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PubMed:1952426 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 78-101 protein denotes glucocorticoid receptor
T2 137-160 cell_type denotes peripheral blood T cell
T3 545-563 protein denotes Phytohemagglutinin
T4 565-568 protein denotes PHA
T5 595-625 cell_type denotes peripheral blood T lymphocytes
T6 942-949 cell_type denotes T cells
T7 1201-1259 protein denotes Peripheral blood mononuclear cell glucocorticoid receptors
T8 1376-1385 protein denotes receptors
T9 1714-1727 cell_type denotes T lymphocytes
T10 1832-1865 protein denotes cellular glucocorticoid receptors

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-44 Sentence denotes Glucocorticoid resistance in chronic asthma.
S2 45-203 Sentence denotes Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro.
S3 204-463 Sentence denotes A total of 37 chronic, severe, nonsmoking asthmatic patients with documented reversible airways obstruction were classified as glucocorticoid-sensitive or -resistant on the basis of changes in FEV1, FVC, and peak expiratory flow (PEF) after oral prednisolone.
S4 464-544 Sentence denotes The resistant patients showed no significant improvements in airflow limitation.
S5 545-812 Sentence denotes Phytohemagglutinin (PHA)-induced proliferation of peripheral blood T lymphocytes from the sensitive but not the resistant asthmatic patients was significantly (p less than 0.01) inhibited by dexamethasone (10(-7) mol/L), reflecting a shift of the dose-response curve.
S6 813-1034 Sentence denotes When all the asthmatic patients were analyzed together, there was a significant correlation between the degree of sensitivity of T cells to dexamethasone and the clinical responsiveness to prednisolone (p less than 0.01).
S7 1035-1200 Sentence denotes No differences were observed between six of the sensitive and resistant patients in the clearance of plasma prednisolone derived from orally administered prednisone.
S8 1201-1331 Sentence denotes Peripheral blood mononuclear cell glucocorticoid receptors were also characterized in five sensitive and seven resistant patients.
S9 1332-1520 Sentence denotes The numbers and binding affinities of these receptors could not account for the observed difference in the susceptibility of these cells to functional inhibition by dexamethasone in vitro.
S10 1521-1747 Sentence denotes These results suggest that clinical glucocorticoid resistance in chronic asthma does not reflect abnormal glucocorticoid clearance but may be due at least partly to a relative insensitivity of T lymphocytes to glucocorticoids.
S11 1748-1866 Sentence denotes This lack of sensitivity is unexplained but is not attributable to abnormalities of cellular glucocorticoid receptors.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 0-14 NP denotes Glucocorticoid
C1 0-25 NP denotes Glucocorticoid resistance
C3 29-43 NP denotes chronic asthma
C5 154-160 NP denotes T cell
C4 137-174 NP denotes peripheral blood T cell proliferation
C6 178-193 NP denotes glucocorticoids
C7 204-264 NP denotes A total of 37 chronic, severe, nonsmoking asthmatic patients
C8 445-462 NP denotes oral prednisolone
C9 464-486 NP denotes The resistant patients
C11 612-625 NP denotes T lymphocytes
C10 545-625 NP denotes Phytohemagglutinin (PHA)-induced proliferation of peripheral blood T lymphocytes
C12 653-685 NP denotes the resistant asthmatic patients
C13 736-764 NP denotes dexamethasone (10(-7) mol/L)
C14 818-844 NP denotes all the asthmatic patients
C15 942-949 NP denotes T cells
C16 953-966 NP denotes dexamethasone
C17 1002-1033 NP denotes prednisolone (p less than 0.01)
C18 1072-1115 NP denotes six of the sensitive and resistant patients
C19 1169-1199 NP denotes orally administered prednisone
C21 1235-1249 NP denotes glucocorticoid
C20 1201-1259 NP denotes Peripheral blood mononuclear cell glucocorticoid receptors
C22 1287-1330 NP denotes five sensitive and seven resistant patients
C23 1370-1385 NP denotes these receptors
C24 1497-1510 NP denotes dexamethasone
C26 1557-1571 NP denotes glucocorticoid
C25 1548-1582 NP denotes clinical glucocorticoid resistance
C27 1586-1600 NP denotes chronic asthma
C28 1714-1727 NP denotes T lymphocytes
C29 1731-1746 NP denotes glucocorticoids
C31 1841-1855 NP denotes glucocorticoid
C30 1832-1865 NP denotes cellular glucocorticoid receptors
R1 C6 C2 coref-ident glucocorticoids,Glucocorticoid
R2 C9 C7 coref-other The resistant patients,"A total of 37 chronic, severe, nonsmoking asthmatic patients"
R3 C11 C5 coref-ident T lymphocytes,T cell
R4 C10 C4 coref-other Phytohemagglutinin (PHA)-induced proliferation of peripheral blood T lymphocytes,peripheral blood T cell proliferation
R5 C12 C9 coref-ident the resistant asthmatic patients,The resistant patients
R6 C14 C9 coref-ident all the asthmatic patients,The resistant patients
R7 C15 C11 coref-ident T cells,T lymphocytes
R8 C16 C13 coref-ident dexamethasone,dexamethasone (10(-7) mol/L)
R9 C17 C8 coref-other prednisolone (p less than 0.01),oral prednisolone
R10 C18 C14 coref-other six of the sensitive and resistant patients,all the asthmatic patients
R11 C19 C8 coref-ident orally administered prednisone,oral prednisolone
R12 C21 C6 coref-ident glucocorticoid,glucocorticoids
R13 C22 C14 coref-other five sensitive and seven resistant patients,all the asthmatic patients
R14 C23 C20 coref-ident these receptors,Peripheral blood mononuclear cell glucocorticoid receptors
R15 C24 C16 coref-ident dexamethasone,dexamethasone
R16 C26 C21 coref-ident glucocorticoid,glucocorticoid
R17 C25 C1 coref-other clinical glucocorticoid resistance,Glucocorticoid resistance
R18 C27 C3 coref-ident chronic asthma,chronic asthma
R19 C28 C15 coref-ident T lymphocytes,T cells
R20 C29 C26 coref-ident glucocorticoids,glucocorticoid
R21 C31 C29 coref-ident glucocorticoid,glucocorticoids
R22 C30 C23 coref-ident cellular glucocorticoid receptors,these receptors

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-25 other_name denotes Glucocorticoid resistance
T2 29-43 other_name denotes chronic asthma
T3 45-76 other_name denotes Glucocorticoid pharmacokinetics
T4 78-101 protein_family_or_group denotes glucocorticoid receptor
T5 137-153 cell_type denotes peripheral blood
T6 154-160 cell_type denotes T cell
T7 178-193 lipid denotes glucocorticoids
T8 235-255 multi_cell denotes nonsmoking asthmatic
T9 256-264 multi_cell denotes patients
T10 397-401 other_name denotes FEV1
T11 403-406 other_name denotes FVC
T12 412-432 other_name denotes peak expiratory flow
T13 434-437 other_name denotes PEF
T14 445-449 lipid denotes oral
T15 450-462 lipid denotes prednisolone
T16 478-486 multi_cell denotes patients
T17 545-563 protein_molecule denotes Phytohemagglutinin
T18 565-568 protein_molecule denotes PHA
T19 595-625 cell_type denotes peripheral blood T lymphocytes
T20 657-676 multi_cell denotes resistant asthmatic
T21 677-685 multi_cell denotes patients
T22 826-844 multi_cell denotes asthmatic patients
T23 942-949 cell_type denotes T cells
T24 953-966 lipid denotes dexamethasone
T25 1002-1014 lipid denotes prednisolone
T26 1136-1142 lipid denotes plasma
T27 1143-1155 lipid denotes prednisolone
T28 1169-1199 lipid denotes orally administered prednisone
T29 1201-1234 cell_type denotes Peripheral blood mononuclear cell
T30 1235-1259 protein_family_or_group denotes glucocorticoid receptors
T31 1292-1301 multi_cell denotes sensitive
T32 1312-1330 multi_cell denotes resistant patients
T33 1376-1385 protein_family_or_group denotes receptors
T34 1497-1510 lipid denotes dexamethasone
T35 1548-1582 other_name denotes clinical glucocorticoid resistance
T36 1586-1600 other_name denotes chronic asthma
T37 1627-1651 other_name denotes glucocorticoid clearance
T38 1714-1727 cell_type denotes T lymphocytes
T39 1731-1746 lipid denotes glucocorticoids
T40 1832-1840 protein_family_or_group denotes cellular
T41 1841-1865 protein_family_or_group denotes glucocorticoid receptors