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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 74-86 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 713-724 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T3 1873-1884 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063

Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 1573-1579 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 1573-1579 Glycan_Motif denotes core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-156 Sentence denotes Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.
TextSentencer_T2 157-285 Sentence denotes Tumors that display a high level of microsatellite instability (MSI-H) accumulate somatic frameshift mutations in several genes.
TextSentencer_T3 286-452 Sentence denotes The compensation of this loss of function by transfection represents a suitable approach to tie respective gene deficiency to alterations in cellular characteristics.
TextSentencer_T4 453-922 Sentence denotes In view of the emerging significance of cell surface glycans as biochemical signals for presentation/activity of various receptors/integrins and for susceptibility to adhesion/growth-regulatory tissue lectins, we examined the glycophenotype in the MSI-H colon cancer cell line HCT116 for activin type 2 receptor (ACVR2), absent in melanoma 2 (AIM2), and transforming growth factor beta-type 2 receptor (TGFBR2) known to be associated with MSI colorectal carcinogenesis.
TextSentencer_T5 923-1111 Sentence denotes A panel of probes specific for functional carbohydrate epitopes including human lectins was used to trace changes in cell surface levels, thereby initiating glycan analysis related to MSI.
TextSentencer_T6 1112-1285 Sentence denotes In particular, the presence of core substitutions and branching in N-glycans, the sialylation status of N- and O-glycans, and the presence of Le(a/x)-epitopes were profiled.
TextSentencer_T7 1286-1388 Sentence denotes Transient transfection affected the glycophenotype, depending on the nature of the gene and the probe.
TextSentencer_T8 1389-1550 Sentence denotes The TGFBR2 presence reduced binding of probes specific for a core substitution and increased branch length in N-glycosylation, even reaching a P-value of 0.0016.
TextSentencer_T9 1551-1673 Sentence denotes ACVR2/AIM2 influenced core 1 mucin-type O-glycosylation differentially, upregulation by ACVR2, and downregulation by AIM2.
TextSentencer_T10 1674-1962 Sentence denotes These alterations of cell surface glycosylation by gene products that are not directly associated with the machinery for glycan generation direct attention to pursue analysis of glycosylation in MSI tumor cells on the level of target glycoproteins and open the way for functional studies.
T1 0-156 Sentence denotes Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.
T2 157-285 Sentence denotes Tumors that display a high level of microsatellite instability (MSI-H) accumulate somatic frameshift mutations in several genes.
T3 286-452 Sentence denotes The compensation of this loss of function by transfection represents a suitable approach to tie respective gene deficiency to alterations in cellular characteristics.
T4 453-922 Sentence denotes In view of the emerging significance of cell surface glycans as biochemical signals for presentation/activity of various receptors/integrins and for susceptibility to adhesion/growth-regulatory tissue lectins, we examined the glycophenotype in the MSI-H colon cancer cell line HCT116 for activin type 2 receptor (ACVR2), absent in melanoma 2 (AIM2), and transforming growth factor beta-type 2 receptor (TGFBR2) known to be associated with MSI colorectal carcinogenesis.
T5 923-1111 Sentence denotes A panel of probes specific for functional carbohydrate epitopes including human lectins was used to trace changes in cell surface levels, thereby initiating glycan analysis related to MSI.
T6 1112-1285 Sentence denotes In particular, the presence of core substitutions and branching in N-glycans, the sialylation status of N- and O-glycans, and the presence of Le(a/x)-epitopes were profiled.
T7 1286-1388 Sentence denotes Transient transfection affected the glycophenotype, depending on the nature of the gene and the probe.
T8 1389-1550 Sentence denotes The TGFBR2 presence reduced binding of probes specific for a core substitution and increased branch length in N-glycosylation, even reaching a P-value of 0.0016.
T9 1551-1673 Sentence denotes ACVR2/AIM2 influenced core 1 mucin-type O-glycosylation differentially, upregulation by ACVR2, and downregulation by AIM2.
T10 1674-1962 Sentence denotes These alterations of cell surface glycosylation by gene products that are not directly associated with the machinery for glycan generation direct attention to pursue analysis of glycosylation in MSI tumor cells on the level of target glycoproteins and open the way for functional studies.
T1 0-156 Sentence denotes Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.
T2 157-285 Sentence denotes Tumors that display a high level of microsatellite instability (MSI-H) accumulate somatic frameshift mutations in several genes.
T3 286-452 Sentence denotes The compensation of this loss of function by transfection represents a suitable approach to tie respective gene deficiency to alterations in cellular characteristics.
T4 453-922 Sentence denotes In view of the emerging significance of cell surface glycans as biochemical signals for presentation/activity of various receptors/integrins and for susceptibility to adhesion/growth-regulatory tissue lectins, we examined the glycophenotype in the MSI-H colon cancer cell line HCT116 for activin type 2 receptor (ACVR2), absent in melanoma 2 (AIM2), and transforming growth factor beta-type 2 receptor (TGFBR2) known to be associated with MSI colorectal carcinogenesis.
T5 923-1111 Sentence denotes A panel of probes specific for functional carbohydrate epitopes including human lectins was used to trace changes in cell surface levels, thereby initiating glycan analysis related to MSI.
T6 1112-1285 Sentence denotes In particular, the presence of core substitutions and branching in N-glycans, the sialylation status of N- and O-glycans, and the presence of Le(a/x)-epitopes were profiled.
T7 1286-1388 Sentence denotes Transient transfection affected the glycophenotype, depending on the nature of the gene and the probe.
T8 1389-1550 Sentence denotes The TGFBR2 presence reduced binding of probes specific for a core substitution and increased branch length in N-glycosylation, even reaching a P-value of 0.0016.
T9 1551-1673 Sentence denotes ACVR2/AIM2 influenced core 1 mucin-type O-glycosylation differentially, upregulation by ACVR2, and downregulation by AIM2.
T10 1674-1962 Sentence denotes These alterations of cell surface glycosylation by gene products that are not directly associated with the machinery for glycan generation direct attention to pursue analysis of glycosylation in MSI tumor cells on the level of target glycoproteins and open the way for functional studies.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1573-1579 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 68-73 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T2 707-712 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

DisGeNET

Id Subject Object Predicate Lexical cue
T0 766-771 gene:92 denotes ACVR2
T1 707-719 disease:C0007102 denotes colon cancer
T2 766-771 gene:92 denotes ACVR2
T3 707-719 disease:C0699790 denotes colon cancer
T4 766-771 gene:92 denotes ACVR2
T5 730-736 disease:C0699790 denotes HCT116
T6 766-771 gene:92 denotes ACVR2
T7 730-736 disease:C0007102 denotes HCT116
T8 766-771 gene:92 denotes ACVR2
T9 907-921 disease:C0596263 denotes carcinogenesis
T10 774-794 gene:9447 denotes absent in melanoma 2
T11 907-921 disease:C0596263 denotes carcinogenesis
T12 796-800 gene:9447 denotes AIM2
T13 730-736 disease:C0699790 denotes HCT116
T14 796-800 gene:9447 denotes AIM2
T15 730-736 disease:C0007102 denotes HCT116
T16 796-800 gene:9447 denotes AIM2
T17 907-921 disease:C0596263 denotes carcinogenesis
T18 856-862 gene:7048 denotes TGFBR2
T19 730-736 disease:C0699790 denotes HCT116
T20 856-862 gene:7048 denotes TGFBR2
T21 730-736 disease:C0007102 denotes HCT116
T22 856-862 gene:7048 denotes TGFBR2
T23 907-921 disease:C0596263 denotes carcinogenesis
R1 T0 T1 associated_with ACVR2,colon cancer
R2 T2 T3 associated_with ACVR2,colon cancer
R3 T4 T5 associated_with ACVR2,HCT116
R4 T6 T7 associated_with ACVR2,HCT116
R5 T8 T9 associated_with ACVR2,carcinogenesis
R6 T10 T11 associated_with absent in melanoma 2,carcinogenesis
R7 T12 T13 associated_with AIM2,HCT116
R8 T14 T15 associated_with AIM2,HCT116
R9 T16 T17 associated_with AIM2,carcinogenesis
R10 T18 T19 associated_with TGFBR2,HCT116
R11 T20 T21 associated_with TGFBR2,HCT116
R12 T22 T23 associated_with TGFBR2,carcinogenesis

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 24-31 FMAID:67257 denotes protein
_T2 24-31 FMAID:165447 denotes protein
_T3 68-73 FMAID:104231 denotes colon
_T4 68-73 FMAID:14543 denotes colon
_T5 81-86 FMAID:169002 denotes cells
_T6 81-86 FMAID:68646 denotes cells
_T7 99-103 FMAID:198663 denotes gene
_T8 128-140 FMAID:200942 denotes cell surface
_T9 128-140 FMAID:212684 denotes cell surface
_T10 133-140 FMAID:146300 denotes surface
_T11 133-140 FMAID:50594 denotes surface
_T12 279-284 FMAID:198663 denotes genes
_T13 393-397 FMAID:198663 denotes gene
_T14 493-505 FMAID:200942 denotes cell surface
_T15 493-505 FMAID:212684 denotes cell surface
_T16 498-505 FMAID:50594 denotes surface
_T17 498-505 FMAID:146300 denotes surface
_T18 584-593 FMAID:165244 denotes integrins
_T19 584-593 FMAID:67222 denotes integrins
_T20 647-653 FMAID:256050 denotes tissue
_T21 707-712 FMAID:14543 denotes colon
_T22 707-712 FMAID:104231 denotes colon
_T23 741-748 FMAID:67843 denotes activin
_T24 741-748 FMAID:90069 denotes activin
_T25 754-764 FMAID:166261 denotes 2 receptor
_T26 754-764 FMAID:61987 denotes 2 receptor
_T27 754-764 FMAID:67669 denotes 2 receptor
_T28 754-764 FMAID:166251 denotes 2 receptor
_T29 844-854 FMAID:67669 denotes 2 receptor
_T30 844-854 FMAID:166251 denotes 2 receptor
_T31 844-854 FMAID:166261 denotes 2 receptor
_T32 844-854 FMAID:61987 denotes 2 receptor
_T33 965-977 FMAID:82737 denotes carbohydrate
_T34 965-977 FMAID:197276 denotes carbohydrate
_T35 1040-1052 FMAID:212684 denotes cell surface
_T36 1040-1052 FMAID:200942 denotes cell surface
_T37 1045-1052 FMAID:146300 denotes surface
_T38 1045-1052 FMAID:50594 denotes surface
_T39 1166-1175 FMAID:226027 denotes branching
_T40 1166-1175 FMAID:226028 denotes branching
_T41 1369-1373 FMAID:198663 denotes gene
_T42 1482-1488 FMAID:226027 denotes branch
_T43 1482-1488 FMAID:226028 denotes branch
_T44 1695-1707 FMAID:212684 denotes cell surface
_T45 1695-1707 FMAID:200942 denotes cell surface
_T46 1700-1707 FMAID:146300 denotes surface
_T47 1700-1707 FMAID:50594 denotes surface
_T48 1725-1729 FMAID:198663 denotes gene
_T49 1879-1884 FMAID:169002 denotes cells
_T50 1879-1884 FMAID:68646 denotes cells
_T51 1908-1921 FMAID:62925 denotes glycoproteins
_T52 1908-1921 FMAID:167256 denotes glycoproteins

uniprot-human

Id Subject Object Predicate Lexical cue
T1 766-771 http://www.uniprot.org/uniprot/P27037 denotes ACVR2
T2 1551-1556 http://www.uniprot.org/uniprot/P27037 denotes ACVR2
T3 1639-1644 http://www.uniprot.org/uniprot/P27037 denotes ACVR2
T4 796-800 http://www.uniprot.org/uniprot/O14862 denotes AIM2
T5 1557-1561 http://www.uniprot.org/uniprot/O14862 denotes AIM2
T6 1668-1672 http://www.uniprot.org/uniprot/O14862 denotes AIM2
T7 820-838 http://www.uniprot.org/uniprot/P01138 denotes growth factor beta
T8 856-862 http://www.uniprot.org/uniprot/P37173 denotes TGFBR2
T9 1393-1399 http://www.uniprot.org/uniprot/P37173 denotes TGFBR2
T10 1578-1585 http://www.uniprot.org/uniprot/Q9BXA4 denotes 1 mucin

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 378-381 http://www.uniprot.org/uniprot/Q06806 denotes tie
T2 1578-1585 http://www.uniprot.org/uniprot/Q02496 denotes 1 mucin

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 74-80 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T2 81-86 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 574-583 http://purl.bioontology.org/ontology/STY/T192 denotes receptors
T4 647-653 http://purl.bioontology.org/ontology/STY/T024 denotes tissue
T5 713-719 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T6 784-792 http://purl.bioontology.org/ontology/NCBITAXON/1369386 denotes melanoma
T7 784-792 http://purl.bioontology.org/ontology/NCBITAXON/45308 denotes melanoma
T8 834-838 http://purl.bioontology.org/ontology/NCBITAXON/158455 denotes beta
T9 834-838 http://purl.bioontology.org/ontology/NCBITAXON/3554 denotes beta
T10 1096-1103 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related
T11 1879-1884 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 427-435 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T2 529-536 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T3 629-635 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T4 820-826 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T5 1194-1205 http://purl.obolibrary.org/obo/GO_0097503 denotes sialylation
T6 1501-1514 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T7 1593-1606 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T8 1708-1721 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T9 1852-1865 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T10 1695-1721 http://purl.obolibrary.org/obo/GO_0033575 denotes cell surface glycosylation

GO-MF

Id Subject Object Predicate Lexical cue
T1 741-748 http://purl.obolibrary.org/obo/GO_0005160 denotes activin
T2 820-838 http://purl.obolibrary.org/obo/GO_0005160 denotes growth factor beta
T3 1417-1424 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 1417-1424 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T5 1417-1424 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T6 1417-1424 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 81-86 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 128-132 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 493-497 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 720-724 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 1040-1044 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6 1695-1699 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T7 128-140 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T8 493-505 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T9 1040-1052 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T10 1695-1707 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T11 1143-1147 http://purl.obolibrary.org/obo/GO_0019013 denotes core
T12 1450-1454 http://purl.obolibrary.org/obo/GO_0019013 denotes core
T13 1573-1577 http://purl.obolibrary.org/obo/GO_0019013 denotes core

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 68-73 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T2 707-712 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T3 647-653 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19293232-3#313#318#gene92 766-771 gene92 denotes ACVR2
19293232-3#321#341#gene9447 774-794 gene9447 denotes absent in melanoma 2
19293232-3#343#347#gene9447 796-800 gene9447 denotes AIM2
19293232-3#403#409#gene7048 856-862 gene7048 denotes TGFBR2
19293232-3#313#318#gene92 766-771 gene92 denotes ACVR2
19293232-3#321#341#gene9447 774-794 gene9447 denotes absent in melanoma 2
19293232-3#343#347#gene9447 796-800 gene9447 denotes AIM2
19293232-3#403#409#gene7048 856-862 gene7048 denotes TGFBR2
19293232-3#254#266#diseaseC0007102 707-719 diseaseC0007102 denotes colon cancer
19293232-3#254#266#diseaseC0699790 707-719 diseaseC0699790 denotes colon cancer
19293232-3#277#283#diseaseC0699790 730-736 diseaseC0699790 denotes HCT116
19293232-3#277#283#diseaseC0007102 730-736 diseaseC0007102 denotes HCT116
19293232-3#277#283#diseaseC0699790 730-736 diseaseC0699790 denotes HCT116
19293232-3#277#283#diseaseC0007102 730-736 diseaseC0007102 denotes HCT116
19293232-3#277#283#diseaseC0699790 730-736 diseaseC0699790 denotes HCT116
19293232-3#277#283#diseaseC0007102 730-736 diseaseC0007102 denotes HCT116
19293232-3#254#266#diseaseC0007102 707-719 diseaseC0007102 denotes colon cancer
19293232-3#254#266#diseaseC0699790 707-719 diseaseC0699790 denotes colon cancer
19293232-3#277#283#diseaseC0699790 730-736 diseaseC0699790 denotes HCT116
19293232-3#277#283#diseaseC0007102 730-736 diseaseC0007102 denotes HCT116
19293232-3#454#468#diseaseC0596263 907-921 diseaseC0596263 denotes carcinogenesis
313#318#gene92254#266#diseaseC0007102 19293232-3#313#318#gene92 19293232-3#254#266#diseaseC0007102 associated_with ACVR2,colon cancer
313#318#gene92254#266#diseaseC0699790 19293232-3#313#318#gene92 19293232-3#254#266#diseaseC0699790 associated_with ACVR2,colon cancer
313#318#gene92277#283#diseaseC0699790 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0699790 associated_with ACVR2,HCT116
313#318#gene92277#283#diseaseC0007102 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0007102 associated_with ACVR2,HCT116
313#318#gene92277#283#diseaseC0699790 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0699790 associated_with ACVR2,HCT116
313#318#gene92277#283#diseaseC0007102 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0007102 associated_with ACVR2,HCT116
313#318#gene92277#283#diseaseC0699790 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0699790 associated_with ACVR2,HCT116
313#318#gene92277#283#diseaseC0007102 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0007102 associated_with ACVR2,HCT116
313#318#gene92254#266#diseaseC0007102 19293232-3#313#318#gene92 19293232-3#254#266#diseaseC0007102 associated_with ACVR2,colon cancer
313#318#gene92254#266#diseaseC0699790 19293232-3#313#318#gene92 19293232-3#254#266#diseaseC0699790 associated_with ACVR2,colon cancer
313#318#gene92277#283#diseaseC0699790 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0699790 associated_with ACVR2,HCT116
313#318#gene92277#283#diseaseC0007102 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0007102 associated_with ACVR2,HCT116
313#318#gene92454#468#diseaseC0596263 19293232-3#313#318#gene92 19293232-3#454#468#diseaseC0596263 associated_with ACVR2,carcinogenesis
321#341#gene9447254#266#diseaseC0007102 19293232-3#321#341#gene9447 19293232-3#254#266#diseaseC0007102 associated_with absent in melanoma 2,colon cancer
321#341#gene9447254#266#diseaseC0699790 19293232-3#321#341#gene9447 19293232-3#254#266#diseaseC0699790 associated_with absent in melanoma 2,colon cancer
321#341#gene9447277#283#diseaseC0699790 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0699790 associated_with absent in melanoma 2,HCT116
321#341#gene9447277#283#diseaseC0007102 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0007102 associated_with absent in melanoma 2,HCT116
321#341#gene9447277#283#diseaseC0699790 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0699790 associated_with absent in melanoma 2,HCT116
321#341#gene9447277#283#diseaseC0007102 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0007102 associated_with absent in melanoma 2,HCT116
321#341#gene9447277#283#diseaseC0699790 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0699790 associated_with absent in melanoma 2,HCT116
321#341#gene9447277#283#diseaseC0007102 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0007102 associated_with absent in melanoma 2,HCT116
321#341#gene9447254#266#diseaseC0007102 19293232-3#321#341#gene9447 19293232-3#254#266#diseaseC0007102 associated_with absent in melanoma 2,colon cancer
321#341#gene9447254#266#diseaseC0699790 19293232-3#321#341#gene9447 19293232-3#254#266#diseaseC0699790 associated_with absent in melanoma 2,colon cancer
321#341#gene9447277#283#diseaseC0699790 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0699790 associated_with absent in melanoma 2,HCT116
321#341#gene9447277#283#diseaseC0007102 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0007102 associated_with absent in melanoma 2,HCT116
321#341#gene9447454#468#diseaseC0596263 19293232-3#321#341#gene9447 19293232-3#454#468#diseaseC0596263 associated_with absent in melanoma 2,carcinogenesis
343#347#gene9447254#266#diseaseC0007102 19293232-3#343#347#gene9447 19293232-3#254#266#diseaseC0007102 associated_with AIM2,colon cancer
343#347#gene9447254#266#diseaseC0699790 19293232-3#343#347#gene9447 19293232-3#254#266#diseaseC0699790 associated_with AIM2,colon cancer
343#347#gene9447277#283#diseaseC0699790 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0699790 associated_with AIM2,HCT116
343#347#gene9447277#283#diseaseC0007102 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0007102 associated_with AIM2,HCT116
343#347#gene9447277#283#diseaseC0699790 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0699790 associated_with AIM2,HCT116
343#347#gene9447277#283#diseaseC0007102 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0007102 associated_with AIM2,HCT116
343#347#gene9447277#283#diseaseC0699790 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0699790 associated_with AIM2,HCT116
343#347#gene9447277#283#diseaseC0007102 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0007102 associated_with AIM2,HCT116
343#347#gene9447254#266#diseaseC0007102 19293232-3#343#347#gene9447 19293232-3#254#266#diseaseC0007102 associated_with AIM2,colon cancer
343#347#gene9447254#266#diseaseC0699790 19293232-3#343#347#gene9447 19293232-3#254#266#diseaseC0699790 associated_with AIM2,colon cancer
343#347#gene9447277#283#diseaseC0699790 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0699790 associated_with AIM2,HCT116
343#347#gene9447277#283#diseaseC0007102 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0007102 associated_with AIM2,HCT116
343#347#gene9447454#468#diseaseC0596263 19293232-3#343#347#gene9447 19293232-3#454#468#diseaseC0596263 associated_with AIM2,carcinogenesis
403#409#gene7048254#266#diseaseC0007102 19293232-3#403#409#gene7048 19293232-3#254#266#diseaseC0007102 associated_with TGFBR2,colon cancer
403#409#gene7048254#266#diseaseC0699790 19293232-3#403#409#gene7048 19293232-3#254#266#diseaseC0699790 associated_with TGFBR2,colon cancer
403#409#gene7048277#283#diseaseC0699790 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0699790 associated_with TGFBR2,HCT116
403#409#gene7048277#283#diseaseC0007102 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0007102 associated_with TGFBR2,HCT116
403#409#gene7048277#283#diseaseC0699790 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0699790 associated_with TGFBR2,HCT116
403#409#gene7048277#283#diseaseC0007102 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0007102 associated_with TGFBR2,HCT116
403#409#gene7048277#283#diseaseC0699790 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0699790 associated_with TGFBR2,HCT116
403#409#gene7048277#283#diseaseC0007102 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0007102 associated_with TGFBR2,HCT116
403#409#gene7048254#266#diseaseC0007102 19293232-3#403#409#gene7048 19293232-3#254#266#diseaseC0007102 associated_with TGFBR2,colon cancer
403#409#gene7048254#266#diseaseC0699790 19293232-3#403#409#gene7048 19293232-3#254#266#diseaseC0699790 associated_with TGFBR2,colon cancer
403#409#gene7048277#283#diseaseC0699790 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0699790 associated_with TGFBR2,HCT116
403#409#gene7048277#283#diseaseC0007102 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0007102 associated_with TGFBR2,HCT116
403#409#gene7048454#468#diseaseC0596263 19293232-3#403#409#gene7048 19293232-3#454#468#diseaseC0596263 associated_with TGFBR2,carcinogenesis
313#318#gene92254#266#diseaseC0007102 19293232-3#313#318#gene92 19293232-3#254#266#diseaseC0007102 associated_with ACVR2,colon cancer
313#318#gene92254#266#diseaseC0699790 19293232-3#313#318#gene92 19293232-3#254#266#diseaseC0699790 associated_with ACVR2,colon cancer
313#318#gene92277#283#diseaseC0699790 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0699790 associated_with ACVR2,HCT116
313#318#gene92277#283#diseaseC0007102 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0007102 associated_with ACVR2,HCT116
313#318#gene92277#283#diseaseC0699790 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0699790 associated_with ACVR2,HCT116
313#318#gene92277#283#diseaseC0007102 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0007102 associated_with ACVR2,HCT116
313#318#gene92277#283#diseaseC0699790 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0699790 associated_with ACVR2,HCT116
313#318#gene92277#283#diseaseC0007102 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0007102 associated_with ACVR2,HCT116
313#318#gene92254#266#diseaseC0007102 19293232-3#313#318#gene92 19293232-3#254#266#diseaseC0007102 associated_with ACVR2,colon cancer
313#318#gene92254#266#diseaseC0699790 19293232-3#313#318#gene92 19293232-3#254#266#diseaseC0699790 associated_with ACVR2,colon cancer
313#318#gene92277#283#diseaseC0699790 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0699790 associated_with ACVR2,HCT116
313#318#gene92277#283#diseaseC0007102 19293232-3#313#318#gene92 19293232-3#277#283#diseaseC0007102 associated_with ACVR2,HCT116
313#318#gene92454#468#diseaseC0596263 19293232-3#313#318#gene92 19293232-3#454#468#diseaseC0596263 associated_with ACVR2,carcinogenesis
321#341#gene9447254#266#diseaseC0007102 19293232-3#321#341#gene9447 19293232-3#254#266#diseaseC0007102 associated_with absent in melanoma 2,colon cancer
321#341#gene9447254#266#diseaseC0699790 19293232-3#321#341#gene9447 19293232-3#254#266#diseaseC0699790 associated_with absent in melanoma 2,colon cancer
321#341#gene9447277#283#diseaseC0699790 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0699790 associated_with absent in melanoma 2,HCT116
321#341#gene9447277#283#diseaseC0007102 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0007102 associated_with absent in melanoma 2,HCT116
321#341#gene9447277#283#diseaseC0699790 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0699790 associated_with absent in melanoma 2,HCT116
321#341#gene9447277#283#diseaseC0007102 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0007102 associated_with absent in melanoma 2,HCT116
321#341#gene9447277#283#diseaseC0699790 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0699790 associated_with absent in melanoma 2,HCT116
321#341#gene9447277#283#diseaseC0007102 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0007102 associated_with absent in melanoma 2,HCT116
321#341#gene9447254#266#diseaseC0007102 19293232-3#321#341#gene9447 19293232-3#254#266#diseaseC0007102 associated_with absent in melanoma 2,colon cancer
321#341#gene9447254#266#diseaseC0699790 19293232-3#321#341#gene9447 19293232-3#254#266#diseaseC0699790 associated_with absent in melanoma 2,colon cancer
321#341#gene9447277#283#diseaseC0699790 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0699790 associated_with absent in melanoma 2,HCT116
321#341#gene9447277#283#diseaseC0007102 19293232-3#321#341#gene9447 19293232-3#277#283#diseaseC0007102 associated_with absent in melanoma 2,HCT116
321#341#gene9447454#468#diseaseC0596263 19293232-3#321#341#gene9447 19293232-3#454#468#diseaseC0596263 associated_with absent in melanoma 2,carcinogenesis
343#347#gene9447254#266#diseaseC0007102 19293232-3#343#347#gene9447 19293232-3#254#266#diseaseC0007102 associated_with AIM2,colon cancer
343#347#gene9447254#266#diseaseC0699790 19293232-3#343#347#gene9447 19293232-3#254#266#diseaseC0699790 associated_with AIM2,colon cancer
343#347#gene9447277#283#diseaseC0699790 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0699790 associated_with AIM2,HCT116
343#347#gene9447277#283#diseaseC0007102 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0007102 associated_with AIM2,HCT116
343#347#gene9447277#283#diseaseC0699790 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0699790 associated_with AIM2,HCT116
343#347#gene9447277#283#diseaseC0007102 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0007102 associated_with AIM2,HCT116
343#347#gene9447277#283#diseaseC0699790 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0699790 associated_with AIM2,HCT116
343#347#gene9447277#283#diseaseC0007102 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0007102 associated_with AIM2,HCT116
343#347#gene9447254#266#diseaseC0007102 19293232-3#343#347#gene9447 19293232-3#254#266#diseaseC0007102 associated_with AIM2,colon cancer
343#347#gene9447254#266#diseaseC0699790 19293232-3#343#347#gene9447 19293232-3#254#266#diseaseC0699790 associated_with AIM2,colon cancer
343#347#gene9447277#283#diseaseC0699790 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0699790 associated_with AIM2,HCT116
343#347#gene9447277#283#diseaseC0007102 19293232-3#343#347#gene9447 19293232-3#277#283#diseaseC0007102 associated_with AIM2,HCT116
343#347#gene9447454#468#diseaseC0596263 19293232-3#343#347#gene9447 19293232-3#454#468#diseaseC0596263 associated_with AIM2,carcinogenesis
403#409#gene7048254#266#diseaseC0007102 19293232-3#403#409#gene7048 19293232-3#254#266#diseaseC0007102 associated_with TGFBR2,colon cancer
403#409#gene7048254#266#diseaseC0699790 19293232-3#403#409#gene7048 19293232-3#254#266#diseaseC0699790 associated_with TGFBR2,colon cancer
403#409#gene7048277#283#diseaseC0699790 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0699790 associated_with TGFBR2,HCT116
403#409#gene7048277#283#diseaseC0007102 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0007102 associated_with TGFBR2,HCT116
403#409#gene7048277#283#diseaseC0699790 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0699790 associated_with TGFBR2,HCT116
403#409#gene7048277#283#diseaseC0007102 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0007102 associated_with TGFBR2,HCT116
403#409#gene7048277#283#diseaseC0699790 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0699790 associated_with TGFBR2,HCT116
403#409#gene7048277#283#diseaseC0007102 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0007102 associated_with TGFBR2,HCT116
403#409#gene7048254#266#diseaseC0007102 19293232-3#403#409#gene7048 19293232-3#254#266#diseaseC0007102 associated_with TGFBR2,colon cancer
403#409#gene7048254#266#diseaseC0699790 19293232-3#403#409#gene7048 19293232-3#254#266#diseaseC0699790 associated_with TGFBR2,colon cancer
403#409#gene7048277#283#diseaseC0699790 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0699790 associated_with TGFBR2,HCT116
403#409#gene7048277#283#diseaseC0007102 19293232-3#403#409#gene7048 19293232-3#277#283#diseaseC0007102 associated_with TGFBR2,HCT116
403#409#gene7048454#468#diseaseC0596263 19293232-3#403#409#gene7048 19293232-3#454#468#diseaseC0596263 associated_with TGFBR2,carcinogenesis

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 68-73 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T2 707-712 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 1179-1188 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycans

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 647-653 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 68-73 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T3 707-712 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 68-80 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T2 157-163 Disease denotes Tumors http://purl.obolibrary.org/obo/MONDO_0005070
T3 707-719 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T4 784-792 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T5 1873-1878 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1573-1579 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 68-80 Phenotype denotes colon cancer HP:0003003
T2 707-719 Phenotype denotes colon cancer HP:0003003
T3 784-792 Phenotype denotes melanoma HP:0002861
T4 1873-1878 Phenotype denotes tumor HP:0002664

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 68-80 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T2 157-163 Disease denotes Tumors http://purl.obolibrary.org/obo/MONDO_0005070
T3 707-719 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T4 784-792 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T5 1873-1878 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 997-1002 OrganismTaxon denotes human 9606

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 74-86 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 713-724 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T3 1873-1884 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 68-73 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T2 647-653 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 707-712 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 68-73 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T2 707-712 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-156 Sentence denotes Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.
TextSentencer_T2 157-285 Sentence denotes Tumors that display a high level of microsatellite instability (MSI-H) accumulate somatic frameshift mutations in several genes.
TextSentencer_T3 286-452 Sentence denotes The compensation of this loss of function by transfection represents a suitable approach to tie respective gene deficiency to alterations in cellular characteristics.
TextSentencer_T4 453-922 Sentence denotes In view of the emerging significance of cell surface glycans as biochemical signals for presentation/activity of various receptors/integrins and for susceptibility to adhesion/growth-regulatory tissue lectins, we examined the glycophenotype in the MSI-H colon cancer cell line HCT116 for activin type 2 receptor (ACVR2), absent in melanoma 2 (AIM2), and transforming growth factor beta-type 2 receptor (TGFBR2) known to be associated with MSI colorectal carcinogenesis.
TextSentencer_T5 923-1111 Sentence denotes A panel of probes specific for functional carbohydrate epitopes including human lectins was used to trace changes in cell surface levels, thereby initiating glycan analysis related to MSI.
TextSentencer_T6 1112-1285 Sentence denotes In particular, the presence of core substitutions and branching in N-glycans, the sialylation status of N- and O-glycans, and the presence of Le(a/x)-epitopes were profiled.
TextSentencer_T7 1286-1388 Sentence denotes Transient transfection affected the glycophenotype, depending on the nature of the gene and the probe.
TextSentencer_T8 1389-1550 Sentence denotes The TGFBR2 presence reduced binding of probes specific for a core substitution and increased branch length in N-glycosylation, even reaching a P-value of 0.0016.
TextSentencer_T9 1551-1673 Sentence denotes ACVR2/AIM2 influenced core 1 mucin-type O-glycosylation differentially, upregulation by ACVR2, and downregulation by AIM2.
TextSentencer_T10 1674-1962 Sentence denotes These alterations of cell surface glycosylation by gene products that are not directly associated with the machinery for glycan generation direct attention to pursue analysis of glycosylation in MSI tumor cells on the level of target glycoproteins and open the way for functional studies.
T1 0-156 Sentence denotes Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.
T2 157-285 Sentence denotes Tumors that display a high level of microsatellite instability (MSI-H) accumulate somatic frameshift mutations in several genes.
T3 286-452 Sentence denotes The compensation of this loss of function by transfection represents a suitable approach to tie respective gene deficiency to alterations in cellular characteristics.
T4 453-922 Sentence denotes In view of the emerging significance of cell surface glycans as biochemical signals for presentation/activity of various receptors/integrins and for susceptibility to adhesion/growth-regulatory tissue lectins, we examined the glycophenotype in the MSI-H colon cancer cell line HCT116 for activin type 2 receptor (ACVR2), absent in melanoma 2 (AIM2), and transforming growth factor beta-type 2 receptor (TGFBR2) known to be associated with MSI colorectal carcinogenesis.
T5 923-1111 Sentence denotes A panel of probes specific for functional carbohydrate epitopes including human lectins was used to trace changes in cell surface levels, thereby initiating glycan analysis related to MSI.
T6 1112-1285 Sentence denotes In particular, the presence of core substitutions and branching in N-glycans, the sialylation status of N- and O-glycans, and the presence of Le(a/x)-epitopes were profiled.
T7 1286-1388 Sentence denotes Transient transfection affected the glycophenotype, depending on the nature of the gene and the probe.
T8 1389-1550 Sentence denotes The TGFBR2 presence reduced binding of probes specific for a core substitution and increased branch length in N-glycosylation, even reaching a P-value of 0.0016.
T9 1551-1673 Sentence denotes ACVR2/AIM2 influenced core 1 mucin-type O-glycosylation differentially, upregulation by ACVR2, and downregulation by AIM2.
T10 1674-1962 Sentence denotes These alterations of cell surface glycosylation by gene products that are not directly associated with the machinery for glycan generation direct attention to pursue analysis of glycosylation in MSI tumor cells on the level of target glycoproteins and open the way for functional studies.
T1 0-156 Sentence denotes Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.
T2 157-285 Sentence denotes Tumors that display a high level of microsatellite instability (MSI-H) accumulate somatic frameshift mutations in several genes.
T3 286-452 Sentence denotes The compensation of this loss of function by transfection represents a suitable approach to tie respective gene deficiency to alterations in cellular characteristics.
T4 453-922 Sentence denotes In view of the emerging significance of cell surface glycans as biochemical signals for presentation/activity of various receptors/integrins and for susceptibility to adhesion/growth-regulatory tissue lectins, we examined the glycophenotype in the MSI-H colon cancer cell line HCT116 for activin type 2 receptor (ACVR2), absent in melanoma 2 (AIM2), and transforming growth factor beta-type 2 receptor (TGFBR2) known to be associated with MSI colorectal carcinogenesis.
T5 923-1111 Sentence denotes A panel of probes specific for functional carbohydrate epitopes including human lectins was used to trace changes in cell surface levels, thereby initiating glycan analysis related to MSI.
T6 1112-1285 Sentence denotes In particular, the presence of core substitutions and branching in N-glycans, the sialylation status of N- and O-glycans, and the presence of Le(a/x)-epitopes were profiled.
T7 1286-1388 Sentence denotes Transient transfection affected the glycophenotype, depending on the nature of the gene and the probe.
T8 1389-1550 Sentence denotes The TGFBR2 presence reduced binding of probes specific for a core substitution and increased branch length in N-glycosylation, even reaching a P-value of 0.0016.
T9 1551-1673 Sentence denotes ACVR2/AIM2 influenced core 1 mucin-type O-glycosylation differentially, upregulation by ACVR2, and downregulation by AIM2.
T10 1674-1962 Sentence denotes These alterations of cell surface glycosylation by gene products that are not directly associated with the machinery for glycan generation direct attention to pursue analysis of glycosylation in MSI tumor cells on the level of target glycoproteins and open the way for functional studies.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-156 Sentence denotes Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.
T2 157-285 Sentence denotes Tumors that display a high level of microsatellite instability (MSI-H) accumulate somatic frameshift mutations in several genes.
T3 286-452 Sentence denotes The compensation of this loss of function by transfection represents a suitable approach to tie respective gene deficiency to alterations in cellular characteristics.
T4 453-922 Sentence denotes In view of the emerging significance of cell surface glycans as biochemical signals for presentation/activity of various receptors/integrins and for susceptibility to adhesion/growth-regulatory tissue lectins, we examined the glycophenotype in the MSI-H colon cancer cell line HCT116 for activin type 2 receptor (ACVR2), absent in melanoma 2 (AIM2), and transforming growth factor beta-type 2 receptor (TGFBR2) known to be associated with MSI colorectal carcinogenesis.
T5 923-1111 Sentence denotes A panel of probes specific for functional carbohydrate epitopes including human lectins was used to trace changes in cell surface levels, thereby initiating glycan analysis related to MSI.
T6 1112-1285 Sentence denotes In particular, the presence of core substitutions and branching in N-glycans, the sialylation status of N- and O-glycans, and the presence of Le(a/x)-epitopes were profiled.
T7 1286-1388 Sentence denotes Transient transfection affected the glycophenotype, depending on the nature of the gene and the probe.
T8 1389-1550 Sentence denotes The TGFBR2 presence reduced binding of probes specific for a core substitution and increased branch length in N-glycosylation, even reaching a P-value of 0.0016.
T9 1551-1673 Sentence denotes ACVR2/AIM2 influenced core 1 mucin-type O-glycosylation differentially, upregulation by ACVR2, and downregulation by AIM2.
T10 1674-1962 Sentence denotes These alterations of cell surface glycosylation by gene products that are not directly associated with the machinery for glycan generation direct attention to pursue analysis of glycosylation in MSI tumor cells on the level of target glycoproteins and open the way for functional studies.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1573-1579 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-156 Sentence denotes Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.
T2 157-285 Sentence denotes Tumors that display a high level of microsatellite instability (MSI-H) accumulate somatic frameshift mutations in several genes.
T3 286-452 Sentence denotes The compensation of this loss of function by transfection represents a suitable approach to tie respective gene deficiency to alterations in cellular characteristics.
T4 453-922 Sentence denotes In view of the emerging significance of cell surface glycans as biochemical signals for presentation/activity of various receptors/integrins and for susceptibility to adhesion/growth-regulatory tissue lectins, we examined the glycophenotype in the MSI-H colon cancer cell line HCT116 for activin type 2 receptor (ACVR2), absent in melanoma 2 (AIM2), and transforming growth factor beta-type 2 receptor (TGFBR2) known to be associated with MSI colorectal carcinogenesis.
T5 923-1111 Sentence denotes A panel of probes specific for functional carbohydrate epitopes including human lectins was used to trace changes in cell surface levels, thereby initiating glycan analysis related to MSI.
T6 1112-1285 Sentence denotes In particular, the presence of core substitutions and branching in N-glycans, the sialylation status of N- and O-glycans, and the presence of Le(a/x)-epitopes were profiled.
T7 1286-1388 Sentence denotes Transient transfection affected the glycophenotype, depending on the nature of the gene and the probe.
T8 1389-1550 Sentence denotes The TGFBR2 presence reduced binding of probes specific for a core substitution and increased branch length in N-glycosylation, even reaching a P-value of 0.0016.
T9 1551-1673 Sentence denotes ACVR2/AIM2 influenced core 1 mucin-type O-glycosylation differentially, upregulation by ACVR2, and downregulation by AIM2.
T10 1674-1962 Sentence denotes These alterations of cell surface glycosylation by gene products that are not directly associated with the machinery for glycan generation direct attention to pursue analysis of glycosylation in MSI tumor cells on the level of target glycoproteins and open the way for functional studies.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 997-1002 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 68-73 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T2 647-653 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 707-712 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 68-73 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T2 707-712 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 68-80 Phenotype denotes colon cancer HP:0003003
T2 707-719 Phenotype denotes colon cancer HP:0003003
T3 784-792 Phenotype denotes melanoma HP:0002861
T4 1873-1878 Phenotype denotes tumor HP:0002664