PubMed:19119312 JSONTXT

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{"project":"DisGeNET5_gene_disease","denotations":[{"id":"19119312-1#22#27#gene672","span":{"begin":77,"end":82},"obj":"gene672"},{"id":"19119312-1#59#74#diseaseC0029925","span":{"begin":114,"end":129},"obj":"diseaseC0029925"},{"id":"19119312-1#59#74#diseaseC1140680","span":{"begin":114,"end":129},"obj":"diseaseC1140680"}],"relations":[{"id":"22#27#gene67259#74#diseaseC0029925","pred":"associated_with","subj":"19119312-1#22#27#gene672","obj":"19119312-1#59#74#diseaseC0029925"},{"id":"22#27#gene67259#74#diseaseC1140680","pred":"associated_with","subj":"19119312-1#22#27#gene672","obj":"19119312-1#59#74#diseaseC1140680"}],"text":"BRCA1, hormone, and tissue-specific tumor suppression.\nGermline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability."}

{"project":"DisGeNet-2017-sample","denotations":[{"id":"T1361","span":{"begin":77,"end":82},"obj":"gene:672"},{"id":"T1362","span":{"begin":114,"end":129},"obj":"disease:C0029925"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T1361","obj":"T1362"},{"id":"R2","pred":"associated_with","subj":"T1361","obj":"T1362"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"BRCA1, hormone, and tissue-specific tumor suppression.\nGermline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":20,"end":26},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":166,"end":172},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":103,"end":109},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"}],"text":"BRCA1, hormone, and tissue-specific tumor suppression.\nGermline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":20,"end":26},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":166,"end":172},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":103,"end":109},"obj":"http://purl.obolibrary.org/obo/UBERON_0000310"}],"text":"BRCA1, hormone, and tissue-specific tumor suppression.\nGermline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability."}