R3 T4 T5 associated_with ASD,22q11.2 deletion syndrome
R4 T6 T7 associated_with ASD,22q11.2 deletion syndrome
R5 T8 T9 associated_with ADORA2A,anxiety
R6 T10 T11 associated_with ASD,anxiety

Allie

Id Subject Object Predicate Lexical cue
SS1_19565319_0_0 0-29 expanded denotes Adenosine A(2A) receptor gene
SS2_19565319_0_0 31-38 abbr denotes ADORA2A
SS1_19565319_1_0 121-146 expanded denotes Autism spectrum disorders
SS2_19565319_1_0 148-152 abbr denotes ASDs
SS1_19565319_2_0 230-259 expanded denotes adenosine A(2A) receptor gene
SS2_19565319_2_0 261-268 abbr denotes ADORA2A
AE1_19565319_0_0 SS1_19565319_0_0 SS2_19565319_0_0 abbreviatedTo Adenosine A(2A) receptor gene,ADORA2A
AE1_19565319_1_0 SS1_19565319_1_0 SS2_19565319_1_0 abbreviatedTo Autism spectrum disorders,ASDs
AE1_19565319_2_0 SS1_19565319_2_0 SS2_19565319_2_0 abbreviatedTo adenosine A(2A) receptor gene,ADORA2A

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
19565319-5#55#64#geners2236624 825-834 geners2236624 denotes rs2236624
19565319-5#99#102#diseaseC1510586 869-872 diseaseC1510586 denotes ASD
55#64#geners223662499#102#diseaseC1510586 19565319-5#55#64#geners2236624 19565319-5#99#102#diseaseC1510586 associated_with rs2236624,ASD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19565319-0#31#38#gene135 31-38 gene135 denotes ADORA2A
19565319-0#31#38#gene135 31-38 gene135 denotes ADORA2A
19565319-0#84#91#diseaseC0003467 84-91 diseaseC0003467 denotes anxiety
19565319-0#84#91#diseaseC0003469 84-91 diseaseC0003469 denotes anxiety
19565319-0#95#119#diseaseC0524528 95-119 diseaseC0524528 denotes autism spectrum disorder
19565319-0#95#119#diseaseC1510586 95-119 diseaseC1510586 denotes autism spectrum disorder
19565319-0#62#70#diseaseC0004352 62-70 diseaseC0004352 denotes autistic
19565319-2#35#42#gene135 261-268 gene135 denotes ADORA2A
19565319-2#63#77#diseaseC0030319 289-303 diseaseC0030319 denotes panic disorder
19565319-2#63#77#diseaseC1868649 289-303 diseaseC1868649 denotes panic disorder
31#38#gene13584#91#diseaseC0003467 19565319-0#31#38#gene135 19565319-0#84#91#diseaseC0003467 associated_with ADORA2A,anxiety
31#38#gene13584#91#diseaseC0003469 19565319-0#31#38#gene135 19565319-0#84#91#diseaseC0003469 associated_with ADORA2A,anxiety
31#38#gene13595#119#diseaseC0524528 19565319-0#31#38#gene135 19565319-0#95#119#diseaseC0524528 associated_with ADORA2A,autism spectrum disorder
31#38#gene13595#119#diseaseC1510586 19565319-0#31#38#gene135 19565319-0#95#119#diseaseC1510586 associated_with ADORA2A,autism spectrum disorder
31#38#gene13562#70#diseaseC0004352 19565319-0#31#38#gene135 19565319-0#62#70#diseaseC0004352 associated_with ADORA2A,autistic
31#38#gene13584#91#diseaseC0003467 19565319-0#31#38#gene135 19565319-0#84#91#diseaseC0003467 associated_with ADORA2A,anxiety
31#38#gene13584#91#diseaseC0003469 19565319-0#31#38#gene135 19565319-0#84#91#diseaseC0003469 associated_with ADORA2A,anxiety
31#38#gene13595#119#diseaseC0524528 19565319-0#31#38#gene135 19565319-0#95#119#diseaseC0524528 associated_with ADORA2A,autism spectrum disorder
31#38#gene13595#119#diseaseC1510586 19565319-0#31#38#gene135 19565319-0#95#119#diseaseC1510586 associated_with ADORA2A,autism spectrum disorder
31#38#gene13562#70#diseaseC0004352 19565319-0#31#38#gene135 19565319-0#62#70#diseaseC0004352 associated_with ADORA2A,autistic
35#42#gene13563#77#diseaseC0030319 19565319-2#35#42#gene135 19565319-2#63#77#diseaseC0030319 associated_with ADORA2A,panic disorder
35#42#gene13563#77#diseaseC1868649 19565319-2#35#42#gene135 19565319-2#63#77#diseaseC1868649 associated_with ADORA2A,panic disorder

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 825-834 SNP:rs2236624 denotes rs2236624
T2 900-909 SNP:rs3761422 denotes rs3761422
T3 911-920 SNP:rs5751876 denotes rs5751876
T4 925-935 SNP:rs35320474 denotes rs35320474