PubMed:19160446
Annnotations
PubTator4TogoVar
Id | Subject | Object | Predicate | Lexical cue | proteinmutation |
---|---|---|---|---|---|
19160446_0 | 555-560 | ProteinMutation | denotes | Q460R | rs2230912 |
LitCoin-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-6 | Sentence | denotes | P2RX7: |
T2 | 7-69 | Sentence | denotes | A bipolar and unipolar disorder candidate susceptibility gene? |
T3 | 70-328 | Sentence | denotes | The chromosomal region 12q24 has been previously implicated by linkage studies of both bipolar disorder and unipolar mood disorder and we have reported two pedigrees segregating both bipolar disorder and Darier's disease that show linkage across this region. |
T4 | 329-483 | Sentence | denotes | The gene P2RX7 is located in this chromosomal region and has been recently reported as a susceptibility gene for bipolar disorder and unipolar depression. |
T5 | 484-649 | Sentence | denotes | The non-synonymous SNP rs2230912 (resulting in amino-acid polymorphism Q460R) showed the strongest association and has been postulated to be pathogenically relevant. |
T6 | 650-811 | Sentence | denotes | We have investigated this gene in a large UK case-control sample (bipolar I disorder N = 687, unipolar recurrent major depression N = 1,036, controls N = 1,204). |
T7 | 812-986 | Sentence | denotes | Neither rs2230912 nor any of 8 other SNPs genotyped across P2RX7 was found to be associated with mood disorder in general, nor specifically with bipolar or unipolar disorder. |
T8 | 987-1139 | Sentence | denotes | Further, sequencing of our two chromosome 12-linked bipolar-Darier families showed no evidence of rare variants at P2RX7 that could explain the linkage. |
T9 | 1140-1296 | Sentence | denotes | Our data do not provide support for rs2230912 or the other polymorphisms studied within the P2RX7 locus, being involved in susceptibility to mood disorders. |
LitCoin-entities
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
5713 | 0-5 | GeneOrGeneProduct | denotes | P2RX7 | NCBIGene:5027 |
5714 | 9-38 | DiseaseOrPhenotypicFeature | denotes | bipolar and unipolar disorder | MESH:D001714|MESH:D003866 |
5715 | 157-173 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | MESH:D001714 |
5716 | 178-200 | DiseaseOrPhenotypicFeature | denotes | unipolar mood disorder | MESH:D003866|MESH:D019964 |
5717 | 253-269 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | MESH:D001714 |
5718 | 274-290 | DiseaseOrPhenotypicFeature | denotes | Darier's disease | MESH:D007644 |
5719 | 338-343 | GeneOrGeneProduct | denotes | P2RX7 | NCBIGene:5027 |
5720 | 442-458 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | MESH:D001714 |
5721 | 463-482 | DiseaseOrPhenotypicFeature | denotes | unipolar depression | MESH:D003866 |
5722 | 507-516 | SequenceVariant | denotes | rs2230912 | DBSNP:rs2230912 |
5723 | 555-560 | SequenceVariant | denotes | Q460R | DBSNP:rs2230912 |
5724 | 716-734 | DiseaseOrPhenotypicFeature | denotes | bipolar I disorder | MESH:D001714 |
5725 | 744-779 | DiseaseOrPhenotypicFeature | denotes | unipolar recurrent major depression | MESH:D003865 |
5726 | 820-829 | SequenceVariant | denotes | rs2230912 | DBSNP:rs2230912 |
5727 | 871-876 | GeneOrGeneProduct | denotes | P2RX7 | NCBIGene:5027 |
5728 | 909-922 | DiseaseOrPhenotypicFeature | denotes | mood disorder | MESH:D019964 |
5729 | 957-985 | DiseaseOrPhenotypicFeature | denotes | bipolar or unipolar disorder | MESH:D001714|MESH:D003866 |
5730 | 1102-1107 | GeneOrGeneProduct | denotes | P2RX7 | NCBIGene:5027 |
5731 | 1176-1185 | SequenceVariant | denotes | rs2230912 | DBSNP:rs2230912 |
5732 | 1232-1237 | GeneOrGeneProduct | denotes | P2RX7 | NCBIGene:5027 |
5733 | 1281-1295 | DiseaseOrPhenotypicFeature | denotes | mood disorders | MESH:D019964 |
LitCoin_Mondo
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 157-173 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | 0004985 |
T2 | 187-200 | DiseaseOrPhenotypicFeature | denotes | mood disorder | 0005371 |
T3 | 253-269 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | 0004985 |
T4 | 274-290 | DiseaseOrPhenotypicFeature | denotes | Darier's disease | 0007417 |
T5 | 442-458 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | 0004985 |
T6 | 716-734 | DiseaseOrPhenotypicFeature | denotes | bipolar I disorder | 0001866 |
T7 | 909-922 | DiseaseOrPhenotypicFeature | denotes | mood disorder | 0005371 |
T8 | 1085-1089 | DiseaseOrPhenotypicFeature | denotes | rare | 0021136 |
T9 | 1281-1295 | DiseaseOrPhenotypicFeature | denotes | mood disorders | 0005371 |
LitCoin-SeqVar
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 507-516 | SequenceVariant | denotes | rs2230912 |
T2 | 555-560 | SequenceVariant | denotes | Q460R |
T3 | 820-829 | SequenceVariant | denotes | rs2230912 |
T4 | 1176-1185 | SequenceVariant | denotes | rs2230912 |
LitCoin-GeneOrGeneProduct-v2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-5 | GeneOrGeneProduct | denotes | P2RX7 |
T2 | 338-343 | GeneOrGeneProduct | denotes | P2RX7 |
T3 | 537-541 | GeneOrGeneProduct | denotes | acid |
T4 | 686-691 | GeneOrGeneProduct | denotes | large |
T5 | 763-768 | GeneOrGeneProduct | denotes | major |
T6 | 843-848 | GeneOrGeneProduct | denotes | other |
T7 | 871-876 | GeneOrGeneProduct | denotes | P2RX7 |
T8 | 1085-1089 | GeneOrGeneProduct | denotes | rare |
T9 | 1102-1107 | GeneOrGeneProduct | denotes | P2RX7 |
T10 | 1193-1198 | GeneOrGeneProduct | denotes | other |
T11 | 1232-1237 | GeneOrGeneProduct | denotes | P2RX7 |
LitCoin-GeneOrGeneProduct-v0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-5 | GeneOrGeneProduct | denotes | P2RX7 |
T2 | 338-343 | GeneOrGeneProduct | denotes | P2RX7 |
T3 | 472-482 | GeneOrGeneProduct | denotes | depression |
T4 | 537-541 | GeneOrGeneProduct | denotes | acid |
T5 | 676-685 | GeneOrGeneProduct | denotes | gene in a |
T6 | 686-691 | GeneOrGeneProduct | denotes | large |
T7 | 695-699 | GeneOrGeneProduct | denotes | case |
T8 | 763-768 | GeneOrGeneProduct | denotes | major |
T9 | 769-779 | GeneOrGeneProduct | denotes | depression |
T10 | 843-848 | GeneOrGeneProduct | denotes | other |
T11 | 871-876 | GeneOrGeneProduct | denotes | P2RX7 |
T12 | 1032-1038 | GeneOrGeneProduct | denotes | linked |
T13 | 1085-1089 | GeneOrGeneProduct | denotes | rare |
T14 | 1102-1107 | GeneOrGeneProduct | denotes | P2RX7 |
T15 | 1193-1198 | GeneOrGeneProduct | denotes | other |
T16 | 1232-1237 | GeneOrGeneProduct | denotes | P2RX7 |
LitCoin-Disease-MeSH
Id | Subject | Object | Predicate | Lexical cue | originalLabel |
---|---|---|---|---|---|
T1 | 157-173 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | D001714 |
T2 | 187-200 | DiseaseOrPhenotypicFeature | denotes | mood disorder | D019964 |
T3 | 253-269 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | D001714 |
T4 | 274-290 | DiseaseOrPhenotypicFeature | denotes | Darier's disease | D007644 |
T5 | 442-458 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | D001714 |
T6 | 463-482 | DiseaseOrPhenotypicFeature | denotes | unipolar depression | D003866 |
T7 | 753-762 | DiseaseOrPhenotypicFeature | denotes | recurrent | D012008 |
T8 | 769-779 | DiseaseOrPhenotypicFeature | denotes | depression | DISEASE |
T9 | 909-922 | DiseaseOrPhenotypicFeature | denotes | mood disorder | D019964 |
T10 | 1281-1295 | DiseaseOrPhenotypicFeature | denotes | mood disorders | D019964 |
LitCoin-GeneOrGeneProduct-v3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-5 | GeneOrGeneProduct | denotes | P2RX7 |
T2 | 338-343 | GeneOrGeneProduct | denotes | P2RX7 |
T3 | 871-876 | GeneOrGeneProduct | denotes | P2RX7 |
T4 | 1102-1107 | GeneOrGeneProduct | denotes | P2RX7 |
T5 | 1232-1237 | GeneOrGeneProduct | denotes | P2RX7 |
LitCoin_Mondo_095
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 157-173 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | 0004985 |
T2 | 187-200 | DiseaseOrPhenotypicFeature | denotes | mood disorder | 0005371 |
T3 | 253-269 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | 0004985 |
T4 | 274-290 | DiseaseOrPhenotypicFeature | denotes | Darier's disease | 0007417 |
T5 | 442-458 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | 0004985 |
T6 | 463-482 | DiseaseOrPhenotypicFeature | denotes | unipolar depression | 0012048|0002009 |
T8 | 716-734 | DiseaseOrPhenotypicFeature | denotes | bipolar I disorder | 0001866 |
T9 | 753-779 | DiseaseOrPhenotypicFeature | denotes | recurrent major depression | 0002009 |
T10 | 909-922 | DiseaseOrPhenotypicFeature | denotes | mood disorder | 0005371 |
LitCoin-MeSH-Disease-2
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 9-38 | DiseaseOrPhenotypicFeature | denotes | bipolar and unipolar disorder | DISEASE |
T2 | 157-173 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | D001714 |
T3 | 187-200 | DiseaseOrPhenotypicFeature | denotes | mood disorder | D019964 |
T4 | 253-269 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | D001714 |
T5 | 274-290 | DiseaseOrPhenotypicFeature | denotes | Darier's disease | D007644 |
T6 | 442-458 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | D001714 |
T7 | 463-482 | DiseaseOrPhenotypicFeature | denotes | unipolar depression | D003866 |
T8 | 716-734 | DiseaseOrPhenotypicFeature | denotes | bipolar I disorder | DISEASE |
T9 | 769-779 | DiseaseOrPhenotypicFeature | denotes | depression | DISEASE |
T10 | 909-922 | DiseaseOrPhenotypicFeature | denotes | mood disorder | D019964 |
T11 | 957-985 | DiseaseOrPhenotypicFeature | denotes | bipolar or unipolar disorder | DISEASE |
T12 | 1281-1295 | DiseaseOrPhenotypicFeature | denotes | mood disorders | D019964 |
LitCoin-MONDO_bioort2019
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T1 | 9-38 | DiseaseOrPhenotypicFeature | denotes | bipolar and unipolar disorder | DISEASE |
T2 | 157-173 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | D001714 |
T3 | 187-200 | DiseaseOrPhenotypicFeature | denotes | mood disorder | D019964 |
T4 | 253-269 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | D001714 |
T5 | 274-290 | DiseaseOrPhenotypicFeature | denotes | Darier's disease | D007644 |
T6 | 442-458 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | D001714 |
T7 | 463-482 | DiseaseOrPhenotypicFeature | denotes | unipolar depression | D003866 |
T8 | 716-734 | DiseaseOrPhenotypicFeature | denotes | bipolar I disorder | DISEASE |
T9 | 769-779 | DiseaseOrPhenotypicFeature | denotes | depression | DISEASE |
T10 | 909-922 | DiseaseOrPhenotypicFeature | denotes | mood disorder | D019964 |
T11 | 957-985 | DiseaseOrPhenotypicFeature | denotes | bipolar or unipolar disorder | DISEASE |
T12 | 1281-1295 | DiseaseOrPhenotypicFeature | denotes | mood disorders | D019964 |
LitCoin-training-merged
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T5 | 1232-1237 | GeneOrGeneProduct | denotes | P2RX7 | |
T4 | 1102-1107 | GeneOrGeneProduct | denotes | P2RX7 | |
T3 | 871-876 | GeneOrGeneProduct | denotes | P2RX7 | |
T2 | 338-343 | GeneOrGeneProduct | denotes | P2RX7 | |
T1 | 0-5 | GeneOrGeneProduct | denotes | P2RX7 | |
T12 | 1281-1295 | DiseaseOrPhenotypicFeature | denotes | mood disorders | D019964 |
T11 | 957-985 | DiseaseOrPhenotypicFeature | denotes | bipolar or unipolar disorder | DISEASE |
T10 | 909-922 | DiseaseOrPhenotypicFeature | denotes | mood disorder | D019964 |
T9 | 769-779 | DiseaseOrPhenotypicFeature | denotes | depression | DISEASE |
T8 | 716-734 | DiseaseOrPhenotypicFeature | denotes | bipolar I disorder | DISEASE |
T7 | 463-482 | DiseaseOrPhenotypicFeature | denotes | unipolar depression | D003866 |
T6 | 442-458 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | D001714 |
T77011 | 274-290 | DiseaseOrPhenotypicFeature | denotes | Darier's disease | D007644 |
T62778 | 253-269 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | D001714 |
T19990 | 187-200 | DiseaseOrPhenotypicFeature | denotes | mood disorder | D019964 |
T95280 | 157-173 | DiseaseOrPhenotypicFeature | denotes | bipolar disorder | D001714 |
T59712 | 9-38 | DiseaseOrPhenotypicFeature | denotes | bipolar and unipolar disorder | DISEASE |
T36950 | 1176-1185 | SequenceVariant | denotes | rs2230912 | |
T1780 | 820-829 | SequenceVariant | denotes | rs2230912 | |
T20044 | 555-560 | SequenceVariant | denotes | Q460R | |
T67781 | 507-516 | SequenceVariant | denotes | rs2230912 |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 338-343 | gene:5027 | denotes | P2RX7 |
T1 | 463-482 | disease:C0041696 | denotes | unipolar depression |
T2 | 338-343 | gene:5027 | denotes | P2RX7 |
T3 | 442-458 | disease:C0005586 | denotes | bipolar disorder |
T4 | 871-876 | gene:5027 | denotes | P2RX7 |
T5 | 909-922 | disease:C0525045 | denotes | mood disorder |
T6 | 1232-1237 | gene:5027 | denotes | P2RX7 |
T7 | 1281-1295 | disease:C0525045 | denotes | mood disorders |
R1 | T0 | T1 | associated_with | P2RX7,unipolar depression |
R2 | T2 | T3 | associated_with | P2RX7,bipolar disorder |
R3 | T4 | T5 | associated_with | P2RX7,mood disorder |
R4 | T6 | T7 | associated_with | P2RX7,mood disorders |
DisGeNET5_variant_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
19160446-7#36#45#geners2230912 | 1176-1185 | geners2230912 | denotes | rs2230912 |
19160446-7#141#155#diseaseC0525045 | 1281-1295 | diseaseC0525045 | denotes | mood disorders |
36#45#geners2230912141#155#diseaseC0525045 | 19160446-7#36#45#geners2230912 | 19160446-7#141#155#diseaseC0525045 | associated_with | rs2230912,mood disorders |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
19160446-2#9#14#gene5027 | 338-343 | gene5027 | denotes | P2RX7 |
19160446-2#113#129#diseaseC0005586 | 442-458 | diseaseC0005586 | denotes | bipolar disorder |
19160446-2#134#153#diseaseC0041696 | 463-482 | diseaseC0041696 | denotes | unipolar depression |
19160446-7#92#97#gene5027 | 1232-1237 | gene5027 | denotes | P2RX7 |
19160446-7#141#155#diseaseC0525045 | 1281-1295 | diseaseC0525045 | denotes | mood disorders |
9#14#gene5027113#129#diseaseC0005586 | 19160446-2#9#14#gene5027 | 19160446-2#113#129#diseaseC0005586 | associated_with | P2RX7,bipolar disorder |
9#14#gene5027134#153#diseaseC0041696 | 19160446-2#9#14#gene5027 | 19160446-2#134#153#diseaseC0041696 | associated_with | P2RX7,unipolar depression |
92#97#gene5027141#155#diseaseC0525045 | 19160446-7#92#97#gene5027 | 19160446-7#141#155#diseaseC0525045 | associated_with | P2RX7,mood disorders |