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PubMed:1946356 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 29-45 DiseaseOrPhenotypicFeature denotes immunodeficiency 0021094
T2 158-161 DiseaseOrPhenotypicFeature denotes can 0012833
T3 238-254 DiseaseOrPhenotypicFeature denotes immunodeficiency 0021094
T4 290-293 DiseaseOrPhenotypicFeature denotes can 0012833
T5 1518-1521 DiseaseOrPhenotypicFeature denotes can 0012833

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 96-102 protein denotes 65-kDa
T2 108-131 protein denotes 50-kDa NF-kappa B dimer
T3 414-425 cell_line denotes THP-1 cells
T4 481-508 protein denotes DNA-protein binding complex
T5 528-551 DNA denotes HIV-1 promoter-enhancer
T6 582-591 RNA denotes viral RNA
T7 649-666 DNA denotes NF-kappa B region
T8 674-688 DNA denotes HIV-1 enhancer
T9 694-735 protein denotes 65-kDa plus 50-kDa NF-kappa B heterodimer
T10 777-795 protein denotes NF-kappa B protein
T11 995-1006 protein denotes heterodimer
T12 1051-1061 protein denotes NF-kappa B
T13 1218-1228 protein denotes NF-kappa B
T14 1262-1289 protein denotes NF-kappa B binding proteins
T15 1335-1354 protein denotes heterodimer complex
T16 1377-1405 protein denotes NF-kappa B-binding complexes
T17 1465-1471 protein denotes 65-kDa
T18 1477-1495 protein denotes 50-kDa heterodimer
T19 1503-1517 DNA denotes HIV-1 enhancer
T20 1549-1558 cell_type denotes monocytes
T21 1596-1606 DNA denotes HIV-1 gene

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-132 Sentence denotes Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer.
S2 133-338 Sentence denotes Although monocytic cells can provide a reservoir for viral production in vivo, their regulation of human immunodeficiency virus type 1 (HIV-1) transcription can be either latent, restricted, or productive.
S3 339-410 Sentence denotes These differences in gene expression have not been molecularly defined.
S4 411-603 Sentence denotes In THP-1 cells with restricted HIV expression, there is an absence of DNA-protein binding complex formation with the HIV-1 promoter-enhancer associated with markedly less viral RNA production.
S5 604-760 Sentence denotes This absence of binding was localized to the NF-kappa B region of the HIV-1 enhancer; the 65-kDa plus 50-kDa NF-kappa B heterodimer was preferentially lost.
S6 761-885 Sentence denotes Adding purified NF-kappa B protein to nuclear extracts from cells with restricted expression overcomes this lack of binding.
S7 886-1071 Sentence denotes In addition, treatment of these nuclear extracts with sodium deoxycholate restored their ability to form the heterodimer, suggesting the presence of an inhibitor of NF-kappa B activity.
S8 1072-1238 Sentence denotes Furthermore, treatment of nuclear extracts from these cells that had restricted expression with lipopolysaccharide increased viral production and NF-kappa B activity.
S9 1239-1365 Sentence denotes Antiserum specific for NF-kappa B binding proteins, but not c-rel-specific antiserum, disrupted heterodimer complex formation.
S10 1366-1449 Sentence denotes Thus, both NF-kappa B-binding complexes are needed for optimal viral transcription.
S11 1450-1618 Sentence denotes Binding of the 65-kDa plus 50-kDa heterodimer to the HIV-1 enhancer can be negatively regulated in monocytes, providing one mechanism restricting HIV-1 gene expression.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 23-58 NP denotes human immunodeficiency virus type 1
C1 23-69 NP denotes human immunodeficiency virus type 1 expression
C3 73-82 NP denotes monocytes
C4 92-131 NP denotes the 65-kDa plus 50-kDa NF-kappa B dimer
C5 142-157 NP denotes monocytic cells
C6 186-210 NP denotes viral production in vivo
C7 212-217 NP denotes their
C9 232-275 NP denotes human immunodeficiency virus type 1 (HIV-1)
C8 232-289 NP denotes human immunodeficiency virus type 1 (HIV-1) transcription
C12 442-445 NP denotes HIV
C11 431-456 NP denotes restricted HIV expression
C10 414-456 NP denotes THP-1 cells with restricted HIV expression
C14 528-533 NP denotes HIV-1
C13 524-551 NP denotes the HIV-1 promoter-enhancer
C15 582-602 NP denotes viral RNA production
C17 674-679 NP denotes HIV-1
C16 670-688 NP denotes the HIV-1 enhancer
C18 690-735 NP denotes the 65-kDa plus 50-kDa NF-kappa B heterodimer
C19 799-815 NP denotes nuclear extracts
C20 821-853 NP denotes cells with restricted expression
C21 912-934 NP denotes these nuclear extracts
C22 969-974 NP denotes their
C23 991-1006 NP denotes the heterodimer
C24 1051-1070 NP denotes NF-kappa B activity
C25 1098-1114 NP denotes nuclear extracts
C27 1120-1131 NP denotes these cells
C28 1132-1136 NP denotes that
C26 1120-1162 NP denotes these cells that had restricted expression
C29 1197-1213 NP denotes viral production
C30 1218-1237 NP denotes NF-kappa B activity
C31 1461-1495 NP denotes the 65-kDa plus 50-kDa heterodimer
C33 1503-1508 NP denotes HIV-1
C32 1499-1517 NP denotes the HIV-1 enhancer
C34 1549-1558 NP denotes monocytes
C36 1596-1601 NP denotes HIV-1
C35 1596-1617 NP denotes HIV-1 gene expression
R1 C5 C3 coref-ident monocytic cells,monocytes
R2 C7 C5 coref-pron their,monocytic cells
R3 C9 C2 coref-ident human immunodeficiency virus type 1 (HIV-1),human immunodeficiency virus type 1
R4 C8 C1 coref-other human immunodeficiency virus type 1 (HIV-1) transcription,human immunodeficiency virus type 1 expression
R5 C12 C9 coref-ident HIV,human immunodeficiency virus type 1 (HIV-1)
R6 C11 C1 coref-other restricted HIV expression,human immunodeficiency virus type 1 expression
R7 C14 C12 coref-ident HIV-1,HIV
R8 C15 C6 coref-other viral RNA production,viral production in vivo
R9 C17 C14 coref-ident HIV-1,HIV-1
R10 C16 C13 coref-ident the HIV-1 enhancer,the HIV-1 promoter-enhancer
R11 C18 C4 coref-ident the 65-kDa plus 50-kDa NF-kappa B heterodimer,the 65-kDa plus 50-kDa NF-kappa B dimer
R12 C20 C10 coref-ident cells with restricted expression,THP-1 cells with restricted HIV expression
R13 C21 C19 coref-ident these nuclear extracts,nuclear extracts
R14 C22 C21 coref-pron their,these nuclear extracts
R15 C23 C18 coref-ident the heterodimer,the 65-kDa plus 50-kDa NF-kappa B heterodimer
R16 C25 C21 coref-ident nuclear extracts,these nuclear extracts
R17 C28 C27 coref-relat that,these cells
R18 C26 C20 coref-ident these cells that had restricted expression,cells with restricted expression
R19 C29 C6 coref-ident viral production,viral production in vivo
R20 C30 C24 coref-ident NF-kappa B activity,NF-kappa B activity
R21 C31 C23 coref-ident the 65-kDa plus 50-kDa heterodimer,the heterodimer
R22 C33 C17 coref-ident HIV-1,HIV-1
R23 C32 C16 coref-ident the HIV-1 enhancer,the HIV-1 enhancer
R24 C34 C5 coref-ident monocytes,monocytic cells
R25 C36 C33 coref-ident HIV-1,HIV-1
R26 C35 C1 coref-ident HIV-1 gene expression,human immunodeficiency virus type 1 expression

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-19 other_name denotes Negative regulation
T2 23-58 virus denotes human immunodeficiency virus type 1
T3 96-102 protein_subunit denotes 65-kDa
T4 108-114 protein_complex denotes 50-kDa
T5 115-125 protein_molecule denotes NF-kappa B
T6 232-267 virus denotes human immunodeficiency virus type 1
T7 269-274 virus denotes HIV-1
T8 414-425 cell_line denotes THP-1 cells
T9 442-456 other_name denotes HIV expression
T10 481-508 protein_complex denotes DNA-protein binding complex
T11 528-533 virus denotes HIV-1
T12 582-591 RNA_family_or_group denotes viral RNA
T13 649-659 protein_molecule denotes NF-kappa B
T14 674-679 virus denotes HIV-1
T15 694-712 protein_complex denotes 65-kDa plus 50-kDa
T16 713-723 protein_molecule denotes NF-kappa B
T17 777-787 protein_molecule denotes NF-kappa B
T18 799-815 cell_component denotes nuclear extracts
T19 832-853 other_name denotes restricted expression
T20 918-934 cell_component denotes nuclear extracts
T21 940-959 other_organic_compound denotes sodium deoxycholate
T22 995-1006 protein_complex denotes heterodimer
T23 1051-1061 protein_molecule denotes NF-kappa B
T24 1098-1114 cell_component denotes nuclear extracts
T25 1141-1162 other_name denotes restricted expression
T26 1168-1186 lipid denotes lipopolysaccharide
T27 1218-1228 protein_molecule denotes NF-kappa B
T28 1262-1272 protein_molecule denotes NF-kappa B
T29 1299-1323 other_organic_compound denotes c-rel-specific antiserum
T30 1335-1354 protein_complex denotes heterodimer complex
T31 1377-1387 protein_molecule denotes NF-kappa B
T32 1421-1448 other_name denotes optimal viral transcription
T33 1465-1471 protein_subunit denotes 65-kDa
T34 1477-1495 protein_complex denotes 50-kDa heterodimer
T35 1503-1508 virus denotes HIV-1
T36 1549-1558 cell_type denotes monocytes
T37 1596-1601 virus denotes HIV-1