PubMed:1954628
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/1954628","sourcedb":"PubMed","sourceid":"1954628","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/1954628","text":"A strong inhibition of HIV-induced cytopathic effects by synthetic (1----6)-alpha-D-mannopyranan sulfate.\nThe anti-HIV effects of mannopyranan sulfate (1) were investigated by using MT-4 cells, namely, an HTLV-I-carrying CD-4 positive cell-line, in vitro. Stereoregular (1----6)-alpha-D-mannopyranan, which had been synthesized by ring-opening polymerization of a 1,6-anhydromannose derivative, was sulfated with piperidine-N-sulfonic acid to provide 1. N.m.r. analysis of 1 indicated that the reactivity of hydroxyl groups was in the order, 3-OH greater than 2-OH much greater than 4-OH. Mannopyranan sulfate having degree of substitution (d.s.) of 1.19-1.83 effectively inhibited HIV-induced cytopathic effects at a concentration of greater than 3.3 micrograms/mL. The anticoagulant activity and the adsorption on concanavalin A of 1 indicated the possibility of selective binding of 1 having d.s. of 1.19-1.83 to HIV-protein.","tracks":[{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":105},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":106,"end":255},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":256,"end":453},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":454,"end":588},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":589,"end":766},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":767,"end":928},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":105},"obj":"Sentence"},{"id":"T2","span":{"begin":106,"end":255},"obj":"Sentence"},{"id":"T3","span":{"begin":256,"end":453},"obj":"Sentence"},{"id":"T4","span":{"begin":454,"end":588},"obj":"Sentence"},{"id":"T5","span":{"begin":589,"end":766},"obj":"Sentence"},{"id":"T6","span":{"begin":767,"end":928},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":336,"end":343},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0004111"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sentences","color":"#ec93cf","default":true},{"id":"Anatomy-UBERON","color":"#93e9ec"}]}]}}