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PubMed:19282391 JSONTXT

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GlyCosmos6-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 262-266 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000
T2 267-274 Body_part denotes surface http://purl.obolibrary.org/obo/UBERON_0002416
T3 1234-1239 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542

Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 108-119 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 1304-1315 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 1430-1441 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 108-119 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 1304-1315 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T3 1430-1441 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-103 Sentence denotes The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.
TextSentencer_T2 104-366 Sentence denotes The sialic acid-like sugar 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-D-galacto-nonulosonic acid, or legion-aminic acid, is found as a virulence-associated cell-surface glycoconjugate in the Gram-negative bacteria Legionella pneumophila and Campylobacter coli.
TextSentencer_T3 367-656 Sentence denotes L. pneumophila serogroup 1 strains, causative agents of Legionnaire's disease, contain an alpha2,4-linked homopolymer of legionaminic acid within their lipopolysaccharide O-chains, whereas the gastrointestinal pathogen C. coli modifies its flagellin with this monosaccharide via O-linkage.
TextSentencer_T4 657-903 Sentence denotes In this work, we have purified and biochemically characterized 11 candidate biosynthetic enzymes from Campylobacter jejuni, thereby fully reconstituting the biosynthesis of legionaminic acid and its CMP-activated form, starting from fructose-6-P.
TextSentencer_T5 904-1161 Sentence denotes This pathway involves unique GDP-linked intermediates, likely providing a cellular mechanism for differentiating between this and similar UDP-linked pathways, such as UDP-2,4-diacetamido-bacillosamine biosynthesis involved in N-linked protein glycosylation.
TextSentencer_T6 1162-1448 Sentence denotes Importantly, these findings provide a facile method for efficient large-scale synthesis of legionaminic acid, and since legionaminic acid and sialic acid share the same D-glycero-D-galacto absolute configuration, this sugar may now be evaluated for its potential as a sialic acid mimic.
T1 0-103 Sentence denotes The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.
T2 104-366 Sentence denotes The sialic acid-like sugar 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-D-galacto-nonulosonic acid, or legion-aminic acid, is found as a virulence-associated cell-surface glycoconjugate in the Gram-negative bacteria Legionella pneumophila and Campylobacter coli.
T3 367-656 Sentence denotes L. pneumophila serogroup 1 strains, causative agents of Legionnaire's disease, contain an alpha2,4-linked homopolymer of legionaminic acid within their lipopolysaccharide O-chains, whereas the gastrointestinal pathogen C. coli modifies its flagellin with this monosaccharide via O-linkage.
T4 657-1161 Sentence denotes In this work, we have purified and biochemically characterized 11 candidate biosynthetic enzymes from Campylobacter jejuni, thereby fully reconstituting the biosynthesis of legionaminic acid and its CMP-activated form, starting from fructose-6-P. This pathway involves unique GDP-linked intermediates, likely providing a cellular mechanism for differentiating between this and similar UDP-linked pathways, such as UDP-2,4-diacetamido-bacillosamine biosynthesis involved in N-linked protein glycosylation.
T5 1162-1448 Sentence denotes Importantly, these findings provide a facile method for efficient large-scale synthesis of legionaminic acid, and since legionaminic acid and sialic acid share the same D-glycero-D-galacto absolute configuration, this sugar may now be evaluated for its potential as a sialic acid mimic.
T1 0-103 Sentence denotes The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.
T2 104-366 Sentence denotes The sialic acid-like sugar 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-D-galacto-nonulosonic acid, or legion-aminic acid, is found as a virulence-associated cell-surface glycoconjugate in the Gram-negative bacteria Legionella pneumophila and Campylobacter coli.
T3 367-656 Sentence denotes L. pneumophila serogroup 1 strains, causative agents of Legionnaire's disease, contain an alpha2,4-linked homopolymer of legionaminic acid within their lipopolysaccharide O-chains, whereas the gastrointestinal pathogen C. coli modifies its flagellin with this monosaccharide via O-linkage.
T4 657-903 Sentence denotes In this work, we have purified and biochemically characterized 11 candidate biosynthetic enzymes from Campylobacter jejuni, thereby fully reconstituting the biosynthesis of legionaminic acid and its CMP-activated form, starting from fructose-6-P.
T5 904-1161 Sentence denotes This pathway involves unique GDP-linked intermediates, likely providing a cellular mechanism for differentiating between this and similar UDP-linked pathways, such as UDP-2,4-diacetamido-bacillosamine biosynthesis involved in N-linked protein glycosylation.
T6 1162-1448 Sentence denotes Importantly, these findings provide a facile method for efficient large-scale synthesis of legionaminic acid, and since legionaminic acid and sialic acid share the same D-glycero-D-galacto absolute configuration, this sugar may now be evaluated for its potential as a sialic acid mimic.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 108-119 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 1304-1315 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 1430-1441 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 262-266 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 860-869 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 320-330 Disease denotes Legionella http://purl.obolibrary.org/obo/MONDO_0005824
T2 423-444 Disease denotes Legionnaire's disease http://purl.obolibrary.org/obo/MONDO_0005824

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 37-50 OrganismTaxon denotes Campylobacter NCBItxid:194
T2 311-319 OrganismTaxon denotes bacteria NCBItxid:2
T3 320-342 OrganismTaxon denotes Legionella pneumophila NCBItxid:446
T4 347-365 OrganismTaxon denotes Campylobacter coli NCBItxid:195
T5 759-779 OrganismTaxon denotes Campylobacter jejuni NCBItxid:197

GlycoBiology-PACDB

Id Subject Object Predicate Lexical cue
_T1 759-779 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC257,LEC564 denotes Campylobacter jejuni

ICD10

Id Subject Object Predicate Lexical cue
T1 423-444 http://purl.bioontology.org/ontology/ICD10/A48.1 denotes Legionnaire's disease

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 125-130 FMAID:196724 denotes sugar
_T2 207-213 FMAID:179799 denotes legion
_T3 214-225 FMAID:196728 denotes aminic acid
_T4 214-225 FMAID:82739 denotes aminic acid
_T5 262-274 FMAID:200942 denotes cell-surface
_T6 262-274 FMAID:212684 denotes cell-surface
_T7 267-274 FMAID:50594 denotes surface
_T8 267-274 FMAID:146300 denotes surface
_T9 275-289 FMAID:196776 denotes glycoconjugate
_T10 275-289 FMAID:82782 denotes glycoconjugate
_T11 519-537 FMAID:82785 denotes lipopolysaccharide
_T12 519-537 FMAID:196779 denotes lipopolysaccharide
_T13 519-537 FMAID:196735 denotes lipopolysaccharide
_T14 519-537 FMAID:82746 denotes lipopolysaccharide
_T15 627-641 FMAID:196730 denotes monosaccharide
_T16 627-641 FMAID:82741 denotes monosaccharide
_T17 944-957 FMAID:74531 denotes intermediates
_T18 944-957 FMAID:179268 denotes intermediates
_T19 1139-1146 FMAID:67257 denotes protein
_T20 1139-1146 FMAID:165447 denotes protein
_T21 1380-1385 FMAID:196724 denotes sugar

uniprot-human

Id Subject Object Predicate Lexical cue
T1 4-7 http://www.uniprot.org/uniprot/P21941 denotes CMP
T2 856-859 http://www.uniprot.org/uniprot/P21941 denotes CMP

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 297-319 http://purl.bioontology.org/ontology/NCBITAXON/130805 denotes Gram-negative bacteria
T2 297-319 http://purl.bioontology.org/ontology/NCBITAXON/130804 denotes Gram-negative bacteria
T3 311-319 http://purl.bioontology.org/ontology/NCBITAXON/2 denotes bacteria
T4 311-319 http://purl.bioontology.org/ontology/NCBITAXON/629395 denotes bacteria
T5 320-330 http://purl.bioontology.org/ontology/NCBITAXON/445 denotes Legionella
T6 320-330 http://purl.bioontology.org/ontology/NCBITAXON/118969 denotes Legionella
T7 320-342 http://purl.bioontology.org/ontology/NCBITAXON/446 denotes Legionella pneumophila
T8 759-779 http://purl.bioontology.org/ontology/NCBITAXON/197 denotes Campylobacter jejuni
T9 987-996 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism
T10 1181-1189 http://purl.bioontology.org/ontology/STY/T033 denotes findings

GO-BP

Id Subject Object Predicate Lexical cue
T1 52-64 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T2 814-826 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T3 1105-1117 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T4 241-250 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T5 241-250 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T6 978-986 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T7 1139-1160 http://purl.obolibrary.org/obo/GO_0006486 denotes protein glycosylation
T8 1147-1160 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T9 1240-1249 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

GO-CC

Id Subject Object Predicate Lexical cue
T1 251-266 http://purl.obolibrary.org/obo/GO_0009986 denotes associated cell
T2 262-266 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 262-274 http://purl.obolibrary.org/obo/GO_0009986 denotes cell-surface

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 1234-1239 http://purl.obolibrary.org/obo/UBERON_0002542 denotes scale

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 125-130 "http://rdf.glycoinfo.org/glycan/G59665TO" denotes sugar
GlycanIUPAC_T2 1380-1385 "http://rdf.glycoinfo.org/glycan/G59665TO" denotes sugar
GlycanIUPAC_T3 125-130 "http://rdf.glycoinfo.org/glycan/G32915EI" denotes sugar
GlycanIUPAC_T4 1380-1385 "http://rdf.glycoinfo.org/glycan/G32915EI" denotes sugar
GlycanIUPAC_T5 125-130 "http://rdf.glycoinfo.org/glycan/G60625TS" denotes sugar
GlycanIUPAC_T6 1380-1385 "http://rdf.glycoinfo.org/glycan/G60625TS" denotes sugar

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1234-1239 http://purl.obolibrary.org/obo/UBERON_0002542 denotes scale