PubMed:19146938 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":161},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":162,"end":180},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":181,"end":440},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":441,"end":463},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":464,"end":572},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":573,"end":719},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":720,"end":728},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":729,"end":876},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":877,"end":1061},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1062,"end":1201},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1202,"end":1213},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1214,"end":1455},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":161},"obj":"Sentence"},{"id":"T2","span":{"begin":162,"end":180},"obj":"Sentence"},{"id":"T3","span":{"begin":181,"end":440},"obj":"Sentence"},{"id":"T4","span":{"begin":441,"end":463},"obj":"Sentence"},{"id":"T5","span":{"begin":464,"end":572},"obj":"Sentence"},{"id":"T6","span":{"begin":573,"end":719},"obj":"Sentence"},{"id":"T7","span":{"begin":720,"end":728},"obj":"Sentence"},{"id":"T8","span":{"begin":729,"end":876},"obj":"Sentence"},{"id":"T9","span":{"begin":877,"end":1061},"obj":"Sentence"},{"id":"T10","span":{"begin":1062,"end":1201},"obj":"Sentence"},{"id":"T11","span":{"begin":1202,"end":1213},"obj":"Sentence"},{"id":"T12","span":{"begin":1214,"end":1455},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease.\nAIM OF THIS STUDY: Aim of the present study is to clarify the effects of yokukansan (TJ-54) on learning and non-cognitive disturbances in the Tg2576 mouse expressing the human form of the APP695SWE (APP-Tg mice), which is considered to be an animal model of Alzheimer's disease.\nMATERIALS AND METHODS: Powdered diets containing 0.5 and 1.0% TJ-54 were given to the mice for 10 months (from 5 to 15 months old). The Morris water-maze test, elevated plus-maze test, and open-field test were performed for evaluation of learning and non-cognitive disturbances.\nRESULTS: Treatment with 1.0% TJ-54 for 5 months shortened the time it took for APP-Tg positive (+) mice to reach the platform in the Morris water-maze test. In the elevated plus-maze test, treatment with 1.0% TJ-54 for 2 months significantly reduced the increased number of entries and the time spent in open arms observed in APP-Tg(+) mice. In an open-field test, treatment of 1.0% TJ-54 for 9 months significantly suppressed the increase in locomotion observed in APP-Tg(+) mice.\nCONCLUSION: These results suggest the possibility that TJ-54 ameliorates learning deficits and non-cognitive defects including a decrease in the anxiety (or disinhibition) and an increase in locomotor activity (hyperactivity) observed in APP-Tg(+) mice."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":1440,"end":1443},"obj":"gene:351"},{"id":"T1","span":{"begin":1347,"end":1354},"obj":"disease:C0003469"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease.\nAIM OF THIS STUDY: Aim of the present study is to clarify the effects of yokukansan (TJ-54) on learning and non-cognitive disturbances in the Tg2576 mouse expressing the human form of the APP695SWE (APP-Tg mice), which is considered to be an animal model of Alzheimer's disease.\nMATERIALS AND METHODS: Powdered diets containing 0.5 and 1.0% TJ-54 were given to the mice for 10 months (from 5 to 15 months old). The Morris water-maze test, elevated plus-maze test, and open-field test were performed for evaluation of learning and non-cognitive disturbances.\nRESULTS: Treatment with 1.0% TJ-54 for 5 months shortened the time it took for APP-Tg positive (+) mice to reach the platform in the Morris water-maze test. In the elevated plus-maze test, treatment with 1.0% TJ-54 for 2 months significantly reduced the increased number of entries and the time spent in open arms observed in APP-Tg(+) mice. In an open-field test, treatment of 1.0% TJ-54 for 9 months significantly suppressed the increase in locomotion observed in APP-Tg(+) mice.\nCONCLUSION: These results suggest the possibility that TJ-54 ameliorates learning deficits and non-cognitive defects including a decrease in the anxiety (or disinhibition) and an increase in locomotor activity (hyperactivity) observed in APP-Tg(+) mice."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"19146938-1#180#183#gene351","span":{"begin":361,"end":364},"obj":"gene351"},{"id":"19146938-1#239#258#diseaseC0002395","span":{"begin":420,"end":439},"obj":"diseaseC0002395"},{"id":"19146938-7#226#229#gene351","span":{"begin":1440,"end":1443},"obj":"gene351"},{"id":"19146938-7#87#104#diseaseC0009241","span":{"begin":1301,"end":1318},"obj":"diseaseC0009241"},{"id":"19146938-7#87#104#diseaseC0338656","span":{"begin":1301,"end":1318},"obj":"diseaseC0338656"},{"id":"19146938-7#133#140#diseaseC0003467","span":{"begin":1347,"end":1354},"obj":"diseaseC0003467"},{"id":"19146938-7#133#140#diseaseC0003469","span":{"begin":1347,"end":1354},"obj":"diseaseC0003469"},{"id":"19146938-7#199#212#diseaseC0424295","span":{"begin":1413,"end":1426},"obj":"diseaseC0424295"}],"relations":[{"id":"180#183#gene351239#258#diseaseC0002395","pred":"associated_with","subj":"19146938-1#180#183#gene351","obj":"19146938-1#239#258#diseaseC0002395"},{"id":"226#229#gene35187#104#diseaseC0009241","pred":"associated_with","subj":"19146938-7#226#229#gene351","obj":"19146938-7#87#104#diseaseC0009241"},{"id":"226#229#gene35187#104#diseaseC0338656","pred":"associated_with","subj":"19146938-7#226#229#gene351","obj":"19146938-7#87#104#diseaseC0338656"},{"id":"226#229#gene351133#140#diseaseC0003467","pred":"associated_with","subj":"19146938-7#226#229#gene351","obj":"19146938-7#133#140#diseaseC0003467"},{"id":"226#229#gene351133#140#diseaseC0003469","pred":"associated_with","subj":"19146938-7#226#229#gene351","obj":"19146938-7#133#140#diseaseC0003469"},{"id":"226#229#gene351199#212#diseaseC0424295","pred":"associated_with","subj":"19146938-7#226#229#gene351","obj":"19146938-7#199#212#diseaseC0424295"}],"text":"Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease.\nAIM OF THIS STUDY: Aim of the present study is to clarify the effects of yokukansan (TJ-54) on learning and non-cognitive disturbances in the Tg2576 mouse expressing the human form of the APP695SWE (APP-Tg mice), which is considered to be an animal model of Alzheimer's disease.\nMATERIALS AND METHODS: Powdered diets containing 0.5 and 1.0% TJ-54 were given to the mice for 10 months (from 5 to 15 months old). The Morris water-maze test, elevated plus-maze test, and open-field test were performed for evaluation of learning and non-cognitive disturbances.\nRESULTS: Treatment with 1.0% TJ-54 for 5 months shortened the time it took for APP-Tg positive (+) mice to reach the platform in the Morris water-maze test. In the elevated plus-maze test, treatment with 1.0% TJ-54 for 2 months significantly reduced the increased number of entries and the time spent in open arms observed in APP-Tg(+) mice. In an open-field test, treatment of 1.0% TJ-54 for 9 months significantly suppressed the increase in locomotion observed in APP-Tg(+) mice.\nCONCLUSION: These results suggest the possibility that TJ-54 ameliorates learning deficits and non-cognitive defects including a decrease in the anxiety (or disinhibition) and an increase in locomotor activity (hyperactivity) observed in APP-Tg(+) mice."}

{"project":"DisGeNet-2017-sample","denotations":[{"id":"T1699","span":{"begin":1440,"end":1443},"obj":"gene:351"},{"id":"T1700","span":{"begin":1301,"end":1318},"obj":"disease:C0009241"},{"id":"T1701","span":{"begin":1347,"end":1354},"obj":"disease:C0003467"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T1699","obj":"T1700"},{"id":"R2","pred":"associated_with","subj":"T1699","obj":"T1700"},{"id":"R3","pred":"associated_with","subj":"T1699","obj":"T1701"},{"id":"R4","pred":"associated_with","subj":"T1699","obj":"T1701"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease.\nAIM OF THIS STUDY: Aim of the present study is to clarify the effects of yokukansan (TJ-54) on learning and non-cognitive disturbances in the Tg2576 mouse expressing the human form of the APP695SWE (APP-Tg mice), which is considered to be an animal model of Alzheimer's disease.\nMATERIALS AND METHODS: Powdered diets containing 0.5 and 1.0% TJ-54 were given to the mice for 10 months (from 5 to 15 months old). The Morris water-maze test, elevated plus-maze test, and open-field test were performed for evaluation of learning and non-cognitive disturbances.\nRESULTS: Treatment with 1.0% TJ-54 for 5 months shortened the time it took for APP-Tg positive (+) mice to reach the platform in the Morris water-maze test. In the elevated plus-maze test, treatment with 1.0% TJ-54 for 2 months significantly reduced the increased number of entries and the time spent in open arms observed in APP-Tg(+) mice. In an open-field test, treatment of 1.0% TJ-54 for 9 months significantly suppressed the increase in locomotion observed in APP-Tg(+) mice.\nCONCLUSION: These results suggest the possibility that TJ-54 ameliorates learning deficits and non-cognitive defects including a decrease in the anxiety (or disinhibition) and an increase in locomotor activity (hyperactivity) observed in APP-Tg(+) mice."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":1029,"end":1033},"obj":"http://purl.obolibrary.org/obo/UBERON_0001460"}],"text":"Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease.\nAIM OF THIS STUDY: Aim of the present study is to clarify the effects of yokukansan (TJ-54) on learning and non-cognitive disturbances in the Tg2576 mouse expressing the human form of the APP695SWE (APP-Tg mice), which is considered to be an animal model of Alzheimer's disease.\nMATERIALS AND METHODS: Powdered diets containing 0.5 and 1.0% TJ-54 were given to the mice for 10 months (from 5 to 15 months old). The Morris water-maze test, elevated plus-maze test, and open-field test were performed for evaluation of learning and non-cognitive disturbances.\nRESULTS: Treatment with 1.0% TJ-54 for 5 months shortened the time it took for APP-Tg positive (+) mice to reach the platform in the Morris water-maze test. In the elevated plus-maze test, treatment with 1.0% TJ-54 for 2 months significantly reduced the increased number of entries and the time spent in open arms observed in APP-Tg(+) mice. In an open-field test, treatment of 1.0% TJ-54 for 9 months significantly suppressed the increase in locomotion observed in APP-Tg(+) mice.\nCONCLUSION: These results suggest the possibility that TJ-54 ameliorates learning deficits and non-cognitive defects including a decrease in the anxiety (or disinhibition) and an increase in locomotor activity (hyperactivity) observed in APP-Tg(+) mice."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":1029,"end":1033},"obj":"http://purl.obolibrary.org/obo/UBERON_0001460"}],"text":"Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease.\nAIM OF THIS STUDY: Aim of the present study is to clarify the effects of yokukansan (TJ-54) on learning and non-cognitive disturbances in the Tg2576 mouse expressing the human form of the APP695SWE (APP-Tg mice), which is considered to be an animal model of Alzheimer's disease.\nMATERIALS AND METHODS: Powdered diets containing 0.5 and 1.0% TJ-54 were given to the mice for 10 months (from 5 to 15 months old). The Morris water-maze test, elevated plus-maze test, and open-field test were performed for evaluation of learning and non-cognitive disturbances.\nRESULTS: Treatment with 1.0% TJ-54 for 5 months shortened the time it took for APP-Tg positive (+) mice to reach the platform in the Morris water-maze test. In the elevated plus-maze test, treatment with 1.0% TJ-54 for 2 months significantly reduced the increased number of entries and the time spent in open arms observed in APP-Tg(+) mice. In an open-field test, treatment of 1.0% TJ-54 for 9 months significantly suppressed the increase in locomotion observed in APP-Tg(+) mice.\nCONCLUSION: These results suggest the possibility that TJ-54 ameliorates learning deficits and non-cognitive defects including a decrease in the anxiety (or disinhibition) and an increase in locomotor activity (hyperactivity) observed in APP-Tg(+) mice."}