> top > docs > PubMed:19542562 > annotations

PubMed:19542562 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-160 Sentence denotes Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase.
T2 161-361 Sentence denotes Smooth muscle-rich tissues respond to mechanical overload by an adaptive hypertrophic growth combined with activation of angiogenesis, which potentiates their mechanical overload-bearing capabilities.
T3 362-574 Sentence denotes Neovascularization is associated with mechanical strain-dependent induction of angiogenic factors such as CCN1, an immediate-early gene-encoded matricellular molecule critical for vascular development and repair.
T4 575-779 Sentence denotes Here we have demonstrated that mechanical strain-dependent induction of the CCN1 gene involves signaling cascades through RhoA-mediated actin remodeling and the p38 stress-activated protein kinase (SAPK).
T5 780-993 Sentence denotes Actin signaling controls serum response factor (SRF) activity via SRF interaction with the myocardin-related transcriptional activator (MRTF)-A and tethering to a single CArG box sequence within the CCN1 promoter.
T6 994-1192 Sentence denotes Such activity was abolished in mechanically stimulated mouse MRTF-A(-/-) cells or upon inhibition of CREB-binding protein (CBP) histone acetyltransferase (HAT) either pharmacologically or by siRNAs.
T7 1193-1327 Sentence denotes Mechanical strain induced CBP-mediated acetylation of histones 3 and 4 at the SRF-binding site and within the CCN1 gene coding region.
T8 1328-1552 Sentence denotes Inhibition of p38 SAPK reduced CBP HAT activity and its recruitment to the SRF.MRTF-A complex, whereas enforced induction of p38 by upstream activators (e.g. MKK3 and MKK6) enhanced both CBP HAT and CCN1 promoter activities.
T9 1553-1751 Sentence denotes Similarly, mechanical overload-induced CCN1 gene expression in vivo was associated with nuclear localization of MRTF-A and enrichment of the CCN1 promoter with both MRTF-A and acetylated histone H3.
T10 1752-1931 Sentence denotes Taken together, these data suggest that signal-controlled activation of SRF, MRTF-A, and CBP provides a novel connection between mechanical stimuli and angiogenic gene expression.

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 175-179 DiseaseOrPhenotypicFeature denotes rich 0015404
T2 1117-1120 DiseaseOrPhenotypicFeature denotes CBP 0010565
T3 1149-1152 DiseaseOrPhenotypicFeature denotes HAT 0018048
T4 1219-1222 DiseaseOrPhenotypicFeature denotes CBP 0010565
T5 1359-1362 DiseaseOrPhenotypicFeature denotes CBP 0010565
T6 1363-1366 DiseaseOrPhenotypicFeature denotes HAT 0018048
T7 1515-1518 DiseaseOrPhenotypicFeature denotes CBP 0010565
T8 1519-1522 DiseaseOrPhenotypicFeature denotes HAT 0018048
T9 1841-1844 DiseaseOrPhenotypicFeature denotes CBP 0010565

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 161-174 http://purl.obolibrary.org/obo/MAT_0000303 denotes Smooth muscle
T2 168-174 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle

bionlp-st-cg-2013-training

Id Subject Object Predicate Lexical cue
T1 50-54 Gene_or_gene_product denotes CCN1
T2 55-60 Gene_or_gene_product denotes CYR61
T3 102-108 Gene_or_gene_product denotes MRTF-A
T4 113-159 Gene_or_gene_product denotes CREB-binding protein histone acetyltransferase
T5 161-187 Tissue denotes Smooth muscle-rich tissues
T6 468-472 Gene_or_gene_product denotes CCN1
T7 542-550 Multi-tissue_structure denotes vascular
T8 651-655 Gene_or_gene_product denotes CCN1
T9 697-701 Gene_or_gene_product denotes RhoA
T10 711-716 Cellular_component denotes actin
T11 736-771 Gene_or_gene_product denotes p38 stress-activated protein kinase
T12 773-777 Gene_or_gene_product denotes SAPK
T13 780-785 Gene_or_gene_product denotes Actin
T14 805-826 Gene_or_gene_product denotes serum response factor
T15 828-831 Gene_or_gene_product denotes SRF
T16 846-849 Gene_or_gene_product denotes SRF
T17 871-923 Gene_or_gene_product denotes myocardin-related transcriptional activator (MRTF)-A
T18 979-983 Gene_or_gene_product denotes CCN1
T19 1049-1054 Organism denotes mouse
T20 1055-1072 Cell denotes MRTF-A(-/-) cells
T21 1055-1061 Gene_or_gene_product denotes MRTF-A
T22 1095-1153 Gene_or_gene_product denotes CREB-binding protein (CBP) histone acetyltransferase (HAT)
T23 1219-1222 Gene_or_gene_product denotes CBP
T24 1247-1257 Gene_or_gene_product denotes histones 3
T25 1262-1263 Gene_or_gene_product denotes 4
T26 1271-1274 Gene_or_gene_product denotes SRF
T27 1303-1307 Gene_or_gene_product denotes CCN1
T28 1342-1350 Gene_or_gene_product denotes p38 SAPK
T29 1359-1366 Gene_or_gene_product denotes CBP HAT
T30 1403-1406 Gene_or_gene_product denotes SRF
T31 1407-1413 Gene_or_gene_product denotes MRTF-A
T32 1453-1456 Gene_or_gene_product denotes p38
T33 1486-1490 Gene_or_gene_product denotes MKK3
T34 1495-1499 Gene_or_gene_product denotes MKK6
T35 1515-1522 Gene_or_gene_product denotes CBP HAT
T36 1527-1531 Gene_or_gene_product denotes CCN1
T37 1592-1596 Gene_or_gene_product denotes CCN1
T38 1665-1671 Gene_or_gene_product denotes MRTF-A
T39 1694-1698 Gene_or_gene_product denotes CCN1
T40 1718-1724 Gene_or_gene_product denotes MRTF-A
T41 1740-1750 Gene_or_gene_product denotes histone H3
T42 1824-1827 Gene_or_gene_product denotes SRF
T43 1829-1835 Gene_or_gene_product denotes MRTF-A
T44 1841-1844 Gene_or_gene_product denotes CBP

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1117-1120 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T2 1149-1152 Disease denotes HAT http://purl.obolibrary.org/obo/MONDO_0018048
T3 1219-1222 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T4 1359-1362 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T5 1363-1366 Disease denotes HAT http://purl.obolibrary.org/obo/MONDO_0018048
T6 1515-1518 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T7 1519-1522 Disease denotes HAT http://purl.obolibrary.org/obo/MONDO_0018048
T8 1841-1844 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 161-174 Body_part denotes Smooth muscle http://purl.obolibrary.org/obo/MAT_0000303

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1049-1054 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 161-174 Body_part denotes Smooth muscle http://purl.obolibrary.org/obo/UBERON_0001135