PubMed:19109131
Annnotations
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 14-32 | DiseaseOrPhenotypicFeature | denotes | autoimmune disease | 0007179 |
| T2 | 73-84 | DiseaseOrPhenotypicFeature | denotes | sensitivity | 0000605 |
| T3 | 101-106 | DiseaseOrPhenotypicFeature | denotes | lupus | 0004670 |
| T4 | 189-217 | DiseaseOrPhenotypicFeature | denotes | systemic lupus erythematosus | 0007915 |
| T5 | 219-222 | DiseaseOrPhenotypicFeature | denotes | SLE | 0007915 |
| T6 | 363-366 | DiseaseOrPhenotypicFeature | denotes | SLE | 0007915 |
| T7 | 371-391 | DiseaseOrPhenotypicFeature | denotes | rheumatoid arthritis | 0008383 |
| T8 | 500-503 | DiseaseOrPhenotypicFeature | denotes | SLE | 0007915 |
| T9 | 688-691 | DiseaseOrPhenotypicFeature | denotes | SLE | 0007915 |
| T10 | 800-811 | DiseaseOrPhenotypicFeature | denotes | sensitivity | 0000605 |
| T11 | 864-867 | DiseaseOrPhenotypicFeature | denotes | SLE | 0007915 |
| T12 | 983-994 | DiseaseOrPhenotypicFeature | denotes | sensitivity | 0000605 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-124 | Sentence | denotes | Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo. |
| TextSentencer_T2 | 125-224 | Sentence | denotes | Increased IFN-alpha signaling is a primary pathogenic factor in systemic lupus erythematosus (SLE). |
| TextSentencer_T3 | 225-392 | Sentence | denotes | STAT4 is a transcription factor that is activated by IFN-alpha signaling, and genetic variation of STAT4 has been associated with risk of SLE and rheumatoid arthritis. |
| TextSentencer_T4 | 393-511 | Sentence | denotes | We measured serum IFN-alpha activity and simultaneous IFN-alpha-induced gene expression in PBMC in a large SLE cohort. |
| TextSentencer_T5 | 512-709 | Sentence | denotes | The risk variant of STAT4 (T allele; rs7574865) was simultaneously associated with both lower serum IFN-alpha activity and greater IFN-alpha-induced gene expression in PBMC in SLE patients in vivo. |
| TextSentencer_T6 | 710-835 | Sentence | denotes | Regression analyses confirmed that the risk allele of STAT4 was associated with increased sensitivity to IFN-alpha signaling. |
| TextSentencer_T7 | 836-1022 | Sentence | denotes | The IFN regulatory factor 5 SLE risk genotype was associated with higher serum IFN-alpha activity; however, STAT4 showed dominant influence on the sensitivity of PBMC to serum IFN-alpha. |
| TextSentencer_T8 | 1023-1124 | Sentence | denotes | These data provide biologic relevance for the risk variant of STAT4 in the IFN-alpha pathway in vivo. |
| T1 | 0-124 | Sentence | denotes | Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo. |
| T2 | 125-224 | Sentence | denotes | Increased IFN-alpha signaling is a primary pathogenic factor in systemic lupus erythematosus (SLE). |
| T3 | 225-392 | Sentence | denotes | STAT4 is a transcription factor that is activated by IFN-alpha signaling, and genetic variation of STAT4 has been associated with risk of SLE and rheumatoid arthritis. |
| T4 | 393-511 | Sentence | denotes | We measured serum IFN-alpha activity and simultaneous IFN-alpha-induced gene expression in PBMC in a large SLE cohort. |
| T5 | 512-709 | Sentence | denotes | The risk variant of STAT4 (T allele; rs7574865) was simultaneously associated with both lower serum IFN-alpha activity and greater IFN-alpha-induced gene expression in PBMC in SLE patients in vivo. |
| T6 | 710-835 | Sentence | denotes | Regression analyses confirmed that the risk allele of STAT4 was associated with increased sensitivity to IFN-alpha signaling. |
| T7 | 836-1022 | Sentence | denotes | The IFN regulatory factor 5 SLE risk genotype was associated with higher serum IFN-alpha activity; however, STAT4 showed dominant influence on the sensitivity of PBMC to serum IFN-alpha. |
| T8 | 1023-1124 | Sentence | denotes | These data provide biologic relevance for the risk variant of STAT4 in the IFN-alpha pathway in vivo. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 49-54 | gene:6775 | denotes | STAT4 |
| T1 | 101-106 | disease:C0024138 | denotes | lupus |
| T2 | 49-54 | gene:6775 | denotes | STAT4 |
| T3 | 101-106 | disease:C0409974 | denotes | lupus |
| T4 | 49-54 | gene:6775 | denotes | STAT4 |
| T5 | 101-106 | disease:C0024141 | denotes | lupus |
| T6 | 49-54 | gene:6775 | denotes | STAT4 |
| T7 | 101-106 | disease:C0024131 | denotes | lupus |
| T8 | 49-54 | gene:6775 | denotes | STAT4 |
| T9 | 14-32 | disease:C0004364 | denotes | autoimmune disease |
| T10 | 219-230 | gene:6775 | denotes | SLE). STAT4 |
| T11 | 363-366 | disease:C0024141 | denotes | SLE |
| T12 | 324-329 | gene:6775 | denotes | STAT4 |
| T13 | 371-391 | disease:C0003873 | denotes | rheumatoid arthritis |
| T14 | 324-329 | gene:6775 | denotes | STAT4 |
| T15 | 363-366 | disease:C0024141 | denotes | SLE |
| T16 | 219-230 | gene:6775 | denotes | SLE). STAT4 |
| T17 | 371-391 | disease:C0003873 | denotes | rheumatoid arthritis |
| T18 | 532-537 | gene:6775 | denotes | STAT4 |
| T19 | 688-691 | disease:C0024141 | denotes | SLE |
| T20 | 840-843 | gene:3447 | denotes | IFN |
| T21 | 864-867 | disease:C0024141 | denotes | SLE |
| T22 | 944-949 | gene:6775 | denotes | STAT4 |
| T23 | 864-867 | disease:C0024141 | denotes | SLE |
| T24 | 840-843 | gene:3439 | denotes | IFN |
| T25 | 864-867 | disease:C0024141 | denotes | SLE |
| R1 | T0 | T1 | associated_with | STAT4,lupus |
| R2 | T2 | T3 | associated_with | STAT4,lupus |
| R3 | T4 | T5 | associated_with | STAT4,lupus |
| R4 | T6 | T7 | associated_with | STAT4,lupus |
| R5 | T8 | T9 | associated_with | STAT4,autoimmune disease |
| R6 | T10 | T11 | associated_with | SLE). STAT4,SLE |
| R7 | T12 | T13 | associated_with | STAT4,rheumatoid arthritis |
| R8 | T14 | T15 | associated_with | STAT4,SLE |
| R9 | T16 | T17 | associated_with | SLE). STAT4,rheumatoid arthritis |
| R10 | T18 | T19 | associated_with | STAT4,SLE |
| R11 | T20 | T21 | associated_with | IFN,SLE |
| R12 | T22 | T23 | associated_with | STAT4,SLE |
| R13 | T24 | T25 | associated_with | IFN,SLE |
DisGeNET5_variant_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 19109131-4#37#46#geners7574865 | 549-558 | geners7574865 | denotes | rs7574865 |
| 19109131-4#176#179#diseaseC0024141 | 688-691 | diseaseC0024141 | denotes | SLE |
| 37#46#geners7574865176#179#diseaseC0024141 | 19109131-4#37#46#geners7574865 | 19109131-4#176#179#diseaseC0024141 | associated_with | rs7574865,SLE |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 19109131-0#49#54#gene6775 | 49-54 | gene6775 | denotes | STAT4 |
| 19109131-0#49#54#gene6775 | 49-54 | gene6775 | denotes | STAT4 |
| 19109131-0#101#106#diseaseC0024131 | 101-106 | diseaseC0024131 | denotes | lupus |
| 19109131-0#101#106#diseaseC0024138 | 101-106 | diseaseC0024138 | denotes | lupus |
| 19109131-0#101#106#diseaseC0024141 | 101-106 | diseaseC0024141 | denotes | lupus |
| 19109131-0#101#106#diseaseC0409974 | 101-106 | diseaseC0409974 | denotes | lupus |
| 19109131-0#14#32#diseaseC0004364 | 14-32 | diseaseC0004364 | denotes | autoimmune disease |
| 19109131-2#0#5#gene6775 | 225-230 | gene6775 | denotes | STAT4 |
| 19109131-2#99#104#gene6775 | 324-329 | gene6775 | denotes | STAT4 |
| 19109131-2#146#166#diseaseC0003873 | 371-391 | diseaseC0003873 | denotes | rheumatoid arthritis |
| 19109131-6#4#7#gene3439 | 840-843 | gene3439 | denotes | IFN |
| 19109131-6#4#7#gene3447 | 840-843 | gene3447 | denotes | IFN |
| 19109131-6#28#31#diseaseC0024141 | 864-867 | diseaseC0024141 | denotes | SLE |
| 49#54#gene6775101#106#diseaseC0024131 | 19109131-0#49#54#gene6775 | 19109131-0#101#106#diseaseC0024131 | associated_with | STAT4,lupus |
| 49#54#gene6775101#106#diseaseC0024138 | 19109131-0#49#54#gene6775 | 19109131-0#101#106#diseaseC0024138 | associated_with | STAT4,lupus |
| 49#54#gene6775101#106#diseaseC0024141 | 19109131-0#49#54#gene6775 | 19109131-0#101#106#diseaseC0024141 | associated_with | STAT4,lupus |
| 49#54#gene6775101#106#diseaseC0409974 | 19109131-0#49#54#gene6775 | 19109131-0#101#106#diseaseC0409974 | associated_with | STAT4,lupus |
| 49#54#gene677514#32#diseaseC0004364 | 19109131-0#49#54#gene6775 | 19109131-0#14#32#diseaseC0004364 | associated_with | STAT4,autoimmune disease |
| 49#54#gene6775101#106#diseaseC0024131 | 19109131-0#49#54#gene6775 | 19109131-0#101#106#diseaseC0024131 | associated_with | STAT4,lupus |
| 49#54#gene6775101#106#diseaseC0024138 | 19109131-0#49#54#gene6775 | 19109131-0#101#106#diseaseC0024138 | associated_with | STAT4,lupus |
| 49#54#gene6775101#106#diseaseC0024141 | 19109131-0#49#54#gene6775 | 19109131-0#101#106#diseaseC0024141 | associated_with | STAT4,lupus |
| 49#54#gene6775101#106#diseaseC0409974 | 19109131-0#49#54#gene6775 | 19109131-0#101#106#diseaseC0409974 | associated_with | STAT4,lupus |
| 49#54#gene677514#32#diseaseC0004364 | 19109131-0#49#54#gene6775 | 19109131-0#14#32#diseaseC0004364 | associated_with | STAT4,autoimmune disease |
| 0#5#gene6775146#166#diseaseC0003873 | 19109131-2#0#5#gene6775 | 19109131-2#146#166#diseaseC0003873 | associated_with | STAT4,rheumatoid arthritis |
| 99#104#gene6775146#166#diseaseC0003873 | 19109131-2#99#104#gene6775 | 19109131-2#146#166#diseaseC0003873 | associated_with | STAT4,rheumatoid arthritis |
| 4#7#gene343928#31#diseaseC0024141 | 19109131-6#4#7#gene3439 | 19109131-6#28#31#diseaseC0024141 | associated_with | IFN,SLE |
| 4#7#gene344728#31#diseaseC0024141 | 19109131-6#4#7#gene3447 | 19109131-6#28#31#diseaseC0024141 | associated_with | IFN,SLE |
DisGeNet-2017-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2846 | 49-54 | gene:6775 | denotes | STAT4 |
| T2847 | 101-106 | disease:C0024131 | denotes | lupus |
| T2848 | 840-843 | gene:3439 | denotes | IFN |
| T2849 | 864-867 | disease:C0024141 | denotes | SLE |
| R1 | T2846 | T2847 | associated_with | STAT4,lupus |
| R2 | T2846 | T2847 | associated_with | STAT4,lupus |
| R3 | T2846 | T2847 | associated_with | STAT4,lupus |
| R4 | T2846 | T2847 | associated_with | STAT4,lupus |
| R5 | T2848 | T2849 | associated_with | IFN,SLE |
| R6 | T2848 | T2849 | associated_with | IFN,SLE |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 405-410 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
| PD-UBERON-AE-B_T2 | 606-611 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
| PD-UBERON-AE-B_T3 | 909-914 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
| PD-UBERON-AE-B_T4 | 1006-1011 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 405-410 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
| PD-UBERON-AE-B_T2 | 606-611 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
| PD-UBERON-AE-B_T3 | 909-914 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
| PD-UBERON-AE-B_T4 | 1006-1011 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |