PubMed:19376776
Annnotations
GlyCosmos6-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 290-294 | Body_part | denotes | cell | http://purl.obolibrary.org/obo/CL_0000000 |
T2 | 295-308 | Body_part | denotes | proliferation | http://purl.obolibrary.org/obo/UBERON_2000098 |
T3 | 449-453 | Body_part | denotes | cell | http://purl.obolibrary.org/obo/CL_0000000 |
T4 | 478-488 | Body_part | denotes | cell cycle | http://purl.obolibrary.org/obo/UBERON_2000098 |
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 238-341 | DRI_Background | denotes | Notch signaling plays a critical role in regulating cell proliferation, differentiation, and apoptosis. |
T2 | 342-512 | DRI_Outcome | denotes | Our previous study showed that overexpression of Notch1 could inhibit human hepatocellular carcinoma (HCC) cell growth by arresting the cell cycle and inducing apoptosis. |
T3 | 513-577 | DRI_Background | denotes | HCC cells are resistant to apoptotic induction by tumor necrosis |
T4 | 612-727 | DRI_Background | denotes | ligand (TRAIL), so new therapeutic approaches have been explored to sensitize HCC cells to TRAIL-induced apoptosis. |
T5 | 728-846 | DRI_Approach | denotes | We are wondering whether and how Notch1 signaling can enhance the sensitivity of HCC cells to TRAIL-induced apoptosis. |
T6 | 847-1028 | DRI_Approach | denotes | In this study, we found that overexpression of ICN, the constitutive activated form of Notch1, up-regulated p53 protein expression in HCC cells by inhibiting proteasome degradation. |
T7 | 1029-1152 | DRI_Background | denotes | p53 up-regulation was further observed in human primary hepatocellular carcinoma cells after activation of Notch signaling. |
T8 | 1153-1300 | DRI_Background | denotes | Inhibition of the Akt/Hdm2 pathway by Notch1 signaling was responsible for the suppression of p53 proteasomal degradation, thus contributing to the |
T9 | 1327-1359 | DRI_Background | denotes | up-regulation of p53 expression. |
T10 | 1360-1539 | DRI_Background | denotes | Accordingly, Notch1 signaling could make HCC cells more sensitive to TRAIL-induced apoptosis, whereas Notch1 signaling lost the synergistic promotion of TRAIL-induced apoptosis in |
T11 | 1559-1572 | DRI_Background | denotes | HCC cells and |
T12 | 1593-1603 | DRI_Background | denotes | HCC cells. |
T13 | 1604-1721 | DRI_Outcome | denotes | The data suggest that enhancement of TRAIL-induced apoptosis by Notch1 signaling is dependent upon p53 up-regulation. |
T14 | 1722-1807 | DRI_Approach | denotes | Furthermore, Notch1 signaling could enhance DR5 expression in a p53-dependent manner. |
T15 | 1808-1840 | DRI_Background | denotes | Taken together, Notch1 signaling |
T16 | 1866-1940 | DRI_Background | denotes | apoptosis in HCC cells by inhibiting Akt/Hdm2-mediated p53 degradation and |
T17 | 1973-1984 | DRI_Background | denotes | expression. |
T18 | 1985-2134 | DRI_Outcome | denotes | Thus, our results suggest that activation of Notch1 signaling may be a promising approach to improve the therapeutic efficacy of TRAIL-resistant HCC. |
PMID_GLOBAL
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 28-33 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
T2 | 111-135 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | 0007256 |
T3 | 418-442 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | 0007256 |
T4 | 444-447 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
T5 | 513-516 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
T6 | 563-568 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
T7 | 690-693 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
T8 | 778-781 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
T9 | 794-805 | DiseaseOrPhenotypicFeature | denotes | sensitivity | 0000605 |
T10 | 809-812 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
T11 | 981-984 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
T12 | 1085-1109 | DiseaseOrPhenotypicFeature | denotes | hepatocellular carcinoma | 0007256 |
T13 | 1401-1404 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
T14 | 1416-1425 | DiseaseOrPhenotypicFeature | denotes | sensitive | 0000605 |
T15 | 1559-1562 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
T16 | 1593-1596 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
T17 | 1879-1882 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
T18 | 2130-2133 | DiseaseOrPhenotypicFeature | denotes | HCC | 0007256 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-237 | Sentence | denotes | Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. |
T2 | 238-341 | Sentence | denotes | Notch signaling plays a critical role in regulating cell proliferation, differentiation, and apoptosis. |
T3 | 342-512 | Sentence | denotes | Our previous study showed that overexpression of Notch1 could inhibit human hepatocellular carcinoma (HCC) cell growth by arresting the cell cycle and inducing apoptosis. |
T4 | 513-727 | Sentence | denotes | HCC cells are resistant to apoptotic induction by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), so new therapeutic approaches have been explored to sensitize HCC cells to TRAIL-induced apoptosis. |
T5 | 728-846 | Sentence | denotes | We are wondering whether and how Notch1 signaling can enhance the sensitivity of HCC cells to TRAIL-induced apoptosis. |
T6 | 847-1152 | Sentence | denotes | In this study, we found that overexpression of ICN, the constitutive activated form of Notch1, up-regulated p53 protein expression in HCC cells by inhibiting proteasome degradation. p53 up-regulation was further observed in human primary hepatocellular carcinoma cells after activation of Notch signaling. |
T7 | 1153-1359 | Sentence | denotes | Inhibition of the Akt/Hdm2 pathway by Notch1 signaling was responsible for the suppression of p53 proteasomal degradation, thus contributing to the Notch1 signaling-mediated up-regulation of p53 expression. |
T8 | 1360-1603 | Sentence | denotes | Accordingly, Notch1 signaling could make HCC cells more sensitive to TRAIL-induced apoptosis, whereas Notch1 signaling lost the synergistic promotion of TRAIL-induced apoptosis in p53-silenced HepG2 HCC cells and p53-defective Hep3B HCC cells. |
T9 | 1604-1721 | Sentence | denotes | The data suggest that enhancement of TRAIL-induced apoptosis by Notch1 signaling is dependent upon p53 up-regulation. |
T10 | 1722-1807 | Sentence | denotes | Furthermore, Notch1 signaling could enhance DR5 expression in a p53-dependent manner. |
T11 | 1808-1984 | Sentence | denotes | Taken together, Notch1 signaling sensitizes TRAIL-induced apoptosis in HCC cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. |
T12 | 1985-2134 | Sentence | denotes | Thus, our results suggest that activation of Notch1 signaling may be a promising approach to improve the therapeutic efficacy of TRAIL-resistant HCC. |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 105-110 | OrganismTaxon | denotes | human | NCBItxid:9606 |
T2 | 412-417 | OrganismTaxon | denotes | human | NCBItxid:9606 |
T3 | 1071-1076 | OrganismTaxon | denotes | human | NCBItxid:9606 |
GlyCosmos6-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 136-141 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T2 | 290-294 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3 | 449-453 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T4 | 478-482 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T5 | 517-522 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T6 | 694-699 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T7 | 813-818 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T8 | 916-925 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
T9 | 985-990 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T10 | 1110-1115 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T11 | 1122-1132 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T12 | 1405-1410 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T13 | 1553-1558 | http://purl.obolibrary.org/obo/CLO_0003704 | denotes | HepG2 |
T14 | 1553-1558 | http://purl.obolibrary.org/obo/CLO_0050856 | denotes | HepG2 |
T15 | 1553-1558 | http://purl.obolibrary.org/obo/CLO_0050858 | denotes | HepG2 |
T16 | 1553-1558 | http://purl.obolibrary.org/obo/CLO_0051858 | denotes | HepG2 |
T17 | 1553-1558 | http://purl.obolibrary.org/obo/CLO_0051859 | denotes | HepG2 |
T18 | 1563-1568 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T19 | 1587-1592 | http://purl.obolibrary.org/obo/CLO_0054295 | denotes | Hep3B |
T20 | 1597-1602 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T21 | 1883-1888 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T22 | 2016-2026 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 28-33 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
T2 | 111-135 | Disease | denotes | hepatocellular carcinoma | http://purl.obolibrary.org/obo/MONDO_0007256 |
T3 | 418-442 | Disease | denotes | hepatocellular carcinoma | http://purl.obolibrary.org/obo/MONDO_0007256 |
T4 | 444-447 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
T5 | 513-516 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
T6 | 563-568 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
T7 | 690-693 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
T8 | 809-812 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
T9 | 981-984 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
T10 | 1085-1109 | Disease | denotes | hepatocellular carcinoma | http://purl.obolibrary.org/obo/MONDO_0007256 |
T11 | 1401-1404 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
T12 | 1559-1562 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
T13 | 1593-1596 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
T14 | 1879-1882 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
T15 | 2130-2133 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 391-397 | gene:4851 | denotes | Notch1 |
T1 | 418-442 | disease:C2239176 | denotes | hepatocellular carcinoma |
T2 | 391-397 | gene:4851 | denotes | Notch1 |
T3 | 444-447 | disease:C2239176 | denotes | HCC |
R1 | T0 | T1 | associated_with | Notch1,hepatocellular carcinoma |
R2 | T2 | T3 | associated_with | Notch1,HCC |
bionlp-st-pc-2013-training
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-6 | Gene_or_gene_product | denotes | Notch1 |
T2 | 28-83 | Gene_or_gene_product | denotes | tumor necrosis factor-related apoptosis-inducing ligand |
T3 | 156-159 | Gene_or_gene_product | denotes | Akt |
T4 | 160-164 | Gene_or_gene_product | denotes | Hdm2 |
T5 | 174-177 | Gene_or_gene_product | denotes | p53 |
T6 | 208-211 | Gene_or_gene_product | denotes | p53 |
T7 | 222-225 | Gene_or_gene_product | denotes | DR5 |
T8 | 238-243 | Gene_or_gene_product | denotes | Notch |
T9 | 391-397 | Gene_or_gene_product | denotes | Notch1 |
T10 | 563-618 | Gene_or_gene_product | denotes | tumor necrosis factor-related apoptosis-inducing ligand |
T11 | 620-625 | Gene_or_gene_product | denotes | TRAIL |
T12 | 703-708 | Gene_or_gene_product | denotes | TRAIL |
T13 | 761-767 | Gene_or_gene_product | denotes | Notch1 |
T14 | 822-827 | Gene_or_gene_product | denotes | TRAIL |
T15 | 894-897 | Gene_or_gene_product | denotes | ICN |
T16 | 934-940 | Gene_or_gene_product | denotes | Notch1 |
T17 | 955-958 | Gene_or_gene_product | denotes | p53 |
T18 | 1029-1032 | Gene_or_gene_product | denotes | p53 |
T19 | 1136-1141 | Gene_or_gene_product | denotes | Notch |
T20 | 1171-1174 | Gene_or_gene_product | denotes | Akt |
T21 | 1175-1179 | Gene_or_gene_product | denotes | Hdm2 |
T22 | 1191-1197 | Gene_or_gene_product | denotes | Notch1 |
T23 | 1247-1250 | Gene_or_gene_product | denotes | p53 |
T24 | 1251-1262 | Cellular_component | denotes | proteasomal |
T25 | 1301-1307 | Gene_or_gene_product | denotes | Notch1 |
T26 | 1344-1347 | Gene_or_gene_product | denotes | p53 |
T27 | 1373-1379 | Gene_or_gene_product | denotes | Notch1 |
T28 | 1429-1434 | Gene_or_gene_product | denotes | TRAIL |
T29 | 1462-1468 | Gene_or_gene_product | denotes | Notch1 |
T30 | 1513-1518 | Gene_or_gene_product | denotes | TRAIL |
T31 | 1540-1543 | Gene_or_gene_product | denotes | p53 |
T32 | 1573-1576 | Gene_or_gene_product | denotes | p53 |
T33 | 1641-1646 | Gene_or_gene_product | denotes | TRAIL |
T34 | 1668-1674 | Gene_or_gene_product | denotes | Notch1 |
T35 | 1703-1706 | Gene_or_gene_product | denotes | p53 |
T36 | 1735-1741 | Gene_or_gene_product | denotes | Notch1 |
T37 | 1766-1769 | Gene_or_gene_product | denotes | DR5 |
T38 | 1786-1789 | Gene_or_gene_product | denotes | p53 |
T39 | 1824-1830 | Gene_or_gene_product | denotes | Notch1 |
T40 | 1852-1857 | Gene_or_gene_product | denotes | TRAIL |
T41 | 1903-1906 | Gene_or_gene_product | denotes | Akt |
T42 | 1907-1911 | Gene_or_gene_product | denotes | Hdm2 |
T43 | 1921-1924 | Gene_or_gene_product | denotes | p53 |
T44 | 1955-1958 | Gene_or_gene_product | denotes | p53 |
T45 | 1969-1972 | Gene_or_gene_product | denotes | DR5 |
T46 | 2030-2036 | Gene_or_gene_product | denotes | Notch1 |
T47 | 2114-2119 | Gene_or_gene_product | denotes | TRAIL |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
19376776-0#28#49#gene7124 | 28-49 | gene7124 | denotes | tumor necrosis factor |
19376776-0#111#135#diseaseC2239176 | 111-135 | diseaseC2239176 | denotes | hepatocellular carcinoma |
19376776-2#49#55#gene4851 | 391-397 | gene4851 | denotes | Notch1 |
19376776-2#76#100#diseaseC2239176 | 418-442 | diseaseC2239176 | denotes | hepatocellular carcinoma |
19376776-2#102#105#diseaseC2239176 | 444-447 | diseaseC2239176 | denotes | HCC |
19376776-5#108#111#gene7157 | 955-958 | gene7157 | denotes | p53 |
19376776-5#182#185#gene7157 | 1029-1032 | gene7157 | denotes | p53 |
19376776-5#134#137#diseaseC2239176 | 981-984 | diseaseC2239176 | denotes | HCC |
19376776-5#238#262#diseaseC2239176 | 1085-1109 | diseaseC2239176 | denotes | hepatocellular carcinoma |
28#49#gene7124111#135#diseaseC2239176 | 19376776-0#28#49#gene7124 | 19376776-0#111#135#diseaseC2239176 | associated_with | tumor necrosis factor,hepatocellular carcinoma |
49#55#gene485176#100#diseaseC2239176 | 19376776-2#49#55#gene4851 | 19376776-2#76#100#diseaseC2239176 | associated_with | Notch1,hepatocellular carcinoma |
49#55#gene4851102#105#diseaseC2239176 | 19376776-2#49#55#gene4851 | 19376776-2#102#105#diseaseC2239176 | associated_with | Notch1,HCC |
108#111#gene7157134#137#diseaseC2239176 | 19376776-5#108#111#gene7157 | 19376776-5#134#137#diseaseC2239176 | associated_with | p53,HCC |
108#111#gene7157238#262#diseaseC2239176 | 19376776-5#108#111#gene7157 | 19376776-5#238#262#diseaseC2239176 | associated_with | p53,hepatocellular carcinoma |
182#185#gene7157134#137#diseaseC2239176 | 19376776-5#182#185#gene7157 | 19376776-5#134#137#diseaseC2239176 | associated_with | p53,HCC |
182#185#gene7157238#262#diseaseC2239176 | 19376776-5#182#185#gene7157 | 19376776-5#238#262#diseaseC2239176 | associated_with | p53,hepatocellular carcinoma |