PubMed:19252170
Annnotations
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 342-361 | DiseaseOrPhenotypicFeature | denotes | embryonal carcinoma | 0003581|0005440|0018843 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 800-806 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 342-361 | Disease | denotes | embryonal carcinoma | http://purl.obolibrary.org/obo/MONDO_0005440 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 800-806 | Glycan | denotes | SSEA-4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84263XI |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 800-806 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 352-361 | Phenotype | denotes | carcinoma | HP:0030731 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 23-39 | Cell | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL:0000066 |
| T2 | 266-282 | Cell | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL:0000066 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 23-39 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
| T2 | 266-282 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
| T3 | 970-975 | Body_part | denotes | spots | http://purl.obolibrary.org/obo/UBERON_2002283 |
| T4 | 1024-1029 | Body_part | denotes | spots | http://purl.obolibrary.org/obo/UBERON_2002283 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 342-361 | Disease | denotes | embryonal carcinoma | MONDO:0003581|MONDO:0005440|MONDO:0018843 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-74 | Sentence | denotes | Proteomics analysis of epithelial cells reprogrammed in cell-free extract. |
| T2 | 75-220 | Sentence | denotes | The functional reprogramming of a differentiated cell to a pluripotent state presents potential beneficial applications in regenerative medicine. |
| T3 | 221-388 | Sentence | denotes | We report here the proteomic profile of 293T epithelial cells reprogrammed to a pluripotent state using undifferentiated embryonal carcinoma (NCCIT) cellular extracts. |
| T4 | 389-570 | Sentence | denotes | 293T cells were reversibly permeabilized with streptolysin O, incubated in an extract of NCCIT cells or a control extract of 293T cells for 1 h, resealed with CaCl(2), and cultured. |
| T5 | 571-735 | Sentence | denotes | OCT4 and SOX2 gene expression were up-regulated in NCCIT extract-treated cells relative to control cells, whereas there was no alteration in DNMT3B gene expression. |
| T6 | 736-913 | Sentence | denotes | Thirty percent of NCCIT extract-treated cells were positive for SSEA-4, and karyotyping confirmed their 293T origin, excluding the possibility of contamination from NCCIT cells. |
| T7 | 914-1003 | Sentence | denotes | Two-dimensional PAGE revealed approximately 400 protein spots for each cell type studied. |
| T8 | 1004-1168 | Sentence | denotes | At least 10 protein spots in the proteome of NCCIT extract-treated cells had an expression profile similar to that of NCCIT and remained unaltered in control cells. |
| T9 | 1169-1318 | Sentence | denotes | Using tandem mass spectrometry, we identified these proteins, which include 78-kDa glucose-regulated protein precursor and tropomyosin alpha-3 chain. |
| T10 | 1319-1444 | Sentence | denotes | This investigation provides the first evidence that proteins are altered in a specific manner in NCCIT extract-treated cells. |
| T11 | 1445-1541 | Sentence | denotes | This is the first report on the proteomic characterization of the nuclear reprogramming process. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 800-806 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-4 | http://www.glycoepitope.jp/epitopes/EP0044 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 23-39 | Body_part | denotes | epithelial cells | FMA:66768 |
| T2 | 266-282 | Body_part | denotes | epithelial cells | FMA:66768 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 23-39 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
| T2 | 266-282 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
| T3 | 970-975 | Body_part | denotes | spots | http://purl.obolibrary.org/obo/UBERON_2002283 |
| T4 | 1024-1029 | Body_part | denotes | spots | http://purl.obolibrary.org/obo/UBERON_2002283 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 352-361 | Phenotype | denotes | carcinoma | HP:0030731 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 23-39 | Cell | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL:0000066 |
| T2 | 266-282 | Cell | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL:0000066 |