PubMed:19553519 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":186},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":187,"end":610},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":611,"end":782},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":783,"end":1050},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":1051,"end":1332},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":186},"obj":"Sentence"},{"id":"T2","span":{"begin":187,"end":610},"obj":"Sentence"},{"id":"T3","span":{"begin":611,"end":782},"obj":"Sentence"},{"id":"T4","span":{"begin":783,"end":1050},"obj":"Sentence"},{"id":"T5","span":{"begin":1051,"end":1332},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":186},"obj":"Sentence"},{"id":"T2","span":{"begin":187,"end":610},"obj":"Sentence"},{"id":"T3","span":{"begin":611,"end":782},"obj":"Sentence"},{"id":"T4","span":{"begin":783,"end":1050},"obj":"Sentence"},{"id":"T5","span":{"begin":1051,"end":1332},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"GlycoBiology-FMA","denotations":[{"id":"_T1","span":{"begin":40,"end":52},"obj":"FMAID:196792"},{"id":"_T2","span":{"begin":40,"end":52},"obj":"FMAID:82797"},{"id":"_T3","span":{"begin":40,"end":67},"obj":"FMAID:196781"},{"id":"_T4","span":{"begin":40,"end":67},"obj":"FMAID:82787"},{"id":"_T5","span":{"begin":56,"end":67},"obj":"FMAID:196792"},{"id":"_T6","span":{"begin":56,"end":67},"obj":"FMAID:82797"},{"id":"_T7","span":{"begin":152,"end":167},"obj":"FMAID:196731"},{"id":"_T8","span":{"begin":152,"end":167},"obj":"FMAID:82742"},{"id":"_T9","span":{"begin":180,"end":185},"obj":"FMAID:198663"},{"id":"_T10","span":{"begin":248,"end":260},"obj":"FMAID:196792"},{"id":"_T11","span":{"begin":248,"end":260},"obj":"FMAID:82797"},{"id":"_T12","span":{"begin":248,"end":275},"obj":"FMAID:196781"},{"id":"_T13","span":{"begin":248,"end":275},"obj":"FMAID:82787"},{"id":"_T14","span":{"begin":264,"end":275},"obj":"FMAID:196792"},{"id":"_T15","span":{"begin":264,"end":275},"obj":"FMAID:82797"},{"id":"_T16","span":{"begin":446,"end":458},"obj":"FMAID:197276"},{"id":"_T17","span":{"begin":446,"end":458},"obj":"FMAID:82737"},{"id":"_T18","span":{"begin":489,"end":504},"obj":"FMAID:82742"},{"id":"_T19","span":{"begin":489,"end":504},"obj":"FMAID:196731"},{"id":"_T20","span":{"begin":913,"end":917},"obj":"FMAID:198663"},{"id":"_T21","span":{"begin":1045,"end":1049},"obj":"FMAID:198663"},{"id":"_T22","span":{"begin":1247,"end":1255},"obj":"FMAID:67745"},{"id":"_T23","span":{"begin":1247,"end":1255},"obj":"FMAID:165656"}],"namespaces":[{"prefix":"FMAID","uri":"http://purl.org/sig/ont/fma/fma"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"uniprot-human","denotations":[{"id":"T5","span":{"begin":1202,"end":1205},"obj":"http://www.uniprot.org/uniprot/P14678"},{"id":"T1","span":{"begin":518,"end":521},"obj":"http://www.uniprot.org/uniprot/P14678"},{"id":"T2","span":{"begin":909,"end":912},"obj":"http://www.uniprot.org/uniprot/P14678"},{"id":"T3","span":{"begin":1041,"end":1044},"obj":"http://www.uniprot.org/uniprot/P14678"},{"id":"T4","span":{"begin":1167,"end":1170},"obj":"http://www.uniprot.org/uniprot/P14678"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":33,"end":37},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T2","span":{"begin":33,"end":37},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T3","span":{"begin":187,"end":210},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/670"},{"id":"T4","span":{"begin":241,"end":245},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T5","span":{"begin":241,"end":245},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T6","span":{"begin":554,"end":559},"obj":"http://purl.bioontology.org/ontology/STY/T096"},{"id":"T7","span":{"begin":1144,"end":1152},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/2"},{"id":"T8","span":{"begin":1144,"end":1152},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/629395"},{"id":"T9","span":{"begin":1323,"end":1331},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/629395"},{"id":"T10","span":{"begin":1323,"end":1331},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/2"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":459,"end":467},"obj":"http://purl.obolibrary.org/obo/GO_0052689"},{"id":"T2","span":{"begin":1222,"end":1231},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T3","span":{"begin":1240,"end":1246},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T4","span":{"begin":1289,"end":1305},"obj":"http://purl.obolibrary.org/obo/GO_0006032"},{"id":"T5","span":{"begin":1296,"end":1305},"obj":"http://purl.obolibrary.org/obo/GO_0009056"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":335,"end":348},"obj":"http://purl.obolibrary.org/obo/GO_0005576"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"NGLY1-deficiency","denotations":[{"id":"PD-NGLY1-deficiency-B_T1","span":{"begin":24,"end":52},"obj":"chem:24139"},{"id":"PD-NGLY1-deficiency-B_T2","span":{"begin":232,"end":260},"obj":"chem:24139"},{"id":"PD-NGLY1-deficiency-B_T3","span":{"begin":277,"end":283},"obj":"chem:24139"},{"id":"PD-NGLY1-deficiency-B_T4","span":{"begin":418,"end":424},"obj":"chem:24139"},{"id":"PD-NGLY1-deficiency-B_T5","span":{"begin":580,"end":586},"obj":"chem:24139"},{"id":"PD-NGLY1-deficiency-B_T6","span":{"begin":599,"end":605},"obj":"chem:24139"},{"id":"PD-NGLY1-deficiency-B_T7","span":{"begin":1078,"end":1084},"obj":"chem:24139"}],"namespaces":[{"prefix":"hgnc","uri":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:"},{"prefix":"omim","uri":"https://www.omim.org/entry/"},{"prefix":"chem","uri":"https://pubchem.ncbi.nlm.nih.gov/compound/"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"GlyTouCan-IUPAC","denotations":[{"id":"GlycanIUPAC_T1","span":{"begin":277,"end":283},"obj":"\"http://rdf.glycoinfo.org/glycan/G26693XF\""},{"id":"GlycanIUPAC_T2","span":{"begin":418,"end":424},"obj":"\"http://rdf.glycoinfo.org/glycan/G26693XF\""},{"id":"GlycanIUPAC_T3","span":{"begin":580,"end":586},"obj":"\"http://rdf.glycoinfo.org/glycan/G26693XF\""},{"id":"GlycanIUPAC_T4","span":{"begin":599,"end":605},"obj":"\"http://rdf.glycoinfo.org/glycan/G26693XF\""},{"id":"GlycanIUPAC_T5","span":{"begin":1078,"end":1084},"obj":"\"http://rdf.glycoinfo.org/glycan/G26693XF\""},{"id":"GlycanIUPAC_T6","span":{"begin":277,"end":283},"obj":"\"http://rdf.glycoinfo.org/glycan/G01864SU\""},{"id":"GlycanIUPAC_T7","span":{"begin":418,"end":424},"obj":"\"http://rdf.glycoinfo.org/glycan/G01864SU\""},{"id":"GlycanIUPAC_T8","span":{"begin":580,"end":586},"obj":"\"http://rdf.glycoinfo.org/glycan/G01864SU\""},{"id":"GlycanIUPAC_T9","span":{"begin":599,"end":605},"obj":"\"http://rdf.glycoinfo.org/glycan/G01864SU\""},{"id":"GlycanIUPAC_T10","span":{"begin":1078,"end":1084},"obj":"\"http://rdf.glycoinfo.org/glycan/G01864SU\""},{"id":"GlycanIUPAC_T11","span":{"begin":277,"end":283},"obj":"\"http://rdf.glycoinfo.org/glycan/G17605FD\""},{"id":"GlycanIUPAC_T12","span":{"begin":418,"end":424},"obj":"\"http://rdf.glycoinfo.org/glycan/G17605FD\""},{"id":"GlycanIUPAC_T13","span":{"begin":580,"end":586},"obj":"\"http://rdf.glycoinfo.org/glycan/G17605FD\""},{"id":"GlycanIUPAC_T14","span":{"begin":599,"end":605},"obj":"\"http://rdf.glycoinfo.org/glycan/G17605FD\""},{"id":"GlycanIUPAC_T15","span":{"begin":1078,"end":1084},"obj":"\"http://rdf.glycoinfo.org/glycan/G17605FD\""},{"id":"GlycanIUPAC_T16","span":{"begin":277,"end":283},"obj":"\"http://rdf.glycoinfo.org/glycan/G41950LU\""},{"id":"GlycanIUPAC_T17","span":{"begin":418,"end":424},"obj":"\"http://rdf.glycoinfo.org/glycan/G41950LU\""},{"id":"GlycanIUPAC_T18","span":{"begin":580,"end":586},"obj":"\"http://rdf.glycoinfo.org/glycan/G41950LU\""},{"id":"GlycanIUPAC_T19","span":{"begin":599,"end":605},"obj":"\"http://rdf.glycoinfo.org/glycan/G41950LU\""},{"id":"GlycanIUPAC_T20","span":{"begin":1078,"end":1084},"obj":"\"http://rdf.glycoinfo.org/glycan/G41950LU\""},{"id":"GlycanIUPAC_T21","span":{"begin":277,"end":283},"obj":"\"http://rdf.glycoinfo.org/glycan/G57195RJ\""},{"id":"GlycanIUPAC_T22","span":{"begin":418,"end":424},"obj":"\"http://rdf.glycoinfo.org/glycan/G57195RJ\""},{"id":"GlycanIUPAC_T23","span":{"begin":580,"end":586},"obj":"\"http://rdf.glycoinfo.org/glycan/G57195RJ\""},{"id":"GlycanIUPAC_T24","span":{"begin":599,"end":605},"obj":"\"http://rdf.glycoinfo.org/glycan/G57195RJ\""},{"id":"GlycanIUPAC_T25","span":{"begin":1078,"end":1084},"obj":"\"http://rdf.glycoinfo.org/glycan/G57195RJ\""},{"id":"GlycanIUPAC_T26","span":{"begin":277,"end":283},"obj":"\"http://rdf.glycoinfo.org/glycan/G85391SA\""},{"id":"GlycanIUPAC_T27","span":{"begin":418,"end":424},"obj":"\"http://rdf.glycoinfo.org/glycan/G85391SA\""},{"id":"GlycanIUPAC_T28","span":{"begin":580,"end":586},"obj":"\"http://rdf.glycoinfo.org/glycan/G85391SA\""},{"id":"GlycanIUPAC_T29","span":{"begin":599,"end":605},"obj":"\"http://rdf.glycoinfo.org/glycan/G85391SA\""},{"id":"GlycanIUPAC_T30","span":{"begin":1078,"end":1084},"obj":"\"http://rdf.glycoinfo.org/glycan/G85391SA\""},{"id":"GlycanIUPAC_T31","span":{"begin":277,"end":283},"obj":"\"http://rdf.glycoinfo.org/glycan/G89565QL\""},{"id":"GlycanIUPAC_T32","span":{"begin":418,"end":424},"obj":"\"http://rdf.glycoinfo.org/glycan/G89565QL\""},{"id":"GlycanIUPAC_T33","span":{"begin":580,"end":586},"obj":"\"http://rdf.glycoinfo.org/glycan/G89565QL\""},{"id":"GlycanIUPAC_T34","span":{"begin":599,"end":605},"obj":"\"http://rdf.glycoinfo.org/glycan/G89565QL\""},{"id":"GlycanIUPAC_T35","span":{"begin":1078,"end":1084},"obj":"\"http://rdf.glycoinfo.org/glycan/G89565QL\""},{"id":"GlycanIUPAC_T36","span":{"begin":277,"end":283},"obj":"\"http://rdf.glycoinfo.org/glycan/G80869MR\""},{"id":"GlycanIUPAC_T37","span":{"begin":418,"end":424},"obj":"\"http://rdf.glycoinfo.org/glycan/G80869MR\""},{"id":"GlycanIUPAC_T38","span":{"begin":580,"end":586},"obj":"\"http://rdf.glycoinfo.org/glycan/G80869MR\""},{"id":"GlycanIUPAC_T39","span":{"begin":599,"end":605},"obj":"\"http://rdf.glycoinfo.org/glycan/G80869MR\""},{"id":"GlycanIUPAC_T40","span":{"begin":1078,"end":1084},"obj":"\"http://rdf.glycoinfo.org/glycan/G80869MR\""},{"id":"GlycanIUPAC_T41","span":{"begin":277,"end":283},"obj":"\"http://rdf.glycoinfo.org/glycan/G55978NL\""},{"id":"GlycanIUPAC_T42","span":{"begin":418,"end":424},"obj":"\"http://rdf.glycoinfo.org/glycan/G55978NL\""},{"id":"GlycanIUPAC_T43","span":{"begin":580,"end":586},"obj":"\"http://rdf.glycoinfo.org/glycan/G55978NL\""},{"id":"GlycanIUPAC_T44","span":{"begin":599,"end":605},"obj":"\"http://rdf.glycoinfo.org/glycan/G55978NL\""},{"id":"GlycanIUPAC_T45","span":{"begin":1078,"end":1084},"obj":"\"http://rdf.glycoinfo.org/glycan/G55978NL\""},{"id":"GlycanIUPAC_T46","span":{"begin":27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id":"GlycanIUPAC_T228","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G83379OG\""},{"id":"GlycanIUPAC_T229","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G83379OG\""},{"id":"GlycanIUPAC_T230","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G14011XB\""},{"id":"GlycanIUPAC_T231","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G14011XB\""},{"id":"GlycanIUPAC_T232","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G83958VZ\""},{"id":"GlycanIUPAC_T233","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G83958VZ\""},{"id":"GlycanIUPAC_T234","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G20877SK\""},{"id":"GlycanIUPAC_T235","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G20877SK\""},{"id":"GlycanIUPAC_T236","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G68459HP\""},{"id":"GlycanIUPAC_T237","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G68459HP\""},{"id":"GlycanIUPAC_T238","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G28586QZ\""},{"id":"GlycanIUPAC_T239","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G28586QZ\""},{"id":"GlycanIUPAC_T240","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G00161GQ\""},{"id":"GlycanIUPAC_T241","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G00161GQ\""},{"id":"GlycanIUPAC_T242","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G85318IT\""},{"id":"GlycanIUPAC_T243","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G85318IT\""},{"id":"GlycanIUPAC_T244","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G11100HO\""},{"id":"GlycanIUPAC_T245","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G11100HO\""},{"id":"GlycanIUPAC_T246","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G50305QW\""},{"id":"GlycanIUPAC_T247","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G50305QW\""},{"id":"GlycanIUPAC_T248","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G42248LP\""},{"id":"GlycanIUPAC_T249","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G42248LP\""},{"id":"GlycanIUPAC_T250","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G13729RG\""},{"id":"GlycanIUPAC_T251","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G13729RG\""},{"id":"GlycanIUPAC_T252","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G17607EQ\""},{"id":"GlycanIUPAC_T253","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G17607EQ\""},{"id":"GlycanIUPAC_T254","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G27508XR\""},{"id":"GlycanIUPAC_T255","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G27508XR\""},{"id":"GlycanIUPAC_T256","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G98899YU\""},{"id":"GlycanIUPAC_T257","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G98899YU\""},{"id":"GlycanIUPAC_T258","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G06712RA\""},{"id":"GlycanIUPAC_T259","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G06712RA\""},{"id":"GlycanIUPAC_T260","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G17231EU\""},{"id":"GlycanIUPAC_T261","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G17231EU\""},{"id":"GlycanIUPAC_T262","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G43770SZ\""},{"id":"GlycanIUPAC_T263","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G43770SZ\""},{"id":"GlycanIUPAC_T264","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G75059LA\""},{"id":"GlycanIUPAC_T265","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G75059LA\""},{"id":"GlycanIUPAC_T266","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G78578OA\""},{"id":"GlycanIUPAC_T267","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G78578OA\""},{"id":"GlycanIUPAC_T268","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G62779DE\""},{"id":"GlycanIUPAC_T269","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G62779DE\""},{"id":"GlycanIUPAC_T270","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G19994FB\""},{"id":"GlycanIUPAC_T271","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G19994FB\""},{"id":"GlycanIUPAC_T272","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G34725DC\""},{"id":"GlycanIUPAC_T273","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G34725DC\""},{"id":"GlycanIUPAC_T274","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G44993OV\""},{"id":"GlycanIUPAC_T275","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G44993OV\""},{"id":"GlycanIUPAC_T276","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G50890DX\""},{"id":"GlycanIUPAC_T277","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G50890DX\""},{"id":"GlycanIUPAC_T278","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G88092VP\""},{"id":"GlycanIUPAC_T279","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G88092VP\""},{"id":"GlycanIUPAC_T280","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G98967JB\""},{"id":"GlycanIUPAC_T281","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G98967JB\""},{"id":"GlycanIUPAC_T282","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G10402KF\""},{"id":"GlycanIUPAC_T283","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G10402KF\""},{"id":"GlycanIUPAC_T284","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G46511TM\""},{"id":"GlycanIUPAC_T285","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G46511TM\""},{"id":"GlycanIUPAC_T286","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G86744JN\""},{"id":"GlycanIUPAC_T287","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G86744JN\""},{"id":"GlycanIUPAC_T288","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G92549GD\""},{"id":"GlycanIUPAC_T289","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G92549GD\""},{"id":"GlycanIUPAC_T290","span":{"begin":284,"end":288},"obj":"\"http://rdf.glycoinfo.org/glycan/G17397CC\""},{"id":"GlycanIUPAC_T291","span":{"begin":1085,"end":1089},"obj":"\"http://rdf.glycoinfo.org/glycan/G17397CC\""}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"GlyCosmos15-Glycan","denotations":[{"id":"T1","span":{"begin":145,"end":151},"obj":"Glycan"},{"id":"T2","span":{"begin":318,"end":324},"obj":"Glycan"},{"id":"T3","span":{"begin":434,"end":440},"obj":"Glycan"},{"id":"T4","span":{"begin":482,"end":488},"obj":"Glycan"},{"id":"T5","span":{"begin":849,"end":855},"obj":"Glycan"},{"id":"T6","span":{"begin":1289,"end":1295},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G97099AY"},{"id":"A7","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY"},{"id":"A2","pred":"glycosmos_id","subj":"T2","obj":"https://glycosmos.org/glycans/show/G97099AY"},{"id":"A8","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY"},{"id":"A3","pred":"glycosmos_id","subj":"T3","obj":"https://glycosmos.org/glycans/show/G97099AY"},{"id":"A9","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY"},{"id":"A4","pred":"glycosmos_id","subj":"T4","obj":"https://glycosmos.org/glycans/show/G97099AY"},{"id":"A10","pred":"image","subj":"T4","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY"},{"id":"A5","pred":"glycosmos_id","subj":"T5","obj":"https://glycosmos.org/glycans/show/G97099AY"},{"id":"A11","pred":"image","subj":"T5","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY"},{"id":"A6","pred":"glycosmos_id","subj":"T6","obj":"https://glycosmos.org/glycans/show/G97099AY"},{"id":"A12","pred":"image","subj":"T6","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"Glycan-GlyCosmos","denotations":[{"id":"T1","span":{"begin":145,"end":151},"obj":"Glycan"},{"id":"T2","span":{"begin":318,"end":324},"obj":"Glycan"},{"id":"T3","span":{"begin":434,"end":440},"obj":"Glycan"},{"id":"T4","span":{"begin":482,"end":488},"obj":"Glycan"},{"id":"T5","span":{"begin":849,"end":855},"obj":"Glycan"},{"id":"T6","span":{"begin":1289,"end":1295},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G97099AY"},{"id":"A7","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY"},{"id":"A2","pred":"glycosmos_id","subj":"T2","obj":"https://glycosmos.org/glycans/show/G97099AY"},{"id":"A8","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY"},{"id":"A3","pred":"glycosmos_id","subj":"T3","obj":"https://glycosmos.org/glycans/show/G97099AY"},{"id":"A9","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY"},{"id":"A4","pred":"glycosmos_id","subj":"T4","obj":"https://glycosmos.org/glycans/show/G97099AY"},{"id":"A10","pred":"image","subj":"T4","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY"},{"id":"A5","pred":"glycosmos_id","subj":"T5","obj":"https://glycosmos.org/glycans/show/G97099AY"},{"id":"A11","pred":"image","subj":"T5","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY"},{"id":"A6","pred":"glycosmos_id","subj":"T6","obj":"https://glycosmos.org/glycans/show/G97099AY"},{"id":"A12","pred":"image","subj":"T6","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"GlyCosmos15-UBERON","denotations":[{"id":"T1","span":{"begin":335,"end":348},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/GO_0005576"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"GlyCosmos15-Taxon","denotations":[{"id":"T1","span":{"begin":187,"end":210},"obj":"Organism"},{"id":"T2","span":{"begin":868,"end":874},"obj":"Organism"},{"id":"T3","span":{"begin":1002,"end":1008},"obj":"Organism"},{"id":"T4","span":{"begin":1137,"end":1143},"obj":"Organism"},{"id":"T5","span":{"begin":1144,"end":1152},"obj":"Organism"},{"id":"T7","span":{"begin":1323,"end":1331},"obj":"Organism"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"670"},{"id":"A2","pred":"db_id","subj":"T2","obj":"662"},{"id":"A3","pred":"db_id","subj":"T3","obj":"662"},{"id":"A4","pred":"db_id","subj":"T4","obj":"662"},{"id":"A5","pred":"db_id","subj":"T5","obj":"2"},{"id":"A6","pred":"db_id","subj":"T5","obj":"629395"},{"id":"A7","pred":"db_id","subj":"T7","obj":"2"},{"id":"A8","pred":"db_id","subj":"T7","obj":"629395"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T1","span":{"begin":0,"end":186},"obj":"Sentence"},{"id":"T2","span":{"begin":187,"end":610},"obj":"Sentence"},{"id":"T3","span":{"begin":611,"end":782},"obj":"Sentence"},{"id":"T4","span":{"begin":783,"end":1050},"obj":"Sentence"},{"id":"T5","span":{"begin":1051,"end":1332},"obj":"Sentence"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":187,"end":210},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":868,"end":874},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":1002,"end":1008},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":1137,"end":1143},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":1144,"end":1152},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":1323,"end":1331},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"670"},{"id":"A2","pred":"db_id","subj":"T2","obj":"662"},{"id":"A3","pred":"db_id","subj":"T3","obj":"662"},{"id":"A4","pred":"db_id","subj":"T4","obj":"662"},{"id":"A5","pred":"db_id","subj":"T5","obj":"2"},{"id":"A6","pred":"db_id","subj":"T5","obj":"629395"},{"id":"A7","pred":"db_id","subj":"T7","obj":"2"},{"id":"A8","pred":"db_id","subj":"T7","obj":"629395"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":335,"end":348},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/GO_0005576"}],"text":"Heterodisaccharide 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a specific inducer of chitinolytic enzyme production in Vibrios harboring chitin oligosaccharide deacetylase genes.\nVibrio parahaemolyticus KN1699 produces 4-O-(N-acetyl-beta-d-glucosaminyl)-d-glucosamine (GlcNAc-GlcN) as a major end product from chitin using two extracellular hydrolases: glycoside hydrolase family 18 chitinase, which produces (GlcNAc)(2) from chitin, and carbohydrate esterase (CE) family 4 chitin oligosaccharide deacetylase (COD), which hydrolyzes the N-acetyl group at the reducing-end GlcNAc residue of (GlcNAc)(2). In this study, we clarified that this heterodisaccharide functions as an inducer of the production of the two above-mentioned chitinolytic enzymes, particularly chitinase. Similar results for chitinase production were obtained with other chitin-decomposing Vibrio strains harboring the CE family 4 COD gene; however, such an increase in chitinase production was not observed in chitinolytic Vibrio strains that did not harbor the COD gene. These results suggest that GlcNAc-GlcN is a unique inducer of chitinase production in Vibrio bacteria that have the COD-producing ability and that the COD involved in the synthesis of this signal compound is one of the key enzymes in the chitin catabolic cascade of these bacteria."}