> top > docs > PubMed:19160446 > annotations

PubMed:19160446 JSONTXT

Annnotations TAB JSON ListView MergeView

PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
19160446_0 555-560 ProteinMutation denotes Q460R rs2230912

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-6 Sentence denotes P2RX7:
T2 7-69 Sentence denotes A bipolar and unipolar disorder candidate susceptibility gene?
T3 70-328 Sentence denotes The chromosomal region 12q24 has been previously implicated by linkage studies of both bipolar disorder and unipolar mood disorder and we have reported two pedigrees segregating both bipolar disorder and Darier's disease that show linkage across this region.
T4 329-483 Sentence denotes The gene P2RX7 is located in this chromosomal region and has been recently reported as a susceptibility gene for bipolar disorder and unipolar depression.
T5 484-649 Sentence denotes The non-synonymous SNP rs2230912 (resulting in amino-acid polymorphism Q460R) showed the strongest association and has been postulated to be pathogenically relevant.
T6 650-811 Sentence denotes We have investigated this gene in a large UK case-control sample (bipolar I disorder N = 687, unipolar recurrent major depression N = 1,036, controls N = 1,204).
T7 812-986 Sentence denotes Neither rs2230912 nor any of 8 other SNPs genotyped across P2RX7 was found to be associated with mood disorder in general, nor specifically with bipolar or unipolar disorder.
T8 987-1139 Sentence denotes Further, sequencing of our two chromosome 12-linked bipolar-Darier families showed no evidence of rare variants at P2RX7 that could explain the linkage.
T9 1140-1296 Sentence denotes Our data do not provide support for rs2230912 or the other polymorphisms studied within the P2RX7 locus, being involved in susceptibility to mood disorders.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
5713 0-5 GeneOrGeneProduct denotes P2RX7 NCBIGene:5027
5714 9-38 DiseaseOrPhenotypicFeature denotes bipolar and unipolar disorder MESH:D001714|MESH:D003866
5715 157-173 DiseaseOrPhenotypicFeature denotes bipolar disorder MESH:D001714
5716 178-200 DiseaseOrPhenotypicFeature denotes unipolar mood disorder MESH:D003866|MESH:D019964
5717 253-269 DiseaseOrPhenotypicFeature denotes bipolar disorder MESH:D001714
5718 274-290 DiseaseOrPhenotypicFeature denotes Darier's disease MESH:D007644
5719 338-343 GeneOrGeneProduct denotes P2RX7 NCBIGene:5027
5720 442-458 DiseaseOrPhenotypicFeature denotes bipolar disorder MESH:D001714
5721 463-482 DiseaseOrPhenotypicFeature denotes unipolar depression MESH:D003866
5722 507-516 SequenceVariant denotes rs2230912 DBSNP:rs2230912
5723 555-560 SequenceVariant denotes Q460R DBSNP:rs2230912
5724 716-734 DiseaseOrPhenotypicFeature denotes bipolar I disorder MESH:D001714
5725 744-779 DiseaseOrPhenotypicFeature denotes unipolar recurrent major depression MESH:D003865
5726 820-829 SequenceVariant denotes rs2230912 DBSNP:rs2230912
5727 871-876 GeneOrGeneProduct denotes P2RX7 NCBIGene:5027
5728 909-922 DiseaseOrPhenotypicFeature denotes mood disorder MESH:D019964
5729 957-985 DiseaseOrPhenotypicFeature denotes bipolar or unipolar disorder MESH:D001714|MESH:D003866
5730 1102-1107 GeneOrGeneProduct denotes P2RX7 NCBIGene:5027
5731 1176-1185 SequenceVariant denotes rs2230912 DBSNP:rs2230912
5732 1232-1237 GeneOrGeneProduct denotes P2RX7 NCBIGene:5027
5733 1281-1295 DiseaseOrPhenotypicFeature denotes mood disorders MESH:D019964

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 157-173 DiseaseOrPhenotypicFeature denotes bipolar disorder 0004985
T2 187-200 DiseaseOrPhenotypicFeature denotes mood disorder 0005371
T3 253-269 DiseaseOrPhenotypicFeature denotes bipolar disorder 0004985
T4 274-290 DiseaseOrPhenotypicFeature denotes Darier's disease 0007417
T5 442-458 DiseaseOrPhenotypicFeature denotes bipolar disorder 0004985
T6 716-734 DiseaseOrPhenotypicFeature denotes bipolar I disorder 0001866
T7 909-922 DiseaseOrPhenotypicFeature denotes mood disorder 0005371
T8 1085-1089 DiseaseOrPhenotypicFeature denotes rare 0021136
T9 1281-1295 DiseaseOrPhenotypicFeature denotes mood disorders 0005371

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 507-516 SequenceVariant denotes rs2230912
T2 555-560 SequenceVariant denotes Q460R
T3 820-829 SequenceVariant denotes rs2230912
T4 1176-1185 SequenceVariant denotes rs2230912

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes P2RX7
T2 338-343 GeneOrGeneProduct denotes P2RX7
T3 537-541 GeneOrGeneProduct denotes acid
T4 686-691 GeneOrGeneProduct denotes large
T5 763-768 GeneOrGeneProduct denotes major
T6 843-848 GeneOrGeneProduct denotes other
T7 871-876 GeneOrGeneProduct denotes P2RX7
T8 1085-1089 GeneOrGeneProduct denotes rare
T9 1102-1107 GeneOrGeneProduct denotes P2RX7
T10 1193-1198 GeneOrGeneProduct denotes other
T11 1232-1237 GeneOrGeneProduct denotes P2RX7

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes P2RX7
T2 338-343 GeneOrGeneProduct denotes P2RX7
T3 472-482 GeneOrGeneProduct denotes depression
T4 537-541 GeneOrGeneProduct denotes acid
T5 676-685 GeneOrGeneProduct denotes gene in a
T6 686-691 GeneOrGeneProduct denotes large
T7 695-699 GeneOrGeneProduct denotes case
T8 763-768 GeneOrGeneProduct denotes major
T9 769-779 GeneOrGeneProduct denotes depression
T10 843-848 GeneOrGeneProduct denotes other
T11 871-876 GeneOrGeneProduct denotes P2RX7
T12 1032-1038 GeneOrGeneProduct denotes linked
T13 1085-1089 GeneOrGeneProduct denotes rare
T14 1102-1107 GeneOrGeneProduct denotes P2RX7
T15 1193-1198 GeneOrGeneProduct denotes other
T16 1232-1237 GeneOrGeneProduct denotes P2RX7

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 157-173 DiseaseOrPhenotypicFeature denotes bipolar disorder D001714
T2 187-200 DiseaseOrPhenotypicFeature denotes mood disorder D019964
T3 253-269 DiseaseOrPhenotypicFeature denotes bipolar disorder D001714
T4 274-290 DiseaseOrPhenotypicFeature denotes Darier's disease D007644
T5 442-458 DiseaseOrPhenotypicFeature denotes bipolar disorder D001714
T6 463-482 DiseaseOrPhenotypicFeature denotes unipolar depression D003866
T7 753-762 DiseaseOrPhenotypicFeature denotes recurrent D012008
T8 769-779 DiseaseOrPhenotypicFeature denotes depression DISEASE
T9 909-922 DiseaseOrPhenotypicFeature denotes mood disorder D019964
T10 1281-1295 DiseaseOrPhenotypicFeature denotes mood disorders D019964

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes P2RX7
T2 338-343 GeneOrGeneProduct denotes P2RX7
T3 871-876 GeneOrGeneProduct denotes P2RX7
T4 1102-1107 GeneOrGeneProduct denotes P2RX7
T5 1232-1237 GeneOrGeneProduct denotes P2RX7

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 157-173 DiseaseOrPhenotypicFeature denotes bipolar disorder 0004985
T2 187-200 DiseaseOrPhenotypicFeature denotes mood disorder 0005371
T3 253-269 DiseaseOrPhenotypicFeature denotes bipolar disorder 0004985
T4 274-290 DiseaseOrPhenotypicFeature denotes Darier's disease 0007417
T5 442-458 DiseaseOrPhenotypicFeature denotes bipolar disorder 0004985
T6 463-482 DiseaseOrPhenotypicFeature denotes unipolar depression 0012048|0002009
T8 716-734 DiseaseOrPhenotypicFeature denotes bipolar I disorder 0001866
T9 753-779 DiseaseOrPhenotypicFeature denotes recurrent major depression 0002009
T10 909-922 DiseaseOrPhenotypicFeature denotes mood disorder 0005371

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 9-38 DiseaseOrPhenotypicFeature denotes bipolar and unipolar disorder DISEASE
T2 157-173 DiseaseOrPhenotypicFeature denotes bipolar disorder D001714
T3 187-200 DiseaseOrPhenotypicFeature denotes mood disorder D019964
T4 253-269 DiseaseOrPhenotypicFeature denotes bipolar disorder D001714
T5 274-290 DiseaseOrPhenotypicFeature denotes Darier's disease D007644
T6 442-458 DiseaseOrPhenotypicFeature denotes bipolar disorder D001714
T7 463-482 DiseaseOrPhenotypicFeature denotes unipolar depression D003866
T8 716-734 DiseaseOrPhenotypicFeature denotes bipolar I disorder DISEASE
T9 769-779 DiseaseOrPhenotypicFeature denotes depression DISEASE
T10 909-922 DiseaseOrPhenotypicFeature denotes mood disorder D019964
T11 957-985 DiseaseOrPhenotypicFeature denotes bipolar or unipolar disorder DISEASE
T12 1281-1295 DiseaseOrPhenotypicFeature denotes mood disorders D019964

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 9-38 DiseaseOrPhenotypicFeature denotes bipolar and unipolar disorder DISEASE
T2 157-173 DiseaseOrPhenotypicFeature denotes bipolar disorder D001714
T3 187-200 DiseaseOrPhenotypicFeature denotes mood disorder D019964
T4 253-269 DiseaseOrPhenotypicFeature denotes bipolar disorder D001714
T5 274-290 DiseaseOrPhenotypicFeature denotes Darier's disease D007644
T6 442-458 DiseaseOrPhenotypicFeature denotes bipolar disorder D001714
T7 463-482 DiseaseOrPhenotypicFeature denotes unipolar depression D003866
T8 716-734 DiseaseOrPhenotypicFeature denotes bipolar I disorder DISEASE
T9 769-779 DiseaseOrPhenotypicFeature denotes depression DISEASE
T10 909-922 DiseaseOrPhenotypicFeature denotes mood disorder D019964
T11 957-985 DiseaseOrPhenotypicFeature denotes bipolar or unipolar disorder DISEASE
T12 1281-1295 DiseaseOrPhenotypicFeature denotes mood disorders D019964

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label
T5 1232-1237 GeneOrGeneProduct denotes P2RX7
T4 1102-1107 GeneOrGeneProduct denotes P2RX7
T3 871-876 GeneOrGeneProduct denotes P2RX7
T2 338-343 GeneOrGeneProduct denotes P2RX7
T1 0-5 GeneOrGeneProduct denotes P2RX7
T12 1281-1295 DiseaseOrPhenotypicFeature denotes mood disorders D019964
T11 957-985 DiseaseOrPhenotypicFeature denotes bipolar or unipolar disorder DISEASE
T10 909-922 DiseaseOrPhenotypicFeature denotes mood disorder D019964
T9 769-779 DiseaseOrPhenotypicFeature denotes depression DISEASE
T8 716-734 DiseaseOrPhenotypicFeature denotes bipolar I disorder DISEASE
T7 463-482 DiseaseOrPhenotypicFeature denotes unipolar depression D003866
T6 442-458 DiseaseOrPhenotypicFeature denotes bipolar disorder D001714
T77011 274-290 DiseaseOrPhenotypicFeature denotes Darier's disease D007644
T62778 253-269 DiseaseOrPhenotypicFeature denotes bipolar disorder D001714
T19990 187-200 DiseaseOrPhenotypicFeature denotes mood disorder D019964
T95280 157-173 DiseaseOrPhenotypicFeature denotes bipolar disorder D001714
T59712 9-38 DiseaseOrPhenotypicFeature denotes bipolar and unipolar disorder DISEASE
T36950 1176-1185 SequenceVariant denotes rs2230912
T1780 820-829 SequenceVariant denotes rs2230912
T20044 555-560 SequenceVariant denotes Q460R
T67781 507-516 SequenceVariant denotes rs2230912

DisGeNET

Id Subject Object Predicate Lexical cue
T0 338-343 gene:5027 denotes P2RX7
T1 463-482 disease:C0041696 denotes unipolar depression
T2 338-343 gene:5027 denotes P2RX7
T3 442-458 disease:C0005586 denotes bipolar disorder
T4 871-876 gene:5027 denotes P2RX7
T5 909-922 disease:C0525045 denotes mood disorder
T6 1232-1237 gene:5027 denotes P2RX7
T7 1281-1295 disease:C0525045 denotes mood disorders
R1 T0 T1 associated_with P2RX7,unipolar depression
R2 T2 T3 associated_with P2RX7,bipolar disorder
R3 T4 T5 associated_with P2RX7,mood disorder
R4 T6 T7 associated_with P2RX7,mood disorders

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
19160446-7#36#45#geners2230912 1176-1185 geners2230912 denotes rs2230912
19160446-7#141#155#diseaseC0525045 1281-1295 diseaseC0525045 denotes mood disorders
36#45#geners2230912141#155#diseaseC0525045 19160446-7#36#45#geners2230912 19160446-7#141#155#diseaseC0525045 associated_with rs2230912,mood disorders

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19160446-2#9#14#gene5027 338-343 gene5027 denotes P2RX7
19160446-2#113#129#diseaseC0005586 442-458 diseaseC0005586 denotes bipolar disorder
19160446-2#134#153#diseaseC0041696 463-482 diseaseC0041696 denotes unipolar depression
19160446-7#92#97#gene5027 1232-1237 gene5027 denotes P2RX7
19160446-7#141#155#diseaseC0525045 1281-1295 diseaseC0525045 denotes mood disorders
9#14#gene5027113#129#diseaseC0005586 19160446-2#9#14#gene5027 19160446-2#113#129#diseaseC0005586 associated_with P2RX7,bipolar disorder
9#14#gene5027134#153#diseaseC0041696 19160446-2#9#14#gene5027 19160446-2#134#153#diseaseC0041696 associated_with P2RX7,unipolar depression
92#97#gene5027141#155#diseaseC0525045 19160446-7#92#97#gene5027 19160446-7#141#155#diseaseC0525045 associated_with P2RX7,mood disorders