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PubMed:1909740 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-81 Sentence denotes Tumor necrosis factor-alpha mRNA accumulation in human myelomonocytic cell lines.
T2 82-163 Sentence denotes Role of transcriptional regulation by DNA sequence motifs and mRNA stabilization.
T3 164-257 Sentence denotes The cytokine TNF mediates many of the pathologic signs of cachexia, inflammation, and sepsis.
T4 258-364 Sentence denotes The current work describes the regulation of TNF in human myelomonocytic cell lines after PMA stimulation.
T5 365-436 Sentence denotes The cell lines exhibit a low level of constitutive TNF mRNA expression.
T6 437-565 Sentence denotes Within 2 to 4 h of PMA exposure, steady state levels of TNF mRNA are markedly elevated in all myelomonocytic cell lines studied.
T7 566-725 Sentence denotes This rise is due to increased mRNA stability, which increased by almost twofold, and to an overall increase in transcription, which rises by more than sixfold.
T8 726-900 Sentence denotes At the level of the genomic TNF gene, a DNase I hypersensitive site is detected within the TNF promoter between -200 to -100 bp relative to the transcription initiation site.
T9 901-1068 Sentence denotes Although absent in nonexpressing erythroleukemia cell lines, the DNase I site is present in uninduced myelomonocytic cell lines and is not changed after PMA induction.
T10 1069-1247 Sentence denotes The PMA induction of c-fos mRNA correlated well with TNF gene induction; expression of genes encoding other proteins in the AP-1 complex (junB and junD) were also induced by PMA.
T11 1248-1418 Sentence denotes The nuclear extracts from resting and induced ML-1 cells contain proteins binding specifically to the AP-1, AP-2, and NF kappa B sequence located within the TNF promoter.
T12 1419-1525 Sentence denotes PMA induction increases the level of a number of specific binding complexes relative to the resting cells.
T13 1526-1600 Sentence denotes The regulatory mechanisms of the human and murine TNF genes are discussed.
T1 0-81 Sentence denotes Tumor necrosis factor-alpha mRNA accumulation in human myelomonocytic cell lines.
T2 82-163 Sentence denotes Role of transcriptional regulation by DNA sequence motifs and mRNA stabilization.
T3 164-257 Sentence denotes The cytokine TNF mediates many of the pathologic signs of cachexia, inflammation, and sepsis.
T4 258-364 Sentence denotes The current work describes the regulation of TNF in human myelomonocytic cell lines after PMA stimulation.
T5 365-436 Sentence denotes The cell lines exhibit a low level of constitutive TNF mRNA expression.
T6 437-565 Sentence denotes Within 2 to 4 h of PMA exposure, steady state levels of TNF mRNA are markedly elevated in all myelomonocytic cell lines studied.
T7 566-725 Sentence denotes This rise is due to increased mRNA stability, which increased by almost twofold, and to an overall increase in transcription, which rises by more than sixfold.
T8 726-900 Sentence denotes At the level of the genomic TNF gene, a DNase I hypersensitive site is detected within the TNF promoter between -200 to -100 bp relative to the transcription initiation site.
T9 901-1068 Sentence denotes Although absent in nonexpressing erythroleukemia cell lines, the DNase I site is present in uninduced myelomonocytic cell lines and is not changed after PMA induction.
T10 1069-1247 Sentence denotes The PMA induction of c-fos mRNA correlated well with TNF gene induction; expression of genes encoding other proteins in the AP-1 complex (junB and junD) were also induced by PMA.
T11 1248-1418 Sentence denotes The nuclear extracts from resting and induced ML-1 cells contain proteins binding specifically to the AP-1, AP-2, and NF kappa B sequence located within the TNF promoter.
T12 1419-1525 Sentence denotes PMA induction increases the level of a number of specific binding complexes relative to the resting cells.
T13 1526-1600 Sentence denotes The regulatory mechanisms of the human and murine TNF genes are discussed.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-32 RNA denotes Tumor necrosis factor-alpha mRNA
T2 49-80 cell_line denotes human myelomonocytic cell lines
T3 120-139 DNA denotes DNA sequence motifs
T4 168-176 protein denotes cytokine
T5 177-180 protein denotes TNF
T6 303-306 protein denotes TNF
T7 310-341 cell_line denotes human myelomonocytic cell lines
T8 369-379 cell_line denotes cell lines
T9 416-424 RNA denotes TNF mRNA
T10 493-501 RNA denotes TNF mRNA
T11 531-556 cell_line denotes myelomonocytic cell lines
T12 746-762 DNA denotes genomic TNF gene
T13 766-793 DNA denotes DNase I hypersensitive site
T14 817-829 DNA denotes TNF promoter
T15 870-899 DNA denotes transcription initiation site
T16 920-960 cell_line denotes nonexpressing erythroleukemia cell lines
T17 966-978 DNA denotes DNase I site
T18 993-1028 cell_line denotes uninduced myelomonocytic cell lines
T19 1090-1100 RNA denotes c-fos mRNA
T20 1122-1125 protein denotes TNF
T21 1193-1205 protein denotes AP-1 complex
T22 1207-1211 protein denotes junB
T23 1216-1220 protein denotes junD
T24 1286-1304 cell_line denotes induced ML-1 cells
T25 1350-1385 DNA denotes AP-1, AP-2, and NF kappa B sequence
T26 1405-1417 DNA denotes TNF promoter
T27 1468-1494 protein denotes specific binding complexes
T28 1511-1524 cell_type denotes resting cells
T29 1559-1585 DNA denotes human and murine TNF genes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-81 Sentence denotes Tumor necrosis factor-alpha mRNA accumulation in human myelomonocytic cell lines.
S2 82-163 Sentence denotes Role of transcriptional regulation by DNA sequence motifs and mRNA stabilization.
S3 164-257 Sentence denotes The cytokine TNF mediates many of the pathologic signs of cachexia, inflammation, and sepsis.
S4 258-364 Sentence denotes The current work describes the regulation of TNF in human myelomonocytic cell lines after PMA stimulation.
S5 365-436 Sentence denotes The cell lines exhibit a low level of constitutive TNF mRNA expression.
S6 437-565 Sentence denotes Within 2 to 4 h of PMA exposure, steady state levels of TNF mRNA are markedly elevated in all myelomonocytic cell lines studied.
S7 566-725 Sentence denotes This rise is due to increased mRNA stability, which increased by almost twofold, and to an overall increase in transcription, which rises by more than sixfold.
S8 726-900 Sentence denotes At the level of the genomic TNF gene, a DNase I hypersensitive site is detected within the TNF promoter between -200 to -100 bp relative to the transcription initiation site.
S9 901-1068 Sentence denotes Although absent in nonexpressing erythroleukemia cell lines, the DNase I site is present in uninduced myelomonocytic cell lines and is not changed after PMA induction.
S10 1069-1247 Sentence denotes The PMA induction of c-fos mRNA correlated well with TNF gene induction; expression of genes encoding other proteins in the AP-1 complex (junB and junD) were also induced by PMA.
S11 1248-1418 Sentence denotes The nuclear extracts from resting and induced ML-1 cells contain proteins binding specifically to the AP-1, AP-2, and NF kappa B sequence located within the TNF promoter.
S12 1419-1525 Sentence denotes PMA induction increases the level of a number of specific binding complexes relative to the resting cells.
S13 1526-1600 Sentence denotes The regulatory mechanisms of the human and murine TNF genes are discussed.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 0-27 NP denotes Tumor necrosis factor-alpha
C1 0-32 NP denotes Tumor necrosis factor-alpha mRNA
C3 49-80 NP denotes human myelomonocytic cell lines
C4 303-306 NP denotes TNF
C5 310-341 NP denotes human myelomonocytic cell lines
C6 365-379 NP denotes The cell lines
C8 493-496 NP denotes TNF
C7 493-501 NP denotes TNF mRNA
C9 527-556 NP denotes all myelomonocytic cell lines
C10 586-610 NP denotes increased mRNA stability
C11 612-617 NP denotes which
C12 654-690 NP denotes an overall increase in transcription
C13 692-697 NP denotes which
C14 764-793 NP denotes a DNase I hypersensitive site
C16 817-820 NP denotes TNF
C15 813-829 NP denotes the TNF promoter
C17 962-978 NP denotes the DNase I site
C18 993-1028 NP denotes uninduced myelomonocytic cell lines
C20 1054-1057 NP denotes PMA
C19 1054-1067 NP denotes PMA induction
C22 1073-1076 NP denotes PMA
C21 1069-1086 NP denotes The PMA induction
C23 1243-1246 NP denotes PMA
C25 1405-1408 NP denotes TNF
C24 1401-1417 NP denotes the TNF promoter
C27 1419-1422 NP denotes PMA
C26 1419-1432 NP denotes PMA induction
R1 C4 C2 coref-ident TNF,Tumor necrosis factor-alpha
R2 C5 C3 coref-ident human myelomonocytic cell lines,human myelomonocytic cell lines
R3 C6 C5 coref-ident The cell lines,human myelomonocytic cell lines
R4 C8 C4 coref-ident TNF,TNF
R5 C7 C1 coref-ident TNF mRNA,Tumor necrosis factor-alpha mRNA
R6 C9 C6 coref-ident all myelomonocytic cell lines,The cell lines
R7 C11 C10 coref-relat which,increased mRNA stability
R8 C13 C12 coref-relat which,an overall increase in transcription
R9 C16 C8 coref-ident TNF,TNF
R10 C17 C14 coref-ident the DNase I site,a DNase I hypersensitive site
R11 C18 C9 coref-other uninduced myelomonocytic cell lines,all myelomonocytic cell lines
R12 C22 C20 coref-ident PMA,PMA
R13 C21 C19 coref-ident The PMA induction,PMA induction
R14 C23 C22 coref-ident PMA,PMA
R15 C25 C16 coref-ident TNF,TNF
R16 C24 C15 coref-ident the TNF promoter,the TNF promoter
R17 C27 C23 coref-ident PMA,PMA
R18 C26 C21 coref-ident PMA induction,The PMA induction

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-32 RNA_family_or_group denotes Tumor necrosis factor-alpha mRNA
T2 49-80 cell_line denotes human myelomonocytic cell lines
T3 90-116 other_name denotes transcriptional regulation
T4 120-139 DNA_domain_or_region denotes DNA sequence motifs
T5 144-162 other_name denotes mRNA stabilization
T6 168-176 protein_family_or_group denotes cytokine
T7 177-180 protein_molecule denotes TNF
T8 222-230 other_name denotes cachexia
T9 232-244 other_name denotes inflammation
T10 250-256 other_name denotes sepsis
T11 303-306 protein_molecule denotes TNF
T12 310-341 cell_line denotes human myelomonocytic cell lines
T13 348-351 other_organic_compound denotes PMA
T14 369-379 cell_line denotes cell lines
T15 416-419 protein_molecule denotes TNF
T16 456-459 other_organic_compound denotes PMA
T17 493-496 protein_molecule denotes TNF
T18 531-556 cell_line denotes myelomonocytic cell lines
T19 596-610 other_name denotes mRNA stability
T20 677-690 other_name denotes transcription
T21 746-753 DNA_domain_or_region denotes genomic
T22 754-757 protein_molecule denotes TNF
T23 766-793 DNA_domain_or_region denotes DNase I hypersensitive site
T24 817-820 protein_molecule denotes TNF
T25 838-853 DNA_substructure denotes -200 to -100 bp
T26 870-899 DNA_domain_or_region denotes transcription initiation site
T27 920-960 cell_line denotes nonexpressing erythroleukemia cell lines
T28 966-978 DNA_domain_or_region denotes DNase I site
T29 993-1028 cell_line denotes uninduced myelomonocytic cell lines
T30 1054-1057 other_organic_compound denotes PMA
T31 1073-1076 other_organic_compound denotes PMA
T32 1090-1100 RNA_molecule denotes c-fos mRNA
T33 1122-1125 protein_molecule denotes TNF
T34 1193-1205 protein_complex denotes AP-1 complex
T35 1207-1211 protein_molecule denotes junB
T36 1216-1220 protein_molecule denotes junD
T37 1243-1246 other_organic_compound denotes PMA
T38 1252-1268 cell_component denotes nuclear extracts
T39 1286-1304 cell_line denotes induced ML-1 cells
T40 1405-1408 protein_molecule denotes TNF
T41 1419-1422 other_organic_compound denotes PMA
T42 1468-1494 protein_complex denotes specific binding complexes
T43 1511-1524 cell_type denotes resting cells
T44 1530-1551 other_name denotes regulatory mechanisms