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PubMed:19545858 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-117 Sentence denotes Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder.
TextSentencer_T2 118-129 Sentence denotes BACKGROUND:
TextSentencer_T3 130-250 Sentence denotes A number of studies have suggested deficits in myelination and glial gene expression in different psychiatric disorders.
TextSentencer_T4 251-421 Sentence denotes We examined the brain expression and genetic/epigenetic regulation of QKI, an oligodendrocyte-specific RNA binding protein important for cell development and myelination.
TextSentencer_T5 422-430 Sentence denotes METHODS:
TextSentencer_T6 431-623 Sentence denotes The microarray-based expression of QKI was evaluated in cortical and subcortical brain regions from suicide victims with a diagnosis of major depression (n = 16) and control subjects (n = 13).
TextSentencer_T7 624-790 Sentence denotes These findings were also assessed with a real-time (quantitative polymerase chain reaction [qPCR]) approach, with QKI protein levels evaluated through immunoblotting.
TextSentencer_T8 791-908 Sentence denotes Identification of a QKI promoter sequence was then used to examine genetic and epigenetic variation at the QKI locus.
TextSentencer_T9 909-917 Sentence denotes RESULTS:
TextSentencer_T10 918-1162 Sentence denotes The messenger RNA (mRNA) levels of multiple transcripts of QKI were evaluated on Affymetrix microarrays, revealing significant reductions in 11 cortical regions and the hippocampus and amygdala of suicide victims compared with control subjects.
TextSentencer_T11 1163-1284 Sentence denotes Microarray findings were confirmed by qPCR, and reduced expression of QKI protein was identified in orbitofrontal cortex.
TextSentencer_T12 1285-1484 Sentence denotes Analysis of promoter variation and methylation state in a subset of individuals did not identify differences at the genetic or epigenetic level between depressed suicide victims and control subjects.
TextSentencer_T13 1485-1497 Sentence denotes CONCLUSIONS:
TextSentencer_T14 1498-1723 Sentence denotes The observation of consistent reductions in multiple isoforms of QKI mRNA in depressed suicide victims supports the growing body of evidence for a role of myelination-related deficits in the etiology of psychiatric disorders.
TextSentencer_T15 1724-1960 Sentence denotes A specific role of QKI in this process is implied by its reduced expression and known interactions with genes involved in oligodendrocyte determination; however, QKI gene variation responsible for these changes remains to be identified.
T1 0-117 Sentence denotes Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder.
T2 118-129 Sentence denotes BACKGROUND:
T3 130-250 Sentence denotes A number of studies have suggested deficits in myelination and glial gene expression in different psychiatric disorders.
T4 251-421 Sentence denotes We examined the brain expression and genetic/epigenetic regulation of QKI, an oligodendrocyte-specific RNA binding protein important for cell development and myelination.
T5 422-430 Sentence denotes METHODS:
T6 431-623 Sentence denotes The microarray-based expression of QKI was evaluated in cortical and subcortical brain regions from suicide victims with a diagnosis of major depression (n = 16) and control subjects (n = 13).
T7 624-790 Sentence denotes These findings were also assessed with a real-time (quantitative polymerase chain reaction [qPCR]) approach, with QKI protein levels evaluated through immunoblotting.
T8 791-908 Sentence denotes Identification of a QKI promoter sequence was then used to examine genetic and epigenetic variation at the QKI locus.
T9 909-917 Sentence denotes RESULTS:
T10 918-1162 Sentence denotes The messenger RNA (mRNA) levels of multiple transcripts of QKI were evaluated on Affymetrix microarrays, revealing significant reductions in 11 cortical regions and the hippocampus and amygdala of suicide victims compared with control subjects.
T11 1163-1284 Sentence denotes Microarray findings were confirmed by qPCR, and reduced expression of QKI protein was identified in orbitofrontal cortex.
T12 1285-1484 Sentence denotes Analysis of promoter variation and methylation state in a subset of individuals did not identify differences at the genetic or epigenetic level between depressed suicide victims and control subjects.
T13 1485-1497 Sentence denotes CONCLUSIONS:
T14 1498-1723 Sentence denotes The observation of consistent reductions in multiple isoforms of QKI mRNA in depressed suicide victims supports the growing body of evidence for a role of myelination-related deficits in the etiology of psychiatric disorders.
T15 1724-1960 Sentence denotes A specific role of QKI in this process is implied by its reduced expression and known interactions with genes involved in oligodendrocyte determination; however, QKI gene variation responsible for these changes remains to be identified.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 977-980 gene:9444 denotes QKI
T1 1115-1122 disease:C0812393 denotes suicide
R1 T0 T1 associated_with QKI,suicide

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19545858-0#20#23#gene9444 20-23 gene9444 denotes QKI
19545858-0#91#116#diseaseC0041696 91-116 diseaseC0041696 denotes major depressive disorder
19545858-0#91#116#diseaseC1269683 91-116 diseaseC1269683 denotes major depressive disorder
19545858-9#65#68#gene9444 1563-1566 gene9444 denotes QKI
19545858-9#203#224#diseaseC0004936 1701-1722 diseaseC0004936 denotes psychiatric disorders
19545858-9#203#224#diseaseC0233514 1701-1722 diseaseC0233514 denotes psychiatric disorders
20#23#gene944491#116#diseaseC0041696 19545858-0#20#23#gene9444 19545858-0#91#116#diseaseC0041696 associated_with QKI,major depressive disorder
20#23#gene944491#116#diseaseC1269683 19545858-0#20#23#gene9444 19545858-0#91#116#diseaseC1269683 associated_with QKI,major depressive disorder
65#68#gene9444203#224#diseaseC0004936 19545858-9#65#68#gene9444 19545858-9#203#224#diseaseC0004936 associated_with QKI,psychiatric disorders
65#68#gene9444203#224#diseaseC0233514 19545858-9#65#68#gene9444 19545858-9#203#224#diseaseC0233514 associated_with QKI,psychiatric disorders

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T915 20-23 gene:9444 denotes QKI
T916 91-116 disease:C0041696 denotes major depressive disorder
T917 1563-1566 gene:9444 denotes QKI
T918 1701-1722 disease:C0004936 denotes psychiatric disorders
R1 T915 T916 associated_with QKI,major depressive disorder
R2 T915 T916 associated_with QKI,major depressive disorder
R3 T917 T918 associated_with QKI,psychiatric disorders
R4 T917 T918 associated_with QKI,psychiatric disorders

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 177-188 http://purl.obolibrary.org/obo/UBERON_0000345 denotes myelination
PD-UBERON-AE-B_T2 409-420 http://purl.obolibrary.org/obo/UBERON_0000345 denotes myelination
PD-UBERON-AE-B_T3 1653-1664 http://purl.obolibrary.org/obo/UBERON_0000345 denotes myelination
PD-UBERON-AE-B_T4 267-272 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T5 512-517 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T6 1103-1111 http://purl.obolibrary.org/obo/UBERON_0001876 denotes amygdala
PD-UBERON-AE-B_T7 1263-1283 http://purl.obolibrary.org/obo/UBERON_0004167 denotes orbitofrontal cortex
PD-UBERON-AE-B_T8 1277-1283 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 267-272 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T2 512-517 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T3 177-188 http://purl.obolibrary.org/obo/UBERON_0000345 denotes myelination
PD-UBERON-AE-B_T4 409-420 http://purl.obolibrary.org/obo/UBERON_0000345 denotes myelination
PD-UBERON-AE-B_T5 1653-1664 http://purl.obolibrary.org/obo/UBERON_0000345 denotes myelination
PD-UBERON-AE-B_T6 1103-1111 http://purl.obolibrary.org/obo/UBERON_0001876 denotes amygdala
PD-UBERON-AE-B_T7 1263-1283 http://purl.obolibrary.org/obo/UBERON_0004167 denotes orbitofrontal cortex
PD-UBERON-AE-B_T8 1277-1283 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex