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PubMed:19545277 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
19545277_0 330-336 ProteinMutation denotes G2019S rs34637584
19545277_1 678-684 ProteinMutation denotes G2019S rs34637584
19545277_2 1429-1435 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T2 0-7 6308 denotes Leucine
T3 0-7 SO:0001437 denotes Leucine
T1 0-7 CHEBI:15603 denotes Leucine
T4 0-7 D007930 denotes Leucine
T5 0-7 CHEBI:25017 denotes Leucine
T6 0-7 D007930 denotes Leucine
T7 13-19 SO:0001068 denotes repeat
T8 44-49 UBERON:6110636 denotes brain
T9 44-49 UBERON:0000955 denotes brain
T11 50-57 PR:000028799 denotes tubulin
T10 50-57 D014404 denotes tubulin
T12 58-62 CHEBI:10545 denotes beta
T13 58-62 CHEBI:30225 denotes beta
T14 63-71 D020033 denotes isoforms
T15 86-97 GO:0005874 denotes microtubule
T17 199-206 6308 denotes leucine
T18 199-206 SO:0001437 denotes leucine
T16 199-206 CHEBI:15603 denotes leucine
T19 199-206 D007930 denotes leucine
T20 199-206 CHEBI:25017 denotes leucine
T21 199-206 D007930 denotes leucine
T22 212-218 SO:0001068 denotes repeat
T23 229-234 PR:Q5S006 denotes LRRK2
T24 229-234 PR:000003033 denotes LRRK2
T25 229-234 PR:Q5S007 denotes LRRK2
T26 273-283 D000067562 denotes late-onset
T27 273-283 D000067562 denotes late-onset
T32 284-303 D010300 denotes Parkinson's disease
T33 284-303 D010300 denotes Parkinson's disease
T36 324-329 PR:Q5S006 denotes LRRK2
T37 324-329 PR:000003033 denotes LRRK2
T38 324-329 PR:Q5S007 denotes LRRK2
T39 338-346 SO:0000109 denotes mutation
T40 384-399 GO:0016301 denotes kinase activity
T41 535-540 D006801 denotes human
T42 541-546 PR:Q5S006 denotes LRRK2
T43 541-546 PR:000003033 denotes LRRK2
T44 541-546 PR:Q5S007 denotes LRRK2
T46 577-584 PR:000028799 denotes tubulin
T45 577-584 D014404 denotes tubulin
T47 585-589 CHEBI:10545 denotes beta
T48 585-589 CHEBI:30225 denotes beta
T49 604-610 9913 denotes bovine
T50 611-616 UBERON:6110636 denotes brain
T51 611-616 UBERON:0000955 denotes brain
T52 626-641 GO:0016310 denotes phosphorylation
T53 651-655 PR:000022679 denotes fold
T54 651-655 PR:Q2FZJ6 denotes fold
T55 651-655 PR:A5I112 denotes fold
T56 651-655 PR:P24186 denotes fold
T57 672-677 PR:Q5S006 denotes LRRK2
T58 672-677 PR:000003033 denotes LRRK2
T59 672-677 PR:Q5S007 denotes LRRK2
T60 686-694 SO:0000109 denotes mutation
T61 699-705 37565 denotes tandem
T62 699-705 SO:0001513 denotes tandem
T63 725-728 SO:0001445 denotes Thr
T68 725-728 PR:P42286 denotes Thr
T66 725-728 CVCL_1M76 denotes Thr
T64 725-728 CHEBI:16857 denotes Thr
T65 725-728 CHEBI:32824 denotes Thr
T67 725-728 CHEBI:32823 denotes Thr
T69 725-728 CHEBI:30013 denotes Thr
T70 750-765 GO:0016310 denotes phosphorylation
T71 750-770 SO:0001811 denotes phosphorylation site
T72 787-796 SO:0000856 denotes conserved
T74 805-812 PR:000028799 denotes tubulin
T73 805-812 D014404 denotes tubulin
T75 813-817 CHEBI:10545 denotes beta
T76 813-817 CHEBI:30225 denotes beta
T78 850-857 PR:000028799 denotes tubulin
T77 850-857 D014404 denotes tubulin
T79 858-862 CHEBI:10545 denotes beta
T80 858-862 CHEBI:30225 denotes beta
T81 891-896 PR:Q5S006 denotes LRRK2
T82 891-896 PR:000003033 denotes LRRK2
T83 891-896 PR:Q5S007 denotes LRRK2
T85 928-935 PR:000028799 denotes tubulin
T84 928-935 D014404 denotes tubulin
T86 936-940 CHEBI:10545 denotes beta
T87 936-940 CHEBI:30225 denotes beta
T88 951-960 SO:0000817 denotes wild-type
T89 961-966 10090 denotes mouse
T90 961-966 D051379 denotes mouse
T91 967-972 UBERON:6110636 denotes brain
T92 967-972 UBERON:0000955 denotes brain
T93 982-987 PR:Q5S006 denotes LRRK2
T94 982-987 PR:000003033 denotes LRRK2
T95 982-987 PR:Q5S007 denotes LRRK2
T96 1018-1023 D006801 denotes human
T98 1018-1044 CVCL_0045 denotes human embryonic kidney 293
T99 1024-1033 P02301 denotes embryonic
T100 1024-1033 PR:000029532 denotes embryonic
T101 1024-1040 UBERON:0002120 denotes embryonic kidney
T103 1074-1079 PR:Q5S006 denotes LRRK2
T104 1074-1079 PR:000003033 denotes LRRK2
T105 1074-1079 PR:Q5S007 denotes LRRK2
T107 1083-1090 PR:000028799 denotes tubulin
T106 1083-1090 D014404 denotes tubulin
T108 1091-1106 GO:0016310 denotes phosphorylation
T109 1111-1119 SO:0001248 denotes assembly
T110 1143-1148 10090 denotes mouse
T111 1143-1148 D051379 denotes mouse
T112 1149-1154 UBERON:6110636 denotes brain
T113 1149-1154 UBERON:0000955 denotes brain
T114 1190-1196 9913 denotes bovine
T115 1197-1202 UBERON:6110636 denotes brain
T116 1197-1202 UBERON:0000955 denotes brain
T117 1217-1222 PR:Q5S006 denotes LRRK2
T118 1217-1222 PR:000003033 denotes LRRK2
T119 1217-1222 PR:Q5S007 denotes LRRK2
T120 1233-1244 GO:0005874 denotes microtubule
T121 1274-1285 GO:0005874 denotes microtubule
T122 1274-1305 D008869 denotes microtubule-associated proteins
T124 1328-1337 MOP:0000569 denotes reduction
T125 1341-1348 GO:0043005 denotes neurite
T126 1359-1364 PR:Q5S006 denotes LRRK2
T127 1359-1364 PR:000003033 denotes LRRK2
T128 1359-1364 PR:Q5S007 denotes LRRK2
T129 1423-1428 PR:Q5S006 denotes LRRK2
T130 1423-1428 PR:000003033 denotes LRRK2
T131 1423-1428 PR:Q5S007 denotes LRRK2
T132 1522-1537 GO:0016310 denotes phosphorylation
T134 1541-1548 PR:000028799 denotes tubulin
T133 1541-1548 D014404 denotes tubulin
T135 1549-1553 CHEBI:10545 denotes beta
T136 1549-1553 CHEBI:30225 denotes beta
T137 1574-1585 GO:0005874 denotes microtubule
T138 1574-1594 GO:0000226 denotes microtubule dynamics

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-166 DRI_Outcome denotes Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?
T2 167-304 DRI_Background denotes Autosomal dominant mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of late-onset Parkinson's disease.
T3 305-504 DRI_Background denotes The most prevalent LRRK2(G2019S) mutation has repeatedly been shown to enhance kinase activity and neurotoxicity, however, the molecular mechanisms leading to neurodegeneration remain poorly defined.
T4 505-695 DRI_Outcome denotes Here we show that recombinant human LRRK2 preferentially phosphorylates tubulin-beta purified from bovine brain and that phosphorylation is three-fold enhanced by the LRRK2(G2019S) mutation.
T5 696-890 DRI_Background denotes By tandem mass spectrometry, Thr107 was identified as phosphorylation site which is highly conserved between tubulin-beta family members and also between tubulin-beta genes of different species.
T6 891-981 DRI_Outcome denotes LRRK2 was co-immunoprecipitated with tubulin-beta both from wild-type mouse brain and from
T7 982-1003 Token_Label.OUTSIDE denotes LRRK2 over-expressing
T8 1003-1051 DRI_Outcome denotes , non-neuronal human embryonic kidney 293 cells.
T9 1052-1163 DRI_Background denotes However, an effect of LRRK2 on tubulin phosphorylation and assembly was only detectable in mouse brain samples.
T10 1164-1394 DRI_Outcome denotes In vitro co-incubation of bovine brain tubulins with LRRK2 increased microtubule stability in the presence of microtubule-associated proteins which may explain the reduction in neurite length in LRRK2-deficient neurons in culture.
T11 1395-1595 DRI_Challenge denotes These findings suggest that LRRK2(G2019S)-induced neurodegeneration in Parkinsonian brains may be partly mediated by increased phosphorylation of tubulin-beta and constraining of microtubule dynamics.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 167-304 DRI_Background denotes Autosomal dominant mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of late-onset Parkinson's disease.
T2 305-504 DRI_Background denotes The most prevalent LRRK2(G2019S) mutation has repeatedly been shown to enhance kinase activity and neurotoxicity, however, the molecular mechanisms leading to neurodegeneration remain poorly defined.
T3 505-695 DRI_Outcome denotes Here we show that recombinant human LRRK2 preferentially phosphorylates tubulin-beta purified from bovine brain and that phosphorylation is three-fold enhanced by the LRRK2(G2019S) mutation.
T4 696-890 DRI_Background denotes By tandem mass spectrometry, Thr107 was identified as phosphorylation site which is highly conserved between tubulin-beta family members and also between tubulin-beta genes of different species.
T5 891-981 DRI_Outcome denotes LRRK2 was co-immunoprecipitated with tubulin-beta both from wild-type mouse brain and from
T6 1003-1051 DRI_Outcome denotes , non-neuronal human embryonic kidney 293 cells.
T7 1052-1163 DRI_Background denotes However, an effect of LRRK2 on tubulin phosphorylation and assembly was only detectable in mouse brain samples.
T8 1164-1394 DRI_Outcome denotes In vitro co-incubation of bovine brain tubulins with LRRK2 increased microtubule stability in the presence of microtubule-associated proteins which may explain the reduction in neurite length in LRRK2-deficient neurons in culture.
T9 1395-1595 DRI_Challenge denotes These findings suggest that LRRK2(G2019S)-induced neurodegeneration in Parkinsonian brains may be partly mediated by increased phosphorylation of tubulin-beta and constraining of microtubule dynamics.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19545277-1#32#60#gene120892 199-227 gene120892 denotes leucine-rich repeat kinase 2
19545277-1#62#67#gene120892 229-234 gene120892 denotes LRRK2
19545277-1#106#136#diseaseC3160718 273-303 diseaseC3160718 denotes late-onset Parkinson's disease
32#60#gene120892106#136#diseaseC3160718 19545277-1#32#60#gene120892 19545277-1#106#136#diseaseC3160718 associated_with leucine-rich repeat kinase 2,late-onset Parkinson's disease
62#67#gene120892106#136#diseaseC3160718 19545277-1#62#67#gene120892 19545277-1#106#136#diseaseC3160718 associated_with LRRK2,late-onset Parkinson's disease