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PubMed:1911548 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 71-77 gene:1437 denotes GM-CSF
T1 164-185 disease:C0023493 denotes human T-cell leukemia
R1 T0 T1 associated_with GM-CSF,human T-cell leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 2-16 protein denotes nuclear factor
T2 17-23 protein denotes NF-GM2
T3 46-63 DNA denotes regulatory region
T4 71-82 DNA denotes GM-CSF gene
T5 170-203 cell_line denotes T-cell leukemia line Jurkat cells
T6 222-232 protein denotes NF-kappa B
T7 248-255 cell_type denotes T cells
T8 268-274 protein denotes lectin
T9 407-418 protein denotes lymphokines
T10 430-478 protein denotes granulocyte-macrophage colony-stimulating factor
T11 480-486 protein denotes GM-CSF
T12 533-548 DNA denotes upstream region
T13 556-577 DNA denotes mouse GM-CSF promoter
T14 599-610 DNA denotes -95 and -73
T15 707-725 DNA denotes DNA-binding motifs
T16 727-730 DNA denotes GM2
T17 735-741 DNA denotes GC-box
T18 747-759 DNA denotes GM2 sequence
T19 793-816 protein denotes inducible factor NF-GM2
T20 840-860 protein denotes constitutive factors
T21 861-863 protein denotes A1
T22 865-867 protein denotes A2
T23 873-874 protein denotes B
T24 906-912 protein denotes GM-CSF
T25 951-974 protein denotes inducible factor NF-GM2
T26 1014-1026 cell_line denotes Jurkat cells
T27 1087-1093 protein denotes NF-GM2
T28 1110-1113 protein denotes p50
T29 1127-1130 protein denotes p65
T30 1194-1200 protein denotes GM-CSF
T31 1205-1248 DNA denotes immunoglobulin kappa (GGAAAGTCCC) enhancers
T32 1279-1282 protein denotes p50
T33 1300-1319 protein denotes protein-DNA complex
T34 1341-1344 protein denotes p50
T35 1376-1379 protein denotes p65
T36 1392-1406 protein denotes NF-GM2 complex
T37 1421-1424 protein denotes p65
T38 1459-1478 protein denotes protein-DNA complex
T39 1517-1531 protein denotes NF-GM2 complex
T40 1567-1571 protein denotes KBF1
T41 1586-1611 protein denotes 50 kDa NF-kappa B protein
T42 1630-1633 protein denotes p50
T43 1637-1643 protein denotes NF-GM2
T44 1665-1683 protein denotes NF-GM2 polypeptide
T45 1734-1748 protein denotes 50 kDa subunit
T46 1752-1762 protein denotes NF-kappa B
T47 1777-1783 protein denotes NF-GM2
T48 1826-1842 DNA denotes kappa B enhancer
T49 1896-1911 DNA denotes GM-CSF promoter
T50 1991-2002 DNA denotes GM-CSF gene
T51 2015-2034 DNA denotes GM2/GC-box sequence
T52 2080-2096 DNA denotes kappa B enhancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
1911548-0#71#77#gene1437 71-77 gene1437 denotes GM-CSF
1911548-0#164#185#diseaseC0023493 164-185 diseaseC0023493 denotes human T-cell leukemia
71#77#gene1437164#185#diseaseC0023493 1911548-0#71#77#gene1437 1911548-0#164#185#diseaseC0023493 associated_with GM-CSF,human T-cell leukemia

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-233 Sentence denotes A nuclear factor NF-GM2 that interacts with a regulatory region of the GM-CSF gene essential for its induction in responses to T-cell activation: purification from human T-cell leukemia line Jurkat cells and similarity to NF-kappa B.
S2 234-488 Sentence denotes Activation of T cells by antigen, lectin, or a combination of phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) leads to the induction of genes for a set of lymphokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF).
S3 489-681 Sentence denotes We demonstrated in earlier studies that the upstream region of the mouse GM-CSF promoter at positions between -95 and -73 is essential for transcriptional activation in response to PMA/A23187.
S4 682-742 Sentence denotes This region contains two DNA-binding motifs, GM2 and GC-box.
S5 743-875 Sentence denotes The GM2 sequence (GGTAGTTCCC) is recognized by an inducible factor NF-GM2; the other (CCGCCC) by constitutive factors A1, A2, and B.
S6 876-1073 Sentence denotes To elucidate the mechanism of GM-CSF gene activation, we have purified the inducible factor NF-GM2 from the nuclear extract of stimulated Jurkat cells on the basis of specific DNA-binding activity.
S7 1074-1249 Sentence denotes The purified NF-GM2 consists of 50 (p50) and 65 kDa (p65) polypeptides and has a binding activity specific for both the GM-CSF and immunoglobulin kappa (GGAAAGTCCC) enhancers.
S8 1250-1407 Sentence denotes Electrophoretically purified p50 alone can form a protein-DNA complex, but in the mixture, p50 associates preferentially with p65 to form the NF-GM2 complex.
S9 1408-1532 Sentence denotes In addition, p65 gave per se, with low affinity, a protein-DNA complex that migrated more slowly than native NF-GM2 complex.
S10 1533-1763 Sentence denotes Furthermore, an antiserum against KBF1 (identical to 50 kDa NF-kappa B protein) reacted with the p50 of NF-GM2, indicating that the NF-GM2 polypeptide cannot be immunologically differentiated from the 50 kDa subunit of NF-kappa B.
S11 1764-1939 Sentence denotes The purified NF-GM2 activated in vitro transcription from the kappa B enhancer, while it failed to stimulate transcription from the GM-CSF promoter harboring the GM2 sequence.
S12 1940-2103 Sentence denotes This suggests that the activation mechanism of the GM-CSF gene through the GM2/GC-box sequence is different from that of genes carrying the kappa B enhancer alone.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-23 NP denotes A nuclear factor NF-GM2
C2 24-28 NP denotes that
C3 67-82 NP denotes the GM-CSF gene
C4 97-100 NP denotes its
C6 127-133 NP denotes T-cell
C5 127-144 NP denotes T-cell activation
C7 191-203 NP denotes Jurkat cells
C8 222-232 NP denotes NF-kappa B
C10 248-255 NP denotes T cells
C9 234-255 NP denotes Activation of T cells
C11 296-361 NP denotes phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187)
C12 430-487 NP denotes granulocyte-macrophage colony-stimulating factor (GM-CSF)
C15 562-568 NP denotes GM-CSF
C14 552-577 NP denotes the mouse GM-CSF promoter
C13 529-610 NP denotes the upstream region of the mouse GM-CSF promoter at positions between -95 and -73
C16 670-680 NP denotes PMA/A23187
C17 682-693 NP denotes This region
C18 703-725 NP denotes two DNA-binding motifs
C20 727-730 NP denotes GM2
C21 735-741 NP denotes GC-box
C19 727-741 NP denotes GM2 and GC-box
C23 747-750 NP denotes GM2
C22 743-772 NP denotes The GM2 sequence (GGTAGTTCCC)
C24 790-816 NP denotes an inducible factor NF-GM2
C26 822-827 NP denotes other
C25 818-836 NP denotes the other (CCGCCC)
C28 906-917 NP denotes GM-CSF gene
C27 889-928 NP denotes the mechanism of GM-CSF gene activation
C29 947-974 NP denotes the inducible factor NF-GM2
C30 1014-1026 NP denotes Jurkat cells
C31 1074-1093 NP denotes The purified NF-GM2
C32 1109-1114 NP denotes (p50)
C33 1126-1131 NP denotes (p65)
C34 1190-1200 NP denotes the GM-CSF
C35 1250-1282 NP denotes Electrophoretically purified p50
C36 1298-1319 NP denotes a protein-DNA complex
C37 1341-1344 NP denotes p50
C38 1376-1379 NP denotes p65
C40 1392-1398 NP denotes NF-GM2
C39 1388-1406 NP denotes the NF-GM2 complex
C41 1421-1424 NP denotes p65
C42 1457-1478 NP denotes a protein-DNA complex
C43 1479-1483 NP denotes that
C45 1517-1523 NP denotes NF-GM2
C44 1510-1531 NP denotes native NF-GM2 complex
C46 1626-1633 NP denotes the p50
C47 1637-1643 NP denotes NF-GM2
C48 1752-1762 NP denotes NF-kappa B
C49 1764-1783 NP denotes The purified NF-GM2
C50 1822-1842 NP denotes the kappa B enhancer
C51 1850-1852 NP denotes it
C53 1896-1902 NP denotes GM-CSF
C52 1892-1911 NP denotes the GM-CSF promoter
C55 1926-1929 NP denotes GM2
C54 1922-1938 NP denotes the GM2 sequence
C57 1959-1983 NP denotes the activation mechanism
C58 1987-2002 NP denotes the GM-CSF gene
C56 1959-2002 NP denotes the activation mechanism of the GM-CSF gene
C59 2015-2018 NP denotes GM2
C61 2019-2025 NP denotes GC-box
C60 2019-2034 NP denotes GC-box sequence
C62 2053-2057 NP denotes that
C63 2076-2096 NP denotes the kappa B enhancer
R1 C2 C1 coref-relat that,A nuclear factor NF-GM2
R2 C4 C1 coref-pron its,A nuclear factor NF-GM2
R3 C7 C6 coref-ident Jurkat cells,T-cell
R4 C10 C7 coref-ident T cells,Jurkat cells
R5 C9 C5 coref-ident Activation of T cells,T-cell activation
R6 C12 C3 coref-ident granulocyte-macrophage colony-stimulating factor (GM-CSF),the GM-CSF gene
R7 C15 C12 coref-ident GM-CSF,granulocyte-macrophage colony-stimulating factor (GM-CSF)
R8 C16 C11 coref-ident PMA/A23187,phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187)
R9 C17 C13 coref-ident This region,the upstream region of the mouse GM-CSF promoter at positions between -95 and -73
R10 C18 C19 coref-appos two DNA-binding motifs,GM2 and GC-box
R11 C23 C20 coref-ident GM2,GM2
R12 C24 C1 coref-ident an inducible factor NF-GM2,A nuclear factor NF-GM2
R13 C26 C21 coref-ident other,GC-box
R14 C28 C15 coref-ident GM-CSF gene,GM-CSF
R15 C29 C24 coref-ident the inducible factor NF-GM2,an inducible factor NF-GM2
R16 C30 C10 coref-ident Jurkat cells,T cells
R17 C31 C29 coref-other The purified NF-GM2,the inducible factor NF-GM2
R18 C34 C28 coref-ident the GM-CSF,GM-CSF gene
R19 C35 C32 coref-other Electrophoretically purified p50,(p50)
R20 C37 C32 coref-ident p50,(p50)
R21 C38 C33 coref-ident p65,(p65)
R22 C40 C29 coref-ident NF-GM2,the inducible factor NF-GM2
R23 C41 C38 coref-ident p65,p65
R24 C42 C36 coref-ident a protein-DNA complex,a protein-DNA complex
R25 C43 C42 coref-relat that,a protein-DNA complex
R26 C45 C40 coref-ident NF-GM2,NF-GM2
R27 C44 C39 coref-ident native NF-GM2 complex,the NF-GM2 complex
R28 C46 C37 coref-ident the p50,p50
R29 C47 C45 coref-ident NF-GM2,NF-GM2
R30 C48 C8 coref-ident NF-kappa B,NF-kappa B
R31 C49 C31 coref-ident The purified NF-GM2,The purified NF-GM2
R32 C51 C49 coref-pron it,The purified NF-GM2
R33 C53 C34 coref-ident GM-CSF,the GM-CSF
R34 C52 C14 coref-ident the GM-CSF promoter,the mouse GM-CSF promoter
R35 C55 C23 coref-ident GM2,GM2
R36 C54 C22 coref-ident the GM2 sequence,The GM2 sequence (GGTAGTTCCC)
R37 C58 C53 coref-ident the GM-CSF gene,GM-CSF
R38 C56 C27 coref-ident the activation mechanism of the GM-CSF gene,the mechanism of GM-CSF gene activation
R39 C59 C55 coref-ident GM2,GM2
R40 C61 C26 coref-ident GC-box,other
R41 C60 C25 coref-ident GC-box sequence,the other (CCGCCC)
R42 C62 C57 coref-pron that,the activation mechanism
R43 C63 C50 coref-ident the kappa B enhancer,the kappa B enhancer

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 2-16 protein_family_or_group denotes nuclear factor
T2 17-23 protein_molecule denotes NF-GM2
T3 46-63 DNA_domain_or_region denotes regulatory region
T4 71-82 DNA_domain_or_region denotes GM-CSF gene
T5 170-190 cell_line denotes T-cell leukemia line
T6 191-203 cell_line denotes Jurkat cells
T7 222-232 protein_molecule denotes NF-kappa B
T8 248-255 cell_type denotes T cells
T9 268-274 protein_family_or_group denotes lectin
T10 296-324 other_organic_compound denotes phorbol-12-myristate acetate
T11 326-329 other_organic_compound denotes PMA
T12 335-352 other_organic_compound denotes calcium ionophore
T13 354-360 other_organic_compound denotes A23187
T14 407-418 protein_family_or_group denotes lymphokines
T15 430-478 protein_molecule denotes granulocyte-macrophage colony-stimulating factor
T16 480-486 protein_molecule denotes GM-CSF
T17 533-548 DNA_domain_or_region denotes upstream region
T18 556-561 DNA_domain_or_region denotes mouse
T19 562-568 protein_molecule denotes GM-CSF
T20 599-610 DNA_domain_or_region denotes -95 and -73
T21 628-654 other_name denotes transcriptional activation
T22 670-680 other_organic_compound denotes PMA/A23187
T23 707-725 DNA_domain_or_region denotes DNA-binding motifs
T24 727-730 DNA_domain_or_region denotes GM2
T25 735-741 DNA_domain_or_region denotes GC-box
T26 747-759 DNA_domain_or_region denotes GM2 sequence
T27 761-771 polynucleotide denotes GGTAGTTCCC
T28 793-816 protein_molecule denotes inducible factor NF-GM2
T29 829-835 polynucleotide denotes CCGCCC
T30 840-860 protein_family_or_group denotes constitutive factors
T31 861-863 protein_molecule denotes A1
T32 865-867 protein_molecule denotes A2
T33 873-874 protein_molecule denotes B
T34 906-912 protein_molecule denotes GM-CSF
T35 951-974 protein_molecule denotes inducible factor NF-GM2
T36 1014-1026 cell_line denotes Jurkat cells
T37 1043-1072 other_name denotes specific DNA-binding activity
T38 1087-1093 protein_molecule denotes NF-GM2
T39 1110-1113 protein_subunit denotes p50
T40 1127-1130 protein_subunit denotes p65
T41 1194-1200 protein_molecule denotes GM-CSF
T42 1205-1227 DNA_domain_or_region denotes immunoglobulin kappa (
T43 1227-1237 polynucleotide denotes GGAAAGTCCC
T44 1279-1282 protein_subunit denotes p50
T45 1300-1319 protein_complex denotes protein-DNA complex
T46 1341-1344 protein_subunit denotes p50
T47 1376-1379 protein_subunit denotes p65
T48 1392-1406 protein_complex denotes NF-GM2 complex
T49 1421-1424 protein_subunit denotes p65
T50 1459-1478 protein_complex denotes protein-DNA complex
T51 1517-1531 protein_complex denotes NF-GM2 complex
T52 1567-1571 protein_molecule denotes KBF1
T53 1586-1611 protein_molecule denotes 50 kDa NF-kappa B protein
T54 1630-1633 protein_subunit denotes p50
T55 1637-1643 protein_molecule denotes NF-GM2
T56 1665-1683 protein_molecule denotes NF-GM2 polypeptide
T57 1734-1748 protein_subunit denotes 50 kDa subunit
T58 1752-1762 protein_molecule denotes NF-kappa B
T59 1777-1783 protein_molecule denotes NF-GM2
T60 1797-1816 other_name denotes vitro transcription
T61 1826-1842 DNA_domain_or_region denotes kappa B enhancer
T62 1896-1911 DNA_domain_or_region denotes GM-CSF promoter
T63 1926-1938 DNA_substructure denotes GM2 sequence
T64 1991-1997 protein_molecule denotes GM-CSF
T65 2015-2034 DNA_domain_or_region denotes GM2/GC-box sequence
T66 2080-2096 DNA_domain_or_region denotes kappa B enhancer