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sentences

Id Subject Object Predicate Lexical cue
T1 0-110 Sentence denotes Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
T2 111-246 Sentence denotes Mouse models have shown the importance of acidic mammalian chitinase activity in settings of chitin exposure and allergic inflammation.
T3 247-357 Sentence denotes However, little is known regarding genetic regulation of AMCase enzymatic activity in human allergic diseases.
T4 358-593 Sentence denotes Resequencing the AMCase gene exons we identified 8 non-synonymous single nucleotide polymorphisms including three novel variants (A290G, G296A, G339T) near the gene area coding for the enzyme active site, all in linkage disequilibrium.
T5 594-765 Sentence denotes AMCase protein isoforms, encoded by two gene-wide haplotypes, and differentiated by these three single nucleotide polymorphisms, were recombinantly expressed and purified.
T6 766-954 Sentence denotes Biochemical analysis revealed the isoform encoded by the variant haplotype displayed a distinct pH profile exhibiting greater retention of chitinase activity at acidic and basic pH values.
T7 955-1167 Sentence denotes Determination of absolute kinetic activity found the variant isoform encoded by the variant haplotype was 4-, 2.5-, and 10-fold more active than the wild type AMCase isoform at pH 2.2, 4.6, and 7.0, respectively.
T8 1168-1298 Sentence denotes Modeling of the AMCase isoforms revealed positional changes in amino acids critical for both pH specificity and substrate binding.
T9 1299-1461 Sentence denotes Genetic association analyses of AMCase haplotypes for asthma revealed significant protective associations between the variant haplotype in several asthma cohorts.
T10 1462-1663 Sentence denotes The structural, kinetic, and genetic data regarding the AMCase isoforms are consistent with the Th2-priming effects of environmental chitin and a role for AMCase in negatively regulating this stimulus.

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 224-232 DiseaseOrPhenotypicFeature denotes allergic 0004980
T2 339-356 DiseaseOrPhenotypicFeature denotes allergic diseases 0005271
T3 1353-1359 DiseaseOrPhenotypicFeature denotes asthma 0004979
T4 1446-1452 DiseaseOrPhenotypicFeature denotes asthma 0004979

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-110 Sentence denotes Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
T2 111-246 Sentence denotes Mouse models have shown the importance of acidic mammalian chitinase activity in settings of chitin exposure and allergic inflammation.
T3 247-357 Sentence denotes However, little is known regarding genetic regulation of AMCase enzymatic activity in human allergic diseases.
T4 358-593 Sentence denotes Resequencing the AMCase gene exons we identified 8 non-synonymous single nucleotide polymorphisms including three novel variants (A290G, G296A, G339T) near the gene area coding for the enzyme active site, all in linkage disequilibrium.
T5 594-765 Sentence denotes AMCase protein isoforms, encoded by two gene-wide haplotypes, and differentiated by these three single nucleotide polymorphisms, were recombinantly expressed and purified.
T6 766-954 Sentence denotes Biochemical analysis revealed the isoform encoded by the variant haplotype displayed a distinct pH profile exhibiting greater retention of chitinase activity at acidic and basic pH values.
T7 955-1167 Sentence denotes Determination of absolute kinetic activity found the variant isoform encoded by the variant haplotype was 4-, 2.5-, and 10-fold more active than the wild type AMCase isoform at pH 2.2, 4.6, and 7.0, respectively.
T8 1168-1298 Sentence denotes Modeling of the AMCase isoforms revealed positional changes in amino acids critical for both pH specificity and substrate binding.
T9 1299-1461 Sentence denotes Genetic association analyses of AMCase haplotypes for asthma revealed significant protective associations between the variant haplotype in several asthma cohorts.
T10 1462-1663 Sentence denotes The structural, kinetic, and genetic data regarding the AMCase isoforms are consistent with the Th2-priming effects of environmental chitin and a role for AMCase in negatively regulating this stimulus.
T1 0-110 Sentence denotes Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
T2 111-246 Sentence denotes Mouse models have shown the importance of acidic mammalian chitinase activity in settings of chitin exposure and allergic inflammation.
T3 247-357 Sentence denotes However, little is known regarding genetic regulation of AMCase enzymatic activity in human allergic diseases.
T4 358-593 Sentence denotes Resequencing the AMCase gene exons we identified 8 non-synonymous single nucleotide polymorphisms including three novel variants (A290G, G296A, G339T) near the gene area coding for the enzyme active site, all in linkage disequilibrium.
T5 594-765 Sentence denotes AMCase protein isoforms, encoded by two gene-wide haplotypes, and differentiated by these three single nucleotide polymorphisms, were recombinantly expressed and purified.
T6 766-954 Sentence denotes Biochemical analysis revealed the isoform encoded by the variant haplotype displayed a distinct pH profile exhibiting greater retention of chitinase activity at acidic and basic pH values.
T7 955-1167 Sentence denotes Determination of absolute kinetic activity found the variant isoform encoded by the variant haplotype was 4-, 2.5-, and 10-fold more active than the wild type AMCase isoform at pH 2.2, 4.6, and 7.0, respectively.
T8 1168-1298 Sentence denotes Modeling of the AMCase isoforms revealed positional changes in amino acids critical for both pH specificity and substrate binding.
T9 1299-1461 Sentence denotes Genetic association analyses of AMCase haplotypes for asthma revealed significant protective associations between the variant haplotype in several asthma cohorts.
T10 1462-1663 Sentence denotes The structural, kinetic, and genetic data regarding the AMCase isoforms are consistent with the Th2-priming effects of environmental chitin and a role for AMCase in negatively regulating this stimulus.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1331-1337 gene:27159 denotes AMCase
T1 1353-1359 disease:C0004096 denotes asthma
T2 1331-1337 gene:27159 denotes AMCase
T3 1446-1452 disease:C0004096 denotes asthma
R1 T0 T1 associated_with AMCase,asthma
R2 T2 T3 associated_with AMCase,asthma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19435888-8#32#38#gene27159 1331-1337 gene27159 denotes AMCase
19435888-8#54#60#diseaseC0004096 1353-1359 diseaseC0004096 denotes asthma
19435888-8#147#153#diseaseC0004096 1446-1452 diseaseC0004096 denotes asthma
32#38#gene2715954#60#diseaseC0004096 19435888-8#32#38#gene27159 19435888-8#54#60#diseaseC0004096 associated_with AMCase,asthma
32#38#gene27159147#153#diseaseC0004096 19435888-8#32#38#gene27159 19435888-8#147#153#diseaseC0004096 associated_with AMCase,asthma

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 204-210 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T2 1595-1601 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1353-1359 Phenotype denotes asthma HP:0002099
T2 1446-1452 Phenotype denotes asthma HP:0002099

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 224-232 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T2 233-245 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T3 339-356 Disease denotes allergic diseases http://purl.obolibrary.org/obo/MONDO_0005271
T4 1353-1359 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T5 1446-1452 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 204-210 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T2 1595-1601 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1353-1359 Phenotype denotes asthma HP:0002099
T2 1446-1452 Phenotype denotes asthma HP:0002099

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 339-356 Disease denotes allergic diseases MONDO:0005271
T2 1353-1359 Disease denotes asthma MONDO:0004979
T3 1446-1452 Disease denotes asthma MONDO:0004979

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 69-74 Organism denotes human 9606
T2 82-91 Organism denotes Mammalian 40674
T3 111-116 Organism denotes Mouse 10088|10090
T5 160-169 Organism denotes mammalian 40674
T6 333-338 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-110 Sentence denotes Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
T2 111-246 Sentence denotes Mouse models have shown the importance of acidic mammalian chitinase activity in settings of chitin exposure and allergic inflammation.
T3 247-357 Sentence denotes However, little is known regarding genetic regulation of AMCase enzymatic activity in human allergic diseases.
T4 358-593 Sentence denotes Resequencing the AMCase gene exons we identified 8 non-synonymous single nucleotide polymorphisms including three novel variants (A290G, G296A, G339T) near the gene area coding for the enzyme active site, all in linkage disequilibrium.
T5 594-765 Sentence denotes AMCase protein isoforms, encoded by two gene-wide haplotypes, and differentiated by these three single nucleotide polymorphisms, were recombinantly expressed and purified.
T6 766-954 Sentence denotes Biochemical analysis revealed the isoform encoded by the variant haplotype displayed a distinct pH profile exhibiting greater retention of chitinase activity at acidic and basic pH values.
T7 955-1167 Sentence denotes Determination of absolute kinetic activity found the variant isoform encoded by the variant haplotype was 4-, 2.5-, and 10-fold more active than the wild type AMCase isoform at pH 2.2, 4.6, and 7.0, respectively.
T8 1168-1298 Sentence denotes Modeling of the AMCase isoforms revealed positional changes in amino acids critical for both pH specificity and substrate binding.
T9 1299-1461 Sentence denotes Genetic association analyses of AMCase haplotypes for asthma revealed significant protective associations between the variant haplotype in several asthma cohorts.
T10 1462-1663 Sentence denotes The structural, kinetic, and genetic data regarding the AMCase isoforms are consistent with the Th2-priming effects of environmental chitin and a role for AMCase in negatively regulating this stimulus.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 69-74 OrganismTaxon denotes human 9606
T2 111-116 OrganismTaxon denotes Mouse 10088|10090
T4 333-338 OrganismTaxon denotes human 9606