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PubMed:19233847 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 665-682 DiseaseOrPhenotypicFeature denotes Angelman syndrome 0007113
T2 1288-1303 DiseaseOrPhenotypicFeature denotes cystic fibrosis 0009061
T3 1574-1577 DiseaseOrPhenotypicFeature denotes can 0012833
T4 1624-1641 DiseaseOrPhenotypicFeature denotes Angelman syndrome 0007113

sentences

Id Subject Object Predicate Lexical cue
T1 0-179 Sentence denotes The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins.
T2 180-304 Sentence denotes Cells are equipped with an efficient quality control system to selectively eliminate abnormally folded and damaged proteins.
T3 305-485 Sentence denotes Initially the cell tries to refold the unfolded proteins with the help of molecular chaperones, and failure to refold leads to their degradation by the ubiquitin proteasome system.
T4 486-584 Sentence denotes But how this proteolytic machinery recognizes the abnormally folded proteins is poorly understood.
T5 585-813 Sentence denotes Here, we report that E6-AP, a HECT domain family ubiquitin ligase implicated in Angelman syndrome, interacts with the substrate binding domain of Hsp70/Hsc70 chaperones and promotes the degradation of chaperone bound substrates.
T6 814-997 Sentence denotes The expression of E6-AP was dramatically induced under a variety of stresses, and overexpression of E6-AP was found to protect against endoplasmic reticulum stress-induced cell death.
T7 998-1234 Sentence denotes The inhibition of proteasome function not only increases the expression of E6-AP but also causes its redistribution around microtubule-organizing center, a subcellular structure for the degradation of the cytoplasmic misfolded proteins.
T8 1235-1375 Sentence denotes E6-AP is also recruited to aggresomes containing the cystic fibrosis transmembrane conductance regulator or expanded polyglutamine proteins.
T9 1376-1469 Sentence denotes Finally, we demonstrate that E6-AP ubiquitinates misfolded luciferase that is bound by Hsp70.
T10 1470-1727 Sentence denotes Our results suggest that E6-AP functions as a cellular quality control ubiquitin ligase and, therefore, can be implicated not only in the pathogenesis of Angelman syndrome but also in the biology of neurodegenerative disorders involving protein aggregation.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 914-919 gene:7337 denotes E6-AP
T1 971-977 disease:C3825627 denotes stress
T2 832-837 gene:7337 denotes E6-AP
T3 971-977 disease:C3825627 denotes stress
T4 1495-1500 gene:7337 denotes E6-AP
T5 1669-1696 disease:C0524851 denotes neurodegenerative disorders
T6 1495-1500 gene:7337 denotes E6-AP
T7 1624-1641 disease:C0162635 denotes Angelman syndrome
R1 T0 T1 associated_with E6-AP,stress
R2 T2 T3 associated_with E6-AP,stress
R3 T4 T5 associated_with E6-AP,neurodegenerative disorders
R4 T6 T7 associated_with E6-AP,Angelman syndrome

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 4-13 Protein denotes ubiquitin
T2 21-26 Protein denotes E6-AP
T3 457-466 Protein denotes ubiquitin
T4 606-611 Protein denotes E6-AP
T5 634-643 Protein denotes ubiquitin
T6 737-742 Protein denotes Hsc70
T7 832-837 Protein denotes E6-AP
T8 914-919 Protein denotes E6-AP
T9 1073-1078 Protein denotes E6-AP
T10 1235-1240 Protein denotes E6-AP
T11 1288-1339 Protein denotes cystic fibrosis transmembrane conductance regulator
T12 1405-1410 Protein denotes E6-AP
T13 1435-1445 Protein denotes luciferase
T14 1495-1500 Protein denotes E6-AP
T15 1541-1550 Protein denotes ubiquitin

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19233847-9#25#30#gene7337 1495-1500 gene7337 denotes E6-AP
19233847-9#154#171#diseaseC0162635 1624-1641 diseaseC0162635 denotes Angelman syndrome
19233847-9#199#226#diseaseC0524851 1669-1696 diseaseC0524851 denotes neurodegenerative disorders
25#30#gene7337154#171#diseaseC0162635 19233847-9#25#30#gene7337 19233847-9#154#171#diseaseC0162635 associated_with E6-AP,Angelman syndrome
25#30#gene7337199#226#diseaseC0524851 19233847-9#25#30#gene7337 19233847-9#199#226#diseaseC0524851 associated_with E6-AP,neurodegenerative disorders

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 665-682 Disease denotes Angelman syndrome http://purl.obolibrary.org/obo/MONDO_0007113
T2 1288-1303 Disease denotes cystic fibrosis http://purl.obolibrary.org/obo/MONDO_0009061
T3 1624-1641 Disease denotes Angelman syndrome http://purl.obolibrary.org/obo/MONDO_0007113

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 961-970 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 1121-1132 Body_part denotes microtubule http://purl.obolibrary.org/obo/GO_0005874
T3 1203-1214 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T4 1304-1317 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020