PubMed:19112106
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 988-996 | Cell | denotes | PG cells | http://purl.obolibrary.org/obo/CL:4033066 |
silkwormbase
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 35-46 | Species:7091 | denotes | Bombyx mori |
| T10 | 423-428 | Chemical:MESH:D008055 | denotes | lipid |
| T11 | 460-470 | Chemical:MESH:D005227 | denotes | fatty acid |
| T12 | 501-505 | Gene:100174941 | denotes | FATP |
| T13 | 839-850 | Species:7091 | denotes | Bombyx mori |
| T14 | 866-872 | Gene:100174941 | denotes | BmFATP |
| T15 | 980-987 | Species:7091 | denotes | B. mori |
| T16 | 1020-1025 | Chemical:MESH:D008055 | denotes | lipid |
| T17 | 1106-1116 | Chemical:MESH:D005227 | denotes | fatty acid |
| T18 | 1132-1147 | Chemical:MESH:D014280 | denotes | triacylglycerol |
| T19 | 1181-1187 | Gene:100174941 | denotes | BmFATP |
| T2 | 47-75 | Gene:100174941 | denotes | fatty acid transport protein |
| T20 | 1268-1284 | Chemical:MESH:D014280 | denotes | triacylglycerols |
| T21 | 1328-1336 | Chemical:MESH:C006787 | denotes | bombykol |
| T22 | 1402-1408 | Gene:100174941 | denotes | BmFATP |
| T23 | 1448-1470 | Chemical:- | denotes | long-chain fatty acids |
| T24 | 1475-1481 | Gene:100174941 | denotes | BmFATP |
| T25 | 1563-1569 | Gene:100174941 | denotes | BmFATP |
| T26 | 1659-1674 | Chemical:MESH:D014280 | denotes | triacylglycerol |
| T27 | 1767-1778 | Chemical:MESH:D005227 | denotes | fatty acids |
| T3 | 77-83 | Gene:100174941 | denotes | BmFATP |
| T4 | 122-150 | Gene:100174941 | denotes | Fatty acid transport protein |
| T5 | 152-156 | Gene:100174941 | denotes | FATP |
| T6 | 257-279 | Chemical:- | denotes | long chain fatty acids |
| T7 | 284-290 | Species:9606 | denotes | humans |
| T8 | 295-299 | Species:10090 | denotes | mice |
| T9 | 305-309 | Gene:26457 | denotes | FATP |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-121 | Sentence | denotes | Functional characterization of the Bombyx mori fatty acid transport protein (BmFATP) within the silkmoth pheromone gland. |
| T2 | 122-280 | Sentence | denotes | Fatty acid transport protein (FATP) is an evolutionarily conserved membrane-bound protein that facilitates the uptake of extracellular long chain fatty acids. |
| T3 | 281-478 | Sentence | denotes | In humans and mice, six FATP isoforms have been identified and their tissue-specific distributions suggest that each plays a discrete role in lipid metabolism in association with fatty acid uptake. |
| T4 | 479-599 | Sentence | denotes | While the presence of FATP homologs in insects has been demonstrated, their functional role remains to be characterized. |
| T5 | 600-778 | Sentence | denotes | Pheromonogenesis is defined as the dynamic period in which all machinery required for sex pheromone biosynthesis is generated and organized within the pheromone gland (PG) cells. |
| T6 | 779-962 | Sentence | denotes | By exploiting this unique system in the PG of the silkmoth, Bombyx mori, we found that BmFATP is predominantly expressed in the PG and undergoes up-regulation 1 day prior to eclosion. |
| T7 | 963-1148 | Sentence | denotes | Before eclosion, B. mori PG cells accumulate cytoplasmic lipid droplets (LDs), which play a role in storing the pheromone (bombykol) precursor fatty acid in the form of triacylglycerol. |
| T8 | 1149-1348 | Sentence | denotes | RNAi-mediated gene silencing of BmFATP in vivo significantly suppressed LD accumulation by preventing the synthesis of triacylglycerols and resulted in a significant reduction in bombykol production. |
| T9 | 1349-1837 | Sentence | denotes | These results, in conjunction with the findings that BmFATP stimulates the uptake of extracellular long-chain fatty acids and BmFATP knockdown reduces cellular long-chain acyl-CoA synthetase activity, suggest that BmFATP plays an essential role in bombykol biosynthesis by stimulating both LD accumulation and triacylglycerol synthesis via a process called vectorial acylation that couples the uptake of extracellular fatty acids with activation to CoA thioesters during pheromonogenesis. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 115-120 | http://purl.obolibrary.org/obo/MAT_0000021 | denotes | gland |
| T2 | 761-766 | http://purl.obolibrary.org/obo/MAT_0000021 | denotes | gland |
silkworm
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 35-46 | Species:7091 | denotes | Bombyx mori |
| T2 | 47-75 | Gene:100174941 | denotes | fatty acid transport protein |
| T3 | 77-83 | Gene:100174941 | denotes | BmFATP |
| T4 | 122-150 | Gene:100174941 | denotes | Fatty acid transport protein |
| T5 | 152-156 | Gene:100174941 | denotes | FATP |
| T6 | 257-279 | Chemical:- | denotes | long chain fatty acids |
| T7 | 284-290 | Species:9606 | denotes | humans |
| T8 | 295-299 | Species:10090 | denotes | mice |
| T9 | 305-309 | Gene:26457 | denotes | FATP |
| T10 | 423-428 | Chemical:MESH:D008055 | denotes | lipid |
| T11 | 460-470 | Chemical:MESH:D005227 | denotes | fatty acid |
| T12 | 501-505 | Gene:100174941 | denotes | FATP |
| T13 | 839-850 | Species:7091 | denotes | Bombyx mori |
| T14 | 866-872 | Gene:100174941 | denotes | BmFATP |
| T15 | 980-987 | Species:7091 | denotes | B. mori |
| T16 | 1020-1025 | Chemical:MESH:D008055 | denotes | lipid |
| T17 | 1106-1116 | Chemical:MESH:D005227 | denotes | fatty acid |
| T18 | 1132-1147 | Chemical:MESH:D014280 | denotes | triacylglycerol |
| T19 | 1181-1187 | Gene:100174941 | denotes | BmFATP |
| T20 | 1268-1284 | Chemical:MESH:D014280 | denotes | triacylglycerols |
| T21 | 1328-1336 | Chemical:MESH:C006787 | denotes | bombykol |
| T22 | 1402-1408 | Gene:100174941 | denotes | BmFATP |
| T23 | 1448-1470 | Chemical:- | denotes | long-chain fatty acids |
| T24 | 1475-1481 | Gene:100174941 | denotes | BmFATP |
| T25 | 1563-1569 | Gene:100174941 | denotes | BmFATP |
| T26 | 1659-1674 | Chemical:MESH:D014280 | denotes | triacylglycerol |
| T27 | 1767-1778 | Chemical:MESH:D005227 | denotes | fatty acids |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 115-120 | Body_part | denotes | gland | http://purl.obolibrary.org/obo/MAT_0000021 |
| T2 | 761-766 | Body_part | denotes | gland | http://purl.obolibrary.org/obo/MAT_0000021 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 35-46 | OrganismTaxon | denotes | Bombyx mori | 7091 |
| T2 | 96-104 | OrganismTaxon | denotes | silkmoth | 7091 |
| T3 | 295-299 | OrganismTaxon | denotes | mice | 10088 |
| T4 | 829-837 | OrganismTaxon | denotes | silkmoth | 7091 |
| T5 | 839-850 | OrganismTaxon | denotes | Bombyx mori | 7091 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 115-120 | Body_part | denotes | gland | http://purl.obolibrary.org/obo/UBERON_0002530 |
| T2 | 189-197 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T5 | 243-256 | Body_part | denotes | extracellular | http://purl.obolibrary.org/obo/GO_0005576 |
| T6 | 350-356 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T7 | 761-766 | Body_part | denotes | gland | http://purl.obolibrary.org/obo/UBERON_0002530 |
| T8 | 1008-1019 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
| T9 | 1434-1447 | Body_part | denotes | extracellular | http://purl.obolibrary.org/obo/GO_0005576 |
| T10 | 1753-1766 | Body_part | denotes | extracellular | http://purl.obolibrary.org/obo/GO_0005576 |