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PubMed:19246455 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes The silkworm mutant lemon (lemon lethal) is a potential insect model for human sepiapterin reductase deficiency.
T2 113-252 Sentence denotes Tetrahydrobiopterin (BH4) is an essential cofactor for aromatic acid hydroxylases, which control the levels of monoamine neurotransmitters.
T3 253-327 Sentence denotes BH4 deficiency has been associated with many neuropsychological disorders.
T4 328-517 Sentence denotes An inherited defect in BH4 biosynthesis is caused by the deficiency of sepiapterin reductase (SPR), which catalyzes the biosynthesis of BH4 from guanosine triphosphate at the terminal step.
T5 518-624 Sentence denotes The human SPR gene has been mapped at the PARK3 locus, which is related to the onset of Parkinson disease.
T6 625-858 Sentence denotes In this study, we report that mutant strains, lemon (lem) and its lethal allele lemon lethal (lem(1)) with yellow body coloration, of the silkworm Bombyx mori could be used as the first insect model for human SPR deficiency diseases.
T7 859-983 Sentence denotes We demonstrated that mutations in the SPR gene (BmSpr) were responsible for the irregular body coloration of lem and lem(l).
T8 984-1202 Sentence denotes Moreover, biochemical analysis revealed that SPR activity in lem(l) larvae was almost completely diminished, resulting in a lethal phenotype that the larvae cannot feed and that die immediately after the first ecdysis.
T9 1203-1325 Sentence denotes Oral administration of BH4 and dopamine to lem(l) larvae effectively increased their survival rates and feeding abilities.
T10 1326-1578 Sentence denotes Our data demonstrate that BmSPR plays a crucial role in the generation of BH4, and monoamine neurotransmitters in silkworms and the lem (lem(l)) mutant strains will be an invaluable resource to address many questions regarding SPR and BH4 deficiencies.

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 79-111 DiseaseOrPhenotypicFeature denotes sepiapterin reductase deficiency 0012994
T2 341-347 DiseaseOrPhenotypicFeature denotes defect 0008568
T3 560-565 DiseaseOrPhenotypicFeature denotes PARK3 0011220
T4 606-623 DiseaseOrPhenotypicFeature denotes Parkinson disease 0005180
T5 834-848 DiseaseOrPhenotypicFeature denotes SPR deficiency 0012994

silkworm

Id Subject Object Predicate Lexical cue
T1 4-12 Species:7091 denotes silkworm
T2 20-25 Species:2708 denotes lemon
T3 27-32 Species:2708 denotes lemon
T4 73-78 Species:9606 denotes human
T5 91-111 Disease:MESH:C536415 denotes reductase deficiency
T6 113-132 Chemical:MESH:C003402 denotes Tetrahydrobiopterin
T7 134-137 Chemical:MESH:C003402 denotes BH4
T8 224-233 Chemical:- denotes monoamine
T9 253-256 Chemical:MESH:C003402 denotes BH4
T10 331-347 Disease:MESH:D030342 denotes inherited defect
T11 351-354 Chemical:MESH:C003402 denotes BH4
T12 385-420 Disease:MESH:C562657 denotes deficiency of sepiapterin reductase
T13 422-425 Gene:6697 denotes SPR
T14 464-467 Chemical:MESH:C003402 denotes BH4
T15 473-495 Chemical:MESH:D006160 denotes guanosine triphosphate
T16 522-527 Species:9606 denotes human
T17 528-531 Gene:6697 denotes SPR
T18 560-565 Gene:5072 denotes PARK3
T19 606-623 Disease:MESH:D010300 denotes Parkinson disease
T20 671-676 Species:2708 denotes lemon
T21 678-681 Species:2708 denotes lem
T22 705-710 Species:2708 denotes lemon
T23 719-722 Species:2708 denotes lem
T24 763-771 Species:7091 denotes silkworm
T25 772-783 Species:7091 denotes Bombyx mori
T26 828-833 Species:9606 denotes human
T27 834-837 Gene:6697 denotes SPR
T28 838-857 Disease:MESH:D030342 denotes deficiency diseases
T29 897-900 Gene:6697 denotes SPR
T30 907-912 Gene:100379197 denotes BmSpr
T31 968-971 Species:2708 denotes lem
T32 976-979 Species:2708 denotes lem
T33 1029-1032 Gene:6697 denotes SPR
T34 1045-1048 Species:2708 denotes lem
T35 1226-1229 Chemical:MESH:C003402 denotes BH4
T36 1234-1242 Chemical:MESH:D004298 denotes dopamine
T37 1246-1249 Species:2708 denotes lem
T38 1352-1357 Gene:100379197 denotes BmSPR
T39 1400-1403 Chemical:MESH:C003402 denotes BH4
T40 1409-1418 Chemical:- denotes monoamine
T41 1440-1449 Species:7091 denotes silkworms
T42 1458-1461 Species:2708 denotes lem
T43 1463-1466 Species:2708 denotes lem
T44 1553-1556 Gene:6697 denotes SPR
T45 1561-1577 Disease:MESH:D010661 denotes BH4 deficiencies

DisGeNET

Id Subject Object Predicate Lexical cue
T0 528-531 gene:6697 denotes SPR
T1 606-623 disease:C0030567 denotes Parkinson disease
T2 560-565 gene:5072 denotes PARK3
T3 606-623 disease:C0030567 denotes Parkinson disease
R1 T0 T1 associated_with SPR,Parkinson disease
R2 T2 T3 associated_with PARK3,Parkinson disease

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19246455-4#10#13#gene6697 528-531 gene6697 denotes SPR
19246455-4#42#47#gene5072 560-565 gene5072 denotes PARK3
19246455-4#88#105#diseaseC0030567 606-623 diseaseC0030567 denotes Parkinson disease
10#13#gene669788#105#diseaseC0030567 19246455-4#10#13#gene6697 19246455-4#88#105#diseaseC0030567 associated_with SPR,Parkinson disease
42#47#gene507288#105#diseaseC0030567 19246455-4#42#47#gene5072 19246455-4#88#105#diseaseC0030567 associated_with PARK3,Parkinson disease

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 606-615 Phenotype denotes Parkinson HP:0001300

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 79-111 Disease denotes sepiapterin reductase deficiency http://purl.obolibrary.org/obo/MONDO_0012994
T2 560-565 Disease denotes PARK3 http://purl.obolibrary.org/obo/MONDO_0011220
T3 606-623 Disease denotes Parkinson disease http://purl.obolibrary.org/obo/MONDO_0005180
T4 834-848 Disease denotes SPR deficiency http://purl.obolibrary.org/obo/MONDO_0012994

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 4-12 OrganismTaxon denotes silkworm 7091
T2 20-25 OrganismTaxon denotes lemon 2708
T3 27-32 OrganismTaxon denotes lemon 2708
T4 73-78 OrganismTaxon denotes human 9606
T5 522-527 OrganismTaxon denotes human 9606
T6 671-676 OrganismTaxon denotes lemon 2708
T7 678-681 OrganismTaxon denotes lem 2708
T8 705-710 OrganismTaxon denotes lemon 2708
T9 719-722 OrganismTaxon denotes lem 2708
T10 763-771 OrganismTaxon denotes silkworm 7091
T11 772-783 OrganismTaxon denotes Bombyx mori 7091
T12 828-833 OrganismTaxon denotes human 9606
T13 968-971 OrganismTaxon denotes lem 2708
T14 976-979 OrganismTaxon denotes lem 2708
T15 1045-1048 OrganismTaxon denotes lem 2708
T16 1246-1249 OrganismTaxon denotes lem 2708
T17 1440-1449 OrganismTaxon denotes silkworms 7091
T18 1458-1461 OrganismTaxon denotes lem 2708
T19 1463-1466 OrganismTaxon denotes lem 2708