> top > docs > PubMed:19319147 > annotations

PubMed:19319147 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage.
T2 126-206 Sentence denotes Warfarin-associated intracerebral hemorrhage (W-ICH) is a severe type of stroke.
T3 207-264 Sentence denotes There is no consensus on the optimal treatment for W-ICH.
T4 265-428 Sentence denotes Using a mouse model, we tested whether the rapid reversal of anticoagulation using human prothrombin complex concentrate (PCC) can reduce hemorrhagic blood volume.
T5 429-566 Sentence denotes Male CD-1 mice were treated with warfarin (2 mg/kg over 24 h), resulting in a mean (+/-s.d.) International Normalized Ratio of 3.5+/-0.9.
T6 567-673 Sentence denotes First, we showed that an intravenous administration of human PCC rapidly reversed anticoagulation in mice.
T7 674-782 Sentence denotes Second, a stereotactic injection of collagenase was administered to induce hemorrhage in the right striatum.
T8 783-895 Sentence denotes Forty-five minutes later, the animals were randomly treated with PCC (100 U/kg) or saline i.v. (n=12 per group).
T9 896-1019 Sentence denotes Twenty-four hours after hemorrhage induction, hemorrhagic blood volume was quantified using a photometric hemoglobin assay.
T10 1020-1168 Sentence denotes The mean hemorrhagic blood volume was reduced in PCC-treated animals (6.5+/-3.1 microL) compared with saline controls (15.3+/-11.2 microL, P=0.015).
T11 1169-1251 Sentence denotes In the saline group, 45% of the mice developed large hematomas (i.e., >15 microL).
T12 1252-1322 Sentence denotes In contrast, such extensive lesions were never found in the PCC group.
T13 1323-1458 Sentence denotes We provide experimental data suggesting PCC to be an effective acute treatment for W-ICH in terms of reducing hemorrhagic blood volume.
T14 1459-1563 Sentence denotes Future studies are needed to assess the therapeutic potential emerging from our finding for human W-ICH.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 65-70 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088
T3 273-278 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088
T5 348-353 OrganismTaxon denotes human NCBItxid:9606
T6 439-443 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T8 622-627 OrganismTaxon denotes human NCBItxid:9606
T9 668-672 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T11 1201-1205 OrganismTaxon denotes mice NCBItxid:10095|NCBItxid:10088
T13 1551-1556 OrganismTaxon denotes human NCBItxid:9606

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
5912 42-52 DiseaseOrPhenotypicFeature denotes hemorrhage MESH:D006470
5913 65-70 OrganismTaxon denotes mouse NCBITaxon:10090
5914 80-88 ChemicalEntity denotes warfarin MESH:D014859
5915 100-124 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage MESH:D002543
5916 126-134 ChemicalEntity denotes Warfarin MESH:D014859
5917 146-170 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage MESH:D002543
5918 172-173 ChemicalEntity denotes W MESH:D014859
5919 174-177 DiseaseOrPhenotypicFeature denotes ICH MESH:D002543
5920 199-205 DiseaseOrPhenotypicFeature denotes stroke MESH:D020521
5921 258-259 ChemicalEntity denotes W MESH:D014859
5922 260-263 DiseaseOrPhenotypicFeature denotes ICH MESH:D002543
5923 273-278 OrganismTaxon denotes mouse NCBITaxon:10090
5924 348-353 OrganismTaxon denotes human NCBITaxon:9606
5925 354-385 ChemicalEntity denotes prothrombin complex concentrate MESH:C025667
5926 387-390 ChemicalEntity denotes PCC MESH:C025667
5927 439-443 OrganismTaxon denotes mice NCBITaxon:10090
5928 462-470 ChemicalEntity denotes warfarin MESH:D014859
5929 622-627 OrganismTaxon denotes human NCBITaxon:9606
5930 628-631 ChemicalEntity denotes PCC MESH:C025667
5931 668-672 OrganismTaxon denotes mice NCBITaxon:10090
5932 710-721 ChemicalEntity denotes collagenase MESH:D017364
5933 749-759 DiseaseOrPhenotypicFeature denotes hemorrhage MESH:D006470
5934 848-851 ChemicalEntity denotes PCC MESH:C025667
5935 920-930 DiseaseOrPhenotypicFeature denotes hemorrhage MESH:D006470
5936 1069-1072 ChemicalEntity denotes PCC MESH:C025667
5937 1201-1205 OrganismTaxon denotes mice NCBITaxon:10090
5938 1222-1231 DiseaseOrPhenotypicFeature denotes hematomas MESH:D006406
5939 1312-1315 ChemicalEntity denotes PCC MESH:C025667
5940 1363-1366 ChemicalEntity denotes PCC MESH:C025667
5941 1406-1407 ChemicalEntity denotes W MESH:D014859
5942 1408-1411 DiseaseOrPhenotypicFeature denotes ICH MESH:D002543
5943 1551-1556 OrganismTaxon denotes human NCBITaxon:9606
5944 1557-1558 ChemicalEntity denotes W MESH:D014859
5945 1559-1562 DiseaseOrPhenotypicFeature denotes ICH MESH:D002543

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 100-124 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage 0013792
T2 146-170 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage 0013792

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 34-41 GeneOrGeneProduct denotes reduces
T2 60-64 GeneOrGeneProduct denotes in a
T3 172-177 GeneOrGeneProduct denotes W-ICH
T4 258-263 GeneOrGeneProduct denotes W-ICH
T5 289-295 GeneOrGeneProduct denotes tested
T6 354-365 GeneOrGeneProduct denotes prothrombin
T7 396-402 GeneOrGeneProduct denotes reduce
T8 429-433 GeneOrGeneProduct denotes Male
T9 434-438 GeneOrGeneProduct denotes CD-1
T10 439-443 GeneOrGeneProduct denotes mice
T11 474-476 GeneOrGeneProduct denotes mg
T12 502-506 GeneOrGeneProduct denotes in a
T13 668-672 GeneOrGeneProduct denotes mice
T14 710-721 GeneOrGeneProduct denotes collagenase
T15 742-748 GeneOrGeneProduct denotes induce
T16 767-772 GeneOrGeneProduct denotes right
T17 794-801 GeneOrGeneProduct denotes minutes
T18 802-807 GeneOrGeneProduct denotes later
T19 879-883 GeneOrGeneProduct denotes n=12
T20 884-887 GeneOrGeneProduct denotes per
T21 896-907 GeneOrGeneProduct denotes Twenty-four
T22 1002-1012 GeneOrGeneProduct denotes hemoglobin
T23 1058-1065 GeneOrGeneProduct denotes reduced
T24 1201-1205 GeneOrGeneProduct denotes mice
T25 1216-1221 GeneOrGeneProduct denotes large
T26 1255-1263 GeneOrGeneProduct denotes contrast
T27 1270-1279 GeneOrGeneProduct denotes extensive
T28 1280-1287 GeneOrGeneProduct denotes lesions
T29 1406-1411 GeneOrGeneProduct denotes W-ICH
T30 1415-1420 GeneOrGeneProduct denotes terms
T31 1424-1432 GeneOrGeneProduct denotes reducing
T32 1539-1546 GeneOrGeneProduct denotes finding
T33 1557-1562 GeneOrGeneProduct denotes W-ICH

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 172-177 GeneOrGeneProduct denotes W-ICH
T2 258-263 GeneOrGeneProduct denotes W-ICH
T3 354-365 GeneOrGeneProduct denotes prothrombin
T4 710-721 GeneOrGeneProduct denotes collagenase
T5 896-907 GeneOrGeneProduct denotes Twenty-four
T6 1002-1012 GeneOrGeneProduct denotes hemoglobin
T7 1058-1065 GeneOrGeneProduct denotes reduced
T8 1216-1221 GeneOrGeneProduct denotes large
T9 1280-1287 GeneOrGeneProduct denotes lesions
T10 1406-1411 GeneOrGeneProduct denotes W-ICH
T11 1557-1562 GeneOrGeneProduct denotes W-ICH

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 42-52 DiseaseOrPhenotypicFeature denotes hemorrhage D006470
T2 100-124 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage D002543
T3 146-170 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage D002543
T4 199-205 DiseaseOrPhenotypicFeature denotes stroke D020521
T5 403-414 DiseaseOrPhenotypicFeature denotes hemorrhagic D006470
T6 749-759 DiseaseOrPhenotypicFeature denotes hemorrhage D006470
T7 920-930 DiseaseOrPhenotypicFeature denotes hemorrhage D006470
T8 942-953 DiseaseOrPhenotypicFeature denotes hemorrhagic D006470
T9 1029-1040 DiseaseOrPhenotypicFeature denotes hemorrhagic D006470
T10 1222-1231 DiseaseOrPhenotypicFeature denotes hematomas D006406
T11 1433-1444 DiseaseOrPhenotypicFeature denotes hemorrhagic D006470

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 354-365 GeneOrGeneProduct denotes prothrombin
T2 1002-1012 GeneOrGeneProduct denotes hemoglobin

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 100-124 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage 0013792
T2 146-170 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage 0013792
T3 199-205 DiseaseOrPhenotypicFeature denotes stroke 0005098
T4 387-390 DiseaseOrPhenotypicFeature denotes PCC 0022673|0004974
T6 392-395 DiseaseOrPhenotypicFeature denotes can 0012833
T7 434-436 DiseaseOrPhenotypicFeature denotes CD 0016063
T8 628-631 DiseaseOrPhenotypicFeature denotes PCC 0022673|0004974
T10 848-851 DiseaseOrPhenotypicFeature denotes PCC 0022673|0004974
T12 1069-1072 DiseaseOrPhenotypicFeature denotes PCC 0022673|0004974
T14 1312-1315 DiseaseOrPhenotypicFeature denotes PCC 0022673|0004974
T16 1363-1366 DiseaseOrPhenotypicFeature denotes PCC 0022673|0004974

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 42-52 DiseaseOrPhenotypicFeature denotes hemorrhage DISEASE|D006470
T3 100-124 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage D002543
T4 146-170 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage D002543
T5 174-177 DiseaseOrPhenotypicFeature denotes ICH DISEASE
T6 199-205 DiseaseOrPhenotypicFeature denotes stroke DISEASE|D020521
T8 260-263 DiseaseOrPhenotypicFeature denotes ICH DISEASE
T9 749-759 DiseaseOrPhenotypicFeature denotes hemorrhage DISEASE|D006470
T11 920-930 DiseaseOrPhenotypicFeature denotes hemorrhage DISEASE|D006470
T13 1222-1231 DiseaseOrPhenotypicFeature denotes hematomas D006406
T14 1408-1411 DiseaseOrPhenotypicFeature denotes ICH DISEASE
T15 1559-1562 DiseaseOrPhenotypicFeature denotes ICH DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 42-52 DiseaseOrPhenotypicFeature denotes hemorrhage D006470
T2 100-124 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage D002543
T3 146-170 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage D002543
T4 174-177 DiseaseOrPhenotypicFeature denotes ICH DISEASE
T5 199-205 DiseaseOrPhenotypicFeature denotes stroke D020521
T6 260-263 DiseaseOrPhenotypicFeature denotes ICH DISEASE
T7 749-759 DiseaseOrPhenotypicFeature denotes hemorrhage D006470
T8 920-930 DiseaseOrPhenotypicFeature denotes hemorrhage D006470
T9 1222-1231 DiseaseOrPhenotypicFeature denotes hematomas D006406
T10 1408-1411 DiseaseOrPhenotypicFeature denotes ICH DISEASE
T11 1559-1562 DiseaseOrPhenotypicFeature denotes ICH DISEASE

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 65-70 OrganismTaxon denotes mouse
T2 273-278 OrganismTaxon denotes mouse
T3 348-353 OrganismTaxon denotes human
T4 439-443 OrganismTaxon denotes mice
T5 622-627 OrganismTaxon denotes human
T6 668-672 OrganismTaxon denotes mice
T7 1201-1205 OrganismTaxon denotes mice
T8 1551-1556 OrganismTaxon denotes human

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 80-88 ChemicalEntity denotes warfarin D014859|http://purl.obolibrary.org/obo/CHEBI_10033
T3 126-134 ChemicalEntity denotes Warfarin D014859|http://purl.obolibrary.org/obo/CHEBI_10033
T5 354-365 ChemicalEntity denotes prothrombin http://purl.obolibrary.org/obo/CHEBI_8583
T6 387-390 ChemicalEntity denotes PCC ChemicalEntity
T7 462-470 ChemicalEntity denotes warfarin D014859|http://purl.obolibrary.org/obo/CHEBI_10033
T9 628-631 ChemicalEntity denotes PCC ChemicalEntity
T10 710-721 ChemicalEntity denotes collagenase D017364|ChemicalEntity
T12 848-851 ChemicalEntity denotes PCC ChemicalEntity
T13 1002-1012 ChemicalEntity denotes hemoglobin http://purl.obolibrary.org/obo/CHEBI_35143
T14 1069-1072 ChemicalEntity denotes PCC ChemicalEntity
T15 1312-1315 ChemicalEntity denotes PCC ChemicalEntity
T16 1363-1366 ChemicalEntity denotes PCC ChemicalEntity

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T16 1363-1366 ChemicalEntity denotes PCC ChemicalEntity
T15 1312-1315 ChemicalEntity denotes PCC ChemicalEntity
T14 1069-1072 ChemicalEntity denotes PCC ChemicalEntity
T13 1002-1012 ChemicalEntity denotes hemoglobin http://purl.obolibrary.org/obo/CHEBI_35143
T12 848-851 ChemicalEntity denotes PCC ChemicalEntity
T10 710-721 ChemicalEntity denotes collagenase ChemicalEntity|D017364
T9 628-631 ChemicalEntity denotes PCC ChemicalEntity
T7 462-470 ChemicalEntity denotes warfarin http://purl.obolibrary.org/obo/CHEBI_10033|D014859
T6 387-390 ChemicalEntity denotes PCC ChemicalEntity
T5 354-365 ChemicalEntity denotes prothrombin http://purl.obolibrary.org/obo/CHEBI_8583
T3 126-134 ChemicalEntity denotes Warfarin http://purl.obolibrary.org/obo/CHEBI_10033|D014859
T1 80-88 ChemicalEntity denotes warfarin http://purl.obolibrary.org/obo/CHEBI_10033|D014859
T2 1002-1012 GeneOrGeneProduct denotes hemoglobin
T4882 354-365 GeneOrGeneProduct denotes prothrombin
T11 1559-1562 DiseaseOrPhenotypicFeature denotes ICH DISEASE
T24843 1408-1411 DiseaseOrPhenotypicFeature denotes ICH DISEASE
T64851 1222-1231 DiseaseOrPhenotypicFeature denotes hematomas D006406
T8 920-930 DiseaseOrPhenotypicFeature denotes hemorrhage D006470
T57988 749-759 DiseaseOrPhenotypicFeature denotes hemorrhage D006470
T31365 260-263 DiseaseOrPhenotypicFeature denotes ICH DISEASE
T48694 199-205 DiseaseOrPhenotypicFeature denotes stroke D020521
T4 174-177 DiseaseOrPhenotypicFeature denotes ICH DISEASE
T4613 146-170 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage D002543
T76063 100-124 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage D002543
T80370 42-52 DiseaseOrPhenotypicFeature denotes hemorrhage D006470
T9166 1551-1556 OrganismTaxon denotes human
T25701 1201-1205 OrganismTaxon denotes mice
T51508 668-672 OrganismTaxon denotes mice
T25854 622-627 OrganismTaxon denotes human
T60085 439-443 OrganismTaxon denotes mice
T30175 348-353 OrganismTaxon denotes human
T67382 273-278 OrganismTaxon denotes mouse
T69342 65-70 OrganismTaxon denotes mouse

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 100-124 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage 0013792
T2 146-170 DiseaseOrPhenotypicFeature denotes intracerebral hemorrhage 0013792
T3 199-205 DiseaseOrPhenotypicFeature denotes stroke 0005098
T4 387-390 DiseaseOrPhenotypicFeature denotes PCC 0004974|0022673
T6 392-395 DiseaseOrPhenotypicFeature denotes can 0012833
T7 434-436 DiseaseOrPhenotypicFeature denotes CD 0016063
T8 628-631 DiseaseOrPhenotypicFeature denotes PCC 0004974|0022673
T10 848-851 DiseaseOrPhenotypicFeature denotes PCC 0004974|0022673
T12 1069-1072 DiseaseOrPhenotypicFeature denotes PCC 0004974|0022673
T14 1312-1315 DiseaseOrPhenotypicFeature denotes PCC 0004974|0022673
T16 1363-1366 DiseaseOrPhenotypicFeature denotes PCC 0004974|0022673