PubMed:19282391
Annnotations
GlyCosmos6-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 262-266 | Body_part | denotes | cell | http://purl.obolibrary.org/obo/CL_0000000 |
T2 | 267-274 | Body_part | denotes | surface | http://purl.obolibrary.org/obo/UBERON_0002416 |
T3 | 1234-1239 | Body_part | denotes | scale | http://purl.obolibrary.org/obo/UBERON_0002542 |
Glycan-Motif
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 108-119 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
T2 | 1304-1315 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
T3 | 1430-1441 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 108-119 | Glycan_Motif | denotes | sialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
T2 | 1304-1315 | Glycan_Motif | denotes | sialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
T3 | 1430-1441 | Glycan_Motif | denotes | sialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-103 | Sentence | denotes | The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors. |
TextSentencer_T2 | 104-366 | Sentence | denotes | The sialic acid-like sugar 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-D-galacto-nonulosonic acid, or legion-aminic acid, is found as a virulence-associated cell-surface glycoconjugate in the Gram-negative bacteria Legionella pneumophila and Campylobacter coli. |
TextSentencer_T3 | 367-656 | Sentence | denotes | L. pneumophila serogroup 1 strains, causative agents of Legionnaire's disease, contain an alpha2,4-linked homopolymer of legionaminic acid within their lipopolysaccharide O-chains, whereas the gastrointestinal pathogen C. coli modifies its flagellin with this monosaccharide via O-linkage. |
TextSentencer_T4 | 657-903 | Sentence | denotes | In this work, we have purified and biochemically characterized 11 candidate biosynthetic enzymes from Campylobacter jejuni, thereby fully reconstituting the biosynthesis of legionaminic acid and its CMP-activated form, starting from fructose-6-P. |
TextSentencer_T5 | 904-1161 | Sentence | denotes | This pathway involves unique GDP-linked intermediates, likely providing a cellular mechanism for differentiating between this and similar UDP-linked pathways, such as UDP-2,4-diacetamido-bacillosamine biosynthesis involved in N-linked protein glycosylation. |
TextSentencer_T6 | 1162-1448 | Sentence | denotes | Importantly, these findings provide a facile method for efficient large-scale synthesis of legionaminic acid, and since legionaminic acid and sialic acid share the same D-glycero-D-galacto absolute configuration, this sugar may now be evaluated for its potential as a sialic acid mimic. |
T1 | 0-103 | Sentence | denotes | The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors. |
T2 | 104-366 | Sentence | denotes | The sialic acid-like sugar 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-D-galacto-nonulosonic acid, or legion-aminic acid, is found as a virulence-associated cell-surface glycoconjugate in the Gram-negative bacteria Legionella pneumophila and Campylobacter coli. |
T3 | 367-656 | Sentence | denotes | L. pneumophila serogroup 1 strains, causative agents of Legionnaire's disease, contain an alpha2,4-linked homopolymer of legionaminic acid within their lipopolysaccharide O-chains, whereas the gastrointestinal pathogen C. coli modifies its flagellin with this monosaccharide via O-linkage. |
T4 | 657-1161 | Sentence | denotes | In this work, we have purified and biochemically characterized 11 candidate biosynthetic enzymes from Campylobacter jejuni, thereby fully reconstituting the biosynthesis of legionaminic acid and its CMP-activated form, starting from fructose-6-P. This pathway involves unique GDP-linked intermediates, likely providing a cellular mechanism for differentiating between this and similar UDP-linked pathways, such as UDP-2,4-diacetamido-bacillosamine biosynthesis involved in N-linked protein glycosylation. |
T5 | 1162-1448 | Sentence | denotes | Importantly, these findings provide a facile method for efficient large-scale synthesis of legionaminic acid, and since legionaminic acid and sialic acid share the same D-glycero-D-galacto absolute configuration, this sugar may now be evaluated for its potential as a sialic acid mimic. |
T1 | 0-103 | Sentence | denotes | The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors. |
T2 | 104-366 | Sentence | denotes | The sialic acid-like sugar 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-D-galacto-nonulosonic acid, or legion-aminic acid, is found as a virulence-associated cell-surface glycoconjugate in the Gram-negative bacteria Legionella pneumophila and Campylobacter coli. |
T3 | 367-656 | Sentence | denotes | L. pneumophila serogroup 1 strains, causative agents of Legionnaire's disease, contain an alpha2,4-linked homopolymer of legionaminic acid within their lipopolysaccharide O-chains, whereas the gastrointestinal pathogen C. coli modifies its flagellin with this monosaccharide via O-linkage. |
T4 | 657-903 | Sentence | denotes | In this work, we have purified and biochemically characterized 11 candidate biosynthetic enzymes from Campylobacter jejuni, thereby fully reconstituting the biosynthesis of legionaminic acid and its CMP-activated form, starting from fructose-6-P. |
T5 | 904-1161 | Sentence | denotes | This pathway involves unique GDP-linked intermediates, likely providing a cellular mechanism for differentiating between this and similar UDP-linked pathways, such as UDP-2,4-diacetamido-bacillosamine biosynthesis involved in N-linked protein glycosylation. |
T6 | 1162-1448 | Sentence | denotes | Importantly, these findings provide a facile method for efficient large-scale synthesis of legionaminic acid, and since legionaminic acid and sialic acid share the same D-glycero-D-galacto absolute configuration, this sugar may now be evaluated for its potential as a sialic acid mimic. |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 108-119 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
T2 | 1304-1315 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
T3 | 1430-1441 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
GlyCosmos6-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 262-266 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T2 | 860-869 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 320-330 | Disease | denotes | Legionella | http://purl.obolibrary.org/obo/MONDO_0005824 |
T2 | 423-444 | Disease | denotes | Legionnaire's disease | http://purl.obolibrary.org/obo/MONDO_0005824 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 37-50 | OrganismTaxon | denotes | Campylobacter | NCBItxid:194 |
T2 | 311-319 | OrganismTaxon | denotes | bacteria | NCBItxid:2 |
T3 | 320-342 | OrganismTaxon | denotes | Legionella pneumophila | NCBItxid:446 |
T4 | 347-365 | OrganismTaxon | denotes | Campylobacter coli | NCBItxid:195 |
T5 | 759-779 | OrganismTaxon | denotes | Campylobacter jejuni | NCBItxid:197 |
GlycoBiology-PACDB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
_T1 | 759-779 | http://acgg.asia/db/diseases/pacdb/lec?ids=LEC257,LEC564 | denotes | Campylobacter jejuni |
ICD10
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 423-444 | http://purl.bioontology.org/ontology/ICD10/A48.1 | denotes | Legionnaire's disease |
GlycoBiology-FMA
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
_T1 | 125-130 | FMAID:196724 | denotes | sugar |
_T2 | 207-213 | FMAID:179799 | denotes | legion |
_T3 | 214-225 | FMAID:196728 | denotes | aminic acid |
_T4 | 214-225 | FMAID:82739 | denotes | aminic acid |
_T5 | 262-274 | FMAID:200942 | denotes | cell-surface |
_T6 | 262-274 | FMAID:212684 | denotes | cell-surface |
_T7 | 267-274 | FMAID:50594 | denotes | surface |
_T8 | 267-274 | FMAID:146300 | denotes | surface |
_T9 | 275-289 | FMAID:196776 | denotes | glycoconjugate |
_T10 | 275-289 | FMAID:82782 | denotes | glycoconjugate |
_T11 | 519-537 | FMAID:82785 | denotes | lipopolysaccharide |
_T12 | 519-537 | FMAID:196779 | denotes | lipopolysaccharide |
_T13 | 519-537 | FMAID:196735 | denotes | lipopolysaccharide |
_T14 | 519-537 | FMAID:82746 | denotes | lipopolysaccharide |
_T15 | 627-641 | FMAID:196730 | denotes | monosaccharide |
_T16 | 627-641 | FMAID:82741 | denotes | monosaccharide |
_T17 | 944-957 | FMAID:74531 | denotes | intermediates |
_T18 | 944-957 | FMAID:179268 | denotes | intermediates |
_T19 | 1139-1146 | FMAID:67257 | denotes | protein |
_T20 | 1139-1146 | FMAID:165447 | denotes | protein |
_T21 | 1380-1385 | FMAID:196724 | denotes | sugar |
uniprot-human
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 4-7 | http://www.uniprot.org/uniprot/P21941 | denotes | CMP |
T2 | 856-859 | http://www.uniprot.org/uniprot/P21941 | denotes | CMP |
GlycoBiology-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 297-319 | http://purl.bioontology.org/ontology/NCBITAXON/130805 | denotes | Gram-negative bacteria |
T2 | 297-319 | http://purl.bioontology.org/ontology/NCBITAXON/130804 | denotes | Gram-negative bacteria |
T3 | 311-319 | http://purl.bioontology.org/ontology/NCBITAXON/2 | denotes | bacteria |
T4 | 311-319 | http://purl.bioontology.org/ontology/NCBITAXON/629395 | denotes | bacteria |
T5 | 320-330 | http://purl.bioontology.org/ontology/NCBITAXON/445 | denotes | Legionella |
T6 | 320-330 | http://purl.bioontology.org/ontology/NCBITAXON/118969 | denotes | Legionella |
T7 | 320-342 | http://purl.bioontology.org/ontology/NCBITAXON/446 | denotes | Legionella pneumophila |
T8 | 759-779 | http://purl.bioontology.org/ontology/NCBITAXON/197 | denotes | Campylobacter jejuni |
T9 | 987-996 | http://purl.bioontology.org/ontology/NCBITAXON/127244 | denotes | mechanism |
T10 | 1181-1189 | http://purl.bioontology.org/ontology/STY/T033 | denotes | findings |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 52-64 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | biosynthesis |
T2 | 814-826 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | biosynthesis |
T3 | 1105-1117 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | biosynthesis |
T4 | 241-250 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | virulence |
T5 | 241-250 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | virulence |
T6 | 978-986 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
T7 | 1139-1160 | http://purl.obolibrary.org/obo/GO_0006486 | denotes | protein glycosylation |
T8 | 1147-1160 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
T9 | 1240-1249 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 251-266 | http://purl.obolibrary.org/obo/GO_0009986 | denotes | associated cell |
T2 | 262-266 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3 | 262-274 | http://purl.obolibrary.org/obo/GO_0009986 | denotes | cell-surface |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1234-1239 | http://purl.obolibrary.org/obo/UBERON_0002542 | denotes | scale |
GlyTouCan-IUPAC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
GlycanIUPAC_T1 | 125-130 | "http://rdf.glycoinfo.org/glycan/G59665TO" | denotes | sugar |
GlycanIUPAC_T2 | 1380-1385 | "http://rdf.glycoinfo.org/glycan/G59665TO" | denotes | sugar |
GlycanIUPAC_T3 | 125-130 | "http://rdf.glycoinfo.org/glycan/G32915EI" | denotes | sugar |
GlycanIUPAC_T4 | 1380-1385 | "http://rdf.glycoinfo.org/glycan/G32915EI" | denotes | sugar |
GlycanIUPAC_T5 | 125-130 | "http://rdf.glycoinfo.org/glycan/G60625TS" | denotes | sugar |
GlycanIUPAC_T6 | 1380-1385 | "http://rdf.glycoinfo.org/glycan/G60625TS" | denotes | sugar |
performance-test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 1234-1239 | http://purl.obolibrary.org/obo/UBERON_0002542 | denotes | scale |