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PubMed:19171932 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 44-46 DiseaseOrPhenotypicFeature denotes R5 0016654
T2 90-92 DiseaseOrPhenotypicFeature denotes R5 0016654
T3 197-199 DiseaseOrPhenotypicFeature denotes R5 0016654
T4 319-321 DiseaseOrPhenotypicFeature denotes R5 0016654
T5 603-605 DiseaseOrPhenotypicFeature denotes R5 0016654
T6 714-716 DiseaseOrPhenotypicFeature denotes R5 0016654
T7 823-825 DiseaseOrPhenotypicFeature denotes R5 0016654
T8 996-998 DiseaseOrPhenotypicFeature denotes R5 0016654
T9 1183-1185 DiseaseOrPhenotypicFeature denotes R5 0016654

sentences

Id Subject Object Predicate Lexical cue
T1 0-196 Sentence denotes AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex.
T2 197-318 Sentence denotes R5/PTG is one of the glycogen targeting subunits of type 1 protein phosphatase, a master regulator of glycogen synthesis.
T3 319-557 Sentence denotes R5/PTG recruits the phosphatase to the places where glycogen synthesis occurs, allowing the activation of glycogen synthase and the inactivation of glycogen phosphorylase, thus increasing glycogen synthesis and decreasing its degradation.
T4 558-662 Sentence denotes In this report, we show that the activity of R5/PTG is regulated by AMP-activated protein kinase (AMPK).
T5 663-767 Sentence denotes We demonstrate that AMPK interacts physically with R5/PTG and modifies its basal phosphorylation status.
T6 768-947 Sentence denotes We have also mapped the major phosphorylation sites of R5/PTG by mass spectrometry analysis, observing that phosphorylation of Ser-8 and Ser-268 increased upon activation of AMPK.
T7 948-1139 Sentence denotes We have recently described that the activity of R5/PTG is down-regulated by the laforin-malin complex, composed of a dual specificity phosphatase (laforin) and an E3-ubiquitin ligase (malin).
T8 1140-1357 Sentence denotes We now demonstrate that phosphorylation of R5/PTG at Ser-8 by AMPK accelerates its laforin/malin-dependent ubiquitination and subsequent proteasomal degradation, which results in a decrease of its glycogenic activity.
T9 1358-1428 Sentence denotes Thus, our results define a novel role of AMPK in glycogen homeostasis.

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 44-46 Protein denotes R5
T2 47-50 Protein denotes PTG
T3 90-92 Protein denotes R5
T4 93-96 Protein denotes PTG
T5 174-181 Protein denotes laforin
T6 182-187 Protein denotes malin
T7 197-199 Protein denotes R5
T8 200-203 Protein denotes PTG
T9 319-321 Protein denotes R5
T10 322-325 Protein denotes PTG
T11 603-605 Protein denotes R5
T12 606-609 Protein denotes PTG
T13 714-716 Protein denotes R5
T14 717-720 Protein denotes PTG
T15 823-825 Protein denotes R5
T16 826-829 Protein denotes PTG
T17 996-998 Protein denotes R5
T18 999-1002 Protein denotes PTG
T19 1028-1035 Protein denotes laforin
T20 1036-1041 Protein denotes malin
T21 1095-1102 Protein denotes laforin
T22 1114-1123 Protein denotes ubiquitin
T23 1132-1137 Protein denotes malin
T24 1183-1185 Protein denotes R5
T25 1186-1189 Protein denotes PTG
T26 1223-1230 Protein denotes laforin
T27 1231-1236 Protein denotes malin

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 738-743 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324