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PubMed:19376776 JSONTXT

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GlyCosmos6-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 290-294 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000
T2 295-308 Body_part denotes proliferation http://purl.obolibrary.org/obo/UBERON_2000098
T3 449-453 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000
T4 478-488 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 238-341 DRI_Background denotes Notch signaling plays a critical role in regulating cell proliferation, differentiation, and apoptosis.
T2 342-512 DRI_Outcome denotes Our previous study showed that overexpression of Notch1 could inhibit human hepatocellular carcinoma (HCC) cell growth by arresting the cell cycle and inducing apoptosis.
T3 513-577 DRI_Background denotes HCC cells are resistant to apoptotic induction by tumor necrosis
T4 612-727 DRI_Background denotes ligand (TRAIL), so new therapeutic approaches have been explored to sensitize HCC cells to TRAIL-induced apoptosis.
T5 728-846 DRI_Approach denotes We are wondering whether and how Notch1 signaling can enhance the sensitivity of HCC cells to TRAIL-induced apoptosis.
T6 847-1028 DRI_Approach denotes In this study, we found that overexpression of ICN, the constitutive activated form of Notch1, up-regulated p53 protein expression in HCC cells by inhibiting proteasome degradation.
T7 1029-1152 DRI_Background denotes p53 up-regulation was further observed in human primary hepatocellular carcinoma cells after activation of Notch signaling.
T8 1153-1300 DRI_Background denotes Inhibition of the Akt/Hdm2 pathway by Notch1 signaling was responsible for the suppression of p53 proteasomal degradation, thus contributing to the
T9 1327-1359 DRI_Background denotes up-regulation of p53 expression.
T10 1360-1539 DRI_Background denotes Accordingly, Notch1 signaling could make HCC cells more sensitive to TRAIL-induced apoptosis, whereas Notch1 signaling lost the synergistic promotion of TRAIL-induced apoptosis in
T11 1559-1572 DRI_Background denotes HCC cells and
T12 1593-1603 DRI_Background denotes HCC cells.
T13 1604-1721 DRI_Outcome denotes The data suggest that enhancement of TRAIL-induced apoptosis by Notch1 signaling is dependent upon p53 up-regulation.
T14 1722-1807 DRI_Approach denotes Furthermore, Notch1 signaling could enhance DR5 expression in a p53-dependent manner.
T15 1808-1840 DRI_Background denotes Taken together, Notch1 signaling
T16 1866-1940 DRI_Background denotes apoptosis in HCC cells by inhibiting Akt/Hdm2-mediated p53 degradation and
T17 1973-1984 DRI_Background denotes expression.
T18 1985-2134 DRI_Outcome denotes Thus, our results suggest that activation of Notch1 signaling may be a promising approach to improve the therapeutic efficacy of TRAIL-resistant HCC.

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 28-33 DiseaseOrPhenotypicFeature denotes tumor 0005070
T2 111-135 DiseaseOrPhenotypicFeature denotes hepatocellular carcinoma 0007256
T3 418-442 DiseaseOrPhenotypicFeature denotes hepatocellular carcinoma 0007256
T4 444-447 DiseaseOrPhenotypicFeature denotes HCC 0007256
T5 513-516 DiseaseOrPhenotypicFeature denotes HCC 0007256
T6 563-568 DiseaseOrPhenotypicFeature denotes tumor 0005070
T7 690-693 DiseaseOrPhenotypicFeature denotes HCC 0007256
T8 778-781 DiseaseOrPhenotypicFeature denotes can 0012833
T9 794-805 DiseaseOrPhenotypicFeature denotes sensitivity 0000605
T10 809-812 DiseaseOrPhenotypicFeature denotes HCC 0007256
T11 981-984 DiseaseOrPhenotypicFeature denotes HCC 0007256
T12 1085-1109 DiseaseOrPhenotypicFeature denotes hepatocellular carcinoma 0007256
T13 1401-1404 DiseaseOrPhenotypicFeature denotes HCC 0007256
T14 1416-1425 DiseaseOrPhenotypicFeature denotes sensitive 0000605
T15 1559-1562 DiseaseOrPhenotypicFeature denotes HCC 0007256
T16 1593-1596 DiseaseOrPhenotypicFeature denotes HCC 0007256
T17 1879-1882 DiseaseOrPhenotypicFeature denotes HCC 0007256
T18 2130-2133 DiseaseOrPhenotypicFeature denotes HCC 0007256

sentences

Id Subject Object Predicate Lexical cue
T1 0-237 Sentence denotes Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression.
T2 238-341 Sentence denotes Notch signaling plays a critical role in regulating cell proliferation, differentiation, and apoptosis.
T3 342-512 Sentence denotes Our previous study showed that overexpression of Notch1 could inhibit human hepatocellular carcinoma (HCC) cell growth by arresting the cell cycle and inducing apoptosis.
T4 513-727 Sentence denotes HCC cells are resistant to apoptotic induction by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), so new therapeutic approaches have been explored to sensitize HCC cells to TRAIL-induced apoptosis.
T5 728-846 Sentence denotes We are wondering whether and how Notch1 signaling can enhance the sensitivity of HCC cells to TRAIL-induced apoptosis.
T6 847-1152 Sentence denotes In this study, we found that overexpression of ICN, the constitutive activated form of Notch1, up-regulated p53 protein expression in HCC cells by inhibiting proteasome degradation. p53 up-regulation was further observed in human primary hepatocellular carcinoma cells after activation of Notch signaling.
T7 1153-1359 Sentence denotes Inhibition of the Akt/Hdm2 pathway by Notch1 signaling was responsible for the suppression of p53 proteasomal degradation, thus contributing to the Notch1 signaling-mediated up-regulation of p53 expression.
T8 1360-1603 Sentence denotes Accordingly, Notch1 signaling could make HCC cells more sensitive to TRAIL-induced apoptosis, whereas Notch1 signaling lost the synergistic promotion of TRAIL-induced apoptosis in p53-silenced HepG2 HCC cells and p53-defective Hep3B HCC cells.
T9 1604-1721 Sentence denotes The data suggest that enhancement of TRAIL-induced apoptosis by Notch1 signaling is dependent upon p53 up-regulation.
T10 1722-1807 Sentence denotes Furthermore, Notch1 signaling could enhance DR5 expression in a p53-dependent manner.
T11 1808-1984 Sentence denotes Taken together, Notch1 signaling sensitizes TRAIL-induced apoptosis in HCC cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression.
T12 1985-2134 Sentence denotes Thus, our results suggest that activation of Notch1 signaling may be a promising approach to improve the therapeutic efficacy of TRAIL-resistant HCC.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 105-110 OrganismTaxon denotes human NCBItxid:9606
T2 412-417 OrganismTaxon denotes human NCBItxid:9606
T3 1071-1076 OrganismTaxon denotes human NCBItxid:9606

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 136-141 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 290-294 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 449-453 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 478-482 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 517-522 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 694-699 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 813-818 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8 916-925 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T9 985-990 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10 1110-1115 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11 1122-1132 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T12 1405-1410 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13 1553-1558 http://purl.obolibrary.org/obo/CLO_0003704 denotes HepG2
T14 1553-1558 http://purl.obolibrary.org/obo/CLO_0050856 denotes HepG2
T15 1553-1558 http://purl.obolibrary.org/obo/CLO_0050858 denotes HepG2
T16 1553-1558 http://purl.obolibrary.org/obo/CLO_0051858 denotes HepG2
T17 1553-1558 http://purl.obolibrary.org/obo/CLO_0051859 denotes HepG2
T18 1563-1568 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19 1587-1592 http://purl.obolibrary.org/obo/CLO_0054295 denotes Hep3B
T20 1597-1602 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T21 1883-1888 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22 2016-2026 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 28-33 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 111-135 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T3 418-442 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T4 444-447 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T5 513-516 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T6 563-568 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T7 690-693 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T8 809-812 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T9 981-984 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T10 1085-1109 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T11 1401-1404 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T12 1559-1562 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T13 1593-1596 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T14 1879-1882 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T15 2130-2133 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256

DisGeNET

Id Subject Object Predicate Lexical cue
T0 391-397 gene:4851 denotes Notch1
T1 418-442 disease:C2239176 denotes hepatocellular carcinoma
T2 391-397 gene:4851 denotes Notch1
T3 444-447 disease:C2239176 denotes HCC
R1 T0 T1 associated_with Notch1,hepatocellular carcinoma
R2 T2 T3 associated_with Notch1,HCC

bionlp-st-pc-2013-training

Id Subject Object Predicate Lexical cue
T1 0-6 Gene_or_gene_product denotes Notch1
T2 28-83 Gene_or_gene_product denotes tumor necrosis factor-related apoptosis-inducing ligand
T3 156-159 Gene_or_gene_product denotes Akt
T4 160-164 Gene_or_gene_product denotes Hdm2
T5 174-177 Gene_or_gene_product denotes p53
T6 208-211 Gene_or_gene_product denotes p53
T7 222-225 Gene_or_gene_product denotes DR5
T8 238-243 Gene_or_gene_product denotes Notch
T9 391-397 Gene_or_gene_product denotes Notch1
T10 563-618 Gene_or_gene_product denotes tumor necrosis factor-related apoptosis-inducing ligand
T11 620-625 Gene_or_gene_product denotes TRAIL
T12 703-708 Gene_or_gene_product denotes TRAIL
T13 761-767 Gene_or_gene_product denotes Notch1
T14 822-827 Gene_or_gene_product denotes TRAIL
T15 894-897 Gene_or_gene_product denotes ICN
T16 934-940 Gene_or_gene_product denotes Notch1
T17 955-958 Gene_or_gene_product denotes p53
T18 1029-1032 Gene_or_gene_product denotes p53
T19 1136-1141 Gene_or_gene_product denotes Notch
T20 1171-1174 Gene_or_gene_product denotes Akt
T21 1175-1179 Gene_or_gene_product denotes Hdm2
T22 1191-1197 Gene_or_gene_product denotes Notch1
T23 1247-1250 Gene_or_gene_product denotes p53
T24 1251-1262 Cellular_component denotes proteasomal
T25 1301-1307 Gene_or_gene_product denotes Notch1
T26 1344-1347 Gene_or_gene_product denotes p53
T27 1373-1379 Gene_or_gene_product denotes Notch1
T28 1429-1434 Gene_or_gene_product denotes TRAIL
T29 1462-1468 Gene_or_gene_product denotes Notch1
T30 1513-1518 Gene_or_gene_product denotes TRAIL
T31 1540-1543 Gene_or_gene_product denotes p53
T32 1573-1576 Gene_or_gene_product denotes p53
T33 1641-1646 Gene_or_gene_product denotes TRAIL
T34 1668-1674 Gene_or_gene_product denotes Notch1
T35 1703-1706 Gene_or_gene_product denotes p53
T36 1735-1741 Gene_or_gene_product denotes Notch1
T37 1766-1769 Gene_or_gene_product denotes DR5
T38 1786-1789 Gene_or_gene_product denotes p53
T39 1824-1830 Gene_or_gene_product denotes Notch1
T40 1852-1857 Gene_or_gene_product denotes TRAIL
T41 1903-1906 Gene_or_gene_product denotes Akt
T42 1907-1911 Gene_or_gene_product denotes Hdm2
T43 1921-1924 Gene_or_gene_product denotes p53
T44 1955-1958 Gene_or_gene_product denotes p53
T45 1969-1972 Gene_or_gene_product denotes DR5
T46 2030-2036 Gene_or_gene_product denotes Notch1
T47 2114-2119 Gene_or_gene_product denotes TRAIL

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19376776-0#28#49#gene7124 28-49 gene7124 denotes tumor necrosis factor
19376776-0#111#135#diseaseC2239176 111-135 diseaseC2239176 denotes hepatocellular carcinoma
19376776-2#49#55#gene4851 391-397 gene4851 denotes Notch1
19376776-2#76#100#diseaseC2239176 418-442 diseaseC2239176 denotes hepatocellular carcinoma
19376776-2#102#105#diseaseC2239176 444-447 diseaseC2239176 denotes HCC
19376776-5#108#111#gene7157 955-958 gene7157 denotes p53
19376776-5#182#185#gene7157 1029-1032 gene7157 denotes p53
19376776-5#134#137#diseaseC2239176 981-984 diseaseC2239176 denotes HCC
19376776-5#238#262#diseaseC2239176 1085-1109 diseaseC2239176 denotes hepatocellular carcinoma
28#49#gene7124111#135#diseaseC2239176 19376776-0#28#49#gene7124 19376776-0#111#135#diseaseC2239176 associated_with tumor necrosis factor,hepatocellular carcinoma
49#55#gene485176#100#diseaseC2239176 19376776-2#49#55#gene4851 19376776-2#76#100#diseaseC2239176 associated_with Notch1,hepatocellular carcinoma
49#55#gene4851102#105#diseaseC2239176 19376776-2#49#55#gene4851 19376776-2#102#105#diseaseC2239176 associated_with Notch1,HCC
108#111#gene7157134#137#diseaseC2239176 19376776-5#108#111#gene7157 19376776-5#134#137#diseaseC2239176 associated_with p53,HCC
108#111#gene7157238#262#diseaseC2239176 19376776-5#108#111#gene7157 19376776-5#238#262#diseaseC2239176 associated_with p53,hepatocellular carcinoma
182#185#gene7157134#137#diseaseC2239176 19376776-5#182#185#gene7157 19376776-5#134#137#diseaseC2239176 associated_with p53,HCC
182#185#gene7157238#262#diseaseC2239176 19376776-5#182#185#gene7157 19376776-5#238#262#diseaseC2239176 associated_with p53,hepatocellular carcinoma