PubMed:19484664
Annnotations
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-78 | Sentence | denotes | Angiotensin converting enzyme gene polymorphism in Turkish asthmatic patients. |
| T2 | 79-135 | Sentence | denotes | Asthma is a chronic inflammatory disease of the airways. |
| T3 | 136-289 | Sentence | denotes | Several candidate genes have been identified with a potential role in the pathogenesis of asthma, including the angiotensin converting enzyme (ACE) gene. |
| T4 | 290-458 | Sentence | denotes | We aimed to investigate the frequency of an ACE gene polymorphism in Turkish asthmatic patients and to determine its impact on clinical parameters and disease severity. |
| T5 | 459-605 | Sentence | denotes | Ninety-seven asthmatic patients (M/F 25/72, mean age 39 +/- 13 years) and 96 healthy subjects (M/F 26/70, mean age 38 +/- 12 years) were included. |
| T6 | 606-757 | Sentence | denotes | At baseline, all participants completed a questionnaire on demographics, symptoms, triggering factors, severity of asthma, and the presence of atopism. |
| T7 | 758-833 | Sentence | denotes | Blood samples were obtained from all patients and genomic DNA was isolated. |
| T8 | 834-1064 | Sentence | denotes | The frequency of the ACE genotypes (I = insertion and D = deletion) among asthmatics and controls were compared: asthmatics showed a 40.2% prevalence of the DD genotype (n = 39), ID was 45.4% (n = 44), and II was 14.4% (n = 14.4). |
| T9 | 1065-1176 | Sentence | denotes | In the control subjects, the frequency of DD was 18.8% (n = 18), ID was 50% (n = 48) and II was 31.3% (n = 30). |
| T10 | 1177-1278 | Sentence | denotes | The DD ACE genotype was significantly more frequent in asthmatics compared with controls (p < 0.001). |
| T11 | 1279-1419 | Sentence | denotes | Asthmatics with the ID ACE genotype showed a higher frequency of drug allergies, although this was not statistically significant (p = 0.08). |
| T12 | 1420-1608 | Sentence | denotes | Asthmatics with the DD genotype appeared to have a higher incidence of asthmatic episode exacerbations due to viral infections, but again this was not statistically significant (p = 0.08). |
| T13 | 1609-1697 | Sentence | denotes | Patients with mild or moderate-severe asthma had similar frequencies of these mutations. |
| T14 | 1698-1939 | Sentence | denotes | We found a higher frequency of the ACE DD gene mutation in Turkish asthmatic patients compared with non-asthmatics, suggesting that this ACE gene polymorphism may be a risk factor for asthma but does not increase the severity of the disease. |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 6107 | 0-29 | GeneOrGeneProduct | denotes | Angiotensin converting enzyme | NCBIGene:1636 |
| 6108 | 59-68 | DiseaseOrPhenotypicFeature | denotes | asthmatic | MESH:D001249 |
| 6109 | 69-77 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
| 6110 | 79-85 | DiseaseOrPhenotypicFeature | denotes | Asthma | MESH:D001249 |
| 6111 | 99-119 | DiseaseOrPhenotypicFeature | denotes | inflammatory disease | MESH:D007249 |
| 6112 | 226-232 | DiseaseOrPhenotypicFeature | denotes | asthma | MESH:D001249 |
| 6113 | 248-277 | GeneOrGeneProduct | denotes | angiotensin converting enzyme | NCBIGene:1636 |
| 6114 | 279-282 | GeneOrGeneProduct | denotes | ACE | NCBIGene:1636 |
| 6115 | 334-337 | GeneOrGeneProduct | denotes | ACE | NCBIGene:1636 |
| 6116 | 367-376 | DiseaseOrPhenotypicFeature | denotes | asthmatic | MESH:D001249 |
| 6117 | 377-385 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
| 6118 | 472-481 | DiseaseOrPhenotypicFeature | denotes | asthmatic | MESH:D001249 |
| 6119 | 482-490 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
| 6120 | 721-727 | DiseaseOrPhenotypicFeature | denotes | asthma | MESH:D001249 |
| 6121 | 749-756 | DiseaseOrPhenotypicFeature | denotes | atopism | MESH:C566404 |
| 6122 | 795-803 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
| 6123 | 855-858 | GeneOrGeneProduct | denotes | ACE | NCBIGene:1636 |
| 6124 | 908-918 | DiseaseOrPhenotypicFeature | denotes | asthmatics | MESH:D001249 |
| 6125 | 947-957 | DiseaseOrPhenotypicFeature | denotes | asthmatics | MESH:D001249 |
| 6126 | 1184-1187 | GeneOrGeneProduct | denotes | ACE | NCBIGene:1636 |
| 6127 | 1232-1242 | DiseaseOrPhenotypicFeature | denotes | asthmatics | MESH:D001249 |
| 6128 | 1279-1289 | DiseaseOrPhenotypicFeature | denotes | Asthmatics | MESH:D001249 |
| 6129 | 1302-1305 | GeneOrGeneProduct | denotes | ACE | NCBIGene:1636 |
| 6130 | 1344-1358 | DiseaseOrPhenotypicFeature | denotes | drug allergies | MESH:D004342 |
| 6131 | 1420-1430 | DiseaseOrPhenotypicFeature | denotes | Asthmatics | MESH:D001249 |
| 6132 | 1491-1500 | DiseaseOrPhenotypicFeature | denotes | asthmatic | MESH:D001249 |
| 6133 | 1530-1546 | DiseaseOrPhenotypicFeature | denotes | viral infections | MESH:D001102 |
| 6134 | 1609-1617 | OrganismTaxon | denotes | Patients | NCBITaxon:9606 |
| 6135 | 1647-1653 | DiseaseOrPhenotypicFeature | denotes | asthma | MESH:D001249 |
| 6136 | 1733-1736 | GeneOrGeneProduct | denotes | ACE | NCBIGene:1636 |
| 6137 | 1765-1774 | DiseaseOrPhenotypicFeature | denotes | asthmatic | MESH:D001249 |
| 6138 | 1775-1783 | OrganismTaxon | denotes | patients | NCBITaxon:9606 |
| 6139 | 1802-1812 | DiseaseOrPhenotypicFeature | denotes | asthmatics | MESH:D001249 |
| 6140 | 1835-1838 | GeneOrGeneProduct | denotes | ACE | NCBIGene:1636 |
| 6141 | 1882-1888 | DiseaseOrPhenotypicFeature | denotes | asthma | MESH:D001249 |
LitCoin_Mondo
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 79-85 | DiseaseOrPhenotypicFeature | denotes | Asthma | 0004979 |
| T2 | 99-119 | DiseaseOrPhenotypicFeature | denotes | inflammatory disease | 0021166 |
| T3 | 226-232 | DiseaseOrPhenotypicFeature | denotes | asthma | 0004979 |
| T4 | 636-645 | DiseaseOrPhenotypicFeature | denotes | completed | 0700063 |
| T5 | 721-727 | DiseaseOrPhenotypicFeature | denotes | asthma | 0004979 |
| T6 | 1344-1358 | DiseaseOrPhenotypicFeature | denotes | drug allergies | 0000775 |
| T7 | 1647-1653 | DiseaseOrPhenotypicFeature | denotes | asthma | 0004979 |
| T8 | 1882-1888 | DiseaseOrPhenotypicFeature | denotes | asthma | 0004979 |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-29 | GeneOrGeneProduct | denotes | Angiotensin converting enzyme |
| T2 | 59-68 | GeneOrGeneProduct | denotes | asthmatic |
| T3 | 248-277 | GeneOrGeneProduct | denotes | angiotensin converting enzyme |
| T4 | 279-282 | GeneOrGeneProduct | denotes | ACE |
| T5 | 318-327 | GeneOrGeneProduct | denotes | frequency |
| T6 | 334-337 | GeneOrGeneProduct | denotes | ACE |
| T7 | 367-376 | GeneOrGeneProduct | denotes | asthmatic |
| T8 | 393-402 | GeneOrGeneProduct | denotes | determine |
| T9 | 407-413 | GeneOrGeneProduct | denotes | impact |
| T10 | 472-481 | GeneOrGeneProduct | denotes | asthmatic |
| T11 | 492-498 | GeneOrGeneProduct | denotes | M/F 25 |
| T12 | 522-527 | GeneOrGeneProduct | denotes | years |
| T13 | 584-589 | GeneOrGeneProduct | denotes | years |
| T14 | 619-622 | GeneOrGeneProduct | denotes | all |
| T15 | 700-707 | GeneOrGeneProduct | denotes | factors |
| T16 | 791-794 | GeneOrGeneProduct | denotes | all |
| T17 | 838-847 | GeneOrGeneProduct | denotes | frequency |
| T18 | 855-858 | GeneOrGeneProduct | denotes | ACE |
| T19 | 908-918 | GeneOrGeneProduct | denotes | asthmatics |
| T20 | 947-957 | GeneOrGeneProduct | denotes | asthmatics |
| T21 | 1027-1033 | GeneOrGeneProduct | denotes | n = 44 |
| T22 | 1040-1042 | GeneOrGeneProduct | denotes | II |
| T23 | 1094-1103 | GeneOrGeneProduct | denotes | frequency |
| T24 | 1154-1156 | GeneOrGeneProduct | denotes | II |
| T25 | 1168-1174 | GeneOrGeneProduct | denotes | n = 30 |
| T26 | 1184-1187 | GeneOrGeneProduct | denotes | ACE |
| T27 | 1232-1242 | GeneOrGeneProduct | denotes | asthmatics |
| T28 | 1279-1289 | GeneOrGeneProduct | denotes | Asthmatics |
| T29 | 1302-1305 | GeneOrGeneProduct | denotes | ACE |
| T30 | 1331-1340 | GeneOrGeneProduct | denotes | frequency |
| T31 | 1420-1430 | GeneOrGeneProduct | denotes | Asthmatics |
| T32 | 1491-1500 | GeneOrGeneProduct | denotes | asthmatic |
| T33 | 1658-1665 | GeneOrGeneProduct | denotes | similar |
| T34 | 1666-1677 | GeneOrGeneProduct | denotes | frequencies |
| T35 | 1687-1696 | GeneOrGeneProduct | denotes | mutations |
| T36 | 1716-1725 | GeneOrGeneProduct | denotes | frequency |
| T37 | 1733-1736 | GeneOrGeneProduct | denotes | ACE |
| T38 | 1745-1753 | GeneOrGeneProduct | denotes | mutation |
| T39 | 1765-1774 | GeneOrGeneProduct | denotes | asthmatic |
| T40 | 1802-1812 | GeneOrGeneProduct | denotes | asthmatics |
| T41 | 1835-1838 | GeneOrGeneProduct | denotes | ACE |
| T42 | 1857-1865 | GeneOrGeneProduct | denotes | may be a |
| T43 | 1871-1877 | GeneOrGeneProduct | denotes | factor |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-29 | GeneOrGeneProduct | denotes | Angiotensin converting enzyme |
| T2 | 59-68 | GeneOrGeneProduct | denotes | asthmatic |
| T3 | 248-277 | GeneOrGeneProduct | denotes | angiotensin converting enzyme |
| T4 | 279-282 | GeneOrGeneProduct | denotes | ACE |
| T5 | 318-327 | GeneOrGeneProduct | denotes | frequency |
| T6 | 334-337 | GeneOrGeneProduct | denotes | ACE |
| T7 | 367-376 | GeneOrGeneProduct | denotes | asthmatic |
| T8 | 407-413 | GeneOrGeneProduct | denotes | impact |
| T9 | 472-481 | GeneOrGeneProduct | denotes | asthmatic |
| T10 | 838-847 | GeneOrGeneProduct | denotes | frequency |
| T11 | 855-858 | GeneOrGeneProduct | denotes | ACE |
| T12 | 908-918 | GeneOrGeneProduct | denotes | asthmatics |
| T13 | 947-957 | GeneOrGeneProduct | denotes | asthmatics |
| T14 | 1094-1103 | GeneOrGeneProduct | denotes | frequency |
| T15 | 1184-1187 | GeneOrGeneProduct | denotes | ACE |
| T16 | 1232-1242 | GeneOrGeneProduct | denotes | asthmatics |
| T17 | 1302-1305 | GeneOrGeneProduct | denotes | ACE |
| T18 | 1331-1340 | GeneOrGeneProduct | denotes | frequency |
| T19 | 1491-1500 | GeneOrGeneProduct | denotes | asthmatic |
| T20 | 1658-1665 | GeneOrGeneProduct | denotes | similar |
| T21 | 1716-1725 | GeneOrGeneProduct | denotes | frequency |
| T22 | 1733-1736 | GeneOrGeneProduct | denotes | ACE |
| T23 | 1765-1774 | GeneOrGeneProduct | denotes | asthmatic |
| T24 | 1802-1812 | GeneOrGeneProduct | denotes | asthmatics |
| T25 | 1835-1838 | GeneOrGeneProduct | denotes | ACE |
| T26 | 1871-1877 | GeneOrGeneProduct | denotes | factor |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 79-85 | DiseaseOrPhenotypicFeature | denotes | Asthma | D001249 |
| T2 | 99-111 | DiseaseOrPhenotypicFeature | denotes | inflammatory | DISEASE |
| T3 | 112-119 | DiseaseOrPhenotypicFeature | denotes | disease | D004194 |
| T4 | 226-232 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 |
| T5 | 441-448 | DiseaseOrPhenotypicFeature | denotes | disease | D004194 |
| T6 | 721-727 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 |
| T7 | 1344-1358 | DiseaseOrPhenotypicFeature | denotes | drug allergies | D004342 |
| T8 | 1530-1546 | DiseaseOrPhenotypicFeature | denotes | viral infections | D014777 |
| T9 | 1647-1653 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 |
| T10 | 1882-1888 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 |
| T11 | 1931-1938 | DiseaseOrPhenotypicFeature | denotes | disease | D004194 |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 99-119 | DiseaseOrPhenotypicFeature | denotes | inflammatory disease | 0021166 |
| T2 | 226-232 | DiseaseOrPhenotypicFeature | denotes | asthma | 0004979 |
| T3 | 721-727 | DiseaseOrPhenotypicFeature | denotes | asthma | 0004979 |
| T4 | 991-993 | DiseaseOrPhenotypicFeature | denotes | DD | 0015613|0009107 |
| T6 | 1107-1109 | DiseaseOrPhenotypicFeature | denotes | DD | 0015613|0009107 |
| T8 | 1181-1183 | DiseaseOrPhenotypicFeature | denotes | DD | 0015613|0009107 |
| T10 | 1440-1442 | DiseaseOrPhenotypicFeature | denotes | DD | 0015613|0009107 |
| T12 | 1530-1546 | DiseaseOrPhenotypicFeature | denotes | viral infections | 0005108 |
| T13 | 1647-1653 | DiseaseOrPhenotypicFeature | denotes | asthma | 0004979 |
| T14 | 1737-1739 | DiseaseOrPhenotypicFeature | denotes | DD | 0015613|0009107 |
| T16 | 1882-1888 | DiseaseOrPhenotypicFeature | denotes | asthma | 0004979 |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 69-77 | OrganismTaxon | denotes | patients |
| T2 | 377-385 | OrganismTaxon | denotes | patients |
| T3 | 482-490 | OrganismTaxon | denotes | patients |
| T4 | 795-803 | OrganismTaxon | denotes | patients |
| T5 | 1775-1783 | OrganismTaxon | denotes | patients |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 59-68 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE |
| T2 | 79-85 | DiseaseOrPhenotypicFeature | denotes | Asthma | D001249 |
| T3 | 99-111 | DiseaseOrPhenotypicFeature | denotes | inflammatory | DISEASE |
| T4 | 112-119 | DiseaseOrPhenotypicFeature | denotes | disease | D004194 |
| T5 | 226-232 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 |
| T6 | 367-376 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE |
| T7 | 441-448 | DiseaseOrPhenotypicFeature | denotes | disease | D004194 |
| T8 | 472-481 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE |
| T9 | 721-727 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 |
| T10 | 749-756 | DiseaseOrPhenotypicFeature | denotes | atopism | DISEASE |
| T11 | 908-918 | DiseaseOrPhenotypicFeature | denotes | asthmatics | DISEASE |
| T12 | 947-957 | DiseaseOrPhenotypicFeature | denotes | asthmatics | DISEASE |
| T13 | 1232-1242 | DiseaseOrPhenotypicFeature | denotes | asthmatics | DISEASE |
| T14 | 1279-1289 | DiseaseOrPhenotypicFeature | denotes | Asthmatics | DISEASE |
| T15 | 1344-1358 | DiseaseOrPhenotypicFeature | denotes | drug allergies | D004342 |
| T16 | 1420-1430 | DiseaseOrPhenotypicFeature | denotes | Asthmatics | DISEASE |
| T17 | 1491-1500 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE |
| T18 | 1530-1546 | DiseaseOrPhenotypicFeature | denotes | viral infections | D014777 |
| T19 | 1647-1653 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 |
| T20 | 1765-1774 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE |
| T21 | 1802-1812 | DiseaseOrPhenotypicFeature | denotes | asthmatics | DISEASE |
| T22 | 1882-1888 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 |
| T23 | 1931-1938 | DiseaseOrPhenotypicFeature | denotes | disease | D004194 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 59-68 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE |
| T2 | 79-85 | DiseaseOrPhenotypicFeature | denotes | Asthma | D001249 |
| T3 | 226-232 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 |
| T4 | 367-376 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE |
| T5 | 472-481 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE |
| T6 | 721-727 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 |
| T7 | 749-756 | DiseaseOrPhenotypicFeature | denotes | atopism | DISEASE |
| T8 | 908-918 | DiseaseOrPhenotypicFeature | denotes | asthmatics | DISEASE |
| T9 | 947-957 | DiseaseOrPhenotypicFeature | denotes | asthmatics | DISEASE |
| T10 | 1232-1242 | DiseaseOrPhenotypicFeature | denotes | asthmatics | DISEASE |
| T11 | 1279-1289 | DiseaseOrPhenotypicFeature | denotes | Asthmatics | DISEASE |
| T12 | 1344-1358 | DiseaseOrPhenotypicFeature | denotes | drug allergies | D004342 |
| T13 | 1420-1430 | DiseaseOrPhenotypicFeature | denotes | Asthmatics | DISEASE |
| T14 | 1491-1500 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE |
| T15 | 1530-1546 | DiseaseOrPhenotypicFeature | denotes | viral infections | D014777 |
| T16 | 1647-1653 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 |
| T17 | 1765-1774 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE |
| T18 | 1802-1812 | DiseaseOrPhenotypicFeature | denotes | asthmatics | DISEASE |
| T19 | 1882-1888 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 0-29 | ChemicalEntity | denotes | Angiotensin converting enzyme | D007703 |
| T2 | 248-277 | ChemicalEntity | denotes | angiotensin converting enzyme | D007703 |
| T3 | 279-282 | ChemicalEntity | denotes | ACE | D007703 |
| T4 | 334-337 | ChemicalEntity | denotes | ACE | D007703 |
| T5 | 855-858 | ChemicalEntity | denotes | ACE | D007703 |
| T6 | 1168-1174 | ChemicalEntity | denotes | n = 30 | C054475 |
| T7 | 1184-1187 | ChemicalEntity | denotes | ACE | D007703 |
| T8 | 1302-1305 | ChemicalEntity | denotes | ACE | D007703 |
| T9 | 1733-1736 | ChemicalEntity | denotes | ACE | D007703 |
| T10 | 1835-1838 | ChemicalEntity | denotes | ACE | D007703 |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
|---|---|---|---|---|---|---|
| T10 | 1835-1838 | ChemicalEntity | denotes | ACE | D007703 | |
| T9 | 1733-1736 | ChemicalEntity | denotes | ACE | D007703 | |
| T8 | 1302-1305 | ChemicalEntity | denotes | ACE | D007703 | |
| T7 | 1184-1187 | ChemicalEntity | denotes | ACE | D007703 | |
| T6 | 1168-1174 | ChemicalEntity | denotes | n = 30 | C054475 | |
| T5 | 855-858 | ChemicalEntity | denotes | ACE | D007703 | |
| T4 | 334-337 | ChemicalEntity | denotes | ACE | D007703 | |
| T3 | 279-282 | ChemicalEntity | denotes | ACE | D007703 | |
| T2 | 248-277 | ChemicalEntity | denotes | angiotensin converting enzyme | D007703 | |
| T1 | 0-29 | ChemicalEntity | denotes | Angiotensin converting enzyme | D007703 | |
| T19 | 1882-1888 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 | |
| T18 | 1802-1812 | DiseaseOrPhenotypicFeature | denotes | asthmatics | DISEASE | |
| T17 | 1765-1774 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE | |
| T16 | 1647-1653 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 | |
| T15 | 1530-1546 | DiseaseOrPhenotypicFeature | denotes | viral infections | D014777 | |
| T14 | 1491-1500 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE | |
| T13 | 1420-1430 | DiseaseOrPhenotypicFeature | denotes | Asthmatics | DISEASE | |
| T12 | 1344-1358 | DiseaseOrPhenotypicFeature | denotes | drug allergies | D004342 | |
| T11 | 1279-1289 | DiseaseOrPhenotypicFeature | denotes | Asthmatics | DISEASE | |
| T39569 | 1232-1242 | DiseaseOrPhenotypicFeature | denotes | asthmatics | DISEASE | |
| T31590 | 947-957 | DiseaseOrPhenotypicFeature | denotes | asthmatics | DISEASE | |
| T87303 | 908-918 | DiseaseOrPhenotypicFeature | denotes | asthmatics | DISEASE | |
| T77096 | 749-756 | DiseaseOrPhenotypicFeature | denotes | atopism | DISEASE | |
| T25510 | 721-727 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 | |
| T53245 | 472-481 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE | |
| T74201 | 367-376 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE | |
| T44052 | 226-232 | DiseaseOrPhenotypicFeature | denotes | asthma | D001249 | |
| T36300 | 79-85 | DiseaseOrPhenotypicFeature | denotes | Asthma | D001249 | |
| T53312 | 59-68 | DiseaseOrPhenotypicFeature | denotes | asthmatic | DISEASE | |
| T79892 | 1775-1783 | OrganismTaxon | denotes | patients | ||
| T38976 | 795-803 | OrganismTaxon | denotes | patients | ||
| T25720 | 482-490 | OrganismTaxon | denotes | patients | ||
| T5012 | 377-385 | OrganismTaxon | denotes | patients | ||
| T58333 | 69-77 | OrganismTaxon | denotes | patients |
Inflammaging
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-78 | Sentence | denotes | Angiotensin converting enzyme gene polymorphism in Turkish asthmatic patients. |
| T2 | 79-135 | Sentence | denotes | Asthma is a chronic inflammatory disease of the airways. |
| T3 | 136-289 | Sentence | denotes | Several candidate genes have been identified with a potential role in the pathogenesis of asthma, including the angiotensin converting enzyme (ACE) gene. |
| T4 | 290-458 | Sentence | denotes | We aimed to investigate the frequency of an ACE gene polymorphism in Turkish asthmatic patients and to determine its impact on clinical parameters and disease severity. |
| T5 | 459-605 | Sentence | denotes | Ninety-seven asthmatic patients (M/F 25/72, mean age 39 +/- 13 years) and 96 healthy subjects (M/F 26/70, mean age 38 +/- 12 years) were included. |
| T6 | 606-757 | Sentence | denotes | At baseline, all participants completed a questionnaire on demographics, symptoms, triggering factors, severity of asthma, and the presence of atopism. |
| T7 | 758-833 | Sentence | denotes | Blood samples were obtained from all patients and genomic DNA was isolated. |
| T8 | 834-1064 | Sentence | denotes | The frequency of the ACE genotypes (I = insertion and D = deletion) among asthmatics and controls were compared: asthmatics showed a 40.2% prevalence of the DD genotype (n = 39), ID was 45.4% (n = 44), and II was 14.4% (n = 14.4). |
| T9 | 1065-1176 | Sentence | denotes | In the control subjects, the frequency of DD was 18.8% (n = 18), ID was 50% (n = 48) and II was 31.3% (n = 30). |
| T10 | 1177-1278 | Sentence | denotes | The DD ACE genotype was significantly more frequent in asthmatics compared with controls (p < 0.001). |
| T11 | 1279-1419 | Sentence | denotes | Asthmatics with the ID ACE genotype showed a higher frequency of drug allergies, although this was not statistically significant (p = 0.08). |
| T12 | 1420-1608 | Sentence | denotes | Asthmatics with the DD genotype appeared to have a higher incidence of asthmatic episode exacerbations due to viral infections, but again this was not statistically significant (p = 0.08). |
| T13 | 1609-1697 | Sentence | denotes | Patients with mild or moderate-severe asthma had similar frequencies of these mutations. |
| T14 | 1698-1939 | Sentence | denotes | We found a higher frequency of the ACE DD gene mutation in Turkish asthmatic patients compared with non-asthmatics, suggesting that this ACE gene polymorphism may be a risk factor for asthma but does not increase the severity of the disease. |
| T1 | 0-78 | Sentence | denotes | Angiotensin converting enzyme gene polymorphism in Turkish asthmatic patients. |
| T2 | 79-135 | Sentence | denotes | Asthma is a chronic inflammatory disease of the airways. |
| T3 | 136-289 | Sentence | denotes | Several candidate genes have been identified with a potential role in the pathogenesis of asthma, including the angiotensin converting enzyme (ACE) gene. |
| T4 | 290-458 | Sentence | denotes | We aimed to investigate the frequency of an ACE gene polymorphism in Turkish asthmatic patients and to determine its impact on clinical parameters and disease severity. |
| T5 | 459-605 | Sentence | denotes | Ninety-seven asthmatic patients (M/F 25/72, mean age 39 +/- 13 years) and 96 healthy subjects (M/F 26/70, mean age 38 +/- 12 years) were included. |
| T6 | 606-757 | Sentence | denotes | At baseline, all participants completed a questionnaire on demographics, symptoms, triggering factors, severity of asthma, and the presence of atopism. |
| T7 | 758-833 | Sentence | denotes | Blood samples were obtained from all patients and genomic DNA was isolated. |
| T8 | 834-1064 | Sentence | denotes | The frequency of the ACE genotypes (I = insertion and D = deletion) among asthmatics and controls were compared: asthmatics showed a 40.2% prevalence of the DD genotype (n = 39), ID was 45.4% (n = 44), and II was 14.4% (n = 14.4). |
| T9 | 1065-1176 | Sentence | denotes | In the control subjects, the frequency of DD was 18.8% (n = 18), ID was 50% (n = 48) and II was 31.3% (n = 30). |
| T10 | 1177-1278 | Sentence | denotes | The DD ACE genotype was significantly more frequent in asthmatics compared with controls (p < 0.001). |
| T11 | 1279-1419 | Sentence | denotes | Asthmatics with the ID ACE genotype showed a higher frequency of drug allergies, although this was not statistically significant (p = 0.08). |
| T12 | 1420-1608 | Sentence | denotes | Asthmatics with the DD genotype appeared to have a higher incidence of asthmatic episode exacerbations due to viral infections, but again this was not statistically significant (p = 0.08). |
| T13 | 1609-1697 | Sentence | denotes | Patients with mild or moderate-severe asthma had similar frequencies of these mutations. |
| T14 | 1698-1939 | Sentence | denotes | We found a higher frequency of the ACE DD gene mutation in Turkish asthmatic patients compared with non-asthmatics, suggesting that this ACE gene polymorphism may be a risk factor for asthma but does not increase the severity of the disease. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 279-282 | gene:1636 | denotes | ACE |
| T1 | 226-232 | disease:C0004096 | denotes | asthma |
| T2 | 855-858 | gene:1636 | denotes | ACE |
| T3 | 908-918 | disease:C0004096 | denotes | asthmatics |
| T4 | 855-858 | gene:1636 | denotes | ACE |
| T5 | 947-957 | disease:C0004096 | denotes | asthmatics |
| T6 | 1184-1187 | gene:1636 | denotes | ACE |
| T7 | 1232-1242 | disease:C0004096 | denotes | asthmatics |
| R1 | T0 | T1 | associated_with | ACE,asthma |
| R2 | T2 | T3 | associated_with | ACE,asthmatics |
| R3 | T4 | T5 | associated_with | ACE,asthmatics |
| R4 | T6 | T7 | associated_with | ACE,asthmatics |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 19484664-10#23#26#gene1636 | 1302-1305 | gene1636 | denotes | ACE |
| 19484664-10#65#79#diseaseC0013182 | 1344-1358 | diseaseC0013182 | denotes | drug allergies |
| 23#26#gene163665#79#diseaseC0013182 | 19484664-10#23#26#gene1636 | 19484664-10#65#79#diseaseC0013182 | associated_with | ACE,drug allergies |