PubMed:19212833 JSONTXT

{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":45,"end":60},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":126,"end":141},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":239,"end":242},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":243,"end":258},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":297,"end":312},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":534,"end":539},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":614,"end":619},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":707,"end":722},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0008315"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0008315"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0014324"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0008315"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0008315"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0005070"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0005070"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0008315"}],"text":"PDLIM4, an actin binding protein, suppresses prostate cancer cell growth.\nWe investigated the molecular function of PDLIM4 in prostate cancer cells. PDLIM4 mRNA and protein-expression levels were reduced in LNCaP, LAPC4, DU145, CWR22, and PC3 prostate cancer cells. The re-expression of PDLIM4 in prostate cancer cells has significantly reduced the cell growth and clonogenicity with G1 phase of cell-cycle arrest. We have shown the direct interaction of PDLIM4 with F-actin. Restoration of PDLIM4 expression resulted in reduction of tumor growth in xenografts. These results suggest that PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":287,"end":293},"obj":"gene:8572"},{"id":"T1","span":{"begin":297,"end":312},"obj":"disease:C0376358"},{"id":"T2","span":{"begin":287,"end":293},"obj":"gene:8572"},{"id":"T3","span":{"begin":297,"end":312},"obj":"disease:C0600139"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"PDLIM4, an actin binding protein, suppresses prostate cancer cell growth.\nWe investigated the molecular function of PDLIM4 in prostate cancer cells. PDLIM4 mRNA and protein-expression levels were reduced in LNCaP, LAPC4, DU145, CWR22, and PC3 prostate cancer cells. The re-expression of PDLIM4 in prostate cancer cells has significantly reduced the cell growth and clonogenicity with G1 phase of cell-cycle arrest. We have shown the direct interaction of PDLIM4 with F-actin. Restoration of PDLIM4 expression resulted in reduction of tumor growth in xenografts. These results suggest that PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells."}

{"project":"CoMAGC","denotations":[{"id":"T1","span":{"begin":149,"end":160},"obj":"Gene"},{"id":"E2","span":{"begin":196,"end":203},"obj":"Negative_regulation"},{"id":"T2","span":{"begin":243,"end":258},"obj":"prostate cancer"},{"id":"T3","span":{"begin":207,"end":212},"obj":"prostate cancer"},{"id":"T4","span":{"begin":214,"end":219},"obj":"prostate cancer"},{"id":"T5","span":{"begin":221,"end":226},"obj":"prostate cancer"},{"id":"T6","span":{"begin":228,"end":233},"obj":"prostate cancer"},{"id":"T7","span":{"begin":239,"end":242},"obj":"prostate cancer"}],"relations":[{"id":"R1","pred":"themeOf","subj":"T1","obj":"E2"},{"id":"R3","pred":"CGE-decreased","subj":"T1","obj":"T2"},{"id":"R4","pred":"CCS-normalTOcancer","subj":"T1","obj":"T2"},{"id":"R5","pred":"PT-observation","subj":"T1","obj":"T2"},{"id":"R3","pred":"IGE-unchanged","subj":"T1","obj":"T2"}],"text":"PDLIM4, an actin binding protein, suppresses prostate cancer cell growth.\nWe investigated the molecular function of PDLIM4 in prostate cancer cells. PDLIM4 mRNA and protein-expression levels were reduced in LNCaP, LAPC4, DU145, CWR22, and PC3 prostate cancer cells. The re-expression of PDLIM4 in prostate cancer cells has significantly reduced the cell growth and clonogenicity with G1 phase of cell-cycle arrest. We have shown the direct interaction of PDLIM4 with F-actin. Restoration of PDLIM4 expression resulted in reduction of tumor growth in xenografts. These results suggest that PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells."}