PubMed:19528665
Annnotations
Glycan-Motif
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 49-59 | https://glytoucan.org/Structures/Glycans/G57321FI | denotes | Tn antigen |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 49-59 | Glycan_Motif | denotes | Tn antigen | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G57321FI |
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 269-274 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
| T2 | 470-475 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
| T3 | 796-801 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
| T4 | 1100-1113 | DiseaseOrPhenotypicFeature | denotes | breast cancer | 0004989|0007254 |
| T6 | 1277-1282 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
| T7 | 1326-1331 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 49-59 | https://glytoucan.org/Structures/Glycans/G57321FI | denotes | Tn antigen |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-136 | Sentence | denotes | A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction. |
| TextSentencer_T2 | 137-253 | Sentence | denotes | Malignant transformation of epithelial cells is frequently associated with the alteration of glycosylation pathways. |
| TextSentencer_T3 | 254-417 | Sentence | denotes | Tn is a common tumor-associated carbohydrate antigen present in 90% of human carcinomas and its expression correlates with metastatic potential and poor prognosis. |
| TextSentencer_T4 | 418-572 | Sentence | denotes | Despite its relevance, the functional role of Tn in tumor biology has not been firmly established probably for the lack of appropriate experimental tools. |
| TextSentencer_T5 | 573-814 | Sentence | denotes | Our aims were to produce highly reactive monoclonal antibodies against Tn making use of synthetically produced Tn and to test their usefulness for in vivo imaging as well as to define their potential functional activity in tumor cell spread. |
| TextSentencer_T6 | 815-936 | Sentence | denotes | We immunized mice with Tn clustered on cationized BSA and screened the positive hybridomas with Tn-biotinylated alginate. |
| TextSentencer_T7 | 937-1222 | Sentence | denotes | Enzyme-linked immuno sorbent assay and immunofluorescence assays revealed that the most reactive anti-Tn IgM mAb (2154F12A4) selectively recognized Tn on the MCF7 breast cancer cell line since its binding to the cell membrane was completely abolished by preincubation with purified Tn. |
| TextSentencer_T8 | 1223-1380 | Sentence | denotes | Importantly, QDot 800-conjugated mAb injected in MCF7-tumor bearing mice specifically bound to primary tumor lesions as well as to metastases in lymph nodes. |
| TextSentencer_T9 | 1381-1626 | Sentence | denotes | In addition, this mAb was able to inhibit cancer cell adhesion to lymphatic endothelium suggesting a novel involvement of Tn in the lymphatic dissemination of cancer cells and hypothesizing future applications in inhibiting lymphatic metastases. |
| T1 | 0-136 | Sentence | denotes | A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction. |
| T2 | 137-253 | Sentence | denotes | Malignant transformation of epithelial cells is frequently associated with the alteration of glycosylation pathways. |
| T3 | 254-417 | Sentence | denotes | Tn is a common tumor-associated carbohydrate antigen present in 90% of human carcinomas and its expression correlates with metastatic potential and poor prognosis. |
| T4 | 418-572 | Sentence | denotes | Despite its relevance, the functional role of Tn in tumor biology has not been firmly established probably for the lack of appropriate experimental tools. |
| T5 | 573-814 | Sentence | denotes | Our aims were to produce highly reactive monoclonal antibodies against Tn making use of synthetically produced Tn and to test their usefulness for in vivo imaging as well as to define their potential functional activity in tumor cell spread. |
| T6 | 815-936 | Sentence | denotes | We immunized mice with Tn clustered on cationized BSA and screened the positive hybridomas with Tn-biotinylated alginate. |
| T7 | 937-1380 | Sentence | denotes | Enzyme-linked immuno sorbent assay and immunofluorescence assays revealed that the most reactive anti-Tn IgM mAb (2154F12A4) selectively recognized Tn on the MCF7 breast cancer cell line since its binding to the cell membrane was completely abolished by preincubation with purified Tn. Importantly, QDot 800-conjugated mAb injected in MCF7-tumor bearing mice specifically bound to primary tumor lesions as well as to metastases in lymph nodes. |
| T8 | 1381-1626 | Sentence | denotes | In addition, this mAb was able to inhibit cancer cell adhesion to lymphatic endothelium suggesting a novel involvement of Tn in the lymphatic dissemination of cancer cells and hypothesizing future applications in inhibiting lymphatic metastases. |
| T1 | 0-136 | Sentence | denotes | A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction. |
| T2 | 137-253 | Sentence | denotes | Malignant transformation of epithelial cells is frequently associated with the alteration of glycosylation pathways. |
| T3 | 254-417 | Sentence | denotes | Tn is a common tumor-associated carbohydrate antigen present in 90% of human carcinomas and its expression correlates with metastatic potential and poor prognosis. |
| T4 | 418-572 | Sentence | denotes | Despite its relevance, the functional role of Tn in tumor biology has not been firmly established probably for the lack of appropriate experimental tools. |
| T5 | 573-814 | Sentence | denotes | Our aims were to produce highly reactive monoclonal antibodies against Tn making use of synthetically produced Tn and to test their usefulness for in vivo imaging as well as to define their potential functional activity in tumor cell spread. |
| T6 | 815-936 | Sentence | denotes | We immunized mice with Tn clustered on cationized BSA and screened the positive hybridomas with Tn-biotinylated alginate. |
| T7 | 937-1222 | Sentence | denotes | Enzyme-linked immuno sorbent assay and immunofluorescence assays revealed that the most reactive anti-Tn IgM mAb (2154F12A4) selectively recognized Tn on the MCF7 breast cancer cell line since its binding to the cell membrane was completely abolished by preincubation with purified Tn. |
| T8 | 1223-1380 | Sentence | denotes | Importantly, QDot 800-conjugated mAb injected in MCF7-tumor bearing mice specifically bound to primary tumor lesions as well as to metastases in lymph nodes. |
| T9 | 1381-1626 | Sentence | denotes | In addition, this mAb was able to inhibit cancer cell adhesion to lymphatic endothelium suggesting a novel involvement of Tn in the lymphatic dissemination of cancer cells and hypothesizing future applications in inhibiting lymphatic metastases. |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 49-59 | http://www.glycoepitope.jp/epitopes/EP0021 | denotes | Tn antigen |
| T2 | 1051-1060 | http://www.glycoepitope.jp/epitopes/AN0779 | denotes | 2154F12A4 |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1368-1379 | http://purl.obolibrary.org/obo/MAT_0000197 | denotes | lymph nodes |
| T2 | 1368-1379 | http://purl.obolibrary.org/obo/MAT_0000442 | denotes | lymph nodes |
| T3 | 1368-1373 | http://purl.obolibrary.org/obo/MAT_0000055 | denotes | lymph |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 29-37 | FMAID:167180 | denotes | antibody |
| _T2 | 102-123 | FMAID:210141 | denotes | lymphatic endothelium |
| _T3 | 112-123 | FMAID:63916 | denotes | endothelium |
| _T4 | 112-123 | FMAID:162384 | denotes | endothelium |
| _T5 | 165-181 | FMAID:197786 | denotes | epithelial cells |
| _T6 | 165-181 | FMAID:67799 | denotes | epithelial cells |
| _T7 | 165-181 | FMAID:165731 | denotes | epithelial cells |
| _T8 | 165-181 | FMAID:169653 | denotes | epithelial cells |
| _T9 | 165-181 | FMAID:67559 | denotes | epithelial cells |
| _T10 | 165-181 | FMAID:69075 | denotes | epithelial cells |
| _T11 | 165-181 | FMAID:83514 | denotes | epithelial cells |
| _T12 | 165-181 | FMAID:165528 | denotes | epithelial cells |
| _T13 | 165-181 | FMAID:169652 | denotes | epithelial cells |
| _T14 | 165-181 | FMAID:66768 | denotes | epithelial cells |
| _T15 | 165-181 | FMAID:164922 | denotes | epithelial cells |
| _T16 | 165-181 | FMAID:69074 | denotes | epithelial cells |
| _T17 | 176-181 | FMAID:169002 | denotes | cells |
| _T18 | 176-181 | FMAID:68646 | denotes | cells |
| _T19 | 286-298 | FMAID:197276 | denotes | carbohydrate |
| _T20 | 286-298 | FMAID:82737 | denotes | carbohydrate |
| _T21 | 299-314 | FMAID:273572 | denotes | antigen present |
| _T22 | 299-314 | FMAID:273565 | denotes | antigen present |
| _T23 | 299-314 | FMAID:273564 | denotes | antigen present |
| _T24 | 625-635 | FMAID:167180 | denotes | antibodies |
| _T25 | 694-698 | FMAID:178661 | denotes | test |
| _T26 | 1042-1045 | FMAID:167182 | denotes | IgM |
| _T27 | 1100-1106 | FMAID:9601 | denotes | breast |
| _T28 | 1100-1106 | FMAID:97486 | denotes | breast |
| _T29 | 1154-1166 | FMAID:76711 | denotes | membrane was |
| _T30 | 1154-1166 | FMAID:183865 | denotes | membrane was |
| _T31 | 1365-1379 | FMAID:107327 | denotes | in lymph nodes |
| _T32 | 1365-1379 | FMAID:277596 | denotes | in lymph nodes |
| _T33 | 1365-1379 | FMAID:16629 | denotes | in lymph nodes |
| _T34 | 1365-1379 | FMAID:91589 | denotes | in lymph nodes |
| _T35 | 1365-1379 | FMAID:91557 | denotes | in lymph nodes |
| _T36 | 1365-1379 | FMAID:161758 | denotes | in lymph nodes |
| _T37 | 1365-1379 | FMAID:61223 | denotes | in lymph nodes |
| _T38 | 1368-1373 | FMAID:217076 | denotes | lymph |
| _T39 | 1368-1373 | FMAID:97585 | denotes | lymph |
| _T40 | 1368-1379 | FMAID:91368 | denotes | lymph nodes |
| _T41 | 1368-1379 | FMAID:5034 | denotes | lymph nodes |
| _T42 | 1447-1468 | FMAID:210141 | denotes | lymphatic endothelium |
| _T43 | 1457-1468 | FMAID:162384 | denotes | endothelium |
| _T44 | 1457-1468 | FMAID:63916 | denotes | endothelium |
| _T45 | 1547-1552 | FMAID:68646 | denotes | cells |
| _T46 | 1547-1552 | FMAID:169002 | denotes | cells |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 8-28 | http://purl.bioontology.org/ontology/STY/T045 | denotes | generated functional |
| T2 | 90-96 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T3 | 176-181 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T4 | 331-341 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinomas |
| T5 | 614-624 | http://purl.bioontology.org/ontology/NCBITAXON/608684 | denotes | monoclonal |
| T6 | 1107-1113 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T7 | 1423-1429 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T8 | 1540-1546 | http://purl.bioontology.org/ontology/NCBITAXON/6754 | denotes | cancer |
| T9 | 1547-1552 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 230-243 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T2 | 299-314 | http://purl.obolibrary.org/obo/GO_0019882 | denotes | antigen present |
| T3 | 1245-1255 | http://purl.obolibrary.org/obo/GO_0000746 | denotes | conjugated |
| T4 | 1430-1443 | http://purl.obolibrary.org/obo/GO_0007155 | denotes | cell adhesion |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 29-37 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
| T2 | 625-635 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibodies |
| T3 | 1134-1141 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
| T4 | 1134-1141 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
| T5 | 1134-1141 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
| T6 | 1134-1141 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 97-101 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T2 | 802-806 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T3 | 1114-1118 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T4 | 1149-1153 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T5 | 176-181 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T6 | 1547-1552 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T7 | 1149-1162 | http://purl.obolibrary.org/obo/GO_0005886 | denotes | cell membrane |
| T8 | 1154-1162 | http://purl.obolibrary.org/obo/GO_0016020 | denotes | membrane |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 112-123 | http://purl.obolibrary.org/obo/UBERON_0001986 | denotes | endothelium |
| T2 | 1457-1468 | http://purl.obolibrary.org/obo/UBERON_0001986 | denotes | endothelium |
| T3 | 1100-1106 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| T4 | 1368-1373 | http://purl.obolibrary.org/obo/UBERON_0002391 | denotes | lymph |
| T5 | 1368-1379 | http://purl.obolibrary.org/obo/UBERON_0000029 | denotes | lymph nodes |
GlycoBiology-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1368-1373 | http://purl.obolibrary.org/obo/MAT_0000055 | denotes | lymph |
| T2 | 1368-1379 | http://purl.obolibrary.org/obo/MAT_0000442 | denotes | lymph nodes |
| T3 | 1368-1379 | http://purl.obolibrary.org/obo/MAT_0000197 | denotes | lymph nodes |
Lectin
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| Lectin_T1 | 49-51 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
| Lectin_T2 | 254-256 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
| Lectin_T3 | 464-466 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
| Lectin_T4 | 644-646 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
| Lectin_T5 | 684-686 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
| Lectin_T6 | 838-840 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
| Lectin_T7 | 911-913 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
| Lectin_T8 | 1039-1041 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
| Lectin_T9 | 1085-1087 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
| Lectin_T10 | 1219-1221 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
| Lectin_T11 | 1503-1505 | https://acgg.asia/db/lfdb/LfDB0021 | denotes | Tn |
GlycoBiology-Epitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoEpitope-B_T1 | 49-59 | http://www.glycoepitope.jp/epitopes/EP0021 | denotes | Tn antigen |
| PD-GlycoEpitope-B_T2 | 1051-1060 | http://www.glycoepitope.jp/epitopes/AN0779 | denotes | 2154F12A4 |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 1368-1373 | http://purl.obolibrary.org/obo/UBERON_0002391 | denotes | lymph |
| PD-UBERON-AE-B_T2 | 1368-1379 | http://purl.obolibrary.org/obo/UBERON_0000029 | denotes | lymph nodes |
| PD-UBERON-AE-B_T3 | 1100-1106 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T4 | 112-123 | http://purl.obolibrary.org/obo/UBERON_0001986 | denotes | endothelium |
| PD-UBERON-AE-B_T5 | 1457-1468 | http://purl.obolibrary.org/obo/UBERON_0001986 | denotes | endothelium |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 49-59 | Glycan | denotes | Tn antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1368-1379 | Body_part | denotes | lymph nodes | http://purl.obolibrary.org/obo/MAT_0000197|http://purl.obolibrary.org/obo/MAT_0000442 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 90-96 | Phenotype | denotes | cancer | HP:0002664 |
| T2 | 269-274 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 331-341 | Phenotype | denotes | carcinomas | HP:0030731 |
| T4 | 470-475 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 796-801 | Phenotype | denotes | tumor | HP:0002664 |
| T6 | 1100-1113 | Phenotype | denotes | breast cancer | HP:0003002 |
| T7 | 1277-1282 | Phenotype | denotes | tumor | HP:0002664 |
| T8 | 1326-1331 | Phenotype | denotes | tumor | HP:0002664 |
| T9 | 1423-1429 | Phenotype | denotes | cancer | HP:0002664 |
| T10 | 1540-1546 | Phenotype | denotes | cancer | HP:0002664 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 90-96 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T2 | 269-274 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T3 | 331-341 | Disease | denotes | carcinomas | http://purl.obolibrary.org/obo/MONDO_0004993 |
| T4 | 470-475 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T5 | 796-801 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T6 | 1100-1113 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T7 | 1277-1282 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T8 | 1326-1331 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T9 | 1354-1379 | Disease | denotes | metastases in lymph nodes | http://purl.obolibrary.org/obo/MONDO_0005438 |
| T10 | 1423-1429 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T11 | 1540-1546 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 49-59 | Glycan | denotes | Tn antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G57321FI |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 49-59 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Tn antigen | http://www.glycoepitope.jp/epitopes/EP0021 |
| T2 | 1051-1060 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 2154F12A4 | http://www.glycoepitope.jp/epitopes/AN0779 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 90-96 | Phenotype | denotes | cancer | HP:0002664 |
| T2 | 269-274 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 331-341 | Phenotype | denotes | carcinomas | HP:0030731 |
| T4 | 470-475 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 796-801 | Phenotype | denotes | tumor | HP:0002664 |
| T6 | 1100-1113 | Phenotype | denotes | breast cancer | HP:0003002 |
| T7 | 1277-1282 | Phenotype | denotes | tumor | HP:0002664 |
| T8 | 1326-1331 | Phenotype | denotes | tumor | HP:0002664 |
| T9 | 1423-1429 | Phenotype | denotes | cancer | HP:0002664 |
| T10 | 1540-1546 | Phenotype | denotes | cancer | HP:0002664 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 90-101 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 165-181 | Cell | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL:0000066 |
| T3 | 796-806 | Cell | denotes | tumor cell | http://purl.obolibrary.org/obo/CL:0001063 |
| T4 | 1107-1118 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T5 | 1423-1434 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T6 | 1540-1552 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 102-123 | Body_part | denotes | lymphatic endothelium | http://purl.obolibrary.org/obo/UBERON_0002042 |
| T2 | 165-181 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
| T3 | 1100-1106 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T4 | 1149-1162 | Body_part | denotes | cell membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T5 | 1368-1379 | Body_part | denotes | lymph nodes | http://purl.obolibrary.org/obo/UBERON_0000029 |
| T6 | 1447-1468 | Body_part | denotes | lymphatic endothelium | http://purl.obolibrary.org/obo/UBERON_0002042 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 325-330 | Organism | denotes | human | 9606 |
| T2 | 828-832 | Organism | denotes | mice | 10088 |
| T3 | 1291-1295 | Organism | denotes | mice | 10088 |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 49-59 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Tn antigen | http://www.glycoepitope.jp/epitopes/EP0021 |
| T2 | 1051-1060 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 2154F12A4 | http://www.glycoepitope.jp/epitopes/AN0779 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-136 | Sentence | denotes | A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction. |
| T2 | 137-253 | Sentence | denotes | Malignant transformation of epithelial cells is frequently associated with the alteration of glycosylation pathways. |
| T3 | 254-417 | Sentence | denotes | Tn is a common tumor-associated carbohydrate antigen present in 90% of human carcinomas and its expression correlates with metastatic potential and poor prognosis. |
| T4 | 418-572 | Sentence | denotes | Despite its relevance, the functional role of Tn in tumor biology has not been firmly established probably for the lack of appropriate experimental tools. |
| T5 | 573-814 | Sentence | denotes | Our aims were to produce highly reactive monoclonal antibodies against Tn making use of synthetically produced Tn and to test their usefulness for in vivo imaging as well as to define their potential functional activity in tumor cell spread. |
| T6 | 815-936 | Sentence | denotes | We immunized mice with Tn clustered on cationized BSA and screened the positive hybridomas with Tn-biotinylated alginate. |
| T7 | 937-1380 | Sentence | denotes | Enzyme-linked immuno sorbent assay and immunofluorescence assays revealed that the most reactive anti-Tn IgM mAb (2154F12A4) selectively recognized Tn on the MCF7 breast cancer cell line since its binding to the cell membrane was completely abolished by preincubation with purified Tn. Importantly, QDot 800-conjugated mAb injected in MCF7-tumor bearing mice specifically bound to primary tumor lesions as well as to metastases in lymph nodes. |
| T8 | 1381-1626 | Sentence | denotes | In addition, this mAb was able to inhibit cancer cell adhesion to lymphatic endothelium suggesting a novel involvement of Tn in the lymphatic dissemination of cancer cells and hypothesizing future applications in inhibiting lymphatic metastases. |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 90-96 | Disease | denotes | cancer | MONDO:0004992 |
| T2 | 269-274 | Disease | denotes | tumor | MONDO:0005070 |
| T3 | 331-341 | Disease | denotes | carcinomas | MONDO:0004993 |
| T4 | 470-475 | Disease | denotes | tumor | MONDO:0005070 |
| T5 | 796-801 | Disease | denotes | tumor | MONDO:0005070 |
| T6 | 1100-1113 | Disease | denotes | breast cancer | MONDO:0004989|MONDO:0007254 |
| T8 | 1277-1282 | Disease | denotes | tumor | MONDO:0005070 |
| T9 | 1326-1331 | Disease | denotes | tumor | MONDO:0005070 |
| T10 | 1354-1379 | Disease | denotes | metastases in lymph nodes | MONDO:0005438 |
| T11 | 1423-1429 | Disease | denotes | cancer | MONDO:0004992 |
| T12 | 1540-1546 | Disease | denotes | cancer | MONDO:0004992 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 112-123 | Body_part | denotes | endothelium | FMA:63916 |
| T2 | 165-181 | Body_part | denotes | epithelial cells | FMA:66768 |
| T3 | 1100-1106 | Body_part | denotes | breast | FMA:9601 |
| T4 | 1149-1162 | Body_part | denotes | cell membrane | FMA:63841 |
| T5 | 1368-1379 | Body_part | denotes | lymph nodes | FMA:5034 |
| T6 | 1457-1468 | Body_part | denotes | endothelium | FMA:63916 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1368-1379 | Body_part | denotes | lymph nodes | http://purl.obolibrary.org/obo/MAT_0000197|http://purl.obolibrary.org/obo/MAT_0000442 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 325-330 | OrganismTaxon | denotes | human | 9606 |
| T2 | 828-832 | OrganismTaxon | denotes | mice | 10088 |
| T3 | 1291-1295 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 102-123 | Body_part | denotes | lymphatic endothelium | http://purl.obolibrary.org/obo/UBERON_0002042 |
| T2 | 165-181 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
| T3 | 1100-1106 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T4 | 1149-1162 | Body_part | denotes | cell membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T5 | 1368-1379 | Body_part | denotes | lymph nodes | http://purl.obolibrary.org/obo/UBERON_0000029 |
| T6 | 1447-1468 | Body_part | denotes | lymphatic endothelium | http://purl.obolibrary.org/obo/UBERON_0002042 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 90-101 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 165-181 | Cell | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL:0000066 |
| T3 | 796-806 | Cell | denotes | tumor cell | http://purl.obolibrary.org/obo/CL:0001063 |
| T4 | 1107-1118 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T5 | 1423-1434 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T6 | 1540-1552 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |