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PubMed:19506293 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 200-203 DiseaseOrPhenotypicFeature denotes can 0012833
T2 407-410 DiseaseOrPhenotypicFeature denotes TOF 0008542
T3 1512-1530 DiseaseOrPhenotypicFeature denotes monocytic leukemia 0004600|0007896

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-111 Sentence denotes A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data.
TextSentencer_T2 112-244 Sentence denotes Effective representation and characterization of biosynthetic pathways of glycosylation can be facilitated by mathematical modeling.
TextSentencer_T3 245-493 Sentence denotes This paper describes the expansion of a previously developed detailed model for N-linked glycosylation with the further application of the model to analyze MALDI-TOF mass spectra of human N-glycans in terms of underlying cellular enzyme activities.
TextSentencer_T4 494-635 Sentence denotes The glycosylation reaction network is automatically generated by the model, based on the reaction specificities of the glycosylation enzymes.
TextSentencer_T5 636-766 Sentence denotes The use of a molecular mass cutoff and a network pruning method typically limits the model size to about 10,000 glycan structures.
TextSentencer_T6 767-914 Sentence denotes This allows prediction of the complete glycan profile and its abundances for any set of assumed enzyme concentrations and reaction rate parameters.
TextSentencer_T7 915-1113 Sentence denotes A synthetic mass spectrum from model-calculated glycan profiles is obtained and enzyme concentrations are adjusted to bring the theoretically calculated mass spectrum into agreement with experiment.
TextSentencer_T8 1114-1278 Sentence denotes The result of this process is a complete characterization of a measured glycan mass spectrum containing hundreds of masses in terms of the activities of 19 enzymes.
TextSentencer_T9 1279-1431 Sentence denotes In addition, a complete annotation of the mass spectrum in terms of glycan structure is produced, including the proportions of isomers within each peak.
TextSentencer_T10 1432-1676 Sentence denotes The method was applied to mass spectrometric data of normal human monocytes and monocytic leukemia (THP1) cells to derive glycosyltransferase activity changes underlying the differences in glycan structure between the normal and diseased cells.
TextSentencer_T11 1677-1867 Sentence denotes Model predictions could lead to a better understanding of the changes associated with disease states, identification of disease-associated biomarkers, and bioengineered glycan modifications.
T1 0-111 Sentence denotes A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data.
T2 112-244 Sentence denotes Effective representation and characterization of biosynthetic pathways of glycosylation can be facilitated by mathematical modeling.
T3 245-493 Sentence denotes This paper describes the expansion of a previously developed detailed model for N-linked glycosylation with the further application of the model to analyze MALDI-TOF mass spectra of human N-glycans in terms of underlying cellular enzyme activities.
T4 494-635 Sentence denotes The glycosylation reaction network is automatically generated by the model, based on the reaction specificities of the glycosylation enzymes.
T5 636-766 Sentence denotes The use of a molecular mass cutoff and a network pruning method typically limits the model size to about 10,000 glycan structures.
T6 767-914 Sentence denotes This allows prediction of the complete glycan profile and its abundances for any set of assumed enzyme concentrations and reaction rate parameters.
T7 915-1113 Sentence denotes A synthetic mass spectrum from model-calculated glycan profiles is obtained and enzyme concentrations are adjusted to bring the theoretically calculated mass spectrum into agreement with experiment.
T8 1114-1278 Sentence denotes The result of this process is a complete characterization of a measured glycan mass spectrum containing hundreds of masses in terms of the activities of 19 enzymes.
T9 1279-1431 Sentence denotes In addition, a complete annotation of the mass spectrum in terms of glycan structure is produced, including the proportions of isomers within each peak.
T10 1432-1676 Sentence denotes The method was applied to mass spectrometric data of normal human monocytes and monocytic leukemia (THP1) cells to derive glycosyltransferase activity changes underlying the differences in glycan structure between the normal and diseased cells.
T11 1677-1867 Sentence denotes Model predictions could lead to a better understanding of the changes associated with disease states, identification of disease-associated biomarkers, and bioengineered glycan modifications.
T1 0-111 Sentence denotes A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data.
T2 112-244 Sentence denotes Effective representation and characterization of biosynthetic pathways of glycosylation can be facilitated by mathematical modeling.
T3 245-493 Sentence denotes This paper describes the expansion of a previously developed detailed model for N-linked glycosylation with the further application of the model to analyze MALDI-TOF mass spectra of human N-glycans in terms of underlying cellular enzyme activities.
T4 494-635 Sentence denotes The glycosylation reaction network is automatically generated by the model, based on the reaction specificities of the glycosylation enzymes.
T5 636-766 Sentence denotes The use of a molecular mass cutoff and a network pruning method typically limits the model size to about 10,000 glycan structures.
T6 767-914 Sentence denotes This allows prediction of the complete glycan profile and its abundances for any set of assumed enzyme concentrations and reaction rate parameters.
T7 915-1113 Sentence denotes A synthetic mass spectrum from model-calculated glycan profiles is obtained and enzyme concentrations are adjusted to bring the theoretically calculated mass spectrum into agreement with experiment.
T8 1114-1278 Sentence denotes The result of this process is a complete characterization of a measured glycan mass spectrum containing hundreds of masses in terms of the activities of 19 enzymes.
T9 1279-1431 Sentence denotes In addition, a complete annotation of the mass spectrum in terms of glycan structure is produced, including the proportions of isomers within each peak.
T10 1432-1676 Sentence denotes The method was applied to mass spectrometric data of normal human monocytes and monocytic leukemia (THP1) cells to derive glycosyltransferase activity changes underlying the differences in glycan structure between the normal and diseased cells.
T11 1677-1867 Sentence denotes Model predictions could lead to a better understanding of the changes associated with disease states, identification of disease-associated biomarkers, and bioengineered glycan modifications.

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 521-528 FMAID:179365 denotes network
_T2 677-684 FMAID:179365 denotes network
_T3 898-902 FMAID:217859 denotes rate
_T4 1498-1507 FMAID:167164 denotes monocytes
_T5 1498-1507 FMAID:62864 denotes monocytes
_T6 1512-1521 FMAID:62864 denotes monocytic
_T7 1512-1521 FMAID:167164 denotes monocytic
_T8 1538-1543 FMAID:169002 denotes cells
_T9 1538-1543 FMAID:68646 denotes cells
_T10 1670-1675 FMAID:68646 denotes cells
_T11 1670-1675 FMAID:169002 denotes cells

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 446-451 http://purl.bioontology.org/ontology/NCBITAXON/62951 denotes terms
T2 1240-1245 http://purl.bioontology.org/ontology/NCBITAXON/62951 denotes terms
T3 1338-1343 http://purl.bioontology.org/ontology/NCBITAXON/62951 denotes terms
T4 1538-1543 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 1670-1675 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 55-63 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T2 466-474 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T3 64-81 http://purl.obolibrary.org/obo/GO_0003824 denotes enzyme activities
T4 475-492 http://purl.obolibrary.org/obo/GO_0003824 denotes enzyme activities
T5 186-199 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 334-347 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T7 498-511 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T8 613-626 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T9 296-305 http://purl.obolibrary.org/obo/GO_0032502 denotes developed
T10 1554-1582 http://purl.obolibrary.org/obo/GO_0016757 denotes glycosyltransferase activity

GO-CC

Id Subject Object Predicate Lexical cue
T1 1538-1543 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 1670-1675 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 31-39 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycan
T2 433-442 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycans

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1512-1530 Disease denotes monocytic leukemia http://purl.obolibrary.org/obo/MONDO_0004600|http://purl.obolibrary.org/obo/MONDO_0007896

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1522-1530 Phenotype denotes leukemia HP:0001909

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 427-432 OrganismTaxon denotes human 9606
T2 1492-1497 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1498-1507 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1498-1507 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 1512-1521 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054