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PubMed:19243381 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-65 Sentence denotes The hypereosinophilic syndromes: current concepts and treatments.
TextSentencer_T2 66-203 Sentence denotes The hypereosinophilic syndromes (HES) encompass a spectrum of diseases that have increased blood eosinophils and tissue damage in common.
TextSentencer_T3 204-302 Sentence denotes The clinical manifestations are protean and may involve any organ system, but especially the skin.
TextSentencer_T4 303-470 Sentence denotes Our understanding of these diseases has drastically changed over the past 15 years, along with new classifications that characterize patients with marked eosinophilia.
TextSentencer_T5 471-595 Sentence denotes One HES variant, myeloproliferative, is actually chronic eosinophilic leukaemia with a unique genetic marker, FIP1L1-PDGFRA.
TextSentencer_T6 596-745 Sentence denotes Such patients are well-controlled by administration of the kinase inhibitor, imatinib, and remissions appear durable with continued imatinib therapy.
TextSentencer_T7 746-862 Sentence denotes FIP1L1-PDGFRA is expressed in several cell lineages, thus explaining increases in neutrophils and mast cells in HES.
TextSentencer_T8 863-984 Sentence denotes The lymphocytic HES variant is associated with T-cell clones producing interleukin-5 (IL-5) and can evolve into lymphoma.
TextSentencer_T9 985-1234 Sentence denotes While myeloproliferative and lymphocytic HES are well established and permit elimination of the term, idiopathic, to these varieties, most HES patients do not fall into these categories and are classified as complex (using the 2006 Workshop Report).
TextSentencer_T10 1235-1489 Sentence denotes A recent study showed that a monoclonal antibody to IL-5, mepolizumab, reduced glucocorticoid therapy in HES patients who did not possess the FIP1L1-PDGFRA mutation while controlling eosinophilia and preventing recurrence or progression of tissue damage.
TextSentencer_T11 1490-1581 Sentence denotes These advances augur well for continued progress in the understanding and treatment of HES.
T1 0-65 Sentence denotes The hypereosinophilic syndromes: current concepts and treatments.
T2 66-203 Sentence denotes The hypereosinophilic syndromes (HES) encompass a spectrum of diseases that have increased blood eosinophils and tissue damage in common.
T3 204-302 Sentence denotes The clinical manifestations are protean and may involve any organ system, but especially the skin.
T4 303-470 Sentence denotes Our understanding of these diseases has drastically changed over the past 15 years, along with new classifications that characterize patients with marked eosinophilia.
T5 471-595 Sentence denotes One HES variant, myeloproliferative, is actually chronic eosinophilic leukaemia with a unique genetic marker, FIP1L1-PDGFRA.
T6 596-745 Sentence denotes Such patients are well-controlled by administration of the kinase inhibitor, imatinib, and remissions appear durable with continued imatinib therapy.
T7 746-862 Sentence denotes FIP1L1-PDGFRA is expressed in several cell lineages, thus explaining increases in neutrophils and mast cells in HES.
T8 863-984 Sentence denotes The lymphocytic HES variant is associated with T-cell clones producing interleukin-5 (IL-5) and can evolve into lymphoma.
T9 985-1234 Sentence denotes While myeloproliferative and lymphocytic HES are well established and permit elimination of the term, idiopathic, to these varieties, most HES patients do not fall into these categories and are classified as complex (using the 2006 Workshop Report).
T10 1235-1489 Sentence denotes A recent study showed that a monoclonal antibody to IL-5, mepolizumab, reduced glucocorticoid therapy in HES patients who did not possess the FIP1L1-PDGFRA mutation while controlling eosinophilia and preventing recurrence or progression of tissue damage.
T11 1490-1581 Sentence denotes These advances augur well for continued progress in the understanding and treatment of HES.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 746-752 gene:81608 denotes FIP1L1
T1 858-861 disease:C1540912 denotes HES
T2 753-759 gene:5156 denotes PDGFRA
T3 858-861 disease:C1540912 denotes HES
T4 934-947 gene:3567 denotes interleukin-5
T5 975-983 disease:C0024299 denotes lymphoma
T6 934-947 gene:3567 denotes interleukin-5
T7 879-882 disease:C1540912 denotes HES
T8 949-953 gene:3567 denotes IL-5
T9 879-882 disease:C1540912 denotes HES
T10 949-953 gene:3567 denotes IL-5
T11 975-983 disease:C0024299 denotes lymphoma
R1 T0 T1 associated_with FIP1L1,HES
R2 T2 T3 associated_with PDGFRA,HES
R3 T4 T5 associated_with interleukin-5,lymphoma
R4 T6 T7 associated_with interleukin-5,HES
R5 T8 T9 associated_with IL-5,HES
R6 T10 T11 associated_with IL-5,lymphoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19243381-6#0#6#gene81608 746-752 gene81608 denotes FIP1L1
19243381-6#7#13#gene5156 753-759 gene5156 denotes PDGFRA
19243381-6#112#115#diseaseC0206141 858-861 diseaseC0206141 denotes HES
19243381-7#71#84#gene3567 934-947 gene3567 denotes interleukin-5
19243381-7#86#90#gene3567 949-953 gene3567 denotes IL-5
19243381-7#16#19#diseaseC0206141 879-882 diseaseC0206141 denotes HES
19243381-7#112#120#diseaseC0024299 975-983 diseaseC0024299 denotes lymphoma
19243381-7#16#19#diseaseC0206141 879-882 diseaseC0206141 denotes HES
19243381-7#112#120#diseaseC0024299 975-983 diseaseC0024299 denotes lymphoma
19243381-9#149#155#gene5156 1384-1390 gene5156 denotes PDGFRA
19243381-9#183#195#diseaseC0014457 1418-1430 diseaseC0014457 denotes eosinophilia
19243381-9#183#195#diseaseC1306759 1418-1430 diseaseC1306759 denotes eosinophilia
0#6#gene81608112#115#diseaseC0206141 19243381-6#0#6#gene81608 19243381-6#112#115#diseaseC0206141 associated_with FIP1L1,HES
7#13#gene5156112#115#diseaseC0206141 19243381-6#7#13#gene5156 19243381-6#112#115#diseaseC0206141 associated_with PDGFRA,HES
71#84#gene356716#19#diseaseC0206141 19243381-7#71#84#gene3567 19243381-7#16#19#diseaseC0206141 associated_with interleukin-5,HES
71#84#gene3567112#120#diseaseC0024299 19243381-7#71#84#gene3567 19243381-7#112#120#diseaseC0024299 associated_with interleukin-5,lymphoma
71#84#gene356716#19#diseaseC0206141 19243381-7#71#84#gene3567 19243381-7#16#19#diseaseC0206141 associated_with interleukin-5,HES
71#84#gene3567112#120#diseaseC0024299 19243381-7#71#84#gene3567 19243381-7#112#120#diseaseC0024299 associated_with interleukin-5,lymphoma
86#90#gene356716#19#diseaseC0206141 19243381-7#86#90#gene3567 19243381-7#16#19#diseaseC0206141 associated_with IL-5,HES
86#90#gene3567112#120#diseaseC0024299 19243381-7#86#90#gene3567 19243381-7#112#120#diseaseC0024299 associated_with IL-5,lymphoma
86#90#gene356716#19#diseaseC0206141 19243381-7#86#90#gene3567 19243381-7#16#19#diseaseC0206141 associated_with IL-5,HES
86#90#gene3567112#120#diseaseC0024299 19243381-7#86#90#gene3567 19243381-7#112#120#diseaseC0024299 associated_with IL-5,lymphoma
149#155#gene5156183#195#diseaseC0014457 19243381-9#149#155#gene5156 19243381-9#183#195#diseaseC0014457 associated_with PDGFRA,eosinophilia
149#155#gene5156183#195#diseaseC1306759 19243381-9#149#155#gene5156 19243381-9#183#195#diseaseC1306759 associated_with PDGFRA,eosinophilia

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1254 1384-1390 gene:5156 denotes PDGFRA
T1255 1418-1430 disease:C0014457 denotes eosinophilia
R1 T1254 T1255 associated_with PDGFRA,eosinophilia
R2 T1254 T1255 associated_with PDGFRA,eosinophilia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 157-162 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 179-185 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 1475-1481 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T4 264-269 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 179-185 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 1475-1481 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 157-162 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T4 264-269 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ