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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-148 Sentence denotes Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors.
T2 149-160 Sentence denotes BACKGROUND:
T3 161-257 Sentence denotes Treatment options are scarce in pretreated advanced non-small-cell lung cancer (NSCLC) patients.
T4 258-365 Sentence denotes RAD001, an oral inhibitor of the mammalian target of rapamycin (mTOR), has shown phase I efficacy in NSCLC.
T5 366-374 Sentence denotes METHODS:
T6 375-653 Sentence denotes Stage IIIb or IV NSCLC patients, with two or fewer prior chemotherapy regimens, one platinum based (stratum 1) or both chemotherapy and epidermal growth factor receptor tyrosine kinase inhibitors (stratum 2), received RAD001 10 mg/day until progression or unacceptable toxicity.
T7 654-704 Sentence denotes Primary objective was overall response rate (ORR).
T8 705-873 Sentence denotes Analyses of markers associated with the mTOR pathway were carried out on archival tumor from a subgroup using immunohistochemistry (IHC) and direct mutation sequencing.
T9 874-882 Sentence denotes RESULTS:
T10 883-953 Sentence denotes Eighty-five patients were enrolled, 42 in stratum 1 and 43 in stratum.
T11 954-1000 Sentence denotes ORR was 4.7% (7.1% stratum 1; 2.3% stratum 2).
T12 1001-1040 Sentence denotes Overall disease control rate was 47.1%.
T13 1041-1130 Sentence denotes Median progression-free survivals (PFSs) were 2.6 (stratum 1) and 2.7 months (stratum 2).
T14 1131-1223 Sentence denotes Common > or =grade 3 events were fatigue, dyspnea, stomatitis, anemia, and thrombocytopenia.
T15 1224-1301 Sentence denotes Pneumonitis, probably or possibly related, mainly grade 1/2, occurred in 25%.
T16 1302-1428 Sentence denotes Cox regression analysis of IHC scores found that only phospho AKT (pAKT) was a significant independent predictor of worse PFS.
T17 1429-1532 Sentence denotes CONCLUSIONS: RAD001 10 mg/day was well tolerated, showing modest clinical activity in pretreated NSCLC.
T18 1533-1607 Sentence denotes Evaluation of RAD001 plus standard therapy for metastatic NSCLC continues.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 1194-1200 OrganismTaxon denotes anemia NCBItxid:12939

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
6229 12-22 ChemicalEntity denotes everolimus MESH:D000068338
6230 24-30 ChemicalEntity denotes RAD001 MESH:D000068338
6231 35-43 OrganismTaxon denotes patients NCBITaxon:9606
6232 58-63 DiseaseOrPhenotypicFeature denotes NSCLC MESH:D002289
6233 132-136 GeneOrGeneProduct denotes EGFR NCBIGene:1956
6234 213-239 DiseaseOrPhenotypicFeature denotes non-small-cell lung cancer MESH:D002289
6235 241-246 DiseaseOrPhenotypicFeature denotes NSCLC MESH:D002289
6236 248-256 OrganismTaxon denotes patients NCBITaxon:9606
6237 258-264 ChemicalEntity denotes RAD001 MESH:D000068338
6238 291-320 GeneOrGeneProduct denotes mammalian target of rapamycin NCBIGene:2475
6239 322-326 GeneOrGeneProduct denotes mTOR NCBIGene:2475
6240 359-364 DiseaseOrPhenotypicFeature denotes NSCLC MESH:D002289
6241 392-397 DiseaseOrPhenotypicFeature denotes NSCLC MESH:D002289
6242 398-406 OrganismTaxon denotes patients NCBITaxon:9606
6243 459-467 ChemicalEntity denotes platinum MESH:D010984
6244 511-559 GeneOrGeneProduct denotes epidermal growth factor receptor tyrosine kinase NCBIGene:1956
6245 593-599 ChemicalEntity denotes RAD001 MESH:D000068338
6246 644-652 DiseaseOrPhenotypicFeature denotes toxicity MESH:D064420
6247 745-749 GeneOrGeneProduct denotes mTOR NCBIGene:2475
6248 787-792 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
6249 895-903 OrganismTaxon denotes patients NCBITaxon:9606
6250 1164-1171 DiseaseOrPhenotypicFeature denotes fatigue MESH:D005221
6251 1173-1180 DiseaseOrPhenotypicFeature denotes dyspnea MESH:D004417
6252 1182-1192 DiseaseOrPhenotypicFeature denotes stomatitis MESH:D013280
6253 1194-1200 DiseaseOrPhenotypicFeature denotes anemia MESH:D000740
6254 1206-1222 DiseaseOrPhenotypicFeature denotes thrombocytopenia MESH:D013921
6255 1224-1235 DiseaseOrPhenotypicFeature denotes Pneumonitis MESH:D011014
6256 1364-1367 GeneOrGeneProduct denotes AKT NCBIGene:207
6257 1369-1373 GeneOrGeneProduct denotes pAKT NCBIGene:207
6258 1442-1448 ChemicalEntity denotes RAD001 MESH:D000068338
6259 1526-1531 DiseaseOrPhenotypicFeature denotes NSCLC MESH:D002289
6260 1547-1553 ChemicalEntity denotes RAD001 MESH:D000068338
6261 1591-1596 DiseaseOrPhenotypicFeature denotes NSCLC MESH:D002289

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 228-239 DiseaseOrPhenotypicFeature denotes lung cancer 0008903
T2 233-239 DiseaseOrPhenotypicFeature denotes cancer 0004992
T3 1182-1192 DiseaseOrPhenotypicFeature denotes stomatitis 0004842
T4 1194-1200 DiseaseOrPhenotypicFeature denotes anemia 0002280
T5 1206-1222 DiseaseOrPhenotypicFeature denotes thrombocytopenia 0002049
T6 1224-1235 DiseaseOrPhenotypicFeature denotes Pneumonitis 0043905

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 132-136 GeneOrGeneProduct denotes EGFR
T2 137-147 GeneOrGeneProduct denotes inhibitors
T3 217-222 GeneOrGeneProduct denotes small
T4 223-227 GeneOrGeneProduct denotes cell
T5 228-232 GeneOrGeneProduct denotes lung
T6 274-283 GeneOrGeneProduct denotes inhibitor
T7 291-320 GeneOrGeneProduct denotes mammalian target of rapamycin
T8 322-326 GeneOrGeneProduct denotes mTOR
T9 366-373 GeneOrGeneProduct denotes METHODS
T10 459-467 GeneOrGeneProduct denotes platinum
T11 468-473 GeneOrGeneProduct denotes based
T12 475-482 GeneOrGeneProduct denotes stratum
T13 511-543 GeneOrGeneProduct denotes epidermal growth factor receptor
T14 544-559 GeneOrGeneProduct denotes tyrosine kinase
T15 560-570 GeneOrGeneProduct denotes inhibitors
T16 572-579 GeneOrGeneProduct denotes stratum
T17 603-605 GeneOrGeneProduct denotes mg
T18 745-749 GeneOrGeneProduct denotes mTOR
T19 771-774 GeneOrGeneProduct denotes out
T20 787-792 GeneOrGeneProduct denotes tumor
T21 853-861 GeneOrGeneProduct denotes mutation
T22 925-932 GeneOrGeneProduct denotes stratum
T23 933-938 GeneOrGeneProduct denotes 1 and
T24 945-952 GeneOrGeneProduct denotes stratum
T25 973-980 GeneOrGeneProduct denotes stratum
T26 984-987 GeneOrGeneProduct denotes 2.3
T27 989-996 GeneOrGeneProduct denotes stratum
T28 1092-1099 GeneOrGeneProduct denotes stratum
T29 1103-1110 GeneOrGeneProduct denotes and 2.7
T30 1119-1126 GeneOrGeneProduct denotes stratum
T31 1237-1245 GeneOrGeneProduct denotes probably
T32 1267-1273 GeneOrGeneProduct denotes mainly
T33 1294-1299 GeneOrGeneProduct denotes in 25
T34 1369-1373 GeneOrGeneProduct denotes pAKT
T35 1452-1454 GeneOrGeneProduct denotes mg
T36 1468-1477 GeneOrGeneProduct denotes tolerated
T37 1503-1511 GeneOrGeneProduct denotes activity

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 132-136 GeneOrGeneProduct denotes EGFR
T2 137-147 GeneOrGeneProduct denotes inhibitors
T3 217-222 GeneOrGeneProduct denotes small
T4 223-227 GeneOrGeneProduct denotes cell
T5 274-283 GeneOrGeneProduct denotes inhibitor
T6 291-320 GeneOrGeneProduct denotes mammalian target of rapamycin
T7 322-326 GeneOrGeneProduct denotes mTOR
T8 459-467 GeneOrGeneProduct denotes platinum
T9 475-482 GeneOrGeneProduct denotes stratum
T10 511-543 GeneOrGeneProduct denotes epidermal growth factor receptor
T11 544-559 GeneOrGeneProduct denotes tyrosine kinase
T12 560-570 GeneOrGeneProduct denotes inhibitors
T13 572-579 GeneOrGeneProduct denotes stratum
T14 745-749 GeneOrGeneProduct denotes mTOR
T15 925-932 GeneOrGeneProduct denotes stratum
T16 945-952 GeneOrGeneProduct denotes stratum
T17 973-980 GeneOrGeneProduct denotes stratum
T18 989-996 GeneOrGeneProduct denotes stratum
T19 1092-1099 GeneOrGeneProduct denotes stratum
T20 1119-1126 GeneOrGeneProduct denotes stratum

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 58-63 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T2 213-239 DiseaseOrPhenotypicFeature denotes non-small-cell lung cancer D002289
T3 241-246 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T4 359-364 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T5 392-397 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T6 644-652 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T7 787-792 DiseaseOrPhenotypicFeature denotes tumor D009369
T8 1009-1016 DiseaseOrPhenotypicFeature denotes disease D004194
T9 1164-1171 DiseaseOrPhenotypicFeature denotes fatigue D005221
T10 1173-1180 DiseaseOrPhenotypicFeature denotes dyspnea D004417
T11 1182-1192 DiseaseOrPhenotypicFeature denotes stomatitis D013280
T12 1194-1200 DiseaseOrPhenotypicFeature denotes anemia D000740
T13 1206-1222 DiseaseOrPhenotypicFeature denotes thrombocytopenia D013921
T14 1224-1235 DiseaseOrPhenotypicFeature denotes Pneumonitis D011014
T15 1526-1531 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T16 1591-1596 DiseaseOrPhenotypicFeature denotes NSCLC D002289

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 132-136 GeneOrGeneProduct denotes EGFR
T2 291-320 GeneOrGeneProduct denotes mammalian target of rapamycin
T3 322-326 GeneOrGeneProduct denotes mTOR
T4 459-467 GeneOrGeneProduct denotes platinum
T5 511-543 GeneOrGeneProduct denotes epidermal growth factor receptor
T6 544-559 GeneOrGeneProduct denotes tyrosine kinase
T7 745-749 GeneOrGeneProduct denotes mTOR

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 58-63 DiseaseOrPhenotypicFeature denotes NSCLC 0005233
T2 213-239 DiseaseOrPhenotypicFeature denotes non-small-cell lung cancer 0005233
T3 241-246 DiseaseOrPhenotypicFeature denotes NSCLC 0005233
T4 359-364 DiseaseOrPhenotypicFeature denotes NSCLC 0005233
T5 392-397 DiseaseOrPhenotypicFeature denotes NSCLC 0005233
T6 787-792 DiseaseOrPhenotypicFeature denotes tumor 0005070
T7 1182-1192 DiseaseOrPhenotypicFeature denotes stomatitis 0004842
T8 1194-1200 DiseaseOrPhenotypicFeature denotes anemia 0002280
T9 1206-1222 DiseaseOrPhenotypicFeature denotes thrombocytopenia 0002049
T10 1224-1235 DiseaseOrPhenotypicFeature denotes Pneumonitis 0043905
T11 1526-1531 DiseaseOrPhenotypicFeature denotes NSCLC 0005233
T12 1591-1596 DiseaseOrPhenotypicFeature denotes NSCLC 0005233

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 58-63 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T2 213-239 DiseaseOrPhenotypicFeature denotes non-small-cell lung cancer D002289
T3 241-246 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T4 359-364 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T5 392-397 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T6 644-652 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T7 787-792 DiseaseOrPhenotypicFeature denotes tumor D009369
T8 1009-1016 DiseaseOrPhenotypicFeature denotes disease D004194
T9 1164-1171 DiseaseOrPhenotypicFeature denotes fatigue D005221
T10 1173-1180 DiseaseOrPhenotypicFeature denotes dyspnea D004417
T11 1182-1192 DiseaseOrPhenotypicFeature denotes stomatitis D013280
T12 1194-1200 DiseaseOrPhenotypicFeature denotes anemia D000740
T13 1206-1222 DiseaseOrPhenotypicFeature denotes thrombocytopenia D013921
T14 1224-1235 DiseaseOrPhenotypicFeature denotes Pneumonitis D011014
T15 1526-1531 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T16 1591-1596 DiseaseOrPhenotypicFeature denotes NSCLC D002289

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 58-63 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T2 213-239 DiseaseOrPhenotypicFeature denotes non-small-cell lung cancer D002289
T3 241-246 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T4 359-364 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T5 392-397 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T6 644-652 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T7 787-792 DiseaseOrPhenotypicFeature denotes tumor D009369
T8 1164-1171 DiseaseOrPhenotypicFeature denotes fatigue D005221
T9 1173-1180 DiseaseOrPhenotypicFeature denotes dyspnea D004417
T10 1182-1192 DiseaseOrPhenotypicFeature denotes stomatitis D013280
T11 1194-1200 DiseaseOrPhenotypicFeature denotes anemia D000740
T12 1206-1222 DiseaseOrPhenotypicFeature denotes thrombocytopenia D013921
T13 1224-1235 DiseaseOrPhenotypicFeature denotes Pneumonitis D011014
T14 1526-1531 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T15 1591-1596 DiseaseOrPhenotypicFeature denotes NSCLC D002289

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 12-22 ChemicalEntity denotes everolimus http://purl.obolibrary.org/obo/CHEBI_68478
T2 24-30 ChemicalEntity denotes RAD001 ChemicalEntity
T3 258-264 ChemicalEntity denotes RAD001 ChemicalEntity
T4 311-320 ChemicalEntity denotes rapamycin D020123|http://purl.obolibrary.org/obo/CHEBI_9168
T6 459-467 ChemicalEntity denotes platinum D010984|http://purl.obolibrary.org/obo/CHEBI_33400|http://purl.obolibrary.org/obo/CHEBI_33364
T9 544-552 ChemicalEntity denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T10 593-599 ChemicalEntity denotes RAD001 ChemicalEntity
T11 1356-1363 ChemicalEntity denotes phospho http://purl.obolibrary.org/obo/CHEBI_48108
T12 1442-1448 ChemicalEntity denotes RAD001 ChemicalEntity
T13 1547-1553 ChemicalEntity denotes RAD001 ChemicalEntity

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 35-43 OrganismTaxon denotes patients
T2 248-256 OrganismTaxon denotes patients
T3 398-406 OrganismTaxon denotes patients
T4 895-903 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T13 1547-1553 ChemicalEntity denotes RAD001 ChemicalEntity
T12 1442-1448 ChemicalEntity denotes RAD001 ChemicalEntity
T11 1356-1363 ChemicalEntity denotes phospho http://purl.obolibrary.org/obo/CHEBI_48108
T10 593-599 ChemicalEntity denotes RAD001 ChemicalEntity
T9 544-552 ChemicalEntity denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T6 459-467 ChemicalEntity denotes platinum http://purl.obolibrary.org/obo/CHEBI_33364|http://purl.obolibrary.org/obo/CHEBI_33400|D010984
T4 311-320 ChemicalEntity denotes rapamycin http://purl.obolibrary.org/obo/CHEBI_9168|D020123
T3 258-264 ChemicalEntity denotes RAD001 ChemicalEntity
T2 24-30 ChemicalEntity denotes RAD001 ChemicalEntity
T1 12-22 ChemicalEntity denotes everolimus http://purl.obolibrary.org/obo/CHEBI_68478
T7 745-749 GeneOrGeneProduct denotes mTOR
T43677 544-559 GeneOrGeneProduct denotes tyrosine kinase
T5 511-543 GeneOrGeneProduct denotes epidermal growth factor receptor
T19404 459-467 GeneOrGeneProduct denotes platinum
T72526 322-326 GeneOrGeneProduct denotes mTOR
T86611 291-320 GeneOrGeneProduct denotes mammalian target of rapamycin
T24760 132-136 GeneOrGeneProduct denotes EGFR
T15 1591-1596 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T14 1526-1531 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T22620 1224-1235 DiseaseOrPhenotypicFeature denotes Pneumonitis D011014
T50116 1206-1222 DiseaseOrPhenotypicFeature denotes thrombocytopenia D013921
T22820 1194-1200 DiseaseOrPhenotypicFeature denotes anemia D000740
T41559 1182-1192 DiseaseOrPhenotypicFeature denotes stomatitis D013280
T27462 1173-1180 DiseaseOrPhenotypicFeature denotes dyspnea D004417
T8 1164-1171 DiseaseOrPhenotypicFeature denotes fatigue D005221
T4657 787-792 DiseaseOrPhenotypicFeature denotes tumor D009369
T98769 644-652 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T43699 392-397 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T87778 359-364 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T26721 241-246 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T788 213-239 DiseaseOrPhenotypicFeature denotes non-small-cell lung cancer D002289
T42559 58-63 DiseaseOrPhenotypicFeature denotes NSCLC D002289
T26640 895-903 OrganismTaxon denotes patients
T52341 398-406 OrganismTaxon denotes patients
T97562 248-256 OrganismTaxon denotes patients
T65178 35-43 OrganismTaxon denotes patients

DisGeNET

Id Subject Object Predicate Lexical cue
T0 132-136 gene:1956 denotes EGFR
T1 58-63 disease:C0007131 denotes NSCLC
R1 T0 T1 associated_with EGFR,NSCLC

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19549709-0#132#136#gene1956 132-136 gene1956 denotes EGFR
19549709-0#58#63#diseaseC0007131 58-63 diseaseC0007131 denotes NSCLC
19549709-2#33#62#gene2475 291-320 gene2475 denotes mammalian target of rapamycin
19549709-2#64#68#gene2475 322-326 gene2475 denotes mTOR
19549709-2#101#106#diseaseC0007131 359-364 diseaseC0007131 denotes NSCLC
132#136#gene195658#63#diseaseC0007131 19549709-0#132#136#gene1956 19549709-0#58#63#diseaseC0007131 associated_with EGFR,NSCLC
33#62#gene2475101#106#diseaseC0007131 19549709-2#33#62#gene2475 19549709-2#101#106#diseaseC0007131 associated_with mammalian target of rapamycin,NSCLC
64#68#gene2475101#106#diseaseC0007131 19549709-2#64#68#gene2475 19549709-2#101#106#diseaseC0007131 associated_with mTOR,NSCLC