PubMed:19394258 / 962-1200 JSONTXT

{"project":"LitCoin-sentences","denotations":[{"id":"T8","span":{"begin":0,"end":238},"obj":"Sentence"}],"text":"In silico analysis of the putative impact of the insertion shows serious clashes in protein conformation: this insertion disrupts the alpha5 helix of the dGK kinase domain, rendering the protein unable to bind purine deoxyribonucleosides."}

{"project":"LitCoin-entities","denotations":[{"id":"6036","span":{"begin":154,"end":157},"obj":"GeneOrGeneProduct"},{"id":"6037","span":{"begin":217,"end":237},"obj":"ChemicalEntity"}],"attributes":[{"id":"A17","pred":"db_id","subj":"6036","obj":"NCBIGene:1716"},{"id":"A18","pred":"db_id","subj":"6037","obj":"MESH:D003853"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"In silico analysis of the putative impact of the insertion shows serious clashes in protein conformation: this insertion disrupts the alpha5 helix of the dGK kinase domain, rendering the protein unable to bind purine deoxyribonucleosides."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T30","span":{"begin":26,"end":34},"obj":"GeneOrGeneProduct"},{"id":"T31","span":{"begin":35,"end":41},"obj":"GeneOrGeneProduct"},{"id":"T32","span":{"begin":84,"end":91},"obj":"GeneOrGeneProduct"},{"id":"T33","span":{"begin":121,"end":129},"obj":"GeneOrGeneProduct"},{"id":"T34","span":{"begin":134,"end":140},"obj":"GeneOrGeneProduct"},{"id":"T35","span":{"begin":141,"end":146},"obj":"GeneOrGeneProduct"},{"id":"T36","span":{"begin":154,"end":157},"obj":"GeneOrGeneProduct"},{"id":"T37","span":{"begin":158,"end":164},"obj":"GeneOrGeneProduct"},{"id":"T38","span":{"begin":187,"end":194},"obj":"GeneOrGeneProduct"},{"id":"T39","span":{"begin":205,"end":209},"obj":"GeneOrGeneProduct"},{"id":"T40","span":{"begin":217,"end":237},"obj":"GeneOrGeneProduct"}],"text":"In silico analysis of the putative impact of the insertion shows serious clashes in protein conformation: this insertion disrupts the alpha5 helix of the dGK kinase domain, rendering the protein unable to bind purine deoxyribonucleosides."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T18","span":{"begin":26,"end":34},"obj":"GeneOrGeneProduct"},{"id":"T19","span":{"begin":35,"end":41},"obj":"GeneOrGeneProduct"},{"id":"T20","span":{"begin":84,"end":91},"obj":"GeneOrGeneProduct"},{"id":"T21","span":{"begin":134,"end":140},"obj":"GeneOrGeneProduct"},{"id":"T22","span":{"begin":141,"end":146},"obj":"GeneOrGeneProduct"},{"id":"T23","span":{"begin":154,"end":157},"obj":"GeneOrGeneProduct"},{"id":"T24","span":{"begin":158,"end":164},"obj":"GeneOrGeneProduct"},{"id":"T25","span":{"begin":187,"end":194},"obj":"GeneOrGeneProduct"},{"id":"T26","span":{"begin":217,"end":237},"obj":"GeneOrGeneProduct"}],"text":"In silico analysis of the putative impact of the insertion shows serious clashes in protein conformation: this insertion disrupts the alpha5 helix of the dGK kinase domain, rendering the protein unable to bind purine deoxyribonucleosides."}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T8","span":{"begin":26,"end":41},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":134,"end":140},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":154,"end":157},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":217,"end":237},"obj":"GeneOrGeneProduct"}],"text":"In silico analysis of the putative impact of the insertion shows serious clashes in protein conformation: this insertion disrupts the alpha5 helix of the dGK kinase domain, rendering the protein unable to bind purine deoxyribonucleosides."}

{"project":"LitCoin-Chemical-MeSH-CHEBI","denotations":[{"id":"T3","span":{"begin":154,"end":157},"obj":"ChemicalEntity"},{"id":"T4","span":{"begin":210,"end":237},"obj":"ChemicalEntity"}],"attributes":[{"id":"A3","pred":"ID:","subj":"T3","obj":"C019165"},{"id":"A4","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_60173"}],"text":"In silico analysis of the putative impact of the insertion shows serious clashes in protein conformation: this insertion disrupts the alpha5 helix of the dGK kinase domain, rendering the protein unable to bind purine deoxyribonucleosides."}

{"project":"LitCoin-training-merged","denotations":[{"id":"T4","span":{"begin":210,"end":237},"obj":"ChemicalEntity"},{"id":"T3","span":{"begin":154,"end":157},"obj":"ChemicalEntity"},{"id":"T11","span":{"begin":217,"end":237},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":154,"end":157},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":134,"end":140},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":26,"end":41},"obj":"GeneOrGeneProduct"}],"attributes":[{"id":"A4","pred":"ID:","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_60173"},{"id":"A3","pred":"ID:","subj":"T3","obj":"C019165"}],"text":"In silico analysis of the putative impact of the insertion shows serious clashes in protein conformation: this insertion disrupts the alpha5 helix of the dGK kinase domain, rendering the protein unable to bind purine deoxyribonucleosides."}