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PubMed:19386898 JSONTXT

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Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 55-60 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T2 65-71 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T3 858-863 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T4 868-874 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T5 923-928 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T6 972-978 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T7 1065-1071 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-98 Sentence denotes Glycosylation-related gene expression profiling in the brain and spleen of scrapie-affected mouse.
TextSentencer_T2 99-257 Sentence denotes A central event in the formation of infectious prions is the conformational change of a host-encoded glycoprotein, PrP(C), into a pathogenic isoform, PrP(Sc).
TextSentencer_T3 258-329 Sentence denotes The molecular requirements for efficient PrP conversion remain unknown.
TextSentencer_T4 330-462 Sentence denotes Altered glycosylation has been linked to various pathologies and the N-glycans harbored by two prion protein isoforms are different.
TextSentencer_T5 463-875 Sentence denotes In order to search for glycosylation-related genes that could mark prion infection, we used a glycosylation-dedicated microarray that allowed the simultaneous analysis of the expression of 165 glycosylation-related genes encoding proteins of the glycosyltransferase, glycosidase, lectin, and sulfotransferase families to compare the gene expression profiles of normal and scrapie-infected mouse brain and spleen.
TextSentencer_T6 876-964 Sentence denotes Eight genes were found upregulated in "scrapie brain" at the final state of the disease.
TextSentencer_T7 965-1023 Sentence denotes In the spleen, five genes presented a modified expression.
TextSentencer_T8 1024-1131 Sentence denotes Three genes were also upregulated in the spleen of infected mice, and two (Pigq and St3gal5) downregulated.
TextSentencer_T9 1132-1229 Sentence denotes All changes were confirmed by qPCR and biochemical analyses applied to Pigq and St3gal5 proteins.
T1 0-98 Sentence denotes Glycosylation-related gene expression profiling in the brain and spleen of scrapie-affected mouse.
T2 99-257 Sentence denotes A central event in the formation of infectious prions is the conformational change of a host-encoded glycoprotein, PrP(C), into a pathogenic isoform, PrP(Sc).
T3 258-329 Sentence denotes The molecular requirements for efficient PrP conversion remain unknown.
T4 330-462 Sentence denotes Altered glycosylation has been linked to various pathologies and the N-glycans harbored by two prion protein isoforms are different.
T5 463-875 Sentence denotes In order to search for glycosylation-related genes that could mark prion infection, we used a glycosylation-dedicated microarray that allowed the simultaneous analysis of the expression of 165 glycosylation-related genes encoding proteins of the glycosyltransferase, glycosidase, lectin, and sulfotransferase families to compare the gene expression profiles of normal and scrapie-infected mouse brain and spleen.
T6 876-964 Sentence denotes Eight genes were found upregulated in "scrapie brain" at the final state of the disease.
T7 965-1023 Sentence denotes In the spleen, five genes presented a modified expression.
T8 1024-1131 Sentence denotes Three genes were also upregulated in the spleen of infected mice, and two (Pigq and St3gal5) downregulated.
T9 1132-1229 Sentence denotes All changes were confirmed by qPCR and biochemical analyses applied to Pigq and St3gal5 proteins.
T1 0-98 Sentence denotes Glycosylation-related gene expression profiling in the brain and spleen of scrapie-affected mouse.
T2 99-257 Sentence denotes A central event in the formation of infectious prions is the conformational change of a host-encoded glycoprotein, PrP(C), into a pathogenic isoform, PrP(Sc).
T3 258-329 Sentence denotes The molecular requirements for efficient PrP conversion remain unknown.
T4 330-462 Sentence denotes Altered glycosylation has been linked to various pathologies and the N-glycans harbored by two prion protein isoforms are different.
T5 463-875 Sentence denotes In order to search for glycosylation-related genes that could mark prion infection, we used a glycosylation-dedicated microarray that allowed the simultaneous analysis of the expression of 165 glycosylation-related genes encoding proteins of the glycosyltransferase, glycosidase, lectin, and sulfotransferase families to compare the gene expression profiles of normal and scrapie-infected mouse brain and spleen.
T6 876-964 Sentence denotes Eight genes were found upregulated in "scrapie brain" at the final state of the disease.
T7 965-1023 Sentence denotes In the spleen, five genes presented a modified expression.
T8 1024-1131 Sentence denotes Three genes were also upregulated in the spleen of infected mice, and two (Pigq and St3gal5) downregulated.
T9 1132-1229 Sentence denotes All changes were confirmed by qPCR and biochemical analyses applied to Pigq and St3gal5 proteins.

ICD10

Id Subject Object Predicate Lexical cue
T1 956-978 http://purl.bioontology.org/ontology/ICD10/D73.9 denotes disease. In the spleen
T2 956-978 http://purl.bioontology.org/ontology/ICD10/D73 denotes disease. In the spleen

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 22-26 FMAID:198663 denotes gene
_T2 38-50 FMAID:165431 denotes profiling in
_T3 38-50 FMAID:67123 denotes profiling in
_T4 55-60 FMAID:146514 denotes brain
_T5 55-60 FMAID:50801 denotes brain
_T6 65-71 FMAID:93671 denotes spleen
_T7 65-71 FMAID:7196 denotes spleen
_T8 65-71 FMAID:188495 denotes spleen
_T9 101-108 FMAID:242678 denotes central
_T10 101-108 FMAID:30328 denotes central
_T11 101-108 FMAID:174816 denotes central
_T12 200-212 FMAID:62925 denotes glycoprotein
_T13 200-212 FMAID:167256 denotes glycoprotein
_T14 431-438 FMAID:165447 denotes protein
_T15 431-438 FMAID:67257 denotes protein
_T16 508-513 FMAID:198663 denotes genes
_T17 678-683 FMAID:198663 denotes genes
_T18 693-701 FMAID:67257 denotes proteins
_T19 693-701 FMAID:165447 denotes proteins
_T20 796-800 FMAID:198663 denotes gene
_T21 858-863 FMAID:146514 denotes brain
_T22 858-863 FMAID:50801 denotes brain
_T23 868-874 FMAID:188495 denotes spleen
_T24 868-874 FMAID:7196 denotes spleen
_T25 868-874 FMAID:93671 denotes spleen
_T26 882-887 FMAID:198663 denotes genes
_T27 923-928 FMAID:50801 denotes brain
_T28 923-928 FMAID:146514 denotes brain
_T29 972-978 FMAID:93671 denotes spleen
_T30 972-978 FMAID:188495 denotes spleen
_T31 972-978 FMAID:7196 denotes spleen
_T32 985-990 FMAID:198663 denotes genes
_T33 1030-1035 FMAID:198663 denotes genes
_T34 1065-1071 FMAID:93671 denotes spleen
_T35 1065-1071 FMAID:188495 denotes spleen
_T36 1065-1071 FMAID:7196 denotes spleen
_T37 1220-1228 FMAID:165447 denotes proteins
_T38 1220-1228 FMAID:67257 denotes proteins

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 1108-1115 http://www.uniprot.org/uniprot/Q9QWF9 denotes St3gal5
T2 1212-1219 http://www.uniprot.org/uniprot/Q9QWF9 denotes St3gal5

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 14-21 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related
T2 109-114 http://purl.bioontology.org/ontology/STY/T051 denotes event
T3 146-152 http://purl.bioontology.org/ontology/NCBITAXON/94464 denotes prions
T4 146-152 http://purl.bioontology.org/ontology/NCBITAXON/94193 denotes prions
T5 425-430 http://purl.bioontology.org/ontology/NCBITAXON/94464 denotes prion
T6 425-430 http://purl.bioontology.org/ontology/NCBITAXON/94193 denotes prion
T7 500-507 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related
T8 530-535 http://purl.bioontology.org/ontology/NCBITAXON/94193 denotes prion
T9 530-535 http://purl.bioontology.org/ontology/NCBITAXON/94464 denotes prion
T10 670-677 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related

GO-BP

Id Subject Object Predicate Lexical cue
T1 0-13 http://purl.obolibrary.org/obo/GO_0070085 denotes Glycosylation
T2 338-351 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T3 486-499 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T4 557-570 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T5 656-669 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 22-37 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T7 796-811 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T8 122-131 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

GO-CC

Id Subject Object Predicate Lexical cue
T1 187-191 http://purl.obolibrary.org/obo/GO_0018995 denotes host

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 55-60 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T2 858-863 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T3 923-928 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T4 65-71 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T5 868-874 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T6 972-978 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T7 1065-1071 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T8 101-108 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 55-60 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T2 65-71 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T3 858-863 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T4 868-874 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T5 923-928 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T6 972-978 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T7 1065-1071 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 399-408 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycans

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 1132-1135 "http://rdf.glycoinfo.org/glycan/G41652MJ" denotes All
GlycanIUPAC_T2 1132-1135 "http://rdf.glycoinfo.org/glycan/G20761YC" denotes All
GlycanIUPAC_T3 1132-1135 "http://rdf.glycoinfo.org/glycan/G19807HM" denotes All
GlycanIUPAC_T4 1132-1135 "http://rdf.glycoinfo.org/glycan/G20351TE" denotes All
GlycanIUPAC_T5 1132-1135 "http://rdf.glycoinfo.org/glycan/G71957MR" denotes All
GlycanIUPAC_T6 1132-1135 "http://rdf.glycoinfo.org/glycan/G59040AE" denotes All
GlycanIUPAC_T7 1132-1135 "http://rdf.glycoinfo.org/glycan/G14987PW" denotes All
GlycanIUPAC_T8 1132-1135 "http://rdf.glycoinfo.org/glycan/G95064PC" denotes All
GlycanIUPAC_T9 1132-1135 "http://rdf.glycoinfo.org/glycan/G39143AQ" denotes All
GlycanIUPAC_T10 1132-1135 "http://rdf.glycoinfo.org/glycan/G65149OO" denotes All
GlycanIUPAC_T11 1132-1135 "http://rdf.glycoinfo.org/glycan/G02766SY" denotes All
GlycanIUPAC_T12 1132-1135 "http://rdf.glycoinfo.org/glycan/G26019KJ" denotes All
GlycanIUPAC_T13 1132-1135 "http://rdf.glycoinfo.org/glycan/G36429CZ" denotes All
GlycanIUPAC_T14 1132-1135 "http://rdf.glycoinfo.org/glycan/G89633TP" denotes All
GlycanIUPAC_T15 1132-1135 "http://rdf.glycoinfo.org/glycan/G28494FO" denotes All
GlycanIUPAC_T16 1132-1135 "http://rdf.glycoinfo.org/glycan/G06219CP" denotes All
GlycanIUPAC_T17 1132-1135 "http://rdf.glycoinfo.org/glycan/G44237SM" denotes All
GlycanIUPAC_T18 1132-1135 "http://rdf.glycoinfo.org/glycan/G57948RL" denotes All
GlycanIUPAC_T19 1132-1135 "http://rdf.glycoinfo.org/glycan/G64016DN" denotes All
GlycanIUPAC_T20 1132-1135 "http://rdf.glycoinfo.org/glycan/G14536PC" denotes All
GlycanIUPAC_T21 1132-1135 "http://rdf.glycoinfo.org/glycan/G14356FW" denotes All
GlycanIUPAC_T22 1132-1135 "http://rdf.glycoinfo.org/glycan/G34565UO" denotes All
GlycanIUPAC_T23 1132-1135 "http://rdf.glycoinfo.org/glycan/G67124MW" denotes All
GlycanIUPAC_T24 1132-1135 "http://rdf.glycoinfo.org/glycan/G71457ZU" denotes All
GlycanIUPAC_T25 1132-1135 "http://rdf.glycoinfo.org/glycan/G55228VZ" denotes All
GlycanIUPAC_T26 1132-1135 "http://rdf.glycoinfo.org/glycan/G31034MJ" denotes All
GlycanIUPAC_T27 1132-1135 "http://rdf.glycoinfo.org/glycan/G25776IP" denotes All
GlycanIUPAC_T28 1132-1135 "http://rdf.glycoinfo.org/glycan/G64442BV" denotes All
GlycanIUPAC_T29 1132-1135 "http://rdf.glycoinfo.org/glycan/G57018LE" denotes All
GlycanIUPAC_T30 1132-1135 "http://rdf.glycoinfo.org/glycan/G61761GX" denotes All
GlycanIUPAC_T31 1132-1135 "http://rdf.glycoinfo.org/glycan/G76318UX" denotes All
GlycanIUPAC_T32 1132-1135 "http://rdf.glycoinfo.org/glycan/G61906ER" denotes All
GlycanIUPAC_T33 1132-1135 "http://rdf.glycoinfo.org/glycan/G68723GR" denotes All
GlycanIUPAC_T34 1132-1135 "http://rdf.glycoinfo.org/glycan/G19540LE" denotes All
GlycanIUPAC_T35 1132-1135 "http://rdf.glycoinfo.org/glycan/G74944PO" denotes All
GlycanIUPAC_T36 1132-1135 "http://rdf.glycoinfo.org/glycan/G89489ZJ" denotes All
GlycanIUPAC_T37 1132-1135 "http://rdf.glycoinfo.org/glycan/G04434YU" denotes All
GlycanIUPAC_T38 1132-1135 "http://rdf.glycoinfo.org/glycan/G21450PB" denotes All
GlycanIUPAC_T39 1132-1135 "http://rdf.glycoinfo.org/glycan/G93629QY" denotes All
GlycanIUPAC_T40 1132-1135 "http://rdf.glycoinfo.org/glycan/G02603TR" denotes All
GlycanIUPAC_T41 1132-1135 "http://rdf.glycoinfo.org/glycan/G40280JP" denotes All
GlycanIUPAC_T42 1132-1135 "http://rdf.glycoinfo.org/glycan/G95259IC" denotes All
GlycanIUPAC_T43 1132-1135 "http://rdf.glycoinfo.org/glycan/G26900FE" denotes All
GlycanIUPAC_T44 1132-1135 "http://rdf.glycoinfo.org/glycan/G21346KK" denotes All
GlycanIUPAC_T45 1132-1135 "http://rdf.glycoinfo.org/glycan/G62509FF" denotes All
GlycanIUPAC_T46 1132-1135 "http://rdf.glycoinfo.org/glycan/G83932AK" denotes All
GlycanIUPAC_T47 1132-1135 "http://rdf.glycoinfo.org/glycan/G96978IB" denotes All
GlycanIUPAC_T48 1132-1135 "http://rdf.glycoinfo.org/glycan/G34275DN" denotes All
GlycanIUPAC_T49 1132-1135 "http://rdf.glycoinfo.org/glycan/G07071JF" denotes All
GlycanIUPAC_T50 1132-1135 "http://rdf.glycoinfo.org/glycan/G80639QD" denotes All
GlycanIUPAC_T51 1132-1135 "http://rdf.glycoinfo.org/glycan/G99460PJ" denotes All
GlycanIUPAC_T52 1132-1135 "http://rdf.glycoinfo.org/glycan/G22024BZ" denotes All
GlycanIUPAC_T53 1132-1135 "http://rdf.glycoinfo.org/glycan/G74097ZY" denotes All
GlycanIUPAC_T54 1132-1135 "http://rdf.glycoinfo.org/glycan/G84439YP" denotes All
GlycanIUPAC_T55 1132-1135 "http://rdf.glycoinfo.org/glycan/G52207WQ" denotes All
GlycanIUPAC_T56 1132-1135 "http://rdf.glycoinfo.org/glycan/G90695MS" denotes All
GlycanIUPAC_T57 1132-1135 "http://rdf.glycoinfo.org/glycan/G50398QX" denotes All
GlycanIUPAC_T58 1132-1135 "http://rdf.glycoinfo.org/glycan/G12166ZT" denotes All
GlycanIUPAC_T59 1132-1135 "http://rdf.glycoinfo.org/glycan/G48368BR" denotes All
GlycanIUPAC_T60 1132-1135 "http://rdf.glycoinfo.org/glycan/G57407RW" denotes All
GlycanIUPAC_T61 1132-1135 "http://rdf.glycoinfo.org/glycan/G00386TY" denotes All
GlycanIUPAC_T62 1132-1135 "http://rdf.glycoinfo.org/glycan/G18723JK" denotes All
GlycanIUPAC_T63 1132-1135 "http://rdf.glycoinfo.org/glycan/G93757OR" denotes All
GlycanIUPAC_T64 1132-1135 "http://rdf.glycoinfo.org/glycan/G29006SI" denotes All
GlycanIUPAC_T65 1132-1135 "http://rdf.glycoinfo.org/glycan/G03099OQ" denotes All
GlycanIUPAC_T66 1132-1135 "http://rdf.glycoinfo.org/glycan/G53739OW" denotes All
GlycanIUPAC_T67 1132-1135 "http://rdf.glycoinfo.org/glycan/G70440ZO" denotes All
GlycanIUPAC_T68 1132-1135 "http://rdf.glycoinfo.org/glycan/G29951RR" denotes All
GlycanIUPAC_T69 1132-1135 "http://rdf.glycoinfo.org/glycan/G58402TI" denotes All
GlycanIUPAC_T70 1132-1135 "http://rdf.glycoinfo.org/glycan/G39875TP" denotes All
GlycanIUPAC_T71 1132-1135 "http://rdf.glycoinfo.org/glycan/G83439QV" denotes All
GlycanIUPAC_T72 1132-1135 "http://rdf.glycoinfo.org/glycan/G41762RC" denotes All
GlycanIUPAC_T73 1132-1135 "http://rdf.glycoinfo.org/glycan/G91604UI" denotes All
GlycanIUPAC_T74 1132-1135 "http://rdf.glycoinfo.org/glycan/G88447WE" denotes All
GlycanIUPAC_T75 1132-1135 "http://rdf.glycoinfo.org/glycan/G93634BS" denotes All
GlycanIUPAC_T76 1132-1135 "http://rdf.glycoinfo.org/glycan/G02587BH" denotes All
GlycanIUPAC_T77 1132-1135 "http://rdf.glycoinfo.org/glycan/G43511MX" denotes All
GlycanIUPAC_T78 1132-1135 "http://rdf.glycoinfo.org/glycan/G64958DH" denotes All
GlycanIUPAC_T79 1132-1135 "http://rdf.glycoinfo.org/glycan/G30384TR" denotes All
GlycanIUPAC_T80 1132-1135 "http://rdf.glycoinfo.org/glycan/G15624EX" denotes All
GlycanIUPAC_T81 1132-1135 "http://rdf.glycoinfo.org/glycan/G22706ST" denotes All
GlycanIUPAC_T82 1132-1135 "http://rdf.glycoinfo.org/glycan/G57408PI" denotes All
GlycanIUPAC_T83 1132-1135 "http://rdf.glycoinfo.org/glycan/G86403XX" denotes All
GlycanIUPAC_T84 1132-1135 "http://rdf.glycoinfo.org/glycan/G78043YB" denotes All
GlycanIUPAC_T85 1132-1135 "http://rdf.glycoinfo.org/glycan/G18952JK" denotes All
GlycanIUPAC_T86 1132-1135 "http://rdf.glycoinfo.org/glycan/G49020ND" denotes All
GlycanIUPAC_T87 1132-1135 "http://rdf.glycoinfo.org/glycan/G63590YW" denotes All
GlycanIUPAC_T88 1132-1135 "http://rdf.glycoinfo.org/glycan/G22793KS" denotes All
GlycanIUPAC_T89 1132-1135 "http://rdf.glycoinfo.org/glycan/G64134SS" denotes All
GlycanIUPAC_T90 1132-1135 "http://rdf.glycoinfo.org/glycan/G17338HY" denotes All
GlycanIUPAC_T91 1132-1135 "http://rdf.glycoinfo.org/glycan/G99745XF" denotes All
GlycanIUPAC_T92 1132-1135 "http://rdf.glycoinfo.org/glycan/G27782HN" denotes All
GlycanIUPAC_T93 1132-1135 "http://rdf.glycoinfo.org/glycan/G57496DC" denotes All
GlycanIUPAC_T94 1132-1135 "http://rdf.glycoinfo.org/glycan/G93169WB" denotes All
GlycanIUPAC_T95 1132-1135 "http://rdf.glycoinfo.org/glycan/G05518TD" denotes All
GlycanIUPAC_T96 1132-1135 "http://rdf.glycoinfo.org/glycan/G62603DN" denotes All
GlycanIUPAC_T97 1132-1135 "http://rdf.glycoinfo.org/glycan/G59574FS" denotes All
GlycanIUPAC_T98 1132-1135 "http://rdf.glycoinfo.org/glycan/G47567WC" denotes All

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 55-60 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T2 858-863 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T3 923-928 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T4 65-71 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
PD-UBERON-AE-B_T5 868-874 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
PD-UBERON-AE-B_T6 972-978 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
PD-UBERON-AE-B_T7 1065-1071 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
PD-UBERON-AE-B_T8 101-108 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 75-82 Disease denotes scrapie http://purl.obolibrary.org/obo/MONDO_0006961
T2 135-145 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T3 536-545 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T4 835-842 Disease denotes scrapie http://purl.obolibrary.org/obo/MONDO_0006961
T5 915-922 Disease denotes scrapie http://purl.obolibrary.org/obo/MONDO_0006961

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes Glycosylation-related gene expression profiling in the brain and spleen of scrapie-affected mouse.
T2 99-257 Sentence denotes A central event in the formation of infectious prions is the conformational change of a host-encoded glycoprotein, PrP(C), into a pathogenic isoform, PrP(Sc).
T3 258-329 Sentence denotes The molecular requirements for efficient PrP conversion remain unknown.
T4 330-462 Sentence denotes Altered glycosylation has been linked to various pathologies and the N-glycans harbored by two prion protein isoforms are different.
T5 463-875 Sentence denotes In order to search for glycosylation-related genes that could mark prion infection, we used a glycosylation-dedicated microarray that allowed the simultaneous analysis of the expression of 165 glycosylation-related genes encoding proteins of the glycosyltransferase, glycosidase, lectin, and sulfotransferase families to compare the gene expression profiles of normal and scrapie-infected mouse brain and spleen.
T6 876-964 Sentence denotes Eight genes were found upregulated in "scrapie brain" at the final state of the disease.
T7 965-1023 Sentence denotes In the spleen, five genes presented a modified expression.
T8 1024-1131 Sentence denotes Three genes were also upregulated in the spleen of infected mice, and two (Pigq and St3gal5) downregulated.
T9 1132-1229 Sentence denotes All changes were confirmed by qPCR and biochemical analyses applied to Pigq and St3gal5 proteins.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 92-97 OrganismTaxon denotes mouse 10088|10090
T3 852-857 OrganismTaxon denotes mouse 10088|10090
T5 1084-1088 OrganismTaxon denotes mice 10088

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 55-60 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T2 65-71 Body_part denotes spleen http://purl.obolibrary.org/obo/MAT_0000085
T3 858-863 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T4 868-874 Body_part denotes spleen http://purl.obolibrary.org/obo/MAT_0000085
T5 923-928 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T6 972-978 Body_part denotes spleen http://purl.obolibrary.org/obo/MAT_0000085
T7 1065-1071 Body_part denotes spleen http://purl.obolibrary.org/obo/MAT_0000085

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 55-60 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 65-71 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T4 858-863 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T6 868-874 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T7 923-928 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T9 972-978 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T10 1065-1071 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106