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PubMed:19318518 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 402-409 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 594-601 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 402-409 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T2 594-601 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 30-42 DiseaseOrPhenotypicFeature denotes tuberculosis 0018076
T2 222-234 DiseaseOrPhenotypicFeature denotes tuberculosis 0018076
T3 393-395 DiseaseOrPhenotypicFeature denotes LM 0002013
T4 1018-1020 DiseaseOrPhenotypicFeature denotes LM 0002013
T5 1221-1230 DiseaseOrPhenotypicFeature denotes infection 0005550

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-203 Sentence denotes Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death.
TextSentencer_T2 204-654 Sentence denotes The Mycobacterium tuberculosis (M.tb) cell wall contains an important group of structurally related mannosylated lipoglycans called phosphatidyl-myo-inositol mannosides (PIMs), lipomannan (LM), and mannose-capped lipoarabinomannan (ManLAM), where the terminal alpha-[1-->2] mannosyl structures on higher order PIMs and ManLAM have been shown to engage C-type lectins such as the macrophage mannose receptor directing M.tb phagosome maturation arrest.
TextSentencer_T3 655-763 Sentence denotes An important gene described in the biosynthesis of these molecules is the mannosyltransferase pimB (Rv0557).
TextSentencer_T4 764-817 Sentence denotes Here, we disrupted pimB in a virulent strain of M.tb.
TextSentencer_T5 818-1207 Sentence denotes We demonstrate that the inactivation of pimB in M.tb does not abolish the production of any of its cell wall mannosylated lipoglycans; however, it results in a quantitative decrease in the ManLAM and LM content without affecting higher order PIMs. This finding indicates gene redundancy or the possibility of an alternative biosynthetic pathway that may compensate for the PimB deficiency.
TextSentencer_T6 1208-1390 Sentence denotes Furthermore, infection of human macrophages by the pimB mutant leads to an alteration in macrophage phenotype concomitant with a significant increase in the rate of macrophage death.
T1 0-203 Sentence denotes Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death.
T2 204-654 Sentence denotes The Mycobacterium tuberculosis (M.tb) cell wall contains an important group of structurally related mannosylated lipoglycans called phosphatidyl-myo-inositol mannosides (PIMs), lipomannan (LM), and mannose-capped lipoarabinomannan (ManLAM), where the terminal alpha-[1-->2] mannosyl structures on higher order PIMs and ManLAM have been shown to engage C-type lectins such as the macrophage mannose receptor directing M.tb phagosome maturation arrest.
T3 655-763 Sentence denotes An important gene described in the biosynthesis of these molecules is the mannosyltransferase pimB (Rv0557).
T4 764-817 Sentence denotes Here, we disrupted pimB in a virulent strain of M.tb.
T5 818-1207 Sentence denotes We demonstrate that the inactivation of pimB in M.tb does not abolish the production of any of its cell wall mannosylated lipoglycans; however, it results in a quantitative decrease in the ManLAM and LM content without affecting higher order PIMs. This finding indicates gene redundancy or the possibility of an alternative biosynthetic pathway that may compensate for the PimB deficiency.
T6 1208-1390 Sentence denotes Furthermore, infection of human macrophages by the pimB mutant leads to an alteration in macrophage phenotype concomitant with a significant increase in the rate of macrophage death.
T1 0-203 Sentence denotes Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death.
T2 204-654 Sentence denotes The Mycobacterium tuberculosis (M.tb) cell wall contains an important group of structurally related mannosylated lipoglycans called phosphatidyl-myo-inositol mannosides (PIMs), lipomannan (LM), and mannose-capped lipoarabinomannan (ManLAM), where the terminal alpha-[1-->2] mannosyl structures on higher order PIMs and ManLAM have been shown to engage C-type lectins such as the macrophage mannose receptor directing M.tb phagosome maturation arrest.
T3 655-763 Sentence denotes An important gene described in the biosynthesis of these molecules is the mannosyltransferase pimB (Rv0557).
T4 764-817 Sentence denotes Here, we disrupted pimB in a virulent strain of M.tb.
T5 818-1207 Sentence denotes We demonstrate that the inactivation of pimB in M.tb does not abolish the production of any of its cell wall mannosylated lipoglycans; however, it results in a quantitative decrease in the ManLAM and LM content without affecting higher order PIMs. This finding indicates gene redundancy or the possibility of an alternative biosynthetic pathway that may compensate for the PimB deficiency.
T6 1208-1390 Sentence denotes Furthermore, infection of human macrophages by the pimB mutant leads to an alteration in macrophage phenotype concomitant with a significant increase in the rate of macrophage death.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 402-409 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 594-601 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

ICD10

Id Subject Object Predicate Lexical cue
T1 30-42 http://purl.bioontology.org/ontology/ICD10/A15-A19.9 denotes tuberculosis
T2 222-234 http://purl.bioontology.org/ontology/ICD10/A15-A19.9 denotes tuberculosis

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T3 181-191 FMAID:167685 denotes macrophage
_T1 149-153 FMAID:217859 denotes rate
_T2 181-191 FMAID:63261 denotes macrophage
_T4 283-303 FMAID:167966 denotes structurally related
_T5 283-303 FMAID:50627 denotes structurally related
_T6 336-361 FMAID:199790 denotes phosphatidyl-myo-inositol
_T7 336-361 FMAID:85436 denotes phosphatidyl-myo-inositol
_T8 349-361 FMAID:196795 denotes myo-inositol
_T9 349-361 FMAID:82800 denotes myo-inositol
_T10 402-409 FMAID:82801 denotes mannose
_T11 402-409 FMAID:196796 denotes mannose
_T12 583-593 FMAID:63261 denotes macrophage
_T13 583-593 FMAID:167685 denotes macrophage
_T14 594-601 FMAID:196796 denotes mannose
_T15 594-601 FMAID:82801 denotes mannose
_T16 626-635 FMAID:83022 denotes phagosome
_T17 626-635 FMAID:90000 denotes phagosome
_T18 668-672 FMAID:198663 denotes gene
_T19 1089-1093 FMAID:198663 denotes gene
_T20 1240-1251 FMAID:167685 denotes macrophages
_T21 1240-1251 FMAID:63261 denotes macrophages
_T22 1297-1307 FMAID:167685 denotes macrophage
_T23 1297-1307 FMAID:63261 denotes macrophage
_T24 1365-1369 FMAID:217859 denotes rate
_T25 1373-1383 FMAID:167685 denotes macrophage
_T26 1373-1383 FMAID:63261 denotes macrophage

uniprot-human

Id Subject Object Predicate Lexical cue
T1 464-476 http://www.uniprot.org/uniprot/Q05639 denotes alpha-[1-->2

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 349-352 http://www.uniprot.org/uniprot/Q9JIF9 denotes myo

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 16-29 http://purl.bioontology.org/ontology/NCBITAXON/46351 denotes Mycobacterium
T2 16-29 http://purl.bioontology.org/ontology/NCBITAXON/1794 denotes Mycobacterium
T3 16-29 http://purl.bioontology.org/ontology/NCBITAXON/33894 denotes Mycobacterium
T4 16-29 http://purl.bioontology.org/ontology/NCBITAXON/98668 denotes Mycobacterium
T5 16-29 http://purl.bioontology.org/ontology/NCBITAXON/230710 denotes Mycobacterium
T6 16-29 http://purl.bioontology.org/ontology/NCBITAXON/370526 denotes Mycobacterium
T7 16-29 http://purl.bioontology.org/ontology/NCBITAXON/1288388 denotes Mycobacterium
T8 16-29 http://purl.bioontology.org/ontology/NCBITAXON/318424 denotes Mycobacterium
T9 16-29 http://purl.bioontology.org/ontology/NCBITAXON/470074 denotes Mycobacterium
T10 16-29 http://purl.bioontology.org/ontology/NCBITAXON/39693 denotes Mycobacterium
T11 16-29 http://purl.bioontology.org/ontology/NCBITAXON/1790 denotes Mycobacterium
T12 16-29 http://purl.bioontology.org/ontology/NCBITAXON/912594 denotes Mycobacterium
T13 16-29 http://purl.bioontology.org/ontology/NCBITAXON/1791 denotes Mycobacterium
T14 16-29 http://purl.bioontology.org/ontology/NCBITAXON/319706 denotes Mycobacterium
T15 16-29 http://purl.bioontology.org/ontology/NCBITAXON/56425 denotes Mycobacterium
T16 16-29 http://purl.bioontology.org/ontology/NCBITAXON/1795 denotes Mycobacterium
T17 16-29 http://purl.bioontology.org/ontology/NCBITAXON/28045 denotes Mycobacterium
T18 16-29 http://purl.bioontology.org/ontology/NCBITAXON/1781 denotes Mycobacterium
T19 16-29 http://purl.bioontology.org/ontology/NCBITAXON/1766 denotes Mycobacterium
T20 16-29 http://purl.bioontology.org/ontology/NCBITAXON/368455 denotes Mycobacterium
T21 16-42 http://purl.bioontology.org/ontology/NCBITAXON/77643 denotes Mycobacterium tuberculosis
T22 30-42 http://purl.bioontology.org/ontology/NCBITAXON/1407443 denotes tuberculosis
T23 208-221 http://purl.bioontology.org/ontology/NCBITAXON/1794 denotes Mycobacterium
T24 208-221 http://purl.bioontology.org/ontology/NCBITAXON/46351 denotes Mycobacterium
T25 208-221 http://purl.bioontology.org/ontology/NCBITAXON/1766 denotes Mycobacterium
T26 208-221 http://purl.bioontology.org/ontology/NCBITAXON/912594 denotes Mycobacterium
T27 208-221 http://purl.bioontology.org/ontology/NCBITAXON/28045 denotes Mycobacterium
T28 208-221 http://purl.bioontology.org/ontology/NCBITAXON/1781 denotes Mycobacterium
T29 208-221 http://purl.bioontology.org/ontology/NCBITAXON/56425 denotes Mycobacterium
T30 208-221 http://purl.bioontology.org/ontology/NCBITAXON/1795 denotes Mycobacterium
T31 208-221 http://purl.bioontology.org/ontology/NCBITAXON/1791 denotes Mycobacterium
T32 208-221 http://purl.bioontology.org/ontology/NCBITAXON/319706 denotes Mycobacterium
T33 208-221 http://purl.bioontology.org/ontology/NCBITAXON/1790 denotes Mycobacterium
T34 208-221 http://purl.bioontology.org/ontology/NCBITAXON/98668 denotes Mycobacterium
T35 208-221 http://purl.bioontology.org/ontology/NCBITAXON/470074 denotes Mycobacterium
T36 208-221 http://purl.bioontology.org/ontology/NCBITAXON/39693 denotes Mycobacterium
T37 208-221 http://purl.bioontology.org/ontology/NCBITAXON/1288388 denotes Mycobacterium
T38 208-221 http://purl.bioontology.org/ontology/NCBITAXON/318424 denotes Mycobacterium
T39 208-221 http://purl.bioontology.org/ontology/NCBITAXON/230710 denotes Mycobacterium
T40 208-221 http://purl.bioontology.org/ontology/NCBITAXON/370526 denotes Mycobacterium
T41 208-221 http://purl.bioontology.org/ontology/NCBITAXON/33894 denotes Mycobacterium
T42 208-221 http://purl.bioontology.org/ontology/NCBITAXON/368455 denotes Mycobacterium
T43 208-234 http://purl.bioontology.org/ontology/NCBITAXON/77643 denotes Mycobacterium tuberculosis
T44 222-234 http://purl.bioontology.org/ontology/NCBITAXON/1407443 denotes tuberculosis
T45 274-279 http://purl.bioontology.org/ontology/STY/T096 denotes group
T46 296-303 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related
T47 1071-1078 http://purl.bioontology.org/ontology/STY/T033 denotes finding

GO-BP

Id Subject Object Predicate Lexical cue
T1 192-202 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T2 197-202 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3 1384-1389 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T4 304-316 http://purl.obolibrary.org/obo/GO_0097502 denotes mannosylated
T5 478-486 http://purl.obolibrary.org/obo/GO_0097502 denotes mannosyl
T6 626-646 http://purl.obolibrary.org/obo/GO_0090382 denotes phagosome maturation
T7 690-702 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T8 793-801 http://purl.obolibrary.org/obo/GO_0009405 denotes virulent
T9 793-801 http://purl.obolibrary.org/obo/GO_0016032 denotes virulent

GO-CC

Id Subject Object Predicate Lexical cue
T1 80-84 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 192-196 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 242-246 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 917-921 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 80-89 http://purl.obolibrary.org/obo/GO_0005618 denotes cell wall
T6 242-251 http://purl.obolibrary.org/obo/GO_0005618 denotes cell wall
T7 917-926 http://purl.obolibrary.org/obo/GO_0005618 denotes cell wall
T8 242-260 http://purl.obolibrary.org/obo/GO_0009277 denotes cell wall contains
T9 626-635 http://purl.obolibrary.org/obo/GO_0045335 denotes phagosome

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 583-610 https://acgg.asia/db/lfdb/LfDB0024 denotes macrophage mannose receptor

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 30-42 Disease denotes tuberculosis http://purl.obolibrary.org/obo/MONDO_0018076
T2 222-234 Disease denotes tuberculosis http://purl.obolibrary.org/obo/MONDO_0018076
T3 1221-1230 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-203 Sentence denotes Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death.
T2 204-654 Sentence denotes The Mycobacterium tuberculosis (M.tb) cell wall contains an important group of structurally related mannosylated lipoglycans called phosphatidyl-myo-inositol mannosides (PIMs), lipomannan (LM), and mannose-capped lipoarabinomannan (ManLAM), where the terminal alpha-[1-->2] mannosyl structures on higher order PIMs and ManLAM have been shown to engage C-type lectins such as the macrophage mannose receptor directing M.tb phagosome maturation arrest.
T3 655-763 Sentence denotes An important gene described in the biosynthesis of these molecules is the mannosyltransferase pimB (Rv0557).
T4 764-817 Sentence denotes Here, we disrupted pimB in a virulent strain of M.tb.
T5 818-1207 Sentence denotes We demonstrate that the inactivation of pimB in M.tb does not abolish the production of any of its cell wall mannosylated lipoglycans; however, it results in a quantitative decrease in the ManLAM and LM content without affecting higher order PIMs. This finding indicates gene redundancy or the possibility of an alternative biosynthetic pathway that may compensate for the PimB deficiency.
T6 1208-1390 Sentence denotes Furthermore, infection of human macrophages by the pimB mutant leads to an alteration in macrophage phenotype concomitant with a significant increase in the rate of macrophage death.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 16-42 OrganismTaxon denotes Mycobacterium tuberculosis 1773
T2 175-180 OrganismTaxon denotes human 9606
T3 208-234 OrganismTaxon denotes Mycobacterium tuberculosis 1773
T4 1234-1239 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 85-89 Body_part denotes wall http://purl.obolibrary.org/obo/UBERON_0000060
T2 181-191 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T3 247-251 Body_part denotes wall http://purl.obolibrary.org/obo/UBERON_0000060
T4 583-593 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T5 922-926 Body_part denotes wall http://purl.obolibrary.org/obo/UBERON_0000060
T6 1240-1251 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T7 1297-1307 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T8 1373-1383 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 181-191 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T3 583-593 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T5 1240-1251 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T7 1297-1307 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T9 1373-1383 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394