| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-67 |
Sentence |
denotes |
Pulmonary preneoplasia--sequential molecular carcinogenetic events. |
| TextSentencer_T2 |
68-280 |
Sentence |
denotes |
Bronchial and bronchioloalveolar carcinogenesis is a multicentric and multistep process, leading to a sequential accumulation of molecular and genetic abnormalities, mainly due to exposure to tobacco carcinogens. |
| TextSentencer_T3 |
281-449 |
Sentence |
denotes |
Concomitantly, a series of morphological alterations of normal bronchial or bronchioloalveolar epithelium occur, resulting in preneoplastic and then neoplastic lesions. |
| TextSentencer_T4 |
450-852 |
Sentence |
denotes |
The three pulmonary preneoplastic changes recognized to date in the lung include bronchial squamous dysplasia and in situ carcinoma, preceding invasive squamous cell carcinoma and basaloid carcinoma, atypical adenomatous hyperplasia, a preneoplastic condition of bronchioloalveolar carcinoma, and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, a proposed precursor for carcinoid tumours. |
| TextSentencer_T5 |
853-1260 |
Sentence |
denotes |
Although the gradual accumulation of molecular alterations has been widely investigated in bronchial carcinogenesis, with the aim of determining new biomarkers for early lung cancer detection in high-risk patients and targeted chemoprevention, lung adenocarcinoma pathogenesis has been only recently highlighted, with the recent discovery of epidermal growth factor receptor mutation pathway in non-smokers. |
| TextSentencer_T6 |
1261-1380 |
Sentence |
denotes |
This review focuses on the current status of molecular pathology in lung cancer and pulmonary preneoplastic conditions. |
| T1 |
0-67 |
Sentence |
denotes |
Pulmonary preneoplasia--sequential molecular carcinogenetic events. |
| T2 |
68-280 |
Sentence |
denotes |
Bronchial and bronchioloalveolar carcinogenesis is a multicentric and multistep process, leading to a sequential accumulation of molecular and genetic abnormalities, mainly due to exposure to tobacco carcinogens. |
| T3 |
281-449 |
Sentence |
denotes |
Concomitantly, a series of morphological alterations of normal bronchial or bronchioloalveolar epithelium occur, resulting in preneoplastic and then neoplastic lesions. |
| T4 |
450-852 |
Sentence |
denotes |
The three pulmonary preneoplastic changes recognized to date in the lung include bronchial squamous dysplasia and in situ carcinoma, preceding invasive squamous cell carcinoma and basaloid carcinoma, atypical adenomatous hyperplasia, a preneoplastic condition of bronchioloalveolar carcinoma, and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, a proposed precursor for carcinoid tumours. |
| T5 |
853-1260 |
Sentence |
denotes |
Although the gradual accumulation of molecular alterations has been widely investigated in bronchial carcinogenesis, with the aim of determining new biomarkers for early lung cancer detection in high-risk patients and targeted chemoprevention, lung adenocarcinoma pathogenesis has been only recently highlighted, with the recent discovery of epidermal growth factor receptor mutation pathway in non-smokers. |
| T6 |
1261-1380 |
Sentence |
denotes |
This review focuses on the current status of molecular pathology in lung cancer and pulmonary preneoplastic conditions. |
