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PubMed:19131502 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-76 Sentence denotes Screening for membrane hormone receptor expression in primary aldosteronism.
TextSentencer_T2 77-87 Sentence denotes OBJECTIVE:
TextSentencer_T3 88-240 Sentence denotes The investigation of expression and functional relevance of G-protein coupled receptors in primary aldosteronism (PA) by molecular and clinical studies.
TextSentencer_T4 241-262 Sentence denotes PATIENTS AND METHODS:
TextSentencer_T5 263-506 Sentence denotes Tissues of 14 aldosterone-producing adenomas (APA), of one unilateral adrenal hyperplasia and of six healthy adult adrenal glands; 12 patients with confirmed PA due to APA; (n=5), idiopathic hyperaldosteronism (n=7) and 8 control subjects (C).
TextSentencer_T6 507-680 Sentence denotes The tissues were subjected to a quantitative PCR for determination of mRNA expression levels of AT2R1, GIPR, MC2R, GnRHR, LHR, TRHR, TSHR, glucagon-R, V1aR, V2R, and 5-HT4R.
TextSentencer_T7 681-855 Sentence denotes The patients and controls were enrolled in a test protocol consisting of stimulation by posture, mixed meal, ACTH, GnRH, TRH, glucagon, vasopressin, and metoclopramide (MCP).
TextSentencer_T8 856-905 Sentence denotes Three patients could be analyzed by both studies.
TextSentencer_T9 906-1004 Sentence denotes A positive response was defined as an aldosterone increase of more than 50% following stimulation.
TextSentencer_T10 1005-1013 Sentence denotes RESULTS:
TextSentencer_T11 1014-1085 Sentence denotes All the tissues revealed AT2R1, MC2R, AVPR, and 5-HT4R mRNA expression.
TextSentencer_T12 1086-1146 Sentence denotes LHR mRNA was found in normal adrenals and 13 adrenal tumors.
TextSentencer_T13 1147-1253 Sentence denotes By contrast with normal adrenals tumorous adrenal tissue expressed GnRHR mRNA (4/15) and TSHR mRNA (1/15).
TextSentencer_T14 1254-1336 Sentence denotes Both the patients and controls responded to posture, ACTH, glucagon, AVP, and MCP.
TextSentencer_T15 1337-1441 Sentence denotes Specific responses were seen in one patient following TRH and three patients following GnRH stimulation.
TextSentencer_T16 1442-1454 Sentence denotes CONCLUSIONS:
TextSentencer_T17 1455-1582 Sentence denotes We provide evidence for peptide hormone responsiveness to various peptide hormones in patients with PA, including GnRH and TRH.
TextSentencer_T18 1583-1723 Sentence denotes A good correlation between clinical and molecular testing could be observed, making an involvement of the receptor expressed in PA possible.
T1 0-76 Sentence denotes Screening for membrane hormone receptor expression in primary aldosteronism.
T2 77-87 Sentence denotes OBJECTIVE:
T3 88-240 Sentence denotes The investigation of expression and functional relevance of G-protein coupled receptors in primary aldosteronism (PA) by molecular and clinical studies.
T4 241-262 Sentence denotes PATIENTS AND METHODS:
T5 263-506 Sentence denotes Tissues of 14 aldosterone-producing adenomas (APA), of one unilateral adrenal hyperplasia and of six healthy adult adrenal glands; 12 patients with confirmed PA due to APA; (n=5), idiopathic hyperaldosteronism (n=7) and 8 control subjects (C).
T6 507-680 Sentence denotes The tissues were subjected to a quantitative PCR for determination of mRNA expression levels of AT2R1, GIPR, MC2R, GnRHR, LHR, TRHR, TSHR, glucagon-R, V1aR, V2R, and 5-HT4R.
T7 681-855 Sentence denotes The patients and controls were enrolled in a test protocol consisting of stimulation by posture, mixed meal, ACTH, GnRH, TRH, glucagon, vasopressin, and metoclopramide (MCP).
T8 856-905 Sentence denotes Three patients could be analyzed by both studies.
T9 906-1004 Sentence denotes A positive response was defined as an aldosterone increase of more than 50% following stimulation.
T10 1005-1013 Sentence denotes RESULTS:
T11 1014-1085 Sentence denotes All the tissues revealed AT2R1, MC2R, AVPR, and 5-HT4R mRNA expression.
T12 1086-1146 Sentence denotes LHR mRNA was found in normal adrenals and 13 adrenal tumors.
T13 1147-1253 Sentence denotes By contrast with normal adrenals tumorous adrenal tissue expressed GnRHR mRNA (4/15) and TSHR mRNA (1/15).
T14 1254-1336 Sentence denotes Both the patients and controls responded to posture, ACTH, glucagon, AVP, and MCP.
T15 1337-1441 Sentence denotes Specific responses were seen in one patient following TRH and three patients following GnRH stimulation.
T16 1442-1454 Sentence denotes CONCLUSIONS:
T17 1455-1582 Sentence denotes We provide evidence for peptide hormone responsiveness to various peptide hormones in patients with PA, including GnRH and TRH.
T18 1583-1723 Sentence denotes A good correlation between clinical and molecular testing could be observed, making an involvement of the receptor expressed in PA possible.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1086-1089 gene:3973 denotes LHR
T1 1131-1145 disease:C0001624 denotes adrenal tumors
T2 1086-1089 gene:960 denotes LHR
T3 1131-1145 disease:C0001624 denotes adrenal tumors
R1 T0 T1 associated_with LHR,adrenal tumors
R2 T2 T3 associated_with LHR,adrenal tumors

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
19131502-8#0#3#gene960 1086-1089 gene960 denotes LHR
19131502-8#0#3#gene3973 1086-1089 gene3973 denotes LHR
19131502-8#45#59#diseaseC0001624 1131-1145 diseaseC0001624 denotes adrenal tumors
0#3#gene96045#59#diseaseC0001624 19131502-8#0#3#gene960 19131502-8#45#59#diseaseC0001624 associated_with LHR,adrenal tumors
0#3#gene397345#59#diseaseC0001624 19131502-8#0#3#gene3973 19131502-8#45#59#diseaseC0001624 associated_with LHR,adrenal tumors

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1519 1086-1089 gene:960 denotes LHR
T1520 1131-1145 disease:C0001624 denotes adrenal tumors
R1 T1519 T1520 associated_with LHR,adrenal tumors
R2 T1519 T1520 associated_with LHR,adrenal tumors

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 263-270 http://purl.obolibrary.org/obo/UBERON_0000479 denotes Tissues
PD-UBERON-AE-B_T2 511-518 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T3 1022-1029 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T4 1197-1203 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T5 378-392 http://purl.obolibrary.org/obo/UBERON_0002369 denotes adrenal glands
PD-UBERON-AE-B_T6 386-392 http://purl.obolibrary.org/obo/UBERON_0002530 denotes glands
PD-UBERON-AE-B_T7 1189-1203 http://purl.obolibrary.org/obo/UBERON_0018303 denotes adrenal tissue

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 378-392 http://purl.obolibrary.org/obo/UBERON_0002369 denotes adrenal glands
PD-UBERON-AE-B_T2 386-392 http://purl.obolibrary.org/obo/UBERON_0002530 denotes glands
PD-UBERON-AE-B_T3 263-270 http://purl.obolibrary.org/obo/UBERON_0000479 denotes Tissues
PD-UBERON-AE-B_T4 511-518 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T5 1022-1029 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T6 1197-1203 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T7 1189-1203 http://purl.obolibrary.org/obo/UBERON_0018303 denotes adrenal tissue