PubMed:1939341
Annnotations
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 823-828 | gene:2353 | denotes | c-fos |
| T1 | 838-854 | disease:C0023470 | denotes | myeloid leukemia |
| R1 | T0 | T1 | associated_with | c-fos,myeloid leukemia |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 117-122 | DNA | denotes | c-fos |
| T2 | 127-132 | DNA | denotes | c-jun |
| T3 | 134-138 | DNA | denotes | AP-1 |
| T4 | 187-215 | cell_type | denotes | human myeloid leukemia cells |
| T5 | 344-380 | DNA | denotes | c-jun and c-fos early response genes |
| T6 | 515-535 | cell_line | denotes | U-937 leukemia cells |
| T7 | 602-621 | cell_type | denotes | monocytic phenotype |
| T8 | 672-714 | RNA | denotes | lamin A, lamin C, and vimentin transcripts |
| T9 | 813-818 | DNA | denotes | c-jun |
| T10 | 823-834 | DNA | denotes | c-fos genes |
| T11 | 838-860 | cell_type | denotes | myeloid leukemia cells |
| T12 | 878-894 | protein | denotes | protein kinase C |
| T13 | 896-899 | protein | denotes | PKC |
| T14 | 976-979 | protein | denotes | PKC |
| T15 | 1062-1068 | protein | denotes | enzyme |
| T16 | 1235-1240 | DNA | denotes | c-jun |
| T17 | 1245-1250 | protein | denotes | c-fos |
| T18 | 1495-1519 | DNA | denotes | c-jun promoter fragments |
| T19 | 1534-1578 | DNA | denotes | chloramphenicol acetyltransferase (CAT) gene |
| T20 | 1593-1596 | protein | denotes | CAT |
| T21 | 1657-1680 | cell_line | denotes | TPA-treated U-937 cells |
| T22 | 1733-1741 | DNA | denotes | promoter |
| T23 | 1760-1777 | DNA | denotes | AP-1 binding site |
| T24 | 1797-1800 | protein | denotes | CAT |
| T25 | 1932-1937 | DNA | denotes | c-jun |
| T26 | 2008-2017 | DNA | denotes | AP-1 site |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 1939341-4#107#112#gene2353 | 823-828 | gene2353 | denotes | c-fos |
| 1939341-4#122#138#diseaseC0023470 | 838-854 | diseaseC0023470 | denotes | myeloid leukemia |
| 107#112#gene2353122#138#diseaseC0023470 | 1939341-4#107#112#gene2353 | 1939341-4#122#138#diseaseC0023470 | associated_with | c-fos,myeloid leukemia |
semrep-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| E1-ti-1 | 14-27 | cui:C0031586 | denotes | phorbol ester |
| E2-ti-1 | 28-35 | cui:C0205263 | denotes | induced |
| E3-ti-1 | 36-45 | cui:C0026473 | denotes | monocytic |
| E4-ti-1 | 65-78 | cui:C0011777 | denotes | dexamethasone |
| E5-ti-1 | 98-113 | cui:C0013081 | denotes | down-regulation |
| E6-ti-1 | 117-122 | cui:C0085301 | denotes | c-fos |
| E7-ti-1 | 127-132 | cui:C0085942 | denotes | c-jun |
| E8-ti-1 | 134-138 | cui:C0002059 | denotes | AP-1 |
| E1-ab-1 | 141-149 | cui:C0205156 | denotes | Previous |
| E2-ab-1 | 150-157 | cui:C0008972 | denotes | studies |
| E3-ab-1 | 174-183 | cui:C0087111 | denotes | treatment |
| E4-ab-1 | 193-209 | cui:C0023470 | denotes | myeloid leukemia |
| E5-ab-1 | 187-215 | cui:C0427861 | denotes | human myeloid leukemia cells |
| E6-ab-1 | 221-257 | cui:C0039654 | denotes | 12-O-tetradecanoylphorbol-13-acetate |
| E7-ab-1 | 283-292 | cui:C0857127 | denotes | induction |
| E8-ab-1 | 296-305 | cui:C0026473 | denotes | monocytic |
| E9-ab-1 | 326-336 | cui:C0185117 | denotes | expression |
| E10-ab-1 | 344-349 | cui:C0085942 | denotes | c-jun |
| E11-ab-1 | 354-359 | cui:C0085301 | denotes | c-fos |
| E12-ab-1 | 360-380 | cui:C0599295 | denotes | early response genes |
| T1 | 216-220 | USES | denotes | with |
| T2 | 216-220 | USES | denotes | with |
| E1-ab-2 | 386-393 | cui:C0150312 | denotes | present |
| E2-ab-2 | 394-398 | cui:C0043227 | denotes | work |
| E3-ab-2 | 421-435 | cui:C0017710 | denotes | glucocorticoid |
| E4-ab-2 | 436-449 | cui:C0011777 | denotes | dexamethasone |
| E5-ab-2 | 459-462 | cui:C0039654 | denotes | TPA |
| E6-ab-2 | 463-470 | cui:C0205263 | denotes | induced |
| E7-ab-2 | 471-480 | cui:C0442805 | denotes | increases |
| E8-ab-2 | 484-489 | cui:C0085942 | denotes | c-jun |
| E9-ab-2 | 494-499 | cui:C0085301 | denotes | c-fos |
| E10-ab-2 | 500-504 | cui:C0035696 | denotes | mRNA |
| E11-ab-2 | 505-511 | cui:C0441889 | denotes | levels |
| E12-ab-2 | 521-529 | cui:C0023418 | denotes | leukemia |
| E13-ab-2 | 515-535 | cui:C0301863 | denotes | U-937 leukemia cells |
| T3 | 421-449 | ISA | denotes | glucocorticoid dexamethasone |
| T4 | 481-483 | COEXISTS_WITH | denotes | in |
| T5 | 481-483 | COEXISTS_WITH | denotes | in |
| T6 | 512-514 | LOCATION_OF | denotes | in |
| T7 | 512-514 | LOCATION_OF | denotes | in |
| E1-ab-3 | 543-551 | cui:C0243095 | denotes | findings |
| E2-ab-3 | 575-580 | cui:C0028778 | denotes | block |
| E3-ab-3 | 584-594 | cui:C0700364 | denotes | appearance |
| E4-ab-3 | 602-611 | cui:C0026473 | denotes | monocytic |
| E5-ab-3 | 612-621 | cui:C0031437 | denotes | phenotype |
| E6-ab-3 | 647-650 | cui:C0039654 | denotes | TPA |
| E7-ab-3 | 651-658 | cui:C0205263 | denotes | induced |
| E8-ab-3 | 659-668 | cui:C0442805 | denotes | increases |
| E9-ab-3 | 672-677 | cui:C0064635 | denotes | lamin |
| E10-ab-3 | 681-688 | cui:C0125261 | denotes | lamin C |
| E11-ab-3 | 694-702 | cui:C1421451 | denotes | vimentin |
| E12-ab-3 | 703-714 | cui:C1519595 | denotes | transcripts |
| T8 | 659-668 | STIMULATES | denotes | increases |
| E1-ab-4 | 722-729 | cui:C0008972 | denotes | studies |
| E2-ab-4 | 753-756 | cui:C0039654 | denotes | TPA |
| E3-ab-4 | 757-764 | cui:C0205263 | denotes | induced |
| E4-ab-4 | 765-774 | cui:C0026473 | denotes | monocytic |
| E5-ab-4 | 795-805 | cui:C0185117 | denotes | expression |
| E6-ab-4 | 813-818 | cui:C0085942 | denotes | c-jun |
| E7-ab-4 | 823-834 | cui:C0085940 | denotes | c-fos genes |
| E8-ab-4 | 846-854 | cui:C0023418 | denotes | leukemia |
| E9-ab-4 | 838-860 | cui:C0887899 | denotes | myeloid leukemia cells |
| E10-ab-4 | 878-894 | cui:C0033634 | denotes | protein kinase C |
| T9 | 835-837 | LOCATION_OF | denotes | in |
| T10 | 835-837 | LOCATION_OF | denotes | in |
| T11 | 865-874 | INTERACTS_WITH | denotes | regulated |
| T12 | 865-874 | INTERACTS_WITH | denotes | regulated |
| E1-ab-5 | 906-913 | cui:C0243095 | denotes | finding |
| E2-ab-5 | 919-932 | cui:C0011777 | denotes | dexamethasone |
| E3-ab-5 | 940-946 | cui:C1280500 | denotes | effect |
| E4-ab-5 | 950-953 | cui:C0039654 | denotes | TPA |
| E5-ab-5 | 954-961 | cui:C0205263 | denotes | induced |
| E6-ab-5 | 976-979 | cui:C0033634 | denotes | PKC |
| E7-ab-5 | 999-1013 | cui:C0017710 | denotes | glucocorticoid |
| E8-ab-5 | 1031-1041 | cui:C0522506 | denotes | downstream |
| E9-ab-5 | 1062-1068 | cui:C0014442 | denotes | enzyme |
| T13 | 962-972 | STIMULATES | denotes | activation |
| E1-ab-6 | 1070-1077 | cui:C0521447 | denotes | Nuclear |
| E2-ab-6 | 1078-1091 | cui:C1519116 | denotes | run-on assays |
| E3-ab-6 | 1114-1123 | cui:C0857127 | denotes | induction |
| E4-ab-6 | 1127-1132 | cui:C0085942 | denotes | c-jun |
| E5-ab-6 | 1137-1142 | cui:C0085301 | denotes | c-fos |
| E6-ab-6 | 1143-1153 | cui:C0185117 | denotes | expression |
| E7-ab-6 | 1157-1160 | cui:C0039654 | denotes | TPA |
| E8-ab-6 | 1177-1192 | cui:C0040649 | denotes | transcriptional |
| E9-ab-6 | 1193-1203 | cui:C0441712 | denotes | mechanisms |
| E10-ab-6 | 1209-1212 | cui:C0039654 | denotes | TPA |
| E11-ab-6 | 1213-1220 | cui:C0205263 | denotes | induced |
| E12-ab-6 | 1221-1231 | cui:C0185117 | denotes | expression |
| E13-ab-6 | 1235-1240 | cui:C0085942 | denotes | c-jun |
| E14-ab-6 | 1245-1250 | cui:C0085301 | denotes | c-fos |
| E15-ab-6 | 1256-1259 | cui:C1518422 | denotes | not |
| E16-ab-6 | 1268-1285 | cui:C0597295 | denotes | protein synthesis |
| E17-ab-6 | 1295-1298 | cui:C0039654 | denotes | TPA |
| E18-ab-6 | 1299-1306 | cui:C0205263 | denotes | induced |
| E19-ab-6 | 1307-1317 | cui:C0185117 | denotes | expression |
| E20-ab-6 | 1326-1331 | cui:C0017337 | denotes | genes |
| E21-ab-6 | 1352-1367 | cui:C0040649 | denotes | transcriptional |
| E22-ab-6 | 1377-1390 | cui:C0011777 | denotes | dexamethasone |
| T14 | 1114-1123 | STIMULATES | denotes | induction |
| T15 | 1114-1123 | STIMULATES | denotes | induction |
| T16 | 1114-1123 | STIMULATES | denotes | induction |
| T17 | 1299-1306 | STIMULATES | denotes | induced |
| E1-ab-7 | 1395-1402 | cui:C1517331 | denotes | further |
| E2-ab-7 | 1414-1421 | cui:C1280500 | denotes | effects |
| E3-ab-7 | 1425-1438 | cui:C0011777 | denotes | dexamethasone |
| E4-ab-7 | 1446-1455 | cui:C1521991 | denotes | molecular |
| E5-ab-7 | 1477-1483 | cui:C0205549 | denotes | series |
| E6-ab-7 | 1487-1494 | cui:C1608885 | denotes | deleted |
| E7-ab-7 | 1497-1500 | cui:C0085296 | denotes | jun |
| E8-ab-7 | 1510-1519 | cui:C0486805 | denotes | fragments |
| E9-ab-7 | 1534-1567 | cui:C0008169 | denotes | chloramphenicol acetyltransferase |
| E10-ab-7 | 1574-1578 | cui:C0017337 | denotes | gene |
| E1-ab-8 | 1580-1589 | cui:C0442805 | denotes | Increases |
| E2-ab-8 | 1593-1596 | cui:C0008168 | denotes | CAT |
| E3-ab-8 | 1593-1605 | cui:C1151922 | denotes | CAT activity |
| E4-ab-8 | 1613-1622 | cui:C0205374 | denotes | transient |
| E5-ab-8 | 1623-1633 | cui:C0185117 | denotes | expression |
| E6-ab-8 | 1657-1660 | cui:C0039654 | denotes | TPA |
| E7-ab-8 | 1661-1668 | cui:C1292734 | denotes | treated |
| E8-ab-8 | 1669-1680 | cui:C0301863 | denotes | U-937 cells |
| E9-ab-8 | 1706-1712 | cui:C0205147 | denotes | region |
| E10-ab-8 | 1760-1764 | cui:C0002059 | denotes | AP-1 |
| E11-ab-8 | 1765-1777 | cui:C0005456 | denotes | binding site |
| T18 | 1580-1589 | AUGMENTS | denotes | Increases |
| E1-ab-9 | 1784-1793 | cui:C0857127 | denotes | induction |
| E2-ab-9 | 1797-1800 | cui:C0008168 | denotes | CAT |
| E3-ab-9 | 1797-1809 | cui:C1151922 | denotes | CAT activity |
| E4-ab-9 | 1814-1823 | cui:C0332324 | denotes | sensitive |
| E5-ab-9 | 1827-1840 | cui:C0011777 | denotes | dexamethasone |
| E1-ab-10 | 1848-1856 | cui:C0243095 | denotes | findings |
| E2-ab-10 | 1870-1883 | cui:C0011777 | denotes | dexamethasone |
| E3-ab-10 | 1899-1902 | cui:C0039654 | denotes | TPA |
| E4-ab-10 | 1903-1910 | cui:C0205263 | denotes | induced |
| E5-ab-10 | 1911-1924 | cui:C0040649 | denotes | transcription |
| E6-ab-10 | 1932-1942 | cui:C0085299 | denotes | c-jun gene |
| E7-ab-10 | 1950-1959 | cui:C0026473 | denotes | monocytic |
| E8-ab-10 | 1979-1989 | cui:C0311403 | denotes | inhibiting |
| E9-ab-10 | 2008-2012 | cui:C0002059 | denotes | AP-1 |
| E10-ab-10 | 2013-2017 | cui:C0205145 | denotes | site |
| T19 | 1903-1910 | STIMULATES | denotes | induced |
| R1 | E3-ab-1 | T1 | subjectOf | treatment,with |
| R2 | E6-ab-1 | T1 | objectOf | 12-O-tetradecanoylphorbol-13-acetate,with |
| R3 | E9-ab-1 | T2 | subjectOf | expression,with |
| R4 | E6-ab-1 | T2 | objectOf | 12-O-tetradecanoylphorbol-13-acetate,with |
| R5 | E4-ab-2 | T3 | subjectOf | dexamethasone,glucocorticoid dexamethasone |
| R6 | E3-ab-2 | T3 | objectOf | glucocorticoid,glucocorticoid dexamethasone |
| R7 | E4-ab-2 | T4 | subjectOf | dexamethasone,in |
| R8 | E8-ab-2 | T4 | objectOf | c-jun,in |
| R9 | E4-ab-2 | T5 | subjectOf | dexamethasone,in |
| R10 | E9-ab-2 | T5 | objectOf | c-fos,in |
| R11 | E13-ab-2 | T6 | subjectOf | U-937 leukemia cells,in |
| R12 | E9-ab-2 | T6 | objectOf | c-fos,in |
| R13 | E13-ab-2 | T7 | subjectOf | U-937 leukemia cells,in |
| R14 | E8-ab-2 | T7 | objectOf | c-jun,in |
| R15 | E10-ab-3 | T8 | subjectOf | lamin C,increases |
| R16 | E9-ab-3 | T8 | objectOf | lamin,increases |
| R17 | E9-ab-4 | T9 | subjectOf | myeloid leukemia cells,in |
| R18 | E7-ab-4 | T9 | objectOf | c-fos genes,in |
| R19 | E9-ab-4 | T10 | subjectOf | myeloid leukemia cells,in |
| R20 | E6-ab-4 | T10 | objectOf | c-jun,in |
| R21 | E10-ab-4 | T11 | subjectOf | protein kinase C,regulated |
| R22 | E7-ab-4 | T11 | objectOf | c-fos genes,regulated |
| R23 | E10-ab-4 | T12 | subjectOf | protein kinase C,regulated |
| R24 | E6-ab-4 | T12 | objectOf | c-jun,regulated |
| R25 | E2-ab-5 | T13 | subjectOf | dexamethasone,activation |
| R26 | E6-ab-5 | T13 | objectOf | PKC,activation |
| R27 | E7-ab-6 | T14 | subjectOf | TPA,induction |
| R28 | E4-ab-6 | T14 | objectOf | c-jun,induction |
| R29 | E7-ab-6 | T15 | subjectOf | TPA,induction |
| R30 | E14-ab-6 | T15 | objectOf | c-fos,induction |
| R31 | E7-ab-6 | T16 | subjectOf | TPA,induction |
| R32 | E5-ab-6 | T16 | objectOf | c-fos,induction |
| R33 | E13-ab-6 | T17 | subjectOf | c-jun,induced |
| R34 | E20-ab-6 | T17 | objectOf | genes,induced |
| R35 | E11-ab-8 | T18 | subjectOf | binding site,Increases |
| R36 | E3-ab-8 | T18 | objectOf | CAT activity,Increases |
| R37 | E2-ab-10 | T19 | subjectOf | dexamethasone,induced |
| R38 | E6-ab-10 | T19 | objectOf | c-jun gene,induced |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-140 | Sentence | denotes | Inhibition of phorbol ester-induced monocytic differentiation by dexamethasone is associated with down-regulation of c-fos and c-jun (AP-1). |
| S2 | 141-381 | Sentence | denotes | Previous studies have shown that treatment of human myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of monocytic differentiation and expression of the c-jun and c-fos early response genes. |
| S3 | 382-536 | Sentence | denotes | The present work demonstrates that the glucocorticoid dexamethasone inhibits TPA-induced increases in c-jun and c-fos mRNA levels in U-937 leukemia cells. |
| S4 | 537-715 | Sentence | denotes | These findings were associated with a block in appearance of the monocytic phenotype, including inhibition of TPA-induced increases in lamin A, lamin C, and vimentin transcripts. |
| S5 | 716-901 | Sentence | denotes | Other studies have demonstrated that TPA-induced monocytic differentiation and expression of the c-jun and c-fos genes in myeloid leukemia cells are regulated by protein kinase C (PKC). |
| S6 | 902-1069 | Sentence | denotes | The finding that dexamethasone has no effect on TPA-induced activation of PKC suggests that this glucocorticoid inhibits signals downstream or parallel to this enzyme. |
| S7 | 1070-1391 | Sentence | denotes | Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone. |
| S8 | 1392-1579 | Sentence | denotes | To further define the effects of dexamethasone at the molecular level, we prepared a series of deleted c-jun promoter fragments linked to the chloramphenicol acetyltransferase (CAT) gene. |
| S9 | 1580-1778 | Sentence | denotes | Increases in CAT activity during transient expression of these constructs in TPA-treated U-937 cells could be assigned to the region (-97 to -20) of the promoter that contains the AP-1 binding site. |
| S10 | 1779-1841 | Sentence | denotes | This induction of CAT activity was sensitive to dexamethasone. |
| S11 | 1842-2018 | Sentence | denotes | These findings suggest that dexamethasone down-regulates TPA-induced transcription of the c-jun gene during monocytic differentiation by inhibiting activation of the AP-1 site. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 36-61 | NP | denotes | monocytic differentiation |
| C2 | 65-78 | NP | denotes | dexamethasone |
| C4 | 127-132 | NP | denotes | c-jun |
| C3 | 117-139 | NP | denotes | c-fos and c-jun (AP-1) |
| C5 | 187-215 | NP | denotes | human myeloid leukemia cells |
| C6 | 221-263 | NP | denotes | 12-O-tetradecanoylphorbol-13-acetate (TPA) |
| C7 | 296-321 | NP | denotes | monocytic differentiation |
| C10 | 344-349 | NP | denotes | c-jun |
| C9 | 344-380 | NP | denotes | c-jun and c-fos early response genes |
| C8 | 326-380 | NP | denotes | expression of the c-jun and c-fos early response genes |
| C11 | 417-449 | NP | denotes | the glucocorticoid dexamethasone |
| C12 | 484-489 | NP | denotes | c-jun |
| C13 | 515-535 | NP | denotes | U-937 leukemia cells |
| C14 | 753-790 | NP | denotes | TPA-induced monocytic differentiation |
| C17 | 813-818 | NP | denotes | c-jun |
| C16 | 813-834 | NP | denotes | c-jun and c-fos genes |
| C15 | 795-834 | NP | denotes | expression of the c-jun and c-fos genes |
| C18 | 838-860 | NP | denotes | myeloid leukemia cells |
| C19 | 878-900 | NP | denotes | protein kinase C (PKC) |
| C20 | 919-932 | NP | denotes | dexamethasone |
| C21 | 976-979 | NP | denotes | PKC |
| C22 | 994-1013 | NP | denotes | this glucocorticoid |
| C23 | 1057-1068 | NP | denotes | this enzyme |
| C26 | 1127-1132 | NP | denotes | c-jun |
| C25 | 1127-1142 | NP | denotes | c-jun and c-fos |
| C24 | 1127-1153 | NP | denotes | c-jun and c-fos expression |
| C27 | 1157-1160 | NP | denotes | TPA |
| C30 | 1235-1240 | NP | denotes | c-jun |
| C29 | 1235-1250 | NP | denotes | c-jun and c-fos |
| C28 | 1209-1250 | NP | denotes | TPA-induced expression of c-jun and c-fos |
| C31 | 1295-1331 | NP | denotes | TPA-induced expression of both genes |
| C32 | 1377-1390 | NP | denotes | dexamethasone |
| C33 | 1425-1438 | NP | denotes | dexamethasone |
| C34 | 1530-1578 | NP | denotes | the chloramphenicol acetyltransferase (CAT) gene |
| C36 | 1593-1596 | NP | denotes | CAT |
| C35 | 1593-1605 | NP | denotes | CAT activity |
| C37 | 1657-1680 | NP | denotes | TPA-treated U-937 cells |
| C38 | 1729-1741 | NP | denotes | the promoter |
| C39 | 1742-1746 | NP | denotes | that |
| C40 | 1756-1777 | NP | denotes | the AP-1 binding site |
| C42 | 1797-1800 | NP | denotes | CAT |
| C41 | 1797-1809 | NP | denotes | CAT activity |
| C43 | 1827-1840 | NP | denotes | dexamethasone |
| C44 | 1870-1883 | NP | denotes | dexamethasone |
| C45 | 1928-1942 | NP | denotes | the c-jun gene |
| C46 | 1950-1975 | NP | denotes | monocytic differentiation |
| C47 | 2004-2017 | NP | denotes | the AP-1 site |
| R1 | C7 | C1 | coref-ident | monocytic differentiation,monocytic differentiation |
| R2 | C10 | C4 | coref-ident | c-jun,c-jun |
| R3 | C9 | C3 | coref-ident | c-jun and c-fos early response genes,c-fos and c-jun (AP-1) |
| R4 | C11 | C2 | coref-ident | the glucocorticoid dexamethasone,dexamethasone |
| R5 | C12 | C10 | coref-ident | c-jun,c-jun |
| R6 | C14 | C7 | coref-ident | TPA-induced monocytic differentiation,monocytic differentiation |
| R7 | C17 | C12 | coref-ident | c-jun,c-jun |
| R8 | C16 | C9 | coref-ident | c-jun and c-fos genes,c-jun and c-fos early response genes |
| R9 | C15 | C8 | coref-ident | expression of the c-jun and c-fos genes,expression of the c-jun and c-fos early response genes |
| R10 | C18 | C5 | coref-ident | myeloid leukemia cells,human myeloid leukemia cells |
| R11 | C20 | C11 | coref-ident | dexamethasone,the glucocorticoid dexamethasone |
| R12 | C21 | C19 | coref-ident | PKC,protein kinase C (PKC) |
| R13 | C22 | C20 | coref-ident | this glucocorticoid,dexamethasone |
| R14 | C23 | C21 | coref-ident | this enzyme,PKC |
| R15 | C26 | C17 | coref-ident | c-jun,c-jun |
| R16 | C25 | C16 | coref-ident | c-jun and c-fos,c-jun and c-fos genes |
| R17 | C24 | C15 | coref-ident | c-jun and c-fos expression,expression of the c-jun and c-fos genes |
| R18 | C27 | C6 | coref-ident | TPA,12-O-tetradecanoylphorbol-13-acetate (TPA) |
| R19 | C30 | C26 | coref-ident | c-jun,c-jun |
| R20 | C29 | C25 | coref-ident | c-jun and c-fos,c-jun and c-fos |
| R21 | C28 | C24 | coref-ident | TPA-induced expression of c-jun and c-fos,c-jun and c-fos expression |
| R22 | C31 | C28 | coref-ident | TPA-induced expression of both genes,TPA-induced expression of c-jun and c-fos |
| R23 | C32 | C20 | coref-ident | dexamethasone,dexamethasone |
| R24 | C33 | C32 | coref-ident | dexamethasone,dexamethasone |
| R25 | C36 | C34 | coref-ident | CAT,the chloramphenicol acetyltransferase (CAT) gene |
| R26 | C37 | C13 | coref-other | TPA-treated U-937 cells,U-937 leukemia cells |
| R27 | C39 | C38 | coref-relat | that,the promoter |
| R28 | C42 | C36 | coref-ident | CAT,CAT |
| R29 | C41 | C35 | coref-ident | CAT activity,CAT activity |
| R30 | C43 | C33 | coref-ident | dexamethasone,dexamethasone |
| R31 | C44 | C43 | coref-ident | dexamethasone,dexamethasone |
| R32 | C45 | C30 | coref-ident | the c-jun gene,c-jun |
| R33 | C46 | C14 | coref-ident | monocytic differentiation,TPA-induced monocytic differentiation |
| R34 | C47 | C40 | coref-ident | the AP-1 site,the AP-1 binding site |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-61 | other_name | denotes | phorbol ester-induced monocytic differentiation |
| T2 | 65-78 | lipid | denotes | dexamethasone |
| T3 | 117-122 | DNA_domain_or_region | denotes | c-fos |
| T4 | 127-132 | DNA_domain_or_region | denotes | c-jun |
| T5 | 134-138 | DNA_domain_or_region | denotes | AP-1 |
| T6 | 187-215 | cell_type | denotes | human myeloid leukemia cells |
| T7 | 221-257 | other_organic_compound | denotes | 12-O-tetradecanoylphorbol-13-acetate |
| T8 | 259-262 | other_organic_compound | denotes | TPA |
| T9 | 296-321 | other_name | denotes | monocytic differentiation |
| T10 | 421-435 | lipid | denotes | glucocorticoid |
| T11 | 436-449 | lipid | denotes | dexamethasone |
| T12 | 459-462 | other_organic_compound | denotes | TPA |
| T13 | 515-535 | cell_line | denotes | U-937 leukemia cells |
| T14 | 602-621 | cell_type | denotes | monocytic phenotype |
| T15 | 647-650 | other_organic_compound | denotes | TPA |
| T16 | 753-756 | other_organic_compound | denotes | TPA |
| T17 | 813-818 | DNA_domain_or_region | denotes | c-jun |
| T18 | 823-834 | DNA_domain_or_region | denotes | c-fos genes |
| T19 | 838-860 | cell_type | denotes | myeloid leukemia cells |
| T20 | 878-894 | protein_molecule | denotes | protein kinase C |
| T21 | 896-899 | protein_molecule | denotes | PKC |
| T22 | 919-932 | lipid | denotes | dexamethasone |
| T23 | 950-953 | other_organic_compound | denotes | TPA |
| T24 | 976-979 | protein_molecule | denotes | PKC |
| T25 | 999-1013 | lipid | denotes | glucocorticoid |
| T26 | 1062-1068 | protein_family_or_group | denotes | enzyme |
| T27 | 1157-1160 | other_organic_compound | denotes | TPA |
| T28 | 1177-1203 | other_name | denotes | transcriptional mechanisms |
| T29 | 1209-1212 | other_organic_compound | denotes | TPA |
| T30 | 1235-1240 | DNA_domain_or_region | denotes | c-jun |
| T31 | 1245-1250 | protein_molecule | denotes | c-fos |
| T32 | 1268-1285 | other_name | denotes | protein synthesis |
| T33 | 1295-1298 | other_organic_compound | denotes | TPA |
| T34 | 1352-1373 | other_name | denotes | transcriptional level |
| T35 | 1377-1390 | lipid | denotes | dexamethasone |
| T36 | 1425-1438 | lipid | denotes | dexamethasone |
| T37 | 1446-1461 | other_name | denotes | molecular level |
| T38 | 1495-1519 | DNA_domain_or_region | denotes | c-jun promoter fragments |
| T39 | 1534-1567 | protein_molecule | denotes | chloramphenicol acetyltransferase |
| T40 | 1569-1572 | protein_molecule | denotes | CAT |
| T41 | 1593-1596 | protein_molecule | denotes | CAT |
| T42 | 1613-1633 | other_name | denotes | transient expression |
| T43 | 1657-1660 | other_organic_compound | denotes | TPA |
| T44 | 1733-1741 | DNA_domain_or_region | denotes | promoter |
| T45 | 1760-1777 | DNA_domain_or_region | denotes | AP-1 binding site |
| T46 | 1797-1800 | protein_molecule | denotes | CAT |
| T47 | 1827-1840 | lipid | denotes | dexamethasone |
| T48 | 1870-1883 | lipid | denotes | dexamethasone |
| T49 | 1899-1902 | other_organic_compound | denotes | TPA |
| T50 | 1932-1937 | DNA_domain_or_region | denotes | c-jun |
| T51 | 1950-1975 | other_name | denotes | monocytic differentiation |
| T52 | 2008-2017 | DNA_domain_or_region | denotes | AP-1 site |
metamap-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1871-1883 | C0011777 | denotes | examethasone |
| T2 | 1828-1841 | C0011777 | denotes | examethasone. |
| T3 | 1426-1439 | C0011777 | denotes | examethasone |
| T4 | 1378-1391 | C0011777 | denotes | examethasone. |
| T5 | 920-933 | C0011777 | denotes | examethasone |
| T6 | 437-449 | C0011777 | denotes | examethasone |
| T7 | 66-79 | C0011777 | denotes | examethasone |
| T8 | 1951-1959 | C0026473 | denotes | onocytic |
| T9 | 766-775 | C0026473 | denotes | onocytic |
| T10 | 603-611 | C0026473 | denotes | onocytic |
| T11 | 297-306 | C0026473 | denotes | onocytic |
| T12 | 37-46 | C0026473 | denotes | onocytic |
| T13 | 15-28 | C0031586 | denotes | horbol ester- |
| T14 | 2009-2013 | C0085828 | denotes | P-1 |
| T15 | 1761-1765 | C0085828 | denotes | P-1 |
| T16 | 135-139 | C0085828 | denotes | P-1) |
| T17 | 99-114 | C0013081 | denotes | own-regulation |
| T18 | 1961-1976 | C0007589 | denotes | ifferentiation |
| T19 | 776-791 | C0007589 | denotes | ifferentiation |
| T20 | 307-322 | C0007589 | denotes | ifferentiation |
| T21 | 47-62 | C0007589 | denotes | ifferentiation |
| T22 | 1900-1903 | C0039654 | denotes | PA- |
| T23 | 1658-1661 | C0039654 | denotes | PA- |
| T24 | 951-954 | C0039654 | denotes | PA- |
| T25 | 754-757 | C0039654 | denotes | PA- |
| T26 | 648-651 | C0039654 | denotes | PA- |
| T27 | 460-463 | C0039654 | denotes | PA- |
| T28 | 222-258 | C0039654 | denotes | 2-O-tetradecanoylphorbol-13-acetate |
| T29 | 558-573 | C0332281 | denotes | ssociated with |
| T30 | 268-283 | C0332281 | denotes | ssociated with |
| T31 | 83-98 | C0332281 | denotes | ssociated with |
| T32 | 634-644 | C0021469 | denotes | nhibition |
| T33 | 1-11 | C0021469 | denotes | nhibition |
| T34 | 128-133 | C0162508 | denotes | -jun |
| T35 | 1904-1911 | C0205263 | denotes | nduced |
| T36 | 1785-1794 | C0205263 | denotes | nduction |
| T37 | 1115-1124 | C0205263 | denotes | nduction |
| T38 | 955-962 | C0205263 | denotes | nduced |
| T39 | 758-765 | C0205263 | denotes | nduced |
| T40 | 652-659 | C0205263 | denotes | nduced |
| T41 | 464-471 | C0205263 | denotes | nduced |
| T42 | 284-293 | C0205263 | denotes | nduction |
| T43 | 29-36 | C0205263 | denotes | nduced |
| T44 | 1912-1925 | C0040649 | denotes | ranscription |
| T45 | 977-980 | C0033634 | denotes | KC |
| T46 | 879-895 | C0033634 | denotes | rotein kinase C |
| T47 | 1000-1013 | C0017710 | denotes | lucocorticoid |
| T48 | 422-436 | C0017710 | denotes | lucocorticoid |
| T49 | 824-835 | C0085940 | denotes | -fos genes |
| T50 | 1935-1943 | C0085299 | denotes | un gene |
| T51 | 1935-1938 | C3536909 | denotes | un |
| T52 | 1498-1501 | C3536909 | denotes | un |
| T53 | 816-819 | C3536909 | denotes | un |
| T54 | 487-490 | C3536909 | denotes | un |
| T55 | 347-350 | C3536909 | denotes | un |
| T56 | 839-854 | C0023470 | denotes | yeloid leukemia |
| T57 | 194-210 | C0023470 | denotes | yeloid leukemia |
| T58 | 1015-1023 | C0018790 | denotes | nhibits |
| T59 | 451-459 | C0018790 | denotes | nhibits |
| T60 | 1165-1173 | C0851285 | denotes | egulated |
| T61 | 866-875 | C0851285 | denotes | egulated |
| T62 | 847-854 | C0023418 | denotes | eukemia |
| T63 | 522-529 | C0023418 | denotes | eukemia |
| T64 | 1624-1634 | C0185117 | denotes | xpression |
| T65 | 796-806 | C0185117 | denotes | xpression |
| T66 | 327-337 | C0185117 | denotes | xpression |
| T67 | 1269-1286 | C0597295 | denotes | rotein synthesis, |
| T68 | 495-500 | C0087140 | denotes | -fos |
| T69 | 355-360 | C0087140 | denotes | -fos |
| T70 | 1766-1778 | C0005456 | denotes | inding site. |
| T71 | 501-505 | C0035696 | denotes | RNA |
| T72 | 1980-1990 | C3463820 | denotes | nhibiting |
| T73 | 1457-1462 | C0441889 | denotes | evel, |
| T74 | 1369-1374 | C0441889 | denotes | evel |
| T75 | 506-512 | C0441889 | denotes | evels |
| T76 | 1581-1590 | C0442805 | denotes | ncreases |
| T77 | 660-669 | C0442805 | denotes | ncreases |
| T78 | 472-481 | C0442805 | denotes | ncreases |
| T79 | 673-680 | C1416877 | denotes | amin A, |
| T80 | 682-689 | C1416877 | denotes | amin C, |
| T81 | 1849-1857 | C2607943 | denotes | indings |
| T82 | 544-552 | C2607943 | denotes | indings |
| T83 | 1858-1865 | C1705535 | denotes | uggest |
| T84 | 981-989 | C1705535 | denotes | uggests |
| T85 | 723-730 | C0947630 | denotes | tudies |
| T86 | 151-158 | C0947630 | denotes | tudies |
| T87 | 1734-1742 | C0086860 | denotes | romoter |
| T88 | 1502-1510 | C0086860 | denotes | romoter |
| T89 | 1991-2001 | C1879547 | denotes | ctivation |
| T90 | 963-973 | C1879547 | denotes | ctivation |
| T91 | 1662-1669 | C1522326 | denotes | reated |
| T92 | 175-184 | C1522326 | denotes | reatment |
| T93 | 1798-1810 | C1151952 | denotes | AT activity |
| T94 | 1594-1606 | C1151952 | denotes | AT activity |
| T95 | 613-622 | C0031437 | denotes | henotype, |
| T96 | 395-399 | C0043227 | denotes | ork |
| T97 | 1063-1069 | C0014442 | denotes | nzyme. |
| T98 | 1112-1113 | C2827734 | denotes | ) |
| T99 | 1207-1208 | C2827735 | denotes | ) |
| T100 | 1293-1294 | C2827736 | denotes | ) |
| T101 | 1748-1756 | C2700400 | denotes | ontains |
| T102 | 1032-1042 | C0522506 | denotes | ownstream |
| T103 | 907-914 | C2825141 | denotes | inding |
| T104 | 624-633 | C0332257 | denotes | ncluding |
| T105 | 1257-1260 | C1518422 | denotes | ot |
| T106 | 585-595 | C0233426 | denotes | ppearance |
| T107 | 1024-1031 | C1710082 | denotes | ignals |
| T108 | 1644-1653 | C2827421 | denotes | onstructs |
| T109 | 1467-1475 | C1521827 | denotes | repared |
| T110 | 164-169 | C1547282 | denotes | hown |
| T111 | 1079-1091 | C1519116 | denotes | un-on assays |
| T112 | 1815-1827 | C0332324 | denotes | ensitive to |
| T113 | 1396-1403 | C1517331 | denotes | urther |
| T114 | 1393-1395 | C1883351 | denotes | o |
| T115 | 704-715 | C1519595 | denotes | ranscripts. |
| T116 | 1716-1718 | C0439082 | denotes | 7 |
| T117 | 2014-2018 | C0205145 | denotes | ite. |
| T118 | 1885-1889 | C0423866 | denotes | own- |
| T119 | 576-581 | C2828370 | denotes | lock |
| T120 | 1415-1422 | C1280500 | denotes | ffects |
| T121 | 1194-1204 | C0441712 | denotes | echanisms, |
| T122 | 938-947 | C1301751 | denotes | o effect |
| T123 | 1046-1054 | C2826345 | denotes | arallel |
| T124 | 1691-1699 | C1552601 | denotes | ssigned |
| T125 | 1707-1713 | C0205147 | denotes | egion |
| T126 | 1336-1345 | C0311403 | denotes | nhibited |
| T127 | 1478-1484 | C2348044 | denotes | eries |
| T128 | 1521-1527 | C1517892 | denotes | inked |
| T129 | 1447-1456 | C1521991 | denotes | olecular |
| T130 | 387-394 | C0150312 | denotes | resent |
| T131 | 142-150 | C0205156 | denotes | revious |
| T132 | 1614-1623 | C0205374 | denotes | ransient |
| T133 | 695-703 | C1421451 | denotes | imentin |
| T134 | 1071-1078 | C0521447 | denotes | uclear |
| T135 | 1780-1784 | C1080058 | denotes | his |
| T136 | 856-861 | C0007634 | denotes | ells |
| T137 | 1488-1495 | C1880274 | denotes | eleted |
| T138 | 1511-1520 | C0332255 | denotes | ragments |