> top > docs > PubMed:19224915 > annotations

PubMed:19224915 JSONTXT

Annnotations TAB JSON ListView MergeView

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 227-236 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T4 241-259 Glycan_Motif denotes galactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T5 356-365 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T8 450-459 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T11 516-525 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T14 1216-1225 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T17 1298-1307 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T20 1427-1436 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T23 1509-1518 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T26 1651-1660 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY
T29 1787-1796 Glycan_Motif denotes sulfatide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G95090DW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G72548RZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40843KY

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 241-259 GlycoEpitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 227-236 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T2 227-236 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T3 227-236 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide
T4 241-259 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactosylceramide
T5 356-365 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T6 356-365 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T7 356-365 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide
T8 450-459 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T9 450-459 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T10 450-459 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide
T11 516-525 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T12 516-525 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T13 516-525 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide
T14 1216-1225 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T15 1216-1225 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T16 1216-1225 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide
T17 1298-1307 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T18 1298-1307 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T19 1298-1307 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide
T20 1427-1436 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T21 1427-1436 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T22 1427-1436 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide
T23 1509-1518 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T24 1509-1518 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T25 1509-1518 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide
T26 1651-1660 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T27 1651-1660 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T28 1651-1660 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide
T29 1787-1796 https://glytoucan.org/Structures/Glycans/G40843KY denotes sulfatide
T30 1787-1796 https://glytoucan.org/Structures/Glycans/G72548RZ denotes sulfatide
T31 1787-1796 https://glytoucan.org/Structures/Glycans/G95090DW denotes sulfatide

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 102-130 DiseaseOrPhenotypicFeature denotes metachromatic leukodystrophy 0009591|0018868
T3 541-566 DiseaseOrPhenotypicFeature denotes lysosomal storage disease 0002561
T4 567-595 DiseaseOrPhenotypicFeature denotes metachromatic leukodystrophy 0009591|0018868
T6 747-775 DiseaseOrPhenotypicFeature denotes metachromatic leukodystrophy 0009591|0018868

sentences

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy.
T2 132-260 Sentence denotes Arylsulfatase A (ASA) catalyzes the intralysosomal desulfation of 3-O-sulfogalactosylceramide (sulfatide) to galactosylceramide.
T3 261-395 Sentence denotes The reaction requires saposin B (Sap B), a non-enzymatic proteinaceous cofactor which presents sulfatide to the catalytic site of ASA.
T4 396-596 Sentence denotes The lack of either ASA or Sap B results in a block of sulfatide degradation, progressive intralysosomal accumulation of sulfatide, and the fatal lysosomal storage disease metachromatic leukodystrophy.
T5 597-776 Sentence denotes We studied the coupled Sap B-ASA reaction in vitro using detergent-free micellar and liposomal assay systems and in vivo using cell culture models of metachromatic leukodystrophy.
T6 777-926 Sentence denotes Under in vitro conditions, the reaction had a narrow pH optimum around pH 4.3 and was inhibited by mono- and divalent cations, phosphate and sulfite.
T7 927-1104 Sentence denotes Bis(monoacylglycero) phosphate and phosphatidic acid were activators of the reaction, underscoring a significant role of acidic phosphoglycerolipids in sphingolipid degradation.
T8 1105-1177 Sentence denotes Desulfation was negligible when Sap B was substituted by Sap A, C, or D.
T9 1178-1400 Sentence denotes Up to a molar ratio between Sap B and sulfatide of 1:5, an elevation of Sap B concentrations caused a sharp increase of sulfatide hydrolysis, indicating the requirement of unexpected high Sap B levels for maximum turnover.
T10 1401-1519 Sentence denotes Feeding of ASA-deficient, sulfatide-storing primary mouse kidney cells with ASA caused partial clearance of sulfatide.
T11 1520-1672 Sentence denotes Co-feeding of Sap B or its precursor prosaposin resulted in the lysosomal uptake of the cofactor but did not promote ASA-catalyzed sulfatide hydrolysis.
T12 1673-1846 Sentence denotes This suggests that Sap B is not a limiting factor of the coupled Sap B-ASA reaction in mouse kidney cells even if sulfatide has accumulated to unphysiologically high levels.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1459-1465 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T2 1766-1772 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney

DisGeNET

Id Subject Object Predicate Lexical cue
T0 38-53 gene:410 denotes arylsulfatase A
T1 102-130 disease:C0023522 denotes metachromatic leukodystrophy
T2 626-629 gene:410 denotes ASA
T3 747-775 disease:C0023522 denotes metachromatic leukodystrophy
R1 T0 T1 associated_with arylsulfatase A,metachromatic leukodystrophy
R2 T2 T3 associated_with ASA,metachromatic leukodystrophy

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19224915-0#38#53#gene410 38-53 gene410 denotes arylsulfatase A
19224915-0#102#130#diseaseC0023522 102-130 diseaseC0023522 denotes metachromatic leukodystrophy
38#53#gene410102#130#diseaseC0023522 19224915-0#38#53#gene410 19224915-0#102#130#diseaseC0023522 associated_with arylsulfatase A,metachromatic leukodystrophy

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 241-259 Glycan denotes galactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1459-1465 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T2 1766-1772 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 116-130 Phenotype denotes leukodystrophy HP:0002415
T2 581-595 Phenotype denotes leukodystrophy HP:0002415
T3 761-775 Phenotype denotes leukodystrophy HP:0002415

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 102-130 Disease denotes metachromatic leukodystrophy http://purl.obolibrary.org/obo/MONDO_0009591|http://purl.obolibrary.org/obo/MONDO_0018868
T3 541-566 Disease denotes lysosomal storage disease http://purl.obolibrary.org/obo/MONDO_0002561
T4 567-595 Disease denotes metachromatic leukodystrophy http://purl.obolibrary.org/obo/MONDO_0009591|http://purl.obolibrary.org/obo/MONDO_0018868
T6 747-775 Disease denotes metachromatic leukodystrophy http://purl.obolibrary.org/obo/MONDO_0009591|http://purl.obolibrary.org/obo/MONDO_0018868

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 241-259 Glycan denotes galactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 241-259 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 116-130 Phenotype denotes leukodystrophy HP:0002415
T2 581-595 Phenotype denotes leukodystrophy HP:0002415
T3 761-775 Phenotype denotes leukodystrophy HP:0002415

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 102-130 Disease denotes metachromatic leukodystrophy MONDO:0009591|MONDO:0018868
T3 541-566 Disease denotes lysosomal storage disease MONDO:0002561
T4 567-595 Disease denotes metachromatic leukodystrophy MONDO:0009591|MONDO:0018868
T6 747-775 Disease denotes metachromatic leukodystrophy MONDO:0009591|MONDO:0018868

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1459-1471 Cell denotes kidney cells http://purl.obolibrary.org/obo/CL:1000497
T2 1766-1778 Cell denotes kidney cells http://purl.obolibrary.org/obo/CL:1000497

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1186-1191 Body_part denotes molar http://purl.obolibrary.org/obo/UBERON_0003655
T2 1459-1471 Body_part denotes kidney cells http://purl.obolibrary.org/obo/CL_1000497
T3 1766-1778 Body_part denotes kidney cells http://purl.obolibrary.org/obo/CL_1000497

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 1453-1458 Organism denotes mouse 10088|10090
T3 1760-1765 Organism denotes mouse 10088|10090

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy.
T2 132-260 Sentence denotes Arylsulfatase A (ASA) catalyzes the intralysosomal desulfation of 3-O-sulfogalactosylceramide (sulfatide) to galactosylceramide.
T3 261-395 Sentence denotes The reaction requires saposin B (Sap B), a non-enzymatic proteinaceous cofactor which presents sulfatide to the catalytic site of ASA.
T4 396-596 Sentence denotes The lack of either ASA or Sap B results in a block of sulfatide degradation, progressive intralysosomal accumulation of sulfatide, and the fatal lysosomal storage disease metachromatic leukodystrophy.
T5 597-776 Sentence denotes We studied the coupled Sap B-ASA reaction in vitro using detergent-free micellar and liposomal assay systems and in vivo using cell culture models of metachromatic leukodystrophy.
T6 777-926 Sentence denotes Under in vitro conditions, the reaction had a narrow pH optimum around pH 4.3 and was inhibited by mono- and divalent cations, phosphate and sulfite.
T7 927-1104 Sentence denotes Bis(monoacylglycero) phosphate and phosphatidic acid were activators of the reaction, underscoring a significant role of acidic phosphoglycerolipids in sphingolipid degradation.
T8 1105-1400 Sentence denotes Desulfation was negligible when Sap B was substituted by Sap A, C, or D. Up to a molar ratio between Sap B and sulfatide of 1:5, an elevation of Sap B concentrations caused a sharp increase of sulfatide hydrolysis, indicating the requirement of unexpected high Sap B levels for maximum turnover.
T9 1401-1519 Sentence denotes Feeding of ASA-deficient, sulfatide-storing primary mouse kidney cells with ASA caused partial clearance of sulfatide.
T10 1520-1672 Sentence denotes Co-feeding of Sap B or its precursor prosaposin resulted in the lysosomal uptake of the cofactor but did not promote ASA-catalyzed sulfatide hydrolysis.
T11 1673-1846 Sentence denotes This suggests that Sap B is not a limiting factor of the coupled Sap B-ASA reaction in mouse kidney cells even if sulfatide has accumulated to unphysiologically high levels.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 241-259 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 541-550 Body_part denotes lysosomal FMA:63836
T2 1459-1465 Body_part denotes kidney FMA:7203
T3 1584-1593 Body_part denotes lysosomal FMA:63836
T4 1766-1772 Body_part denotes kidney FMA:7203

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1459-1465 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T2 1766-1772 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1453-1458 OrganismTaxon denotes mouse 10088|10090
T3 1760-1765 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1186-1191 Body_part denotes molar http://purl.obolibrary.org/obo/UBERON_0003655
T2 1459-1471 Body_part denotes kidney cells http://purl.obolibrary.org/obo/CL_1000497
T3 1766-1778 Body_part denotes kidney cells http://purl.obolibrary.org/obo/CL_1000497

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1459-1471 Cell denotes kidney cells http://purl.obolibrary.org/obo/CL:1000497
T2 1766-1778 Cell denotes kidney cells http://purl.obolibrary.org/obo/CL:1000497